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Maria Teresa Mandara, Luca Motta, Pietro Calò
In cats, lymphoma (lymphosarcoma) is the most common neoplasm affecting the spinal cord and the second most common intracranial tumour. Although lymphoma commonly develops in the spinal cord as a part of a multicentric process, a primary form may occur. Lymphoma can exhibit a wide range of morphological patterns, including intraparenchymal brain mass, lymphomatosis cerebri, intravascular lymphoma, lymphomatous choroiditis and meningitis, extradural, intradural-extramedullary or intramedullary lymphoma in the spinal cord, or neurolymphomatosis in the peripheral nerves...
October 2016: Veterinary Journal
Loïc Le Guennec, Thierry Maisonobe, Sylvain Choquet, Audrey Massein, Arièle Azoulay-Cayla, Nicolas Villain, Frederique Archambaud, Khe Hoang-Xuan, Ahmed Idbaih
No abstract text is available yet for this article.
August 9, 2016: Leukemia & Lymphoma
Ali Ozan Oner, Kursat Okuyucu, Engin Alagoz, Bilal Battal, Nuri Arslan
Neurolymphomatosis (NL) is a rarely seen neurologic involvement of the systematic lymphoma. Its diagnosis is challenging, and requires biopsy. In cases where biopsy is not appropriate, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) may aid in diagnosis. Here, we present a 54-year old male patient diagnosed with Burkitt lymphoma who underwent FDG-PET/CT in order to evaluate the treatment response after chemotherapy and radiotherapy. On viewing PET/CT images of the patient who complained of pain and weakness in his upper extremities after therapy, linear FDG uptake was observed in bilateral cervical 5 (C5), left cervical 6 (C6), bilateral cervical 7 (C7), and right lumbar 4 (L4) nerve roots...
September 2016: World Journal of Nuclear Medicine
Panagiotis A Sideras, John Matthews, S M Nazmus Sakib, Franka Ofikwu, Vadim Spektor
Neurolymphomatosis is a rare neurological syndrome in lymphomas. It is reported as infiltration of peripheral nerves by lymphoma. It is important to distinguish neurolymphomatosis from other types of neuropathies, particularly infectious and inflammatory conditions. However, it is difficult to isolate a cancer-related inflammatory vasculitis and mononeuritis multiplex without definitive histopathologic examination. In this report, we describe a case of non-Hodgkin's lymphoma involving the peroneal nerve and presenting as neurolymphomatosis...
August 26, 2016: Clinical Imaging
Christopher L Groth, Kathryn S Nevel, Kelly G Gwathmey, Fahad F Bahakin, David E Jones
INTRODUCTION: Acute neuropathic pain and weakness with a sensory level in a patient with a history of lymphoma has a broad differential diagnosis. Evaluation of such a presentation often includes MRI, neurophysiologic studies, and cerebrospinal fluid evaluation. We report a patient with splenic marginal zone lymphoma who developed acute weakness, sensory loss, and neuropathic pain due to neurolymphomatosis. METHODS: Clinical evaluation, MRI of the lumbar spine, cerebrospinal fluid evaluation, electrodiagnostic (EDX) studies, and biopsy of the dorsal nerve root were undertaken...
September 14, 2016: Muscle & Nerve
Y X Yu, J Y Liu, S Yao
No abstract text is available yet for this article.
September 1, 2016: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
Wenzhuan He, Weizhen Wang, Cristy Gustas, Jozef Malysz, Divpreet Kaur
Sciatic nerve neuropathy due to infiltrating of a high grade B-cell lymphoma is a very rare situation and has not often been reported. We report a case with a previous history of indolent lymphoma who presented with isolated sciatic nerve neuropathy and was found to have diffuse large B cell lymphoma involving the sciatic nerve. Although the current case is not a primary sciatic nerve lymphoma given the systematic involvement shown on MRI and PET/CT scan, the case represents a neurolymphomatosis of the sciatic nerve given the direct invasion of the lymphoma cells into the sciatic nerve...
