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https://www.readbyqxmd.com/read/29165823/identification-of-predisposing-factors-for-osteonecrosis-of-the-jaw-after-marginal-mandibulectomy-in-the-surgical-management-of-oral-squamous-cell-carcinoma
#1
Ran Ito, Jung-Ju Huang, Wei-Chuan Hsieh, Huang-Kai Kao, William Wei-Kai Lao, Ku-Hao Fang, Yenlin Huang, Yu-Liang Chang, Ming-Huei Cheng, Kai-Ping Chang
BACKGROUND: The aim of this study is to evaluate osteonecrosis of the jaw (ONJ) with the extent of marginal mandibulectomy. METHODS: Between January 2006 and December 2012, 3087 patients undergoing ablative resection were consecutively enrolled. Among them, 345 cases undergoing marginal mandibulectomy were retrospectively reviewed. RESULTS: The occurrence of ONJ was 5.51% and associated with body mass index, overall stage, diabetes, concomitant mandibulotomy, and radiotherapy (P = 0...
November 22, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29165475/effect-of-the-water-fraction-isolated-from-fructus-ligustri-lucidi-extract-on-bone-metabolism-via-antagonizing-a-calcium-sensing-receptor-in-experimental-type-1-diabetic-rats
#2
Nan-Nan Sha, Yong-Jian Zhao, Dong-Feng Zhao, Daniel Kam-Wah Mok, Qi Shi, Yong-Jun Wang, Yan Zhang
Our previous studies have demonstrated that the extract of Fructus Ligustri Lucidi (FLL) can maintain in vivo calcium homeostasis in aged and ovariectomized rats. This study was designed to elucidate the action of water fraction isolated from the FLL extract on bone metabolism and a calcium-sensing receptor (CaSR) in parathyroid glands and kidneys of diabetic rats. The streptozotocin-induced diabetic rats were treated with vehicle, FLL extract, and the water fraction (WF) isolated from the FLL extract for 4 weeks...
November 22, 2017: Food & Function
https://www.readbyqxmd.com/read/29164325/effects-of-recreational-football-on-women-s-fitness-and-health-adaptations-and-mechanisms
#3
REVIEW
Peter Krustrup, Eva Wulff Helge, Peter R Hansen, Per Aagaard, Marie Hagman, Morten B Randers, Maysa de Sousa, Magni Mohr
The review describes the fitness and health effects of recreational football in women aged 18-65 years. The review documents that 2 × 1 h of recreational football training for 12-16 weeks causes marked improvements in maximal oxygen uptake (5-15%) and myocardial function in women. Moreover, mean arterial blood pressure was shown to decrease by 2-5 mmHg in normotensive women and 6-8 mmHg in hypertensive women. This review also show that short-term (< 4 months) and medium-term (4-16 months) recreational football training has major beneficial impact on metabolic health profile in women, with fat losses of 1-3 kg and improvements in blood lipid profile...
November 21, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29163363/human-prolactin-point-mutations-and-their-projected-effect-on-vasoinhibin-generation-and-vasoinhibin-related-diseases
#4
Jakob Triebel, Christin J Friedrich, Andreas Leuchs, Gonzalo Martínez de la Escalera, Carmen Clapp, Thomas Bertsch
Background: A dysregulation of the generation of vasoinhibin hormones by proteolytic cleavage of prolactin (PRL) has been brought into context with diabetic retinopathy, retinopathy of prematurity, preeclampsia, pregnancy-induced hypertension, and peripartum cardiomyopathy. Factors governing vasoinhibin generation are incompletely characterized, and the composition of vasoinhibin isoforms in human tissues or compartments, such as the circulation, is unknown. The aim of this study was to determine the possible contribution of PRL point mutations to the generation of vasoinhibins as well as to project their role in vasoinhibin-related diseases...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29163027/mechanisms-of-osteoarthritic-pain-studies-in-humans-and-experimental-models
#5
REVIEW
Annett Eitner, Gunther O Hofmann, Hans-Georg Schaible
Pain due to osteoarthritis (OA) is one of the most frequent causes of chronic pain. However, the mechanisms of OA pain are poorly understood. This review addresses the mechanisms which are thought to be involved in OA pain, derived from studies on pain mechanisms in humans and in experimental models of OA. Three areas will be considered, namely local processes in the joint associated with OA pain, neuronal mechanisms involved in OA pain, and general factors which influence OA pain. Except the cartilage all structures of the joints are innervated by nociceptors...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29162538/metformin-promotes-the-proliferation-and-differentiation-of-murine-preosteoblast-by-regulating-the-expression-of-sirt6-and-oct4
#6
Wei Mu, Zhuoran Wang, Chuanyu Ma, Yunyun Jiang, Nannan Zhang, Kaiqiang Hu, Liyuan Li, Zhao Wang
Osteopenia, osteoporosis and bone salt metabolism disorder are common diseases in the aged and diabetics. From case reports of patients with T2DM, we have observed that metformin can decrease risk of bone fracture and promote bone formation. However, the underlying mechanism of metformin's effect on bone metabolism remains unknown. In our research, we show that metformin can promote proliferation of murine preosteoblast by regulating AMPK-mTORC2 and AKT-mTORC1 signaling axis. Furthermore, we have observed that metformin can promote SIRT6 expression before and during differentiation of murine preosteoblast...
