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https://www.readbyqxmd.com/read/29229486/screening-for-spontaneous-preterm-birth-and-resultant-therapies-to-reduce-neonatal-morbidity-and-mortality-a-review
#1
REVIEW
Angelica V Glover, Tracy A Manuck
Despite considerable effort aimed at decreasing the incidence of spontaneous preterm birth, it remains the leading cause of perinatal morbidity and mortality. Screening strategies are imperfect. Approaches used to identify women considered by historical factors to be low risk for preterm delivery (generally considered to be women with singleton pregnancies without a history of a previous preterm birth) as well as those at high risk for preterm birth (those with a previous preterm birth, short cervix, or multiple gestation) continue to evolve...
December 9, 2017: Seminars in Fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29229117/outcomes-of-fetuses-with-primary-hydrothorax-that-undergo-prenatal-intervention-prenatal-intervention-for-hydrothorax
#2
Rodrigo A Mon, Marjorie C Treadwell, Deborah R Berman, Lori Day, Jeannie Kreutzman, George B Mychaliska, Erin E Perrone
BACKGROUND: Primary hydrothorax is a congenital anomaly affecting 1 in 10,000-15,000 pregnancies. The natural history of this condition is variable with some fetuses having spontaneous resolution and others showing progression. The associated pulmonary hypoplasia leads to increased perinatal morbidity and mortality. Optimal prenatal intervention remains controversial. METHODS: After obtaining the Institutional Review Board approval, a retrospective review of all patients evaluated for a fetal pleural effusion in the Fetal Diagnosis and Treatment Center at The University of Michigan, between 2006 and 2016 was performed...
January 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29228154/comparative-transcriptomic-analysis-of-human-placentae-at-term-and-preterm-delivery
#3
Alison G Paquette, Heather M Brockway, Nathan D Price, Louis J Muglia
Purpose: Preterm birth affects 1 out of every 10 infants in the United States, resulting in substantial neonatal morbidity and mortality. Currently, there are few predictive markers and few treatment options to prevent preterm birth. A healthy, functioning placenta is essential to positive pregnancy outcomes. Previous studies have suggested that placental pathology may play a role in preterm birth etiology. Therefore, we tested the hypothesis that preterm placentae may exhibit unique transcriptomic signatures compared to term samples reflective of their abnormal biology leading to this adverse outcome...
December 4, 2017: Biology of Reproduction
https://www.readbyqxmd.com/read/29226752/influence-of-time-of-delivery-on-risk-of-adverse-neonatal-outcome-in-different-size-of-delivery-units-a-retrospective-cohort-study-in-finland
#4
Elina Karalis, Mika Gissler, Anna-Maija Tapper, Veli-Matti Ulander
PURPOSE: To evaluate the impact of time of birth on adverse neonatal outcome in singleton term hospital births. MATERIALS AND METHODS: Medical Birth Register Data in Finland from 2005 to 2009. Study population was all hospital births (n = 263 901), excluding multiple pregnancies, preterm births < 37 weeks, major congenital anomalies or birth defects, and antepartum stillbirths. Main outcome measures were either 1-minute Apgar score 0-3, 5-minute Apgar score 0-6, or umbilical artery pH < 7...
December 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29222137/benefits-of-probiotics-in-preterm-neonates-in-low-income-and-medium-income-countries-a-systematic-review-of-randomised-controlled-trials
#5
Girish Deshpande, Gayatri Jape, Shripada Rao, Sanjay Patole
OBJECTIVE: Although there is an overall reduction in underfive mortality rate, the progress in reducing neonatal mortality rate has been very slow. Over the last 20 years, preterm births have steadily increased in low-income and medium-income countries (LMICs) particularly in sub-Saharan Africa and South Asia. Preterm birth is associated with increased mortality and morbidity, particularly in LMICs. Based on systematic reviews of randomised controlled trials (RCTs), many neonatal units in high-income countries have adopted probiotics as standard of care for preterm neonates...
December 7, 2017: BMJ Open
https://www.readbyqxmd.com/read/29216559/pregnancy-outcomes-and-ethanol-cook-stove-intervention-a-randomized-controlled-trial-in-ibadan-nigeria
#6
Donee A Alexander, Amanda Northcross, Theodore Karrison, Oludare Morhasson-Bello, Nathaniel Wilson, Omolola M Atalabi, Anindita Dutta, Damilola Adu, Tope Ibigbami, John Olamijulo, Dayo Adepoju, Oladosu Ojengbede, Christopher O Olopade
BACKGROUND: Household air pollution (HAP) exposure has been linked to adverse pregnancy outcomes. OBJECTIVES: A randomized controlled trial was undertaken in Ibadan, Nigeria to determine the impact of cooking with ethanol on pregnancy outcomes. METHODS: Three-hundred-twenty-four pregnant women were randomized to either the control (continued cooking using kerosene/firewood stove, n=162) or intervention group (received ethanol stove, n=162)...
