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Preterm mortality

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https://www.readbyqxmd.com/read/28526452/gestational-age-at-initiation-of-17-alpha-hydroxyprogesterone-caproate-and-recurrent-preterm-birth
#1
Angela Ning, Catherine J Vladutiu, Sarah K Dotters-Katz, William H Goodnight, Tracy A Manuck
BACKGROUND: Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality in non-anomalous neonates in the US. Women with a previous early spontaneous PTB are at highest risk for recurrence. Weekly intramuscular 17-alpha hydroxyprogesterone caproate (17-OHPC) reduces the risk of recurrent prematurity. Though current guidelines recommend 17-OHPC initiation between 16-20 weeks', in clinical practice, 17-OHPC is started across a spectrum of gestational ages. OBJECTIVE: To examine the relationship between the gestational age at 17-OHPC initiation and recurrent PTB among women a prior spontaneous PTB 16-28 weeks' gestation...
May 16, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28522317/the-association-between-cytochrome-p450-3a-progesterone-receptor-polymorphisms-plasma-17-ohpc-concentrations-and-spontaneous-preterm-birth
#2
Martha L Bustos, Steve N Caritis, Kathleen A Jablonski, Uma M Reddy, Yoram Sorokin, John M Thorp, Michael W Varner, Ronald J Wapner, Jay D Iams, Marshall W Carpenter, Alan M Peaceman, Brian M Mercer, Anthony Sciscione, Dwight J Rouse, Susan M Ramin
BACKGROUND: Infants born before 37 weeks' gestation are of public health concern since complications associated with preterm birth are the leading cause of mortality in children under 5 years of age and a major cause of morbidity and lifelong disability. The administration of 17-hydroxyprogesterone caproate (17-OHPC) reduces preterm birth by 33% in women with history spontaneous preterm birth (SPTB). We demonstrated previously that plasma concentrations of 17-OHPC vary widely among pregnant women and that women with 17-OHPC plasma concentrations in the lowest quartile had SPTB rates of 40% vs rates of 25% in those women with higher concentrations...
May 15, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28506266/impact-of-preterm-birth-on-infant-mortality-for-newborns-with-congenital-heart-defects-the-epicard-population-based-cohort-study
#3
Enora Laas, Nathalie Lelong, Pierre-Yves Ancel, Damien Bonnet, Lucile Houyel, Jean-François Magny, Thibaut Andrieu, François Goffinet, Babak Khoshnood
BACKGROUND: Congenital heart defects (CHD) and preterm birth (PTB) are major causes of infant mortality. However, limited data exist on risk of mortality associated with PTB for newborns with CHD. Our objective was to assess impact of PTB on risk of infant mortality for newborns with CHD, while taking into account the role of associated anomalies and other potentially confounding factors. METHODS: We used data on 2172 live births from a prospective population-based cohort study of CHD (the EPICARD Study) and compared neonatal, post-neonatal and overall infant mortality for infants born at <32, 32-34 and 35-36 weeks vs...
May 15, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28505223/association-of-short-antenatal-corticosteroid-administration-to-birth-intervals-with-survival-and-morbidity-among-very-preterm-infants-results-from-the-epice-cohort
#4
Mikael Norman, Aurelie Piedvache, Klaus Børch, Lene Drasbek Huusom, Anna-Karin Edstedt Bonamy, Elizabeth A Howell, Pierre-Henri Jarreau, Rolf F Maier, Ole Pryds, Liis Toome, Heili Varendi, Tom Weber, Emilija Wilson, Arno Van Heijst, Marina Cuttini, Jan Mazela, Henrique Barros, Patrick Van Reempts, Elizabeth S Draper, Jennifer Zeitlin
Importance: Administration-to-birth intervals of antenatal corticosteroids (ANS) vary. The significance of this variation is unclear. Specifically, to our knowledge, the shortest effective administration-to-birth interval is unknown. Objective: To explore the associations between ANS administration-to-birth interval and survival and morbidity among very preterm infants. Design, Setting, and Participants: The Effective Perinatal Intensive Care in Europe (EPICE) study, a population-based prospective cohort study, gathered data from 19 regions in 11 European countries in 2011 and 2012 on 4594 singleton infants with gestational ages between 24 and 31 weeks, without severe anomalies and unexposed to repeated courses of ANS...
