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Sepsis in newborn

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https://www.readbyqxmd.com/read/29137607/improved-referral-and-survival-of-newborns-after-scaling-up-of-intensive-care-in-suriname
#1
Rens Zonneveld, Natanael Holband, Anna Bertolini, Francesca Bardi, Neirude P A Lissone, Peter H Dijk, Frans B Plötz, Amadu Juliana
BACKGROUND: Scaling up neonatal care facilities in developing countries can improve survival of newborns. Recently, the only tertiary neonatal care facility in Suriname transitioned to a modern environment in which interventions to improve intensive care were performed. This study evaluates impact of this transition on referral pattern and outcomes of newborns. METHODS: A retrospective chart study amongst newborns admitted to the facility was performed and outcomes of newborns between two 9-month periods before and after the transition in March 2015 were compared...
November 14, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/29134255/identification-of-generic-and-pathogen-specific-cord-blood-monocyte-transcriptomes-reveals-a-largely-conserved-response-in-preterm-and-term-newborn-infants
#2
Emma de Jong, David G Hancock, Julie Hibbert, Christine Wells, Peter Richmond, Karen Simmer, David Burgner, Tobias Strunk, Andrew J Currie
Escherichia coli and Staphylococcus epidermidis are predominant causes of neonatal sepsis, particularly affecting preterm infants. Susceptibility to infection has been attributed to "immature" innate monocyte defences, but no studies have assessed global transcriptional responses of neonatal monocytes to these pathogens. Here, we aimed to identify and characterise the neonatal monocyte transcriptional responses to E. coli and S. epidermidis and the role of common modifiers such as gestational age (GA) and exposure to chorioamnionitis (a common complication of preterm birth) to better understand early life innate immune responses...
November 13, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29117328/maternal-disease-with-group-b-streptococcus-and-serotype-distribution-worldwide-systematic-review-and-meta-analyses
#3
Jennifer Hall, Nadine Hack Adams, Linda Bartlett, Anna C Seale, Theresa Lamagni, Fiorella Bianchi-Jassir, Joy E Lawn, Carol J Baker, Clare Cutland, Paul T Heath, Margaret Ip, Kirsty Le Doare, Shabir A Madhi, Craig E Rubens, Samir K Saha, Stephanie Schrag, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Michael G Gravett
Background: Infections such as group B Streptococcus (GBS) are an important cause of maternal sepsis, yet limited data on epidemiology exist. This article, the third of 11, estimates the incidence of maternal GBS disease worldwide. Methods: We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data on invasive GBS disease in women pregnant or within 42 days postpartum...
November 6, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29103237/inflammatory-response-in-preterm-newborns-born-after-prolonged-premature-rupture-of-membranes-is-there-a-correlation-with-placental-histological-findings
#4
Neri Katz, Letizia Schreiber, Anat Oron, Sarel Halachmi, David Kohelet
BACKGROUND: Preterm birth is the leading cause of morbidity and mortality among neonates in the United States. Early recognition of sepsis in this population is a challenging task since overt clinical signs can be difficult to determine. C-reactive protein (CRP), one of the most frequently non-specific used laboratory test, can indirectly aid the diagnosis of neonatal sepsis. OBJECTIVES: To evaluate the relationship between histological findings in the placenta of preterm newborns born after prolonged rupture of membranes, CRP levels, and blood cultures...
October 2017: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29099699/epidemiological-features-of-the-perinatal-risk-factors-and-neonatal-outcomes-in-georgia-pilot-study
#5
N Tskimanauri, N Khachapuridze, T Chanadiri, S Bakhtadze
The purpose of this work was to identify and evaluate the epidemiological features, like the point prevalence of the perinatal risk factors and related to them pathological conditions revealing at the neonatal period. The descriptive population based prospective pilot study of children population of age 0-2 years was con-ducted in the City Tbilisi (in clinical centers "Medcapital", "family center N3" and "Valeo"), also in medical centers of districts of Mtsketa and Dusheti in period January 2015- January 2017...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29096709/strategies-for-preventing-group-b-streptococcal-infections-in-newborns-a-nation-wide-survey-of-italian-policies
#6
Chryssoula Tzialla, Alberto Berardi, Claudio Farina, Pierangelo Clerici, Alessandro Borghesi, Elsa Viora, Paolo Scollo, Mauro Stronati
BACKGROUND: There are no Italian data regarding the strategies for preventing neonatal group B streptococcal (GBS) infection. We conducted a national survey in order to explore obstetrical, neonatal and microbiological practices for the GBS prevention. METHODS: Three distinct questionnaires were sent to obstetricians, neonatologists and microbiologists. Questionnaires included data on prenatal GBS screening, maternal risk factors, intrapartum antibiotic prophylaxis, microbiological information concerning specimen processing and GBS antimicrobial susceptibility...
