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https://www.readbyqxmd.com/read/29353395/comparison-of-osteoporosis-in-us-adults-with-type-1-and-type-2-diabetes-mellitus
#1
S C DeShields, T D Cunningham
PURPOSE: We examined bone mineral density (BMD) and osteoporosis prevalence in those with type 1 compared to type 2 diabetes derived from a nationally representative sample from the civilian community in the United States. METHODS: Data from the National Health and Nutrition Examination Survey (NHANES) for 2005-2006, 2007-2008, 2009-2010, and 2013-2014 were merged to obtain a large sample of diabetics at least 20 years of age with participation in the interview and medical examination...
January 20, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29353038/cereblon-crbn-deletion-reverses-streptozotocin-induced-diabetic-osteoporosis-in-mice
#2
Cong Yao, Xiong Guo, Wan-Xia Yao, Chun Zhang
Diabetes mellitus is a major cause to induce osteoporosis. Though the pathogenesis of osteoporosis progression has been well investigated, its still not fully understood. Recently, cereblon (CRBN) was considered as a negative modulator of adenosine monophosphate-activated protein kinase (AMPK) in vitro and in vivo. Here, we presented results indicating that CRBN could effectively regulate osteoporosis development. In STZ-induced wild type (WT) mice with diabetes, the osteoclasts were highly increased along with the deterioration of bone structure...
January 15, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29352218/nutritional-deficiencies-and-bone-metabolism-after-endobarrier-in-obese-type-2-patients-with-diabetes
#3
Nuria Vilarrasa, Alexandra Fabregat, Silvia Toro, Amador García Gordejuela, Anna Casajoana, Mónica Montserrat, Pilar Garrido, Rafael López-Urdiales, Núria Virgili, Alejandra Planas-Vilaseca, Andreu Simó-Servat, Jordi Pujol
Endobarrier® is a minimally invasive, reversible endoscopic treatment for obesity. It provokes malabsorption along 60 cm of the small intestine, which can contribute to the development of vitamin deficiencies and to changes in bone mineral density (BMD). To determine the prevalence of nutrient deficiencies, changes in body composition and BMD during the first year after Endobarrier® placement. Twenty-one patients with type 2 diabetes met inclusion criteria. Levels of vitamins, micro and macronutrients were assessed prior and at 1, 3 and 12 months post-operatively...
January 19, 2018: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29350883/peri-implant-conditions-and-levels-of-advanced-glycation-end-products-among-patients-with-different-glycemic-control
#4
Zeyad H Al-Sowygh, Siti Mariam Ab Ghani, Konstantinos Sergis, Fahim Vohra, Zohaib Akram
BACKGROUND: A close relationship between poor glycemic control and peri-implant break down has been demonstrated. It is hypothesized that levels of advanced glycation end products (AGEs) in peri-implant sulcular fluid (PISF) are higher with increased glycemic levels in type 2 diabetes mellitus patients. PURPOSE: In the present study, we examined the clinical and radiographic peri-implant parameters and levels of AGEs among different glycemic levels in diabetic patients and assessed whether the levels of AGEs correlate with clinical peri-implant parameters...
January 19, 2018: Clinical Implant Dentistry and related Research
https://www.readbyqxmd.com/read/29350343/syringic-acid-a-phenolic-acid-promotes-osteoblast-differentiation-by-stimulation-of-runx2-expression-and-targeting-of-smad7-by-mir-21-in-mouse-mesenchymal-stem-cells
#5
B Arumugam, K Balagangadharan, N Selvamurugan
Syringic acid (SA), a phenolic acid, has been used in Chinese and Indian medicine for treating diabetes but its role in osteogenesis has not yet been investigated. In the present study, at the molecular and cellular levels, we evaluated the effects of SA on osteoblast differentiation. At the cellular level, there was increased alkaline phosphatase (ALP) activity and calcium deposition by SA treatment in mouse mesenchymal stem cells (mMSCs). At the molecular level, SA treatment of these cells stimulated expression of Runx2, a bone transcription factor, and of osteoblast differentiation marker genes such as ALP, type I collagen, and osteocalcin...