May 15, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28495266/maternal-pre-pregnancy-infection-with-hepatitis-b-virus-and-the-risk-of-preterm-birth-a-population-based-cohort-study
#5
Jue Liu, Shikun Zhang, Min Liu, Qiaomei Wang, Haiping Shen, Yiping Zhang
BACKGROUND: Preterm birth is the leading cause of child death in children younger than 5 years. Large cohort studies in developed countries have shown that maternal hepatitis B virus infection is associated with preterm birth, but there is little reliable evidence from China and other developing countries, where hepatitis B virus prevalence is intermediate or high. Hence, we designed this study to investigate the association between pre-pregnancy hepatitis B virus infection and risk of preterm and early preterm birth...
June 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28493508/apgar-score-components-at-5-minutes-risks-and-prediction-of-neonatal-mortality
#6
Sven Cnattingius, Mikael Norman, Fredrik Granath, Gunnar Petersson, Olof Stephansson, Thomas Frisell
BACKGROUND: The Apgar score consists of five components: heart rate, respiratory effort, muscle tone, reflex irritability, and colour. Although the Apgar score has been used for 60 years, the specific contribution of the Apgar score components with respect to risks and prediction of neonatal mortality remains unknown. Likewise, the value of reduced scores (including less than five Apgar score components) has rarely been investigated. METHODS: In a population-based cohort study of 148 765 liveborn singleton infants in Sweden 2008-2013, we investigated components of Apgar score at 5 min with respect to relative risks and prediction (using ROC curves, sensitivity, and positive predictive values) of neonatal mortality...
May 11, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/28490415/maternal-and-perinatal-characteristics-of-small-for-gestational-age-newborns-ten-year-experience-of-a-single-center
#7
Nihal Şahin Uysal, Çağrı Gülümser, Filiz Bilgin Yanık
OBJECTIVE: The aim of this study was to analyze the maternal and perinatal characteristics of small for gestational age (SGA) newborns compared to appropriate for gestational age (AGA) newborns in singleton pregnancies managed at our hospital between January 2006 and December 2015. MATERIAL AND METHODS: The study (n=456) and control (n=4925) groups included pregnancies resulting in SGA and AGA newborns, respectively. Additionally, two SGA subgroups were defined according to abnormal (n=34) and normal (n=57) Doppler findings...
May 11, 2017: Journal of the Turkish German Gynecological Association
https://www.readbyqxmd.com/read/28488361/clonidine-for-sedation-and-analgesia-for-neonates-receiving-mechanical-ventilation
#8
REVIEW
Olga Romantsik, Maria Grazia Calevo, Elisabeth Norman, Matteo Bruschettini
BACKGROUND: Although routine administration of pharmacologic sedation or analgesia during mechanical ventilation in preterm neonates is not recommended, its use in clinical practice remains common. Alpha-2 agonists, mainly clonidine and dexmedetomidine, are used as adjunctive (or alternative) sedative agents alongside opioids and benzodiazepines. Clonidine has not been systematically assessed for use in neonatal sedation during ventilation. OBJECTIVES: To assess whether clonidine administered to term and preterm newborn infants receiving mechanical ventilation reduces morbidity and mortality rates...
May 10, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28486979/mediation-of-the-effect-of-malaria-in-pregnancy-on-stillbirth-and-neonatal-death-in-an-area-of-low-transmission-observational-data-analysis
#9
Kerryn A Moore, Freya J I Fowkes, Jacher Wiladphaingern, Nan San Wai, Moo Kho Paw, Mupawjay Pimanpanarak, Verena I Carrara, Jathee Raksuansak, Julie A Simpson, Nicholas J White, François Nosten, Rose McGready
BACKGROUND: Malaria in pregnancy is preventable and contributes significantly to the estimated 5.5 million stillbirths and neonatal deaths that occur annually. The contribution of malaria in pregnancy in areas of low transmission has not been quantified, and the roles of maternal anaemia, small-for-gestational-age status, and preterm birth in mediating the effect of malaria in pregnancy on stillbirth and neonatal death are poorly elucidated. METHODS: We analysed observational data routinely collected at antenatal clinics on the Thai-Myanmar border (1986-2015)...
