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copd mobile

Rafael Mesquita, Frits M E Franssen, Sarah Houben-Wilke, Nicole H M K Uszko-Lencer, Lowie E G W Vanfleteren, Yvonne M J Goërtz, Fabio Pitta, Emiel F M Wouters, Martijn A Spruit
BACKGROUND: It remains unknown whether and to what extent impaired left ventricular ejection fraction (LVEF) affects physical and psychological status in COPD. We aimed to compare health outcome measures between COPD patients with and without impaired LVEF after adjusting for age, sex, BMI and FEV1. METHODS: Impaired LVEF was defined as values <50%. 85 COPD patients with impaired LVEF and 85 COPD patients with normal LVEF were matched for sex, age, BMI and FEV1...
October 11, 2016: International Journal of Cardiology
Joseph M Czerniecki, Aaron P Turner, Rhonda M Williams, Mary Lou Thompson, Greg Landry, Kevin Hakimi, Rebecca Speckman, Daniel C Norvell
OBJECTIVE: The objective of this study was the development of AMPREDICT-Mobility, a tool to predict the probability of independence in either basic or advanced (iBASIC or iADVANCED) mobility 1 year after dysvascular major lower extremity amputation. METHODS: Two prospective cohort studies during consecutive 4-year periods (2005-2009 and 2010-2014) were conducted at seven medical centers. Multiple demographic and biopsychosocial predictors were collected in the periamputation period among individuals undergoing their first major amputation because of complications of peripheral arterial disease or diabetes...
October 14, 2016: Journal of Vascular Surgery
Nienke Nakken, Daisy J A Janssen, Esther H A van den Bogaart, Monique van Vliet, Geeuwke J de Vries, Gerben P Bootsma, Michiel H M Gronenschild, Jeannet M L Delbressine, Jean W M Muris, Emiel F M Wouters, Martijn A Spruit
BACKGROUND AND OBJECTIVE: Loved ones (proxies) of patients with COPD are confronted with the patients' limitations in activities of daily living (ADLs). However, it remains unknown whether proxies are able to correctly estimate the problematic ADLs of the patient. Therefore, we aimed to investigate the level of agreement between patient-reported and proxy-reported problematic ADLs of the patient. METHODS: Stable outpatients with moderate to very severe COPD (n = 194) and their resident proxies (n = 194) were included in this cross-sectional study...
October 12, 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
Vibe Maria Laden Nielsen, Jacob Madsen, Anette Aasen, Anne Pernille Toft-Petersen, Kenneth Lübcke, Bodil Steen Rasmussen, Erika Frischknecht Christensen
BACKGROUND: Patients with acute respiratory failure are at risk of deterioration during prehospital transport. Ventilatory support with continuous positive airway pressure (CPAP) can be initiated in the prehospital setting. The objective of the study is to evaluate adherence to treatment and effectiveness of CPAP as an addition to standard care. METHODS: In North Denmark Region, patients with acute respiratory failure, whom paramedics assessed as suffering from acute cardiopulmonary oedema, acute exacerbation of chronic obstructive pulmonary disease or asthma were treated with CPAP using 100 % O2 from 1 March 2014 to 3 May 2015...
October 10, 2016: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
D P Dargan, F Callachand, O J Diamond, C K Connolly
INTRODUCTION: Intracapsular femoral neck fractures remain associated with high rates of post-traumatic femoral head necrosis, non-union, and revision surgery. AIM: Our aim was to identify factors associated with revision surgery in intracapsular femoral neck fractures treated with sliding hip screws (SHS) in adults aged <65 years. PATIENTS AND METHODS: Consecutive admissions were identified retrospectively from the Royal Victoria Hospital, Belfast, which was the largest volume hospital on the National Hip Fracture Database...
September 6, 2016: Injury
George S Alexopoulos, Jo Anne Sirey, Samprit Banerjee, Dimitris N Kiosses, Cristina Pollari, Richard S Novitch, Amanda Artis, Patrick J Raue
OBJECTIVE: Personalized Intervention for Depressed Patients with COPD (PID-C), a treatment mobilizing patients to participate in their care, was found more effective than usual care. To further improve its efficacy, we developed a Problem Solving-Adherence (PSA) intervention integrating problem solving into adherence enhancement procedures. We tested the hypothesis that PSA is more effective than PID-C in reducing depressive symptoms. Exploratory analyses sought to identify patients with distinct depressive symptom trajectories and compare their clinical profiles...