November 18, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/29162268/diabetes-and-healing-outcomes-in-lower-extremity-fractures-a-systematic-review
#7
Hilary Gortler, Jessyca Rusyn, Charles Godbout, Jas Chahal, Emil H Schemitsch, Aaron Nauth
OBJECTIVE: The purpose of this study was to review the rates of adverse healing outcomes following surgical fixation of lower extremity fractures in diabetic patients and matched controls. MATERIALS AND METHODS: Searches of PubMed, MEDLINE, CINAHL and Embase were performed for studies published between the date of database inception and July 6, 2015. Patient characteristics and the incidence of adverse healing outcomes (nonunion, malunion, delayed union, infection and reoperation) were extracted from each study...
November 18, 2017: Injury
https://www.readbyqxmd.com/read/29160901/dietary-advanced-glycation-end-products-have-sex-and-age-dependent-effects-on-vertebral-bone-microstructure-and-mechanical-function-in-mice
#8
Svenja Illien-Jünger, Paolo Palacio-Mancheno, William F Kindschuh, Xue Chen, Grazyna E Sroga, Deepak Vashishth, James C Iatridis
Back pain is a leading cause of global disability that can arise from vertebral fracture and osteoporosis. While poor general health and obesity are among the strongest risk factors for back pain, there is remarkably little known about how diet influences spinal diseases. Advanced glycation endproducts (AGEs) are implicated in increased fracture risk, yet no studies investigated how dietary AGEs affect spinal health. We tested the hypothesis that high dietary AGE ingestion will diminish vertebral structure and function in a sex- and age-dependent manner...
November 21, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29160796/role-of-galectin-3-in-bone-cell-differentiation-bone-pathophysiology-and-vascular-osteogenesis
#9
REVIEW
Carla Iacobini, Claudia Blasetti Fantauzzi, Giuseppe Pugliese, Stefano Menini
Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate cartilage, where it favors chondrocyte survival and cartilage matrix mineralization. It was also shown to be highly expressed in differentiating osteoblasts and osteoclasts, in concomitance with expression of osteogenic markers and Runt-related transcription factor 2 and with the appearance of a mature phenotype...
November 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29160182/enhanced-bone-regeneration-via-diabetic-cell-based-adenoviral-bmp2-gene-therapy-in-diabetic-animals
#10
Shin-Young Park, Kyoung-Hwa Kim, Chan Ho Park, Seung-Yun Shin, In-Chul Rhuy, Yong-Moo Lee, Yang Jo Seol
The application of bone morphogenetic protein 2 (BMP-2) has been extensively investigated to improve diabetes-impaired bone healing; however, the delivery of BMP-2 via gene therapy for bone regeneration has rarely been investigated in diabetic animals. In this study, we aimed to evaluate which cells induce more new bone formation in diabetic animals when cell-based BMP2 gene therapy is applied. For this purpose, we harvested bone marrow stromal cells (BMSCs) twice in the same animal before (non-diabetic BMSCs; nBMSCs) and after diabetes induction (diabetic BMSCs; dBMSCs) using modified bone marrow ablation methods...