May 10, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28486373/medical-and-obstetric-complications-among-pregnant-women-with-liver-cirrhosis
#10
Anna Palatnik, Mary E Rinella
OBJECTIVE: To evaluate clinical characteristics and obstetric outcomes in pregnant women with liver cirrhosis. METHODS: This was a retrospective matched cohort study of women with liver cirrhosis between January 2005 and January 2016 in a university hospital. Women in a case group were matched to women in a control group according to year of delivery, age, body mass index, and parity in a 1:4 ratio. Bivariable and multivariable analyses were performed to compare the prevalence of the primary composite outcome, which included any one of the following: fetal or neonatal demise, placental abruption, preeclampsia, preterm delivery at less than 37 weeks of gestation, and small-for-gestational age neonate between women in the case group and those in the control group...
May 5, 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28485984/vascular-endothelial-mitochondrial-function-predicts-death-or-pulmonary-outcomes-in-preterm-infants
#11
Jegen Kandasamy, Nelida Olave, Scott W Ballinger, Namasivayam Ambalavanan
RATIONALE: Vascular endothelial mitochondrial dysfunction contributes to the pathogenesis of several oxidant stress associated disorders. Oxidant stress is a major contributor to the pathogenesis of bronchopulmonary dysplasia (BPD), a chronic lung disease of prematurity that often leads to sequelae in adult survivors. OBJECTIVES: This study was conducted to identify whether differences in mitochondrial bioenergetic function and oxidant generation in HUVEC (human umbilical venous endothelial cells) obtained from extremely preterm infants were associated with risk for BPD or death before 36 weeks post-menstrual age...
May 9, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28483819/short-term-and-long-term-outcomes-of-preterm-neonates-with-acute-severe-pulmonary-hypertension-following-rescue-treatment-with-inhaled-nitric-oxide
#12
Michelle Baczynski, Shannon Ginty, Dany E Weisz, Patrick J McNamara, Edmond Kelly, Prakeshkumar Shah, Amish Jain
OBJECTIVE: To describe short-term and long-term outcomes of preterm neonates with severe acute pulmonary hypertension (aPHT) in relation to response to rescue inhaled nitric oxide (iNO) therapy. DESIGN: Retrospective cohort studyover a 6 year period. SETTING: Tertiary neonatal intensive care unit. PATIENTS: 89 neonates <35 weeks gestational age (GA) who received rescue iNO for aPHT, including 62 treated at ≤3 days of age (early aPHT)...
May 8, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28474752/parents-experiences-of-caring-for-preterm-infants-after-discharge-with-grandmothers-as-their-main-support
#13
Esther Abena Adama, Sara Bayes, Deborah Sundin
AIM: To explore parents of preterm infants' experiences of caring for their preterm infants with the grandmother as their primary support after discharge. BACKGROUND: Preterm delivery is the major cause of high neonatal mortality in Sub-Saharan Africa. There is poor neonatal health outcome in the Ghanaian community with some illnesses culturally classified as not-for-hospital. In the community, grandmothers or elderly women provide support for new parents and decide treatment options for sick infants...
May 5, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28472058/poractant-alfa-versus-bovine-lipid-extract-surfactant-for-infants-24-0-to-31-6-weeks-gestational-age-a-randomized-controlled-trial
#14
Brigitte Lemyre, Christoph Fusch, Georg M Schmölzer, Nicole Rouvinez Bouali, Deepti Reddy, Nicholas Barrowman, Nicole Huneault-Purney, Thierry Lacaze-Masmonteil
OBJECTIVES: To compare the efficacy and safety of poractant alfa and bovine lipid extract surfactant in preterm infants. STUDY DESIGN: Randomized, partially-blinded, multicenter trial. Infants <32 weeks needing surfactant before 48 hours were randomly assigned to receive poractant alfa or bovine lipid extract surfactant. The primary outcome was being alive and extubated at 48 hours post-randomization. Secondary outcomes included need for re-dosing, duration of respiratory support and oxygen, bronchopulmonary dysplasia, mortality and complications during administration...
2017: PloS One
https://www.readbyqxmd.com/read/28471443/the-role-of-near-infrared-spectroscopy-monitoring-in-preterm-infants
#15
P Korček, Z Straňák, J Širc, G Naulaers
Neurological morbidities such as peri/intraventricular hemorrhage and periventricular leukomalacia largely determine the neurodevelopmental outcome of vulnerable preterm infants and our aim should be to minimize their occurrence or severity. Bed-side neuromonitoring could provide valuable pieces of information about possible hemodynamic disturbances that are significantly associated with neurological morbidities and increased mortality. Near-infrared spectroscopy offers evaluation of regional cerebral oxygenation, which in conjunction with other non-invasive methods may give us a more complete picture about end-organ perfusion...
