Wenwei Luo, Xiao Fu, Hongming Huang, Peina Wu, Yanmei Wang, Zhifeng Liu, Shiqi He, Limin Pang, Dongdong Ren, Yong Cui
OBJECTIVES: Planar cell polarity (PCP) signaling, essential for uniform alignment and directional beating of motile cilia, has been investigated in multiciliated epithelia. As a complex structure connecting the middle ear to the nasopharynx, the eustachian tube (ET) is important in the onset of ear-nose-throat diseases. However, PCP signaling, including the orientation that is important for ciliary motility and clearance function in the ET, has not been studied. We evaluated PCP in the ET epithelium...
April 13, 2024: Laryngoscope