October 2016: Clinical Neurology and Neurosurgery
Ritu Shree, Manoj Kumar Goyal, Manish Modi, Balan Louis Gaspar, Bishan Dass Radotra, Chirag Kamal Ahuja, Bhagwant Rai Mittal, Gaurav Prakash
Neurolymphomatosis (NL) defined as infiltration of the central nervous system or the peripheral nervous system (PNS) by malignant lymphoma cells is a rare clinical entity. However, the increasing use of fluorodeoxyglucose positron-emission tomography (FDG-PET) and magnetic resonance imaging in evaluating PNS disorders is resulting in; this condition being recognized more frequently. Here; we report five NL patients and review the current literature. We report five patients with non-Hodgkin's lymphoma (NHL) and NL, all of whom were men aged 47-69 years...
July 2016: Journal of Clinical Neurology
Nguyen Xuan Canh, Ngo Van Tan, Tran Thanh Tung, Nguyen Truong Son, Simone Maurea
Neurolymphomatosis is a rare manifestation of non-Hodgkin lymphoma characterized by infiltration of peripheral nerves, nerve roots, plexus and cranial nerves by malignant lymphocytes. This report presents positron emission tomography/computed tomography (PET/CT)imaging with 2-deoxy-2-(18)F-fluoro-D-glucose ((18)F-FDG) in 3 cases of non-Hodgkin lymphoma with nerve infiltration, including one newly diagnosed lymphoma, one recurrent lymphoma in previous nerve lesions and one newly recurrent lymphoma. PET/CT could reveal the affected neural structures including cranial nerves, spinal nerve roots, brachial plexus, cervicothoracic ganglion, intercostal nerves, branches of the vagus nerve, lumbosacral plexus and sciatic nerves...
2014: Asia Ocean J Nucl Med Biol
Bryan Gammon, Benjamin R Gammon, Youn H Kim, Jinah Kim
Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a clonal proliferation of gamma-delta T cells with a cytotoxic phenotype that is typically characterized by an aggressive clinical course with ulcerative plaques or subcutaneous nodules. In this report, the authors describe a patient who developed an ulcerated tumor on the left upper extremity and painful papules and nodules on the right lower extremity. Interestingly, several of the papulonodules on the right lower extremity underwent spontaneous involution...
September 2016: American Journal of Dermatopathology
Hisanori Kinoshita, Hodaka Yamakado, Toshiyuki Kitano, Akihiro Kitamura, Hirofumi Yamashita, Masakazu Miyamoto, Takefumi Hitomi, Tomohisa Okada, Yuji Nakamoto, Nobukatsu Sawamoto, Akifumi Takaori-Kondo, Ryosuke Takahashi
Neurolymphomatosis (NL) is a rare condition involving the infiltration of lymphoma cells into the peripheral nervous system. NL can be primary or secondary in the setting of an unknown or known hematologic malignancy, respectively. Here, we report five cases in which F-18 2-fluoro-2-deoxy-glucose positron emission tomography/computed tomography (F-18 FDG-PET/CT) had great value for diagnosing NL. Two cases were rare primary NL, and the other three were secondary NL. Clinical presentations were asymmetric sensorimotor disturbances in the extremities with or without involvement of cranial nerves...
September 2016: Journal of Neurology
Aaron Kt Tong, Shirlyn Hs Neo, Tian Yue Kok
No abstract text is available yet for this article.
November 2015: Annals of the Academy of Medicine, Singapore
Masashi Sakurai, Kazushi Azuma, Arata Nagai, Toru Fujioka, Yuji Sunden, Akinori Shimada, Takehito Morita
A 9-year-old male mixed breed cat showed chronic progressive neurological symptoms, which are represented by ataxia and seizures. At necropsy, spinal roots and spinal ganglions at the level of sixth cervical nerve to second thoracic nerve were bilaterally swollen and replaced by white mass lesions. Right brachial plexus and cranial nerves (III, V and VII) were also swollen. A mass lesion was found in the right frontal lobe of the cerebrum. Histologically, neoplastic lymphocytes extensively involved the peripheral nerves, and they infiltrated into the cerebral and spinal parenchyma according to the peripheral nerve tract...