November 21, 2017: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29160051/irisin-as-a-regulator-of-bone-and-glucose-metabolism-a-narrative-review
#11
Silvia I Briganti, Gianluigi Gaspa, Gaia Tabacco, Anda M Naciu, Roberto Cesareo, Silvia Manfrini, Andrea Palermo
In humans, irisin is produced mainly by skeletal muscle in response to physical activity. It has been demonstrated that irisin plays a pivotal role in inducing fat browning and regulating energy expenditure. New findings from various studies conducted in both animals and humans suggest that irisin can affect bone and glucose metabolism. In particular, irisin is able to increase bone cortical mass by stimulating the osteoblast pathways, and irisin levels are inversely correlated with the incidence of fragility fractures among postmenopausal women affected by osteoporosis...
November 20, 2017: Minerva Endocrinologica
https://www.readbyqxmd.com/read/29158852/curative-metatarsal-bone-surgery-combined-with-intralesional-administration-of-recombinant-human-epidermal-growth-factor-in-diabetic-neuropathic-ulceration-of-the-forefoot-a-prospective-open-uncontrolled-nonrandomized-observational-study
#12
Aristides L Garcia Herrera, Ridel de Jesús Febles Sanabria, Liliana de Los Ángeles Acosta Cabadilla, Miriam Moliner Cartaya
Background: Curative surgery is performed for a foot with ulcers and loss of protective sensation to heal the wound and prevent amputation. Evidence supports that patients with diabetes have decreased concentrations of growth factors in their tissues, notably epidermal growth factor (EGF). Injecting EGF deep into the bottom of the wound and its contours encourages a more effective response in terms of granulation tissue growth and wound closure. Objective: To assess the effectiveness and safety of curative metatarsal bone surgery combined with intralesional administration of human recombitant EGF in neuropathic diabetic forefoot ulceration...
2017: Current Therapeutic Research, Clinical and Experimental
https://www.readbyqxmd.com/read/29158420/superoxide-production-by-nadph-oxidase-intensifies-macrophage-antiviral-responses-during-diabetogenic-coxsackievirus-infection
#13
Ashley R Burg, Shaonli Das, Lindsey E Padgett, Zachary E Koenig, Hubert M Tse
Coxsackievirus B infections are suspected environmental triggers of type 1 diabetes (T1D) and macrophage antiviral responses may provide a link to virus-induced T1D. We previously demonstrated an important role for NADPH oxidase (NOX)-derived superoxide production during T1D pathogenesis, as NOX-deficient NOD mice (NOD.Ncf1(m1J) ) were protected against T1D due, in part, to impaired proinflammatory TLR signaling in NOD.Ncf1(m1J) macrophages. Therefore, we hypothesized that loss of NOX-derived superoxide would dampen diabetogenic antiviral macrophage responses and protect from virus-induced diabetes...
November 20, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29156149/quantitative-evaluation-of-vertebral-microvascular-permeability-and-fat-fraction-in-alloxan-induced-diabetic-rabbits
#14
Lei Hu, Yun Fei Zha, Li Wang, Liang Li, Dong Xing, Wei Gong, Jiao Wang, Yuan Lin, Fei Fei Zeng, Xue Song Lu
Purpose To determine longitudinal relationships between lumbar vertebral bone marrow permeability and marrow adipose tissue in a rabbit diabetes model by using quantitative dynamic contrast agent-enhanced (DCE) magnetic resonance (MR) imaging and iterative decomposition of water and fat with the echo asymmetry and least-squares estimation quantitation (IDEAL IQ) sequence. Materials and Methods Twenty rabbits were randomly assigned to the diabetic (n = 10) or control (n = 10) group. All rabbits underwent sagittal MR imaging of the lumbar region at fixed time points (0, 4, 8, 12, and 16 weeks after alloxan injection)...
November 20, 2017: Radiology
https://www.readbyqxmd.com/read/29155440/severe-hypoglycemia-caused-by-lenalidomide
#15
Daniel J Przybylski, Ruemu Birhiray, David J Reeves
Lenalidomide is commonly used for multiple myeloma as either induction or maintenance therapy. The agent is associated with a host of adverse effects, but hypoglycemia has only been reported in one phase I trial in patients with solid tumors. We describe a 74-year-old woman who experienced grade 3 hypoglycemia (blood glucose level 35 mg/dL) likely related to lenalidomide. Her medical history was significant for refractory myeloma and type 2 diabetes mellitus. Lenalidomide was started as maintenance therapy following autologous bone marrow transplantation...
