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https://www.readbyqxmd.com/read/29781963/comorbidities-and-mobility-in-lower-limb-prosthesis-users
#1
Shane R Wurdeman, Phillip M Stevens, James H Campbell
OBJECTIVE: To determine the impact of comorbidities on mobility in patients with lower limb prostheses. DESIGN: Cohort database chart review examining mobility in lower limb prosthesis users grouped according to comorbidities. Regression models were used to determine significant predictor comorbidities for mobility. General linear univariate models were implemented to investigate differences in mobility among cohorts (n=596). RESULTS: Patient age and history of stroke, peripheral vascular disease, and anxiety/panic disorders were predictors of decreased mobility...
May 17, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29780024/the-neutrophil-mobilizing-cytokine-interleukin-26-in-the-airways-of-long-term-tobacco-smokers
#2
Karlhans Fru Che, Ellen Tufvesson, Sara Tengvall, Elisa Lappi-Blanco, Riitta Kaarteenaho, Bettina Levänen, Marie Ekberg, Annelie Brauner, Åsa M Wheelock, Leif Bjermer, C Magnus Sköld, Anders Lindén
Long-term tobacco smokers with chronic obstructive pulmonary disease (COPD) or chronic bronchitis display an excessive accumulation of neutrophils in the airways; an inflammation that responds poorly to established therapy. Thus, there is a need to identify new molecular targets for the development of effective therapy. Here, we hypothesized that the neutrophil-mobilizing cytokine interleukin (IL)-26 (IL-26) is involved in airway inflammation amongst long-term tobacco smokers with or without COPD, chronic bronchitis or colonization by pathogenic bacteria...
May 23, 2018: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29779389/-prevalence-and-severity-of-chronic-parodontitis-and-oral-mucosal-lesions-in-chronic-obstructive-lung-disease
#3
Ágnes Bán, Zsolt Ferenc Németh, Adrienn Szauter, Szilvia Soós, Márta Balaskó
INTRODUCTION: Chronic parodontitis is a prevalent oral disease that may lead to the loss of teeth independently of caries. Some systemic diseases (e.g., diabetes mellitus, chronic renal failure) may aggravate chronic parodontitis. On the other hand, this oral disease may aggravate other systemic diseases. Earlier studies suggested a correlation between chronic parodontitis and very severe chronic obstructive pulmonary disease (COPD). AIM: The aim of our study was the investigation of the correlation between chronic parodontitis and chronic obstructive pulmonary disease...
May 2018: Orvosi Hetilap
https://www.readbyqxmd.com/read/29764800/mindfulness-based-symptom-and-stress-management-apps-for-adults-with-chronic-lung-disease-systematic-search-in-app-stores
#4
REVIEW
Otis L Owens, Jenay M Beer, Ligia I Reyes, David G Gallerani, Amanda R Myhren-Bennett, Karen K McDonnell
BACKGROUND: Up to 70% of lung cancer survivors are affected by chronic obstructive pulmonary disease (COPD), a common, debilitating, comorbid disease. Lung cancer and COPD are both characterized by symptoms such as breathlessness, fatigue, and psychological distress. These distressing chronic symptoms are exacerbated by stress and detract from an individual's quality of life. OBJECTIVE: The aim of this study was to identify and evaluate evidence-based, commercially available apps for promoting mindfulness-based strategies among adults with a COPD or lung cancer history (ie, chronic lung disease)...
May 15, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29736245/pharmacological-properties-of-revefenacin-td-4208-a-novel-nebulized-long-acting-and-lung-selective-muscarinic-antagonist-at-human-recombinant-muscarinic-receptors-and-in-rat-guinea-pig-and-human-isolated-airway-tissues
#5
Sharath S Hegde, M Teresa Pulido-Rios, Mark A Luttmann, James J Foley, Gerald E Hunsberger, Tod Steinfeld, TaeWeon Lee, Yuhua Ji, Mathai M Mammen, Jeffrey R Jasper
Revefenacin (TD-4208) is a novel, long-acting, and lung-selective muscarinic cholinergic receptor (mAChR) antagonist in development as a nebulized inhalation solution for the treatment of chronic obstructive pulmonary disease (COPD) patients. This study evaluated the pharmacology of revefenacin at human recombinant mAChRs and in airway tissues from rats, guinea pigs, and humans. At human recombinant mAChRs, revefenacin displayed high affinity (pKI  = 8.2-9.8) and behaved as a competitive antagonist (pKI, apparent = 9...