November 2, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/29090355/microbiological-comparison-of-blood-culture-and-amplification-of-16s-rdna-methods-in-combination-with-dgge-for-detection-of-neonatal-sepsis-in-blood-samples
#7
Isela García-Gudiño, Eucario Yllescas-Medrano, Rolando Maida-Claros, Diana Soriano-Becerril, Nestor F Díaz, Guadalupe García-López, Anayansí Molina-Hernández, Oscar Flores-Herrera, Francisco J Zavala-Díaz de la Serna, María Del Rosario Peralta-Pérez, Héctor Flores-Herrera
It is estimated that 15% of all newborns admitted to the neonatal intensive care unit (NICU) for suspected sepsis receive multiple broad-spectrum antibiotics without pathogen identification. The gold standard for bacterial sepsis detection is blood culture, but the sensitivity of this method is very low. Recently, amplification and analysis of the 16S ribosomal DNA (rDNA) bacterial gene in combination with denaturing gradient gel electrophoresis (DGGE) has proven to be a useful approach for identifying bacteria that are difficult to isolate by standard culture methods...
October 31, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/29082903/invasive-candidiasis-in-a-neonatal-intensive-care-unit-in-lagos-nigeria
#8
Beatrice Nkolika Ezenwa, Rita Okeoghene Oladele, Patricia Eyanya Akintan, Iretiola Bamikeolu Fajolu, Phillip Olayiwola Oshun, Oyinlola Omoniyi Oduyebo, Veronica Chinyere Ezeaka
BACKGROUND: Invasive candidiasis has been identified globally as a major cause of morbidity and mortality in neonatal intensive care units (NICU). Systemic candidiasis presents like bacterial sepsis and can involve multiple organs. OBJECTIVE: The objective of this study was to determine the prevalence of Candida infection in a NICU at a tertiary hospital in Nigeria and to identify its associated risk factors. MATERIALS AND METHODS: The study was a retrospective descriptive study of all cases of culture-proven invasive Candida infection (ICI) in neonates admitted to the NICU over a 4-year period...
July 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29081936/the-role-of-interleukin-6-in-the-early-diagnosis-of-sepsis-in-premature-infants
#9
Mehrdad Mirzarahimi, Manouchehr Barak, Abdolkarim Eslami, Afsaneh Enteshari-Moghaddam
Septicemia is one of the major causes of mortality and morbidity in newborns. The aim of this study was to investigate the role of interleukin-6 (IL-6) in the early diagnosis of Sepsis in premature newborns. This cross-sectional study was conducted on preterm infants admitted to NICU of Hospital Buali in Ardabil city, Iran. C-reactive protein (CRP), IL-6 and complete blood count tests have been done in baseline, third and seventh day. Collected data analyzed by one-sample t-test, repeated measures and ANOVA in SPSS...
October 6, 2017: Pediatric Reports
https://www.readbyqxmd.com/read/29074716/antimicrobial-resistance-in-uk-neonatal-units-neonin-infection-surveillance-network
#10
Benjamin Cailes, Christina Kortsalioudaki, Jim Buttery, Santosh Pattnayak, Anne Greenough, Jean Matthes, Alison Bedford Russell, Nigel Kennea, Paul T Heath
OBJECTIVE: To define the susceptibilities of the common causative pathogens of neonatal sepsis in the UK. DESIGN: Retrospective analysis of the prospectively collected neonIN infection surveillance network data between 2005 and 2014. SETTING: 30 neonatal units in the UK. PATIENTS: Newborns admitted to participating neonatal units who return a positive blood, cerebrospinal fluid or urine culture and are treated with at least 5 days of appropriate antibiotics...