November 20, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/29150938/regulation-of-calcification-in-human-aortic-smooth-muscle-cells-infected-with-high-glucose-treated-porphyromonas-gingivalis
#16
Te-Chuan Chen, Chien-Tsong Lin, Shao-Ju Chien, Shun-Fu Chang, Cheng-Nan Chen
Porphyromonas (P.) gingivalis infection leading to the periodontitis has been associated with the development of systemic diseases, including cardiovascular diseases and diabetes. However, the effect of a high concentration of glucose (HG) on the invasion efficiency of P. gingivalis and the consequent modulation of pathogenesis in vascular cells, especially in the vascular smooth muscle cells (VSMCs), remains unclear. Hence, the aim of this study was to investigate whether treating P. gingivalis with HG could change its invasion capability and result in VSMC calcification and the underlying mechanism...
November 18, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29149826/novel-functions-of-microrna-17-92-cluster-in-the-endocrine-system
#17
Shan Wan, Xiang Chen, Yuedong He, Xijie Yu
BACKGROUND: MiR-17-92 cluster is coded by MIR17HG in chromosome 13, which is highly conserved in vertebrates. Published literatures have proved that miR-17-92 cluster critically regulates tumorigenesis and metastasis. Recent researches showed that the miR-17-92 cluster also plays novel functions in the endocrine system. OBJECTIVE: To summarize recent findings on the physiological and pathological roles of miR-17-92 cluster in bone, lipid and glucose metabolisms...
November 17, 2017: Current Drug Targets
https://www.readbyqxmd.com/read/29148129/development-of-functional-electrical-stimulation-rowing-the-rowstim-series
#18
Brian Andrews, Robin Gibbons, Garry Wheeler
Potentially, functional electrical stimulation (FES)-assisted exercise may have an important therapeutic role in reducing comorbidities associated with spinal cord injury (SCI). Here, we present an overview of these secondary life-threatening conditions, discuss the rationale behind the development of a hybrid exercise called FES rowing, and describe our experience in developing FES rowing technology. FES rowing and sculling are unique forms of adaptive rowing for those with SCI. The paralyzed leg musculature is activated by multiple channels of electrical pulses delivered via self-adhesive electrodes attached to the skin...
November 2017: Artificial Organs
https://www.readbyqxmd.com/read/29146187/lox-related-collagen-crosslink-changes-act-as-an-initiator-of-bone-fragility-in-a-zdf-rats-model
#19
Xun Xiao, Jie Ren, Jun Chen, Zhaohui Liu, Ye Tian, Neel R Nabar, Min Wang, Liang Hao
Diabetes mellitus type 2 (DM2) results in bone abnormalities that manifest as increased bone fragility. Bone consists of two phases, the mineral phase and the matrix phase, and disorders in both are seen in DM2. However, the phase in which DM2 mediated bone fragility is initiated is still unknown. In this study, a male Zucker diabetic fatty (fa/fa) (ZDF) rat model was used to investigate the underlying mechanism initiating DM2 mediated bone fragility. The fracture surface morphology, pre- and post-yield bone mechanical behavior, insoluble collagen volume, lysyl oxidase family (LOX) enzyme levels and correlation analysis was performed to determine the relationship between insoluble collagen and post-yield behavior...
November 13, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29144812/increased-bone-turnover-in-type-2-diabetes-patients-randomized-to-bariatric-surgery-vs-medical-therapy-at-5-years
#20
Megan R Crawford, Nathan Pham, Leila Khan, James F Bena, Philip R Schauer, Sangeeta R Kashyap
OBJECTIVE: The aim of our study was to determine the 5 year outcomes of bariatric surgery vs. intensive medical therapy on bone turnover in patients with type 2 diabetes (T2DM) from the STAMPEDE trial. METHODS: This is an ancillary investigation of a 5 year randomized control trial at a single tertiary care center involving 95 patients aged 48.5 ± 8 years with obesity (BMI: 36.5±3.6 kg/m(2)) and uncontrolled T2DM (HbA1C: 9.3 ±1.6%). Patients were randomized to intensive medical therapy (IMT; N=25), Roux-en-Y gastric bypass (RYGB; N=37), or sleeve gastrectomy (SG; N=33) for diabetes treatment...
November 16, 2017: Endocrine Practice
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