January 19, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29346119/the-role-of-tedizolid-in-skin-and-soft-tissue-infections
#6
Emilio Bouza, Patricia Muñoz, Almudena Burillo
PURPOSE OF REVIEW: Tedizolid is a second-generation oxazolidinone with activity against Gram-positive bacteria, including MRSA isolates resistant to linezolid. Pivotal clinical trials showed that tedizolid at 200 mg once-daily for 6 days is not inferior to linezolid 600 mg twice daily for 10 days in patients with SSTI. The comparison of adverse events is favorable to tedizolid under the circumstances of the clinical trials. This is a review of recent literature on tedizolid, its use in special populations and potential adverse effects...
January 15, 2018: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29344692/the-epidemiology-of-wrist-fractures-in-older-men-the-osteoporotic-fractures-in-men-mros-study
#7
N C Wright, E R Hooker, C M Nielson, K E Ensrud, S L Harrison, E S Orwoll, E Barrett-Connor
There is limited wrist fracture information on men. Our goal was to calculate frequency and identify risk factors for wrist fracture in the Osteoporotic Fractures in Men (MrOS) study. We confirmed that fracture history and certain medications are predictors, and identified novel predictors including markers of kidney function and physical performance. INTRODUCTION: To calculate the incidence of wrist fractures and their risk factors in older community-dwelling men from the US Osteoporotic Fractures in Men (MrOS) study...
January 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29344492/bilateral-hypopyon-uveitis-in-chronic-myeloid-leukemia
#8
Mudit Tyagi, Vishal Govindhari, Rajeev R Pappuru, Vikas Ambiya
Background: A leukemic hypopyon is considered an early sign of central nervous system involvement or systemic relapse. A differential diagnosis of masquerade syndromes should be considered in cases of hypopyon uveitis that are atypical or unresponsive to treatment. We report a case of a 45-year-old man who presented with bilateral hypopyon uveitis and was subsequently diagnosed as having chronic myeloid leukemia. Method: Retrospective case review. Results: A 45-year-old diabetic male presented with diminished vision in both eyes for 10 days...
December 2017: Ocular Oncology and Pathology
https://www.readbyqxmd.com/read/29343193/perinatal-sclerostin-concentrations-in-abnormal-fetal-growth-the-impact-of-gestational-diabetes
#9
Despina D Briana, Maria Boutsikou, Antonios Marmarinos, Dimitrios Gourgiotis, Ariadne Malamitsi-Puchner
OBJECTIVE: To prospectively evaluate maternal and cord blood concentrations of sclerostin -an osteocyte-secreted factor, inhibiting osteoblast differentiation and bone formation and associated with adverse metabolism- in pregnancies with normal and abnormal fetal growth. METHODS: Plasma sclerostin concentrations were determined by ELISA in 80 maternal and 80 cord blood samples from asymmetric intrauterine-growth-restricted (IUGR, n = 30), large-for-gestational-age (LGA, n = 30) and appropriate-for-gestational-age (AGA, n = 20) singleton full-term pregnancies...
January 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29342321/contributions-of-material-properties-and-structure-to-increased-bone-fragility-for-a-given-bone-mass-in-the-ucd-t2dm-rat-model-of-type-2-diabetes
#10
Claire Acevedo, Meghan Sylvia, Eric Schaible, James L Graham, Kimber L Stanhope, Lionel N Metz, Bernd Gludovatz, Ann V Schwartz, Robert O Ritchie, Tamara N Alliston, Peter J Havel, Aaron J Fields
Adults with type 2 diabetes (T2D) have a higher fracture risk for a given bone quantity, but the mechanisms remain unclear. Using a rat model of polygenic obese T2D, we demonstrate that diabetes significantly reduces whole-bone strength for a given bone mass (micro-CT-derived BMC), and we quantify the roles of T2D-induced deficits in material properties versus bone structure, i.e., geometry and microarchitecture. Lumbar vertebrae and ulnae were harvested from 6-month-old lean Sprague-Dawley rats, obese Sprague-Dawley rats, and diabetic obese UCD-T2DM rats (diabetic for 69 ± 7 days; blood glucose >200 mg/dl)...