October 26, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29073796/death-audit-in-the-neonatal-icu-of-a-tertiary-care-hospital-in-bangladesh-a-retrospective-chart-review
#11
Sanjoy Kumer Dey, Sharmin Afroze, Tariqul Islam, Ismat Jahan, Mohammad Kamrul Hassan Shabuj, Suraiya Begum, Mohammod Jobayer Chisti, Mohammad Abdul Mannan, Mohammod Shahidullah
BACKGROUND: Expectant reduction of neonatal mortality and formulation of preventive strategies can only be achieved by analysis of risk factors in a particular setting. This study aimed to document incidence of neonatal death and to analyze the risk factors associated with neonatal death. METHODS: This retrospective study was carried out in department of Neonatology, Bangabandhu Sheikh Mujib Medical University (BSMMU) over a 12-month period from January to December 2015...
October 26, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29050043/-malpractice-claims-against-pediatricians-analysis-of-expert-testimonies-from-the-medical-service-of-health-insurance-companies-between-2000-and-2014
#12
Heiko Steinhauer, Joachim Holzschuh, Thomas Böhler
Background In Germany, few data are available on medical malpractice claims against pediatricians. On behalf of Statutory Health Insurance Companies their Medical Service (MDK) regularly offers expert testimony in case of allegations during pediatric treatment. Methods Analysis of 374 written pediatric testimonies, documented between September 1st, 2000 and August 31st, 2014. Results 193 allegations against pediatricians were analysed separately for each sector of care (35% concerning outpatients, 28% normal inpatients, and 37% patients treated in an intensive care unit, ICU)...
November 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29049359/analysis-of-pd-1-expression-in-the-monocyte-subsets-from-non-septic-and-septic-preterm-neonates
#13
Magdalena Zasada, Marzena Lenart, Magdalena Rutkowska-Zapała, Małgorzata Stec, Wojciech Durlak, Andrzej Grudzień, Agnieszka Krzeczkowska, Nina Mól, Marta Pilch, Maciej Siedlar, Przemko Kwinta
Programmed death-1 (PD-1) receptor system represents a part of recently reported immunoregulatory pathway. PD-1 is an immune checkpoint molecule, which plays an important role in downregulating the immune system proinflammatory activity. Until recently, PD-1 expression was not established on immune cells of the preterm infants. The study objectives were to confirm expression of the PD-1 receptors on the monocytes isolated from very low birth weight newborns (VLBW), and to analyze their expression during the first week of life and late-onset sepsis...
2017: PloS One
https://www.readbyqxmd.com/read/29049058/the-neonatal-microbiome-implications-for-neonatal-intensive-care-unit-nurses
#14
Jeannie Rodriguez, Sheila Jordan, Abby Mutic, Taylor Thul
Nursing care of the neonate in the neonatal intensive care unit (NICU) is complex, due in large part to various physiological challenges. A newer and less well-known physiological consideration is the neonatal microbiome, the community of microorganisms, both helpful and harmful, that inhabit the human body. The neonatal microbiome is influenced by the maternal microbiome, mode of infant birth, and various aspects of NICU care such as feeding choice and use of antibiotics. The composition and diversity of the microbiome is thought to influence key health outcomes including development of necrotizing enterocolitis, late-onset sepsis, altered physical growth, and poor neurodevelopment...
November 2017: MCN. the American Journal of Maternal Child Nursing
https://www.readbyqxmd.com/read/29042061/analysis-of-selected-aspects-of-inflammasome-function-in-the-monocytes-from-neonates-born-extremely-and-very-prematurely
#15
Magdalena Zasada, Marzena Lenart, Magdalena Rutkowska-Zapała, Małgorzata Stec, Nina Mól, Ola Czyz, Maciej Siedlar, Przemko Kwinta
BACKGROUND: Inflammasomes regulate activation of caspase-1, which cleaves and activates interleukin (IL)-1β and IL-18, the cytokines that trigger pro-inflammatory and antimicrobial responses. There is very little known about inflammasome function in the subsets of monocytes (MO) isolated from preterm neonates born extremely and very prematurely. METHODS: A group of 76 very low birth weight patients without early-onset sepsis was divided into extremely preterm (<28 gestational week) or very preterm (28-32 gestational week) neonates...