December 4, 2017: Environment International
https://www.readbyqxmd.com/read/29215314/prenatal-perceived-stress-and-adverse-birth-outcomes-among-puerto-rican-women
#7
Kathleen Szegda, Elizabeth R Bertone-Johnson, Penelope Pekow, Sally Powers, Glenn Markenson, Nancy Dole, Lisa Chasan-Taber
BACKGROUND: Preterm birth and low birthweight contribute substantially to the disproportionately high infant mortality rates experienced by Puerto Ricans in the United States. The purpose of this study was to examine whether the timing and pattern of prenatal psychosocial stress increased risk of adverse birth outcomes in this high-risk population. MATERIALS AND METHODS: Proyecto Buena Salud was a prospective cohort study conducted from 2006 to 2011 among predominantly Puerto Rican women...
December 7, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29212432/maternity-leave-duration-and-adverse-pregnancy-outcomes-an-international-country-level-comparison
#8
Emma Kwegyir-Afful, George Adu, Evelien R Spelten, Kimmo Räsänen, Jos Verbeek
AIM: Preterm birth and low birthweight (LBW) lead to infant morbidity and mortality. The causes are unknown. This study evaluates the association between duration of maternity leave and birth outcomes at country level. METHOD: We compiled data on duration of maternity leave for 180 countries of which 36 specified prenatal leave, 190 specified income, 183 specified preterm birth rates and 185 specified the LBW rate. Multivariate and seemingly unrelated regression analyses were done in STATA...
December 1, 2017: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29210350/rotavirus-vaccine-will-improve-child-survival-by-more-than-just-preventing-diarrhea-evidence-from-bangladesh
#9
Senjuti Saha, Mathuram Santosham, Manzoor Hussain, Robert E Black, Samir K Saha
Despite the high burden of rotavirus diarrhea, uptake of rotavirus vaccines in Asia remains low. This primarily stems from a perception of rotavirus as a non-life-threatening pathogen amidst a background of competing health priorities and limited resources. In the largest pediatric hospital of Bangladesh, where there is a fierce competition for beds, we found that between November 2015 and October 2016, 12% of 23,064 admissions were due to gastrointestinal infections, 54% of which were caused by rotavirus. One in four cases requiring hospitalization, or 5,879 cases, was refused because of unavailability of beds...
December 4, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29209482/the-place-for-prophylactic-cerclage-in-the-infertile-patient-with-established-cervical-incompetence-who-conceived-twins-after-septum-reduction
#10
Jennifer Deanna, Omar Abuzied, Fahmi Islam, Ivana Vettriano, Frederico Rocha, Mostafa Abuzeid
Introduction: It is well known that cervical incompetence and associated preterm birth confers greater morbidity and mortality on birth outcomes, with an additional increased risk of cervical incompetence in higher order gestations. While the pathophysiology of cervical incompetence has yet to be elucidated, research has identified risk factors and assessed outcomes of numerous interventions. Cervical cerclage has been shown, in certain situations involving singleton pregnancies, to improve outcomes...
June 2017: Facts, Views & Vision in ObGyn
https://www.readbyqxmd.com/read/29208662/antenatal-corticosteroids-in-impending-preterm-deliveries-before-25-weeks-gestation
#11
Mangesh Deshmukh, Sanjay Patole
Antenatal corticosteroid (ANC) use before 25 weeks' gestation is controversial. Our previous systematic review (eight observational studies, n=10 109) showed that ANC exposure was associated with significantly reduced mortality and severe intraventricular haemorrhage (IVH)/periventricular leukomalacia (PVL) in neonates born <25 weeks. We update our review by adding data (n=3334) from a recent study. We used Cochrane methodology and summarised the results using GRADE (The Grading of Recommendations Assessment, Development and Evaluation) guidelines...
December 5, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29207782/prediction-of-delivery-in-women-with-threatening-preterm-labour-using-phosphorylated-insulin-like-growth-factor-binding-protein-1-and-cervical-length-using-transvaginal-ultrasound
#12
Amrita Kumari, Vandana Saini, P K Jain, Mamta Gupta
Introduction: Preterm delivery remains a challenge in Obstetrics as it is responsible for significant cause of perinatal morbidity and mortality. At present there is no standard test for prediction of preterm labour for timely referral to a center with NICU facilities. Aim: To evaluate the effectiveness of the cervical phosphorylated insulin like growth factor binding protein-1(phIGFBP-1), cervical length measurement and combination of phIGFBP-1 with cervical length for Predicting Preterm Labour (PTL)...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29198051/doula-services-within-a-healthy-start-program-increasing-access-for-an-underserved-population
#13
Mary-Powel Thomas, Gabriela Ammann, Ellen Brazier, Philip Noyes, Aletha Maybank
PURPOSE: Women of color in the United States, particularly in high-poverty neighborhoods, experience high rates of poor birth outcomes, including cesarean section, preterm birth, low birthweight, and infant mortality. Doula care has been linked to improvements in many perinatal outcomes, but women of color and low-income women often face barriers in accessing doula support. DESCRIPTION: To address this issue, the New York City Department of Health and Mental Hygiene's Healthy Start Brooklyn introduced the By My Side Birth Support Program in 2010...