May 4, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28469102/prevalence-of-congenital-heart-disease-among-infants-from-2012-to-2014-in-langfang-china
#16
Peng-Fei Sun, Gui-Chun Ding, Min-Yu Zhang, Sheng-Nan He, Yu Gao, Jian-Hua Wang
BACKGROUND: Congenital heart disease (CHD) is the most common congenital malformations with high mortality and morbidity. The prevalence of CHD reported previously ranged from 4 per 1000 live births to 50 per 1000 live births. In this cross-sectional study, we aimed to document the prevalence of CHD in Langfang district of Hebei Province, China by analyzing data collected by hospitals located in 11 the counties of the district, as supported by a public health campaign. METHODS: A total of 67,718 consecutive 3-month-old infants were included from July 19, 2012 to July 18, 2014...
May 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28468653/a-description-of-the-methods-of-the-aspirin-supplementation-for-pregnancy-indicated-risk-reduction-in-nulliparas-aspirin-study
#17
Matthew K Hoffman, Shivaprasad S Goudar, Bhalachandra S Kodkany, Norman Goco, Marion Koso-Thomas, Menachem Miodovnik, Elizabeth M McClure, Dennis D Wallace, Jennifer J Hemingway-Foday, Antoinette Tshefu, Adrien Lokangaka, Carl L Bose, Elwyn Chomba, Musaku Mwenechanya, Waldemar A Carlo, Ana Garces, Nancy F Krebs, K Michael Hambidge, Sarah Saleem, Robert L Goldenberg, Archana Patel, Patricia L Hibberd, Fabian Esamai, Edward A Liechty, Robert Silver, Richard J Derman
BACKGROUND: Preterm birth (PTB) remains the leading cause of neonatal mortality and long term disability throughout the world. Though complex in its origins, a growing body of evidence suggests that first trimester administration of low dose aspirin (LDA) may substantially reduce the rate of PTB. METHODS: Hypothesis: LDA initiated in the first trimester reduces the risk of preterm birth. Study Design Type: Prospective randomized, placebo-controlled, double-blinded multi-national clinical trial conducted in seven low and middle income countries...
May 3, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28459851/correction-mortality-and-length-of-stay-of-very-low-birth-weight-and-very-preterm-infants-a-eurohope-study
#18
Dino Numerato, Giovanni Fattore, Fabrizio Tediosi, Rinaldo Zanini, Mikko Peltola, Helen Banks, Péter Mihalicza, Liisa Lehtonen, Sofia Sveréus, Richard Heijink, Søren Toksvig Klitkou, Eilidh Fletcher, Amber A van der Heijden, Fredrik Lundberg, Eelco Over, Unto Häkkinen, Timo T Seppälä
[This corrects the article DOI: 10.1371/journal.pone.0131685.].
2017: PloS One
https://www.readbyqxmd.com/read/28456800/inhaled-glucocorticoids-and-pneumonia-in-preterm-infants-post-hoc-results-from-the-neurosis-trial
#19
Alexander Koch, Karen Kreutzer, Gabriele von Oldershausen, Christian F Poets, Dirk Bassler
BACKGROUND: Inhaled glucocorticoids may increase the risk of pneumonia in adults. Thus, respiratory infections may be a potential explanation for the non-significantly increased mortality seen in the glucocorticoid group in the largest randomized trial on inhaled glucocorticoids for preventing bronchopulmonary dysplasia in preterm infants published to date (NEuroSIS). OBJECTIVE: To evaluate the effect of inhaled budesonide on the risk of death due to respiratory infections in the NEuroSIS trial...
April 29, 2017: Neonatology
https://www.readbyqxmd.com/read/28455705/hofbauer-cells-placental-macrophages-of-fetal-origin
#20
Leticia Reyes, Bryce Wolfe, Thaddeus Golos
Pregnancy complications such as preterm birth, miscarriage, maternal and/or neonatal morbidities, and mortality can be manifestations of underlying placental pathology. Hofbauer cells refer to a heterogeneous population of fetal macrophages that reside within the functional unit of the placenta known as the chorionic villus. Hofbauer cells can be detected within the connective tissue matrix of the placenta as early as 4 weeks post-conception and are present throughout pregnancy. These cells are implicated in a wide array of functions important for a successful pregnancy including placental morphogenesis, immune regulation, control of stromal water content, and the transfer of ions and serum proteins across the maternal-fetal barrier...
2017: Results and Problems in Cell Differentiation
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