January 17, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29336868/the-therapeutic-potential-of-targeting-the-peripheral-endocannabinoid-cb1-receptor-system
#11
REVIEW
Joseph Tam, Liad Hinden, Adi Drori, Shiran Udi, Shahar Azar, Saja Baraghithy
Endocannabinoids (eCBs) are internal lipid mediators recognized by the cannabinoid-1 and -2 receptors (CB1R and CB2R, respectively), which also mediate the different physiological effects of marijuana. The endocannabinoid system, consisting of eCBs, their receptors, and the enzymes involved in their biosynthesis and degradation, is present in a vast number of peripheral organs. In this review we describe the role of the eCB/CB1R system in modulating the metabolism in several peripheral organs. We assess how eCBs, via activating the CB1R, contribute to obesity and regulate food intake...
January 11, 2018: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/29335796/association-between-frailty-and-bone-loss-in-patients-undergoing-maintenance-hemodialysis
#12
Kei Yoneki, Jun Kitagawa, Keika Hoshi, Manae Harada, Takaaki Watanabe, Takahiro Shimoda, Ryota Matsuzawa, Atsushi Yoshida, Yusuke Matsunaga, Yasuo Takeuchi, Kentaro Kamiya, Atsuhiko Matsunaga
Frailty is significantly associated with bone loss in the general population. However, it is unclear whether this association also exists in patients undergoing hemodialysis who have chronic kidney disease-mineral and bone disorder (CKD-MBD). This study aimed to assess the association between frailty and bone loss in patients undergoing hemodialysis. This cross-sectional study included 214 (90 women, 124 men) Japanese outpatients undergoing maintenance hemodialysis three times per week, with a mean age of 67...
January 15, 2018: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29335343/association-between-glucocorticoid-exposure-and-healthcare-expenditures-for-potential-glucocorticoid-related-adverse-events-in-patients-with-rheumatoid-arthritis
#13
Jennie H Best, Amanda M Kong, Gregory M Lenhart, Khaled Sarsour, Marni Stott-Miller, Yong Hwang
OBJECTIVE: Oral glucocorticoid (OGC) use for rheumatoid arthritis (RA) is debated because of the adverse event (AE) profile of OGC. We evaluated the associations between cumulative doses of OGC and potential OGC-related AE, and quantified the associated healthcare expenditures. METHODS: Using the MarketScan databases, patients ≥ 18 years old who have RA with continuous enrollment from January 1 to December 31, 2012 (baseline), and from January 1 to December 31, 2013 (evaluation period), were identified...
January 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29334750/-remission-of-steroid-resistant-stills-disease-treated-with-anakinra-evidenced-by-fdg-pet-ct-examination-case-report
#14
Zdeněk Adam, Jana Skřičková, Milan Krtička, Zdeněk Řehák, Renata Koukalová, Andrea Šprláková, Marta Krejčí, Luděk Pour, Zdenka Adamová, Eva Pourová, Zdeněk Král
After elimination of infectious causes, neoplastic causes and the systemic autoimmune disease of connective tissue, a patient with high fevers over 39 °C was diagnosed with Stills disease. High doses of prednisone led to resolution of symptoms, however after reducing the doses of prednisone to 15 mg, high fevers over 39 °C returned, as well as joint pains. The high doses of prednisone led to decompensation of diabetes mellitus even with 4 daily insulin dosages. Therefore it was proceeded to regular subcutaneous administration of anakinra once a day...
2018: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29334695/complex-interplay-among-adiposity-insulin-resistance-and-bone-health
#15
REVIEW
C Ma, K T Tonks, J R Center, D Samocha-Bonet, J R Greenfield
Obesity and osteoporosis are common public health problems. Paradoxically, while obesity is associated with higher bone density, type 2 diabetic obese individuals have an increased fracture risk. Although obesity and insulin resistance co-exist, some obese individuals remain insulin-sensitive. We suggest that the apparent paradox relating obesity, bone density and fracture risk in type 2 diabetes may be at least partly influenced by differences in bone strength and quality between insulin-resistant and insulin-sensitive obese individuals...