December 2, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/29197867/topical-coconut-oil-in-very-preterm-infants-an-open-label-randomised-controlled-trial
#14
Tobias Strunk, Sameer Pupala, Julie Hibbert, Dorota Doherty, Sanjay Patole
BACKGROUND: The immature fragile skin of preterm infants represents an inadequate protective barrier. The emollient and anti-infective properties of coconut oil make it a potentially beneficial topical agent for this population. OBJECTIVES: Our aim was to evaluate feasibility, safety, and the effects of topical coconut oil on skin condition in very preterm infants. METHODS: An open-label randomised controlled trial in preterm infants <30 weeks' gestation was conducted...
December 1, 2017: Neonatology
https://www.readbyqxmd.com/read/29191292/long-term-childhood-outcomes-after-interventions-for-prevention-and-management-of-preterm-birth
#15
REVIEW
Sarah R Murray, Sarah J Stock, Jane E Norman
Globally, preterm birth rates are rising and have a significant impact on neonatal morbidity and mortality. Preterm birth remains difficult to prevent and a number of strategies for preterm birth prevention (progesterone, cervical pessaries, cervical cerclage, tocolytics, and antibiotics) have been identified. While some of these show more promise, there is a paucity of evidence regarding the long-term effects of these strategies on childhood outcomes. Strategies used to improve the health of babies if born preterm, such as antenatal magnesium sulfate for fetal neuroprotection and antenatal corticosteroids for fetal lung maturation, show evidence of short-term benefit but lack large-scale follow-up data of long-term childhood outcomes...
December 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/29190738/cervical-hsv-2-infection-causes-cervical-remodeling-and-increases-risk-for-ascending-infection-and-preterm-birth
#16
Devin McGee, Arianna Smith, Sharra Poncil, Amanda Patterson, Alison I Bernstein, Karen Racicot
Preterm birth (PTB), or birth before 37 weeks gestation, is the leading cause of neonatal mortality worldwide. Cervical viral infections have been established as risk factors for PTB in women, although the mechanism leading to increased risk is unknown. Using a mouse model of pregnancy, we determined that intra-vaginal HSV2 infection caused increased rates of preterm birth following an intra-vaginal bacterial infection. HSV2 infection resulted in histological changes in the cervix mimicking cervical ripening, including significant collagen remodeling and increased hyaluronic acid synthesis...
2017: PloS One
https://www.readbyqxmd.com/read/29187658/-pregnancy-complications-among-women-with-polycystic-ovary-syndrome-in-china-a-meta-analysis
#17
Tingting Wang, Hanlin Fu, Lizhang Chen, Yang Xu
To estimate the status of pregnancy complications among women with polycystic ovary syndrome (PCOS) through a systematic review of published literatures.
 Methods: Systematic literature searches were conducted in PubMed, Web of Science, Medline, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang, Weipu and China Biology Medicine disc (CBMdisc), as well as the relevant articles published from inception to April 1st 2017, which reported the prevalence of pregnancy complications among women with PCOS...
November 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29187036/persistence-of-villous-immaturity-in-term-deliveries-following-intrauterine-transfusion-for-parvovirus-b19-infection-and-rhd-associated-hemolytic-disease-of-the-fetus-and-newborn
#18
Whitney A McCarthy, Edwina J Popek
Common causes of fetal anemia and hydrops include parvovirus B19 infection during the first 2 trimesters of pregnancy, as well as maternal alloimmunization to RhD with subsequent hemolytic disease of the fetus and newborn (HDFN) in an RhD positive fetus. Although both of these conditions have historically caused significant fetal morbidity and mortality, the advent of intrauterine transfusion (IUT) over the last few decades have dramatically improved outcomes. Prior literature has extensively documented placental changes associated with untreated parvovirus infection and RhD HDFN in intrauterine fetal demises and preterm births; however, histopathologic changes in term placentas from term infants treated with IUT have not been reported...
January 1, 2017: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29184860/safety-of-umbilical-cord-milking-in-very-preterm-neonates-a-randomized-controlled-study
#19
Soo-Youn Song, Youjin Kim, Byung-Hun Kang, Heon-Jong Yoo, Mina Lee
Objective: To investigate the safety of umbilical cord milking on both the mother and neonate among very preterm deliveries of less than 33 weeks of gestation. Methods: Pregnant women who were expected to deliver at between 24 0/7 and 32 6/7 weeks of gestation were randomized to either the umbilical cord milking or immediate cord clamping group. Maternal and neonatal data associated with delivery, in addition to neonatal morbidity and mortality data, were collected and analyzed...
November 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/29181841/epidural-therapy-for-the-treatment-of-severe-pre-eclampsia-in-non-labouring-women
#20
REVIEW
Amita Ray, Sujoy Ray
BACKGROUND: Pre-eclampsia is a pregnancy-specific multi-organ disorder, which is characterised by hypertension and multisystem organ involvement and which has significant maternal and fetal morbidity and mortality. Failure of the placental vascular remodelling and reduced uteroplacental flow form the etiopathological basis of pre-eclampsia. There are several established therapies for pre-eclampsia including antihypertensives and anticonvulsants. Most of these therapies aim at controlling the blood pressure or preventing complications of elevated blood pressure, or both...
November 28, 2017: Cochrane Database of Systematic Reviews
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