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epithelial thickness mapping

Shiro Jimi, Francesco De Francesco, Giuseppe A Ferraro, Michele Riccio, Shuuji Hara
The mouse excisional dorsal full-thickness wound model with a silicon splint fixed on the skin has been widely used to mimic human wound healing. However, the method cannot accurately quantify dermal remodeling, since the initial point of epithelialization on the wound surface is unclear. To overcome this limitation, we have developed a novel mouse excisional wound model to assess the degree of epithelial extension and regeneration, using a plastic ring-shaped splint fixed beneath the surrounding epidermal tissue...
September 14, 2016: Journal of Cellular Physiology
Ronald H Silverman, Raksha Urs, Arindam RoyChoudhury, Timothy J Archer, Marine Gobbe, Dan Z Reinstein
PURPOSE: Scanning Scheimpflug provides information regarding corneal thickness and 2-surface topography while arc-scanned high-frequency ultrasound allows depiction of the epithelial and stromal thickness distributions. Both techniques are useful in detection of keratoconus. Our aim was to develop and test a keratoconus classifier combining information from both methods. METHODS: We scanned 111 normal and 30 clinical keratoconus subjects with Artemis-1 and Pentacam data...
August 8, 2016: European Journal of Ophthalmology
S Catalan, L Cadarso, F Esteves, J Salgado-Borges, M Lopez, C Cadarso
Purpose. To compare the characteristics of asymmetric keratoconic eyes and normal eyes by Fourier domain optical coherence tomography (OCT) corneal mapping. Methods. Retrospective corneal and epithelial thickness OCT data for 74 patients were compared in three groups of eyes: keratoconic (n = 22) and normal fellow eyes (n = 22) in patients with asymmetric keratoconus and normal eyes (n = 104) in healthy subjects. Areas under the curve (AUC) of receiver operator characteristic (ROC) curves for each variable were compared across groups to indicate their discrimination capacity...
2016: Journal of Ophthalmology
Dan Z Reinstein, Marine Gobbe, Timothy J Archer, Glenn I Carp
PURPOSE: Case series report of normal-appearing eyes after hyperopic LASIK exhibiting diurnal shift in refractive error found to correlate with diurnal shifts in epithelial thickness profile. METHODS: Patients complaining of diurnal shift in vision during the course of the day with more hyperopia on waking and decreasing hyperopia in the evening in the absence of abnormal epithelial or slit-lamp findings were examined. Diurnal concomitant measurement of refraction, topography, and Artemis very high-frequency digital ultrasound scanning (VHFDU) (ArcScan Inc...
June 1, 2016: Journal of Refractive Surgery
Hossein Rabbani, Rahele Kafieh, Mahdi Kazemian Jahromi, Sahar Jorjandi, Alireza Mehri Dehnavi, Fedra Hajizadeh, Alireza Peyman
Optical Coherence Tomography (OCT) is one of the most informative methodologies in ophthalmology and provides cross sectional images from anterior and posterior segments of the eye. Corneal diseases can be diagnosed by these images and corneal thickness maps can also assist in the treatment and diagnosis. The need for automatic segmentation of cross sectional images is inevitable since manual segmentation is time consuming and imprecise. In this paper, segmentation methods such as Gaussian Mixture Model (GMM), Graph Cut, and Level Set are used for automatic segmentation of three clinically important corneal layer boundaries on OCT images...
2016: International Journal of Biomedical Imaging
Marcony R Santhiago, Natalia T Giacomin, David Smadja, Samir J Bechara
This review outlines risk factors of post-laser in situ keratomileusis (LASIK) ectasia that can be detected preoperatively and presents a new metric to be considered in the detection of ectasia risk. Relevant factors in refractive surgery screening include the analysis of intrinsic biomechanical properties (information obtained from corneal topography/tomography and patient's age), as well as the analysis of alterable biomechanical properties (information obtained from the amount of tissue altered by surgery and the remaining load-bearing tissue)...
2016: Clinical Ophthalmology
Yan Li, Winston Chamberlain, Ou Tan, Robert Brass, Jack L Weiss, David Huang
PURPOSE: To screen for subclinical keratoconus by analyzing corneal, epithelial, and stromal thickness map patterns with Fourier-domain optical coherence tomography (OCT). SETTING: Four centers in the United States. DESIGN: Cross-sectional observational study. METHODS: Eyes of normal subjects, subclinical keratoconus eyes, and the topographically normal eye of a unilateral keratoconus patient were studied. Corneas were scanned using a 26,000 Hz Fourier-domain OCT system (RTVue)...