November 2016: American Journal of Geriatric Psychiatry
Sigrid N W Vorrink, Helianthe S M Kort, Thierry Troosters, Pieter Zanen, Jan-Willem J Lammers
Physical inactivity in patients with chronic obstructive pulmonary disease (COPD) is associated with poor health status and increased disease burden. The present study aims to test the efficacy of a previously developed mobile (m)Health intervention to improve or maintain physical activity in patients with COPD after pulmonary rehabilitation.A randomised controlled trial was performed in 32 physiotherapy practices in the Netherlands. COPD patients were randomised into intervention or usual care groups. The intervention consisted of a smartphone application for the patients and a monitoring website for the physiotherapists...
October 2016: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
Reem Kayyali, Vilius Savickas, Martijn A Spruit, Evangelos Kaimakamis, Roshan Siva, Richard W Costello, John Chang, Barbara Pierscionek, Nikki Davies, Anouk W Vaes, Rita Paradiso, Nada Philip, Eleni Perantoni, Shona D'Arcy, Andreas Raptopoulos, Shereen Nabhani-Gebara
OBJECTIVES: To ascertain the stakeholders' views and devise recommendations for further stages of the Wearable Sensing and Smart Cloud Computing for Integrated Care to Chronic Obstructive Pulmonary Disease (COPD) Patients with Co-morbidities (WELCOME) system development. This system aims to create a wearable vest to monitor physiological signals for patients concerned incorporating an inhaler adherence monitoring, weight, temperature, blood pressure and glucose metres, and a mobile health application for communication with healthcare professionals (HCPs)...
2016: BMJ Open
Dionne E Smid, Martijn A Spruit, Sarah Houben-Wilke, Jean W M Muris, Gernot G U Rohde, Emiel F M Wouters, Frits M E Franssen
INTRODUCTION: Care for patients with chronic obstructive pulmonary disease (COPD) can be provided in primary, secondary or tertiary care. Whether and to what extent patients with COPD treated in various healthcare settings differ in disease burden and healthcare utilization remains unknown. Therefore, daily symptoms, functional mobility, mood status, health status and healthcare utilization were compared between COPD patients in various care settings, to explore possibilities for healthcare-optimization...
September 2016: Respiratory Medicine
Roger Mark Engel, Peter Gonski, Ken Beath, Subramanyam Vemulpad
STUDY DESIGN: Randomized clinical trial. OBJECTIVE: To investigate the effect of including manual therapy (MT) in a pulmonary rehabilitation program for patients with chronic obstructive pulmonary disease (COPD). BACKGROUND: The primary source of exercise limitation in people with COPD is dyspnea. The dyspnea is partly caused by changes in chest wall mechanics, with an increase in chest wall rigidity (CWR) contributing to a decrease in lung function...
May 2016: Journal of Manual & Manipulative Therapy
Sante Di Gioia, Carla Sardo, Stefano Castellani, Barbara Porsio, Giuliana Belgiovine, Annalucia Carbone, Gaetano Giammona, Gennara Cavallaro, Massimo Conese
Asthma, chronic obstructive pulmonary disease, cystic fibrosis, and idiopathic pulmonary fibrosis, are among the most common chronic diseases and their prevalence is increasing. Each of these diseases is characterized by the secretion of cytokines and pro-inflammatory molecules which are thought to play a critical role in their pathogenesis. Moreover, immune cells, particularly neutrophils, macrophages and dendritic cells as well structural cells such as epithelial and airway smooth muscle cells are also involved in the pathogenic cycle of these diseases...
August 24, 2016: Current Drug Delivery
Nuno Morais, Joana Cruz, Alda Marques
BACKGROUND: There is limited evidence regarding interactions between pulmonary (dys)function, posture, and mobility of the upper body quadrant in patients with chronic obstructive pulmonary disease (COPD). OBJECTIVES: This exploratory study aimed to investigate whether postural alignment and mobility of the upper quadrant are related to changes in pulmonary function and compare such variables between patients with COPD and healthy individuals. METHOD: Fifteen patients with COPD (67...
July 2016: Brazilian Journal of Physical Therapy
T N Zaripova, L V Zhilyakova, Z P Bulanova
UNLABELLED: The importance of the development of the new methods for the rehabilitation of the patients presenting with chronic obstructive pulmonary disease under conditions of the spa and health resort-based treatment arises from the high prevalence and the progressive character of this disease, poor quality of the patients' life, great economic losses due to the reduction of the working capacity of the patients, and the high cost of COPD treatment. AIM: The objective of the present study was to substantiate the advisability of inclusion of high-frequency intrapulmonary ventilation in the program of the therapeutic and rehabilitative treatment of the patients with COPD based at a spa and health resort facility...