June 2018: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/29731655/immune-regulating-effects-of-exercise-on-cigarette-smoke-induced-inflammation
#6
REVIEW
Ashkan Madani, Katharina Alack, Manuel Jonas Richter, Karsten Krüger
Long-term cigarette smoking (LTCS) represents an important risk factor for cardiac infarction and stroke and the central risk factor for the development of a bronchial carcinoma, smoking-associated interstitial lung fibrosis, and chronic obstructive pulmonary disease. The pathophysiologic development of these diseases is suggested to be promoted by chronic and progressive inflammation. Cigarette smoking induces repetitive inflammatory insults followed by a chronic and progressive activation of the immune system...
2018: Journal of Inflammation Research
https://www.readbyqxmd.com/read/29729133/impact-of-multiple-chronic-conditions-on-activity-limitations-among-older-mexican-american-care-recipients
#7
Diane M Collins, Brian Downer, Amit Kumar, Shilpa Krishnan, Chih-Ying Li, Kyriakos S Markides, Amol M Karmarkar
INTRODUCTION: Older Mexican Americans are living longer with multiple chronic conditions (MCCs). This has placed greater demands on caregivers to assist with basic activities of daily living (ADL) or instrumental activities of daily living (IADL). To understand the needs of older Mexican-American care recipients, we examined the impact of MCC on ADL and IADL limitations. METHODS: We analyzed data from 485 Mexican American care-receiving/caregiving dyads. Selected MCCs in the analysis were diabetes, hypertension, stroke, heart disease, arthritis, emphysema/chronic obstructive pulmonary disease, cognitive impairment, depression, and cancer...
May 3, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29715295/mobility-limitations-related-to-reduced-pulmonary-function-among-aging-people-with-chronic-obstructive-pulmonary-disease
#8
Francesc Medina-Mirapeix, Roberto Bernabeu-Mora, Mª Piedad Sánchez-Martínez, Joaquina Montilla-Herrador, Myriam Bernabeu-Mora, Pilar Escolar-Reina
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a major cause of disability. We aimed to analyse the impact of reduced pulmonary function on non-respiratory impairments and mobility activity limitations in an elderly population with COPD and to elucidate which specific limitations on mobility are related to reduced pulmonary function. METHODS: Cross-sectional study of 110 patients with COPD, recruited from public and university hospital. The effect of impaired pulmonary function on the risk of non-respiratory impairments and mobility limitations was analysed using validated measures, including: the 6-Minute Walk Test (6MWT), skeletal muscle strength, the Short Physical Performance Battery (SPPB), and self-reported mobility questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29670673/pm2-5-induced-the-expression-of-fibrogenic-mediators-via-hmgb1-rage-signaling-in-human-airway-epithelial-cells
#9
Weifeng Zou, Fang He, Sha Liu, Jinding Pu, Jinxing Hu, Qing Sheng, Tao Zhu, Tianhua Zhu, Bing Li, Pixin Ran
Background: The aim of the present study was to test whether fine particulate matter (PM2.5) induces the expression of platelet-derived growth factor-AB (PDGF-AB), PDGF-BB, and transforming growth factor- β 1 (TGF- β 1) in human bronchial epithelial cells (HBECs) in vitro via high-mobility group box 1 (HMGB1) receptor for advanced glycation end products (RAGE) signaling. Methods: Sprague-Dawley rats were exposed to motor vehicle exhaust (MVE) or clean air. HBECs were either transfected with a small interfering RNA (siRNA) targeting HMGB1 or incubated with anti-RAGE antibodies and subsequently stimulated with PM2...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29643055/findings-of-the-chronic-obstructive-pulmonary-disease-sitting-and-exacerbations-trial-copd-seat-in-reducing-sedentary-time-using-wearable-and-mobile-technologies-with-educational-support-randomized-controlled-feasibility-trial
#10
Mark W Orme, Amie E Weedon, Paula M Saukko, Dale W Esliger, Mike D Morgan, Michael C Steiner, John W Downey, Lauren B Sherar, Sally J Singh
BACKGROUND: Targeting sedentary time post exacerbation may be more relevant than targeting structured exercise for individuals with chronic obstructive pulmonary disease. Focusing interventions on sitting less and moving more after an exacerbation may act as a stepping stone to increase uptake to pulmonary rehabilitation. OBJECTIVE: The aim of this paper was to conduct a randomized trial examining trial feasibility and the acceptability of an education and self-monitoring intervention using wearable technology to reduce sedentary behavior for individuals with chronic obstructive pulmonary disease admitted to hospital for an acute exacerbation...