February 2016: Journal of Cataract and Refractive Surgery
Raksha Urs, Harriet O Lloyd, Dan Z Reinstein, Ronald H Silverman
PURPOSE: To compare corneal thickness and epithelial thickness measurements in maps obtained using the RTVue spectral domain optical coherence tomography (SD-OCT) system and the Artemis 2 immersion arc-scanning very-high-frequency ultrasound (VHF-US) system. SETTING: Department of Ophthalmology, Columbia University Medical Center, New York, New York, USA. DESIGN: Comparative study. METHODS: Eyes of normal volunteers were scanned with the SD-OCT system followed by the VHF-US system and then again by the SD-OCT system...
January 2016: Journal of Cataract and Refractive Surgery
Pablo Zoroquiain, Maria Sb Ganimi, Sarah Alghamdi, Julia V Burnier, Sultan S Aldrees, Miguel N Burnier
Conjunctival melanoma is a rare malignant tumour of the eye. Its diagnosis represents a challenge for general pathologists due to low exposure to ocular biopsies and a broad differential diagnosis. In addition, conjunctival samples are often small and are associated with a high frequency of artefacts due to their processing. Here, we present the first case to date of a traumatic iridial extrusion masquerading as a conjunctival melanocytic neoplasm. An 83-year-old Asian man presented with a conjunctival-pigmented nodule surrounded by an area of diffuse pigmentation...
2016: Ecancermedicalscience
Nadia Zakaria, Sorcha Ní Dhubhghaill, Michiel Taal, Zwi Berneman, Carina Koppen, Marie-José Tassignon
PURPOSE: Cultivated limbal epithelial stem cell transplantation (CLET) is a surgical approach reserved for severe stem cell deficiency and anterior segment pathology. The recipient cornea typically displays a highly vascularized pannus that must be dissected before graft placement. Extensive pannus dissection, however, can result in corneal thinning and increase the risk of ectasia and ultimately, of perforation. We aimed to examine the value of anterior segment optical coherence tomography (AS-OCT) intraoperatively during pannus resection and long-term postoperative follow-up of CLET surgery...
November 2015: Asia-Pacific Journal of Ophthalmology
Dan Z Reinstein, Timothy J Archer, Raksha Urs, Marine Gobbe, Arindam RoyChoudhury, Ronald H Silverman
PURPOSE: To assess the effectiveness of a keratoconus-detection algorithm derived from Artemis very high-frequency (VHF) digital ultrasound (ArcScan Inc., Morrison, CO) epithelial thickness maps in the fellow eye from a series of patients with unilateral keratoconus. METHODS: The study included 10 patients with moderate to advanced keratoconus in one eye but a clinically and algorithmically topographically normal fellow eye. VHF digital ultrasound epithelial thickness data were acquired and a previously developed classification model was applied for identification of keratoconus to the clinically normal fellow eyes...
November 2015: Journal of Refractive Surgery
Allen W Cowley, Chun Yang, Vikash Kumar, Jozef Lazar, Howard Jacob, Aron M Geurts, Pengyuan Liu, Alex Dayton, Theresa Kurth, Mingyu Liang
A 1.37 Mbp region of chromosome 13 previously identified by exclusion mapping was consistently associated with a reduction of salt-induced hypertension in the Dahl salt-sensitive (SS) rat. This region contained five genes that were introgressed from the salt-insensitive Brown Norway (BN) rat. The goal of the present study was to further narrow that region to identify the gene(s) most likely to protect from salt-induced hypertension. The studies yielded a subcongenic SS rat strain containing a 0.71 Mbp insert from BN (26-P strain) in which salt-induced hypertension was reduced by 24 mmHg...
January 2016: Physiological Genomics
Demelza R Koehn, Kacie J Meyer, Michael G Anderson
PURPOSE: Central corneal thickness (CCT) is a quantitative trait associated with keratoconus and primary open-angle glaucoma. Although CCT is highly heritable, known genetic variations explain only a fraction of the phenotypic variability. The purpose of this study was to identify additional CCT-influencing loci using inbred strains of mice. METHODS: Cohorts of 82 backcrossed (N2) and 99 intercrossed (F2) mice were generated from crosses between recombinant inbred BXD24/TyJ and wild-derived CAST/EiJ mice...
August 2015: Investigative Ophthalmology & Visual Science
Xiangjun Chen, Aleksandar Stojanovic, Yanhua Liu, Yunyun Chen, Yang Zhou, Tor Paaske Utheim
PURPOSE: To study the corneal epithelial and stromal thickness profile changes after photorefractive keratectomy (PRK) for myopia. METHODS: Retrospective analysis of the postoperative corneal epithelial and stromal thickness profile changes in 46 left eyes of 46 patients treated with PRK for myopia. Corneal and epithelial thickness maps within the central 6 mm were obtained by anterior segment spectral-domain optical coherence tomography preoperatively and at 1, 3, and 6 months postoperatively...