2016: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
Brittany M Salter, Fizza Manzoor, Suzanne Beaudin, Melanie Kjarsgaard, Parameswaran Nair, Gail M Gauvreau, Roma Sehmi
Chronic obstructive pulmonary disease (COPD) is characterized by fixed airflow limitation and progressive decline of lung function and punctuated by occasional exacerbations. The disease pathogenesis may involve activation of the bone marrow stimulating mobilization and lung-homing of progenitor cells. We investigated the hypothesis that lower circulating numbers of vascular endothelial progenitor cells (VEPCs) are a consequence of increased lung-sequestration in COPD. Nonatopic, current or ex-smokers with diagnosed COPD and nonatopic, nonsmoking normal controls were enrolled...
2016: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
Alina Sorina Voica, Cristian Oancea, Emanuela Tudorache, Alexandru F Crisan, Ovidiu Fira-Mladinescu, Voicu Tudorache, Bogdan Timar
BACKGROUND/OBJECTIVE: Chronic obstructive pulmonary disease (COPD) is a respiratory disease that results in airflow limitation and respiratory distress, also having many nonrespiratory manifestations that affect both function and mobility. Preliminary evidence suggests that balance deficits constitute an important secondary impairment in individuals with COPD. Our objective was to investigate balance performance in two groups of COPD patients with different body compositions and to observe which of these groups are more likely to experience falls in the future...
2016: International Journal of Chronic Obstructive Pulmonary Disease
Alexey E Alekseev, Rita Guzun, Santiago Reyes, Christophe Pison, Uwe Schlattner, Vitaly A Selivanov, Marta Cascante
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is characterized by the inability of patients to sustain a high level of ventilation resulting in perceived exertional discomfort and limited exercise capacity of leg muscles at average intracellular ATP levels sufficient to support contractility. METHODS: Myosin ATPase activity in biopsy samples from healthy and COPD individuals was implemented as a local nucleotide sensor to determine ATP diffusion coefficients within myofibrils...
October 2016: Biochimica et Biophysica Acta
Marina Bitsaki, Christos Koutras, George Koutras, Frank Leymann, Frank Steimle, Sebastian Wagner, Matthias Wieland
Lack of time or economic difficulties prevent chronic obstructive pulmonary disease patients from communicating regularly with their physicians, thus inducing exacerbation of their chronic condition and possible hospitalization. Enhancing Chronic patients' Health Online proposes a new, sustainable and innovative business model that provides at low cost and at significant savings to the national health system, a preventive health service for chronic obstructive pulmonary disease patients, by combining human medical expertise with state-of-the-art online service delivery based on cloud computing, service-oriented architecture, data analytics, and mobile applications...
April 21, 2016: Health Informatics Journal
Qun Wu, Di Jiang, Jennifer L Matsuda, Kristina Ternyak, Bicheng Zhang, Hong Wei Chu
Cigarette smoke (CS)-induced airway epithelial senescence has been implicated in the pathogenesis of chronic obstructive pulmonary disease (COPD), although the underlying mechanisms remain largely unknown. Growth differentiation factor (GDF) 15 is increased in airway epithelium of smokers with COPD and CS-exposed human airway epithelial cells, but its role in CS-induced airway epithelial senescence is unclear. In this study, we first analyzed expression of GDF15 and cellular senescence markers in airway epithelial cells of current smokers and nonsmokers...
September 2016: American Journal of Respiratory Cell and Molecular Biology
Grazia Panigada, Luca Masotti, Claudia Rosi, Laila Teghini, Barbara Cimolato, Maria Chiara Bertieri, Chiara Angotti, Anna Maria Romagnoli, Irene Cascinelli, Veronica De Crescenzo, Alba Dainelli, Giuseppa Levantino, Lucia Raimondi, Rossella Nassi, Roberta Mastriforti, Paola Lambelet, Valentina Carli, Anna Frullini, Maddalena Grazzini, Lucia Ciucciarelli, Sara Bucherelli, Alessandra Petrioli, Carlotta Casati
BACKGROUND: Literature lacks on sex differences in acute pulmonary embolism (PE). Therefore, the aim of our study was to provide information about sex difference in thromboembolic burden, prognostic assessment and outcomes of PE. MATERIALS AND METHODS: We analyzed and compared differences between females and males retrieving data of a multicenter, observational, retrospective, cohort study aimed to analyze characteristics of PE patients admitted in Internal Medicine wards of Tuscany, Italy...
June 2016: Acta Clinica Belgica
Nuno Morais, Joana Cruz, Alda Marques
Background There is limited evidence regarding interactions between pulmonary (dys)function, posture, and mobility of the upper body quadrant in patients with chronic obstructive pulmonary disease (COPD). Objectives This exploratory study aimed to investigate whether postural alignment and mobility of the upper quadrant are related to changes in pulmonary function and compare such variables between patients with COPD and healthy individuals. Method Fifteen patients with COPD (67.93±9.71yrs) and 15 healthy controls (66...
April 8, 2016: Brazilian Journal of Physical Therapy
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