October 5, 2017: Immunobiology
https://www.readbyqxmd.com/read/29036682/perinatal-risk-factors-for-neonatal-early-onset-group-b-streptococcal-sepsis-after-initiation-of-risk-based-maternal-intrapartum-antibiotic-prophylaxis-a-case-control-study
#16
Sridhar Santhanam, Sumita Arun, Grace Rebekah, Nithya J Ponmudi, Jolly Chandran, Ruby Jose, Atanu Kumar Jana
Objectives: To identify the perinatal risk factors for early-onset Group B Streptococcus (EOGBS) sepsis in neonates after inception of a risk-based maternal intrapartum antibiotic prophylaxis strategy in 2004. Design: Case control study. Methods: All newborn with early onset GBS sepsis (born between 2004 and 2013) were deemed to be "cases" and controls were selected in a 1:4 ratio. Results: More than three per vaginal (PV) examinations [odds ratio (OR) 8...
September 23, 2017: Journal of Tropical Pediatrics
https://www.readbyqxmd.com/read/29029763/serotype-virulence-profile-antimicrobial-resistance-and-macrolide-resistance-determinants-in-streptococcus-agalactiae-isolates-in-pregnant-women-and-neonates-in-catalonia-spain
#17
Yuly López, Elena Parra, Virginio Cepas, Isabel Sanfeliú, Teresa Juncosa, Antonia Andreu, Mariona Xercavins, Josefa Pérez, Sergi Sanz, Andrea Vergara, Jordi Bosch, Sara Maria Soto
INTRODUCTION: Streptococcus agalactiae, or group B streptococci (GBS), is the main aetiological agent of early neonatal sepsis in developed countries. This microorganism belongs to the gastrointestinal tract microbiota wherefrom it can colonize the vagina and be vertically transmitted to the child either before or at birth, and subsequently cause infection in the newborn. Approximately, 50% of newborns born to women with GBS become colonized, with 1-2% developing early neonatal infection if no preventive intervention is performed...
October 10, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/28987479/nurses-early-recognition-of-neonatal-sepsis
#18
Michele Boettiger, Lynda Tyer-Viola, Joseph Hagan
OBJECTIVE: To determine nurses' perceptions of the most common physiologic and behavioral indicators of neonatal sepsis. DESIGN: Descriptive correlational study. SETTING: A women's and children's hospital in an academic medical center in the southwestern United States. PARTICIPANTS: Nurses (N = 181) who cared for neonates in the mother-infant and NICU settings. METHODS: Participants completed an e-mail survey developed from the literature to ascertain their perceptions of which physiologic and behavioral indicators were most often associated with neonatal sepsis...
November 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
https://www.readbyqxmd.com/read/28980093/incidence-of-fever-and-positive-bacterial-cultures-in-neonates-receiving-prostaglandin
#19
Fares Alghanem, Stephanie L Rakestraw, Kurt R Schumacher, Gabe E Owens
Prostaglandin E (PGE1) is necessary to maintain ductus arteriosus patency in many newborns with congenital heart disease. Because PGE1 therapy commonly leads to fever, and given this population's fragile state, a complete sepsis workup is often performed in febrile, but otherwise asymptomatic, patients. This practice of liberal evaluation with bacterial cultures, empiric antibiotic treatment, and delays in essential surgical intervention may result in poor resource utilization and lead to increased iatrogenic morbidity...
October 4, 2017: Pediatric Cardiology
https://www.readbyqxmd.com/read/28969232/scrub-typhus-in-a-new-born
#20
Mamta Jajoo, Dipti Kumar, Sameeksha Manchanda
Scrub typhus is an acute febrile mite-born rickettsial infection caused by Orientia tsutsugamushi (formely called Rickettsiatsutsugamushi). This infection is very uncommon in neonates. We report a case of 19-day-old newborn presenting with clinical features mimicking severe sepsis but was subsequently diagnosed with primary scrub typhus infection. The timely treatment resulted in dramatic response and complete recovery.
August 2017: Journal of Clinical and Diagnostic Research: JCDR
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