January 15, 2018: Clinical Obesity
https://www.readbyqxmd.com/read/29333578/insulin-resistance-and-bone-a-biological-partnership
#16
Caterina Conte, Solomon Epstein, Nicola Napoli
Despite a clear association between type 2 diabetes (T2D) and fracture risk, the pathogenesis of bone fragility in T2D has not been clearly elucidated. Insulin resistance is the primary defect in T2D. Insulin signalling regulates both bone formation and bone resorption, but whether insulin resistance can affect bone has not been established. On the other hand, evidence exists that bone might play a role in the regulation of glucose metabolism. This article reviews the available experimental and clinical evidence on the interplay between bone and insulin resistance...
January 15, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29333574/unique-metabolic-activation-of-adipose-tissue-macrophages-in-obesity-promotes-inflammatory-responses
#17
Lily Boutens, Guido J Hooiveld, Sourabh Dhingra, Robert A Cramer, Mihai G Netea, Rinke Stienstra
AIMS/HYPOTHESIS: Recent studies have identified intracellular metabolism as a fundamental determinant of macrophage function. In obesity, proinflammatory macrophages accumulate in adipose tissue and trigger chronic low-grade inflammation, that promotes the development of systemic insulin resistance, yet changes in their intracellular energy metabolism are currently unknown. We therefore set out to study metabolic signatures of adipose tissue macrophages (ATMs) in lean and obese conditions...
January 14, 2018: Diabetologia
https://www.readbyqxmd.com/read/29331722/effect-of-vitamin-d-supplementation-on-serum-sclerostin-levels-in-chronic-kidney-disease
#18
REVIEW
Ashok Kumar Yadav, Vivek Kumar, Debasish Banerjee, Krishan Lal Gupta, Vivekanand Jha
Vitamin D deficiency, cardiovascular disease and abnormal bone mineral metabolism are common in chronic kidney disease (CKD). Abnormal bone mineral metabolism has been linked to vascular calcification in CKD. Sclerostin has emerged as an important messenger in cross talk between bone-vascular axis. We analyzed sclerostin in subjects who participated in the randomized, double blind, placebo controlled trial investigating the effect of cholecalciferol supplementation on vascular function in non-diabetic CKD stage G3-4 and vitamin D ≤20ng/ml [CTRI/2013/05/003648]...
January 10, 2018: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29331307/risk-factors-of-sensorineural-hearing-loss-in-patients-with-unilateral-safe-chronic-suppurative-otitis-media
#19
Abd Elrheem Ahmed Singer, Osama G Abdel-Naby Awad, Rafeek Mohamed Abd El-Kader, Ahmed Rabeh Mohamed
PURPOSE: Chronic suppurative otitis media (CSOM) is the major cause of hearing impairment, especially conductive hearing loss. Few patients also had sensorineural component, the sensorineural hearing loss (SNHL) in CSOM is controversial, especially for safe mucosal type. This study aims to assess the relationship between the frequency of SNHL development in patients with safe mucosal CSOM and its relation to patient's age, sex, duration of disease, size of perforation and different audiological findings...
January 5, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29331301/marrow-adipose-tissue-imaging-in-humans
#20
Vibha Singhal, Miriam A Bredella
Bone strength is affected not only by bone mineral density (BMD) and bone microarchitecture but also its microenvironment. Recent studies have focused on the role of marrow adipose tissue (MAT) in the pathogenesis of bone loss. Osteoblasts and adipocytes arise from a common mesenchymal stem cell within bone marrow and many osteoporotic states, including aging, medication use, immobility, over - and undernutrition are associated with increased marrow adiposity. Advancements in imaging technology allow the non-invasive quantification of MAT...
January 10, 2018: Bone
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