April 11, 2018: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/29604964/selective-inhibition-of-histamine-evoked-ca-2-signals-by-compartmentalized-camp-in-human-bronchial-airway-smooth-muscle-cells
#11
Philippa Dale, Victoria Head, Mark R Dowling, Colin W Taylor
Intracellular Ca2+ and cAMP typically cause opposing effects on airway smooth muscle contraction. Receptors that stimulate these pathways are therapeutic targets in asthma and chronic obstructive pulmonary disease. However, the interactions between different G protein-coupled receptors (GPCRs) that evoke cAMP and Ca2+ signals in human bronchial airway smooth muscle cells (hBASMCs) are poorly understood. We measured Ca2+ signals in cultures of fluo-4-loaded hBASMCs alongside measurements of intracellular cAMP using mass spectrometry or [3 H]-adenine labeling...
May 2018: Cell Calcium
https://www.readbyqxmd.com/read/29581847/mandatory-role-of-hmga1-in-human-airway-epithelial-normal-differentiation-and-post-injury-regeneration
#12
Haijun Zhang, Jing Yang, Matthew S Walters, Michelle R Staudt, Yael Strulovici-Barel, Jacqueline Salit, Jason G Mezey, Philip L Leopold, Ronald G Crystal
Due to high levels of expression in aggressive tumors, high mobility group AT-hook 1 (HMGA1) has recently attracted attention as a potential anti-tumor target. However, HMGA1 is also expressed in normal somatic progenitor cells, raising the question: how might systemic anti-HMGA1 therapies affect the structure and function of normal tissue differentiation? In the present study, RNA sequencing data demonstrated HMGA1 is highly expressed in human airway basal stem/progenitor cells (BC), but decreases with BC differentiation in air-liquid interface cultures (ALI)...
March 6, 2018: Oncotarget
https://www.readbyqxmd.com/read/29558756/evaluation-and-exploration-on-the-effect-of-the-management-of-chronic-obstructive-pulmonary-disease-in-rural-areas-through-internet-based-network-consulting-room-br-br
#13
Yan Yan, Li Liu, Jing Zeng, Liang Zhang
OBJECTIVE: This study aims to improve the management quality of chronic obstructive pulmonary disease (COPD) in rural areas. METHODS: Two hundred forty discharged COPD patients were divided into an intervention group and a control group. In the intervention group, 120 patients established contact with doctors through the network consulting room, namely doctor's mobile platform, and were managed through video, voice, and text by the doctors, and kept in close contact with the doctors after discharge (education, consultation), and received electronic prescriptions, and drugs were sent to the door by online retailers...
March 20, 2018: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/29549456/quality-of-life-and-life-satisfaction-are-severely-impaired-in-patients-with-long-term-invasive-ventilation-following-icu-treatment-and-unsuccessful-weaning
#14
Sophie Emilia Huttmann, Friederike Sophie Magnet, Christian Karagiannidis, Jan Hendrik Storre, Wolfram Windisch
BACKGROUND: Health-related quality of life (HRQL), life satisfaction, living conditions, patients' attitudes towards life and death, expectations, beliefs and unmet needs are all poorly understood aspects associated with patients receiving invasive home mechanical ventilation (HMV) following ICU treatment and unsuccessful weaning. Therefore, the present study aimed to assess (1) HRQL, (2) life satisfaction and (3) patients' perspectives on life and death associated with invasive HMV as the consequence of unsuccessful weaning...
March 16, 2018: Annals of Intensive Care
https://www.readbyqxmd.com/read/29545694/effect-of-increased-functional-residual-capacity-on-the-active-range-of-thoracic-axial-rotation-in-healthy-young-men
#15
Akira Kubo, Masahiro Ishizaka, Yoshiki Takeuchi, Keita Shimura
[Purpose] To understand the effect of increased functional residual capacity (FRC) on the active range of thoracic axial rotation (AROTAR) in healthy young men. [Subjects and Methods] Thirty-nine right-handed healthy male volunteers (age=20.1 ± 1.6 years) participated in this study. A standard plastic goniometer was used to measure the AROTAR in the supine position with both glenohumeral joints fully flexed. AROTAR was recorded at the resting expiration level (REL) and for 4 different FRC levels: 500, 1,000, 1,500, and 2,000 ml air inhaled at REL...