July 2015: Journal of Refractive Surgery
Cyril Temstet, Otman Sandali, Nacim Bouheraoua, Taous Hamiche, Alice Galan, Mohamed El Sanharawi, Elena Basli, Laurent Laroche, Vincent Borderie
PURPOSE: To determine whether optical coherence tomography (OCT) epithelial mapping can improve the detection of form fruste keratoconus. SETTING: French National Eye Hospital, Paris 6 Pierre & Marie Curie University, Paris, France. DESIGN: Retrospective comparative study. METHODS: Eyes with normal corneas, form fruste keratoconus, moderate keratoconus, or severe keratoconus were assessed using Fourier-domain OCT (RTVue 5...
April 2015: Journal of Cataract and Refractive Surgery
Dan Z Reinstein, Marine Gobbe, Timothy J Archer, Gerhard Youssefi, Hugo F S Sutton
PURPOSE: To illustrate the concept of using a stromal surface topography-guided procedure for therapeutic repair after a complication following primary laser refractive surgery. METHODS: One case example of therapeutic retreatment for short nasal flap after primary LASIK performed in September 2000 is presented. The Artemis very high-frequency digital ultrasound arc-scanner (Arc-Scan, Inc., Morrison, CO) was used to obtain layered corneal thickness including epithelial thickness profile...
January 2015: Journal of Refractive Surgery
Raffaele Strippoli, Jesús Loureiro, Vanessa Moreno, Ignacio Benedicto, María Luisa Pérez Lozano, Olga Barreiro, Teijo Pellinen, Susana Minguet, Miguel Foronda, Maria Teresa Osteso, Enrique Calvo, Jesús Vázquez, Manuel López Cabrera, Miguel Angel del Pozo
Peritoneal dialysis (PD) is a form of renal replacement therapy whose repeated use can alter dialytic function through induction of epithelial-mesenchymal transition (EMT) and fibrosis, eventually leading to PD discontinuation. The peritoneum from Cav1-/- mice showed increased EMT, thickness, and fibrosis. Exposure of Cav1-/- mice to PD fluids further increased peritoneal membrane thickness, altered permeability, and increased the number of FSP-1/cytokeratin-positive cells invading the sub-mesothelial stroma...
January 2015: EMBO Molecular Medicine
Anastasios John Kanellopoulos, George Asimellis
PURPOSE: To investigate epithelial thickness-distribution characteristics in a large group of keratoconic patients and their correlation to normal eyes employing anterior-segment optical coherence tomography (AS-OCT). MATERIALS AND METHODS: The study group (n=160 eyes) consisted of clinically diagnosed keratoconus eyes; the control group (n=160) consisted of nonkeratoconic eyes. Three separate, three-dimensional epithelial thickness maps were obtained employing AS-OCT, enabling investigation of the pupil center, average, mid-peripheral, superior, inferior, maximum, minimum, and topographic epithelial thickness variability...
2014: Clinical Ophthalmology
Jiaxu Hong, Tingting Qian, Yujing Yang, Chunhui Jiang, Zuguo Liu, Xinghuai Sun, Sophie X Deng, Jianjiang Xu
PURPOSE: To map the corneal epithelial thickness in vivo with Fourier-domain optical coherence tomography in long-term soft contact lens (SCL) wearers. METHODS: This is a cross-sectional observational study. Forty eyes from 40 normal subjects who had never worn SCL and 40 eyes from 40 SCL wearers who had worn lenses for more than 2 years were enrolled. Corneal epithelium over the entire cornea was topographically imaged using a novel optical coherence tomography system...
December 2014: Optometry and Vision Science: Official Publication of the American Academy of Optometry
Xinhan Cui, Jiaxu Hong, Fei Wang, Sophie X Deng, Yujing Yang, Xiaoyu Zhu, Dan Wu, Yujin Zhao, Jianjiang Xu
PURPOSE: To investigate the features of corneal epithelial thickness topography with Fourier-domain optical coherence tomography (OCT) in dry eye patients. METHODS: In this cross-sectional study, 100 symptomatic dry eye patients and 35 normal subjects were enrolled. All participants answered the ocular surface disease index questionnaire and were subjected to OCT, corneal fluorescein staining, tear breakup time, Schirmer 1 test without anesthetic (S1t), and meibomian morphology...
December 2014: Optometry and Vision Science: Official Publication of the American Academy of Optometry
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