July 1, 2016: Journal of Veterinary Medical Science
My Pham, Mohammed Awad
Neurolymphomatosis (NL) is a rare neurological manifestation of lymphoma characterized by malignant lymphoma cells infiltrating cranial or peripheral nerve, or their roots. We present the first reported Australian case of a patient whose initial presentation of relapsed mantle cell lymphoma was NL. Our case highlights that clinical and imaging findings of NL often mimic other neuropathies, and hence presents unique challenges that may lead to delayed diagnosis and management. We emphasize the importance of considering NL in the differential diagnosis and combining imaging with other diagnostic modalities such as lumbar puncture (LP) to aid in the diagnosis of NL particularly where there is acute neurological deterioration...
January 2016: Asian Journal of Neurosurgery
Antoinette de Jong, Rogier Mous, Guus A M S van Dongen, Otto S Hoekstra, Rutger A J Nievelstein, Bart de Keizer
No abstract text is available yet for this article.
June 2016: American Journal of Hematology
Makoto Usami, Kazuyuki Murase, Kohichi Takada, Kazutaka Iijima, Masahiro Yoshida, Ayumi Tatekoshi, Akari Hashimoto, Satoshi Iyama, Tsutomu Sato, Masayoshi Kobune, Risyu Takimoto, Mitsunori Kaya, Toshihiko Yamashita, Reina Morita, Tadashi Hasegawa, Junji Kato
Neurolymphomatosis is a rare manifestation of malignant lymphoma. The involvement of peripheral nerves has mostly been described as dissemination of a systemic lymphoma. In contrast, primary peripheral nerve lymphoma is extremely rare. A 68-year-old man presented in January 2014 with a sensory disturbance in the left lower extremity. There were no obvious findings on MRI or CT that could account for his symptoms. After 1 year of symptomatic treatment, the patient was managed conservatively for an additional year...
January 2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
Masayuki Umeda, Tadakazu Kondo, Momoko Nishikori, Toshiyuki Kitano, Masakatsu Hishizawa, Norimitsu Kadowaki, Akifumi Takaori-Kondo
Currently, there is no standard treatment for neurolymphomatosis because of the scarcity of clinical studies. Here, we report the successful treatment of neurolymphomatosis caused by follicular lymphoma with bendamustine, which could be an effective treatment option for this condition.
January 2016: Clinical Case Reports
Faiq Shaikh, Derek Savells, Omer Awan, Faisal Inayat, Ammar Chaudhry, Nivedita Jerath, Michael M Graham
Neurolymphomatosis (NL) is a rare disease characterized by malignant lymphocytes infiltrating various structures of the nervous system. It typically manifests as a neuropathy involving the peripheral nerves, nerve roots, plexuses, or cranial nerves. It often presents as a complication of lymphoma, but it can be the presenting feature of recurrent lymphoma. It is essential to identify and initiate treatment early with chemotherapy and/or radiation therapy in all cases of nodal or visceral (including neural) involvement with lymphoma...
2015: Curēus
Alexandra von Altrock, Martin Ganter, Ulrike Schwittlick, Andreas Beineke
Multicentric lymphomas, usually of B-cell origin, are rather common neoplasms in pigs, which usually affect lymph nodes and different organ systems. An uncommon manifestation of malignant lymphoma represents neoplastic peripheral nerve involvement, which has been reported in human medicine. So far, only single cases of lymphoma with manifestation in peripheral nerves (known as neurolymphomatosis) without leukemic conversion have been mentioned in different animal species others than swine. The present case report describes the occurrence of a multicentric T-cell lymphoma in a fattening pig with marked leukocytosis...
September 2015: Berliner und Münchener Tierärztliche Wochenschrift
Yihan Wang, JianChao Wang, Chong Jiang, Qian Peng, Mingpeng Wu, Xuelei Ma
OBJECTIVE: Neurolymphomatosis (NL) is a rare neurological manifestation of lymphoma. Clinical symptoms of NL differ greatly according to the sites involved and diagnosis with conventional imaging techniques may sometimes be difficult. We herein describe the case of a 58 years old man presenting as radiculopathy with a history of non-Hodgkin's lymphoma (NHL). Computed tomography (CT) was unrevealing and magnetic resonance imaging (MRI) was contraindicated. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT) was performed and revealed multiple hypermetabolic lesions along the nerve roots, which corresponded to the patient's neurological symptoms...
September 2015: Hellenic Journal of Nuclear Medicine
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