February 2018: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29538536/comparison-of-diaphragmatic-mobility-between-copd-patients-with-and-without-thoracic-hyperkyphosis-a-cross-sectional-study
#16
Márcia Aparecida Gonçalves, Bruna Estima Leal, Liseane Gonçalves Lisboa, Michelle Gonçalves de Souza Tavares, Wellington Pereira Yamaguti, Elaine Paulin
OBJECTIVE: To compare diaphragmatic mobility, lung function, and respiratory muscle strength between COPD patients with and without thoracic hyperkyphosis; to determine the relationship of thoracic kyphosis angle with diaphragmatic mobility, lung function, and respiratory muscle strength in COPD patients; and to compare diaphragmatic mobility and thoracic kyphosis between male and female patients with COPD. METHODS: Participants underwent anthropometry, spirometry, thoracic kyphosis measurement, and evaluation of diaphragmatic mobility...
January 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29424188/revolving-door-respiratory-patients-a-rehabilitative-perspective
#17
Massimiliano Polastri, Lara Pisani, Andrea Dell'Amore, Stefano Nava
Rehabilitation is an integral component of care for patients affected by either acute or chronic pulmonary diseases. The key elements of rehabilitation treatment for critical respiratory patients are as follows: weaning from mechanical ventilation, respiratory therapy, physical reconditioning, and occupational therapy. It should be noted that patients affected by pulmonary diseases are prone to hospital re-admission due to frequent exacerbations, especially in cases with more severe stages of chronic obstructive pulmonary disease...
September 22, 2017: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/29402358/-effect-of-early-mobilization-on-diaphragmatic-function-in-patients-with-mechanical-ventilation-a-prospective-randomized-controlled-study
#18
Shengqiang Yang, Jinggang Liu, Wenbao Yang, Jiyin Yuan, Suqiu Meng, Maoling Liang, Qibiao Shi
OBJECTIVE: To investigate the effect of early mobilization on diaphragmatic function in patients with mechanical ventilation (MV). METHODS: Sixty chronic obstructive pulmonary disease with acute exacerbation (AECOPD) patients with respiratory failure (RF) and underwent MV admitted to intensive care unit (ICU) of Huxi Affiliated Hospital of Jining Medical College from January 2016 to January 2017 were enrolled. The patients were divided into treatment group (n = 30) and control group (n = 30) by randomly number table method...
February 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29258735/the-effects-of-inspiratory-muscle-training-based-on-the-perceptions-of-patients-with-advanced-lung-disease-a-qualitative-study
#19
Mariana Hoffman, Marcella G Assis, Valéria Maria Augusto, Bruna Mara F Silveira, Verônica F Parreira
BACKGROUND: Advanced lung disease is a chronic non-neoplastic disease that compromises activities of daily living. Treatment includes pulmonary rehabilitation and inspiratory muscle training. Studies have shown the effectiveness of inspiratory muscle training in lung disease patients, but literature is scarce on the patients' perceptions about this topic. OBJECTIVE: To explore the perceptions of patients with advanced lung disease about inspiratory muscle training...
December 8, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/29247229/salford-lung-study-in-chronic-obstructive-pulmonary-disease-sls-copd-follow-up-interviews-on-patient-centred-outcomes
#20
Lynda Doward, Henrik Svedsater, Diane Whalley, Rebecca Crawford, David Leather, James Lay-Flurrie, Nick Bosanquet
This study investigated patient perceptions, experiences and management of COPD throughout the SLS COPD study. Follow-up interviews were conducted with 400 patients who completed SLS COPD; a mixed-methods approach was used to collect quantitative and qualitative information. Structured interviews using closed-ended questions were conducted with 360 patients, detailing aspects of background/lifestyle information and COPD. Extended interviews containing open-ended questions on perceptions of COPD and quality of life (QoL) in addition to the closed-ended questions were completed by 40 further patients...
December 15, 2017: NPJ Primary Care Respiratory Medicine
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