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Neurolymphomatosis

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https://www.readbyqxmd.com/read/29261639/active-leprosy-neuritis-detected-on-fdg-pet-ct
#1
Shambo Guha Roy, Girish Kumar Parida, Sarthak Tripathy, Chandan J Das, Rakesh Kumar
Uses of FDG PET/CT have been previously documented in multiple series in peripheral nerve pathologies, including neurolymphomatosis, peripheral nerve sheath tumor, and plexopathies. We present the case of a 24-year-old man with leprosy neuritis who underwent FDG PET/CT. We suggest that FDG PET/CT can be used as an adjunct tool to monitor neuritis in leprosy patients.
December 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29200675/neurolymphomatosis-a-surreal-presentation-of-lymphoma
#2
Shikha Khandelwal, Suvinay Saxena, Disha J Hansalia
Background: Neurolymphomatosis is a neurologic complication poorly recognized by neurologists and oncologists and presents usually several months after successful treatment of systemic lymphoma. Other disorders that must be differentiated from these entities include peripheral-nerve or nerve root compression and paraneoplastic neuropathy. Aim: To describe the unusual occurrence of neurolymphomatosis in a patient of B-cell lymphoma. Method: Diagnosis was made by demonstration of enhancement of nerve roots on Magnetic Resonance Imaging of the brachial, lumbosacral plexus, peripheral nerves or by increased hyper-metabolic activity along the course of affected nerves on fluorodeoxyglucose positron emission tomography (FDG-PET)...
July 2017: Indian Journal of Medical and Paediatric Oncology
https://www.readbyqxmd.com/read/29181546/-neurolymphomatosis-two-case-reports
#3
C Brand, A Pala, A Scheuerle, K Scheglmann, R König, W Kratzer, C R Wirtz, G Antoniadis, M T Pedro
No abstract text is available yet for this article.
November 27, 2017: Der Nervenarzt
https://www.readbyqxmd.com/read/28941783/-cauda-equina-syndrome-secondary-to-neurolymphomatosis-case-report-and-literature-review
#4
Herbert Daniel Jiménez Zapata, Luis Mariano Rojas Medina, Rodrigo Carrasco Moro, Aurora Martínez Rodrigo, Mónica García-Cosio Piqueras
Neurolymphomatosis is a rare disorder characterised by infiltration of neoplastic lymphocytes into the peripheral nervous system. A wide variety of symptoms can manifest depending on its nature and location, making its diagnosis a real challenge. Treatment is based on methotrexate, although various chemotherapy regimens are currently available for patients with systemic disease. We present the case of a male patient with neurolymphomatosis of the cauda equina, together with a review of all cases published to date...
September 20, 2017: Neurocirugía
https://www.readbyqxmd.com/read/28939669/neurolymphomatosis-of-the-thoracic-sympathetic-chain
#5
Leon D Kaulen, Francine M Foss, Robert K Fulbright, Anita Huttner, Joachim M Baehring
No abstract text is available yet for this article.
October 31, 2017: Neurology
https://www.readbyqxmd.com/read/28750592/fdg-pet-ct-evaluation-in-neurolymphomatosis-imaging-characteristics-and-clinical-outcomes
#6
Tima Davidson, Meirav Kedmi, Abraham Avigdor, Orna Komisar, Bar Chikman, Merav Lidar, Elinor Goshen, S Tzila Zwas, Simona Ben-Haim
Neurolymphomatosis (NL) often represents unidentified non-Hodgkin lymphoma relapses. Considering its severity, early detection and treatment are crucial. We outline one hospital's (18)F-FDG-PET-CT imaging findings of NL, along with the patients' clinical characteristics. Clinical records and imaging findings of 19 NL patients, PET-CT diagnosed, were retrospectively reviewed. Patient data, FDG-PET-CT findings and the presence of coexisting diseases, especially CNS involvement, were documented. Available MRI and clinical data verified the findings...
July 28, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28584377/neurolymphomatosis-in-primary-cutaneous-cd4-pleomorphic-small-medium-sized-t-cell-lymphoma-mimicking-hansen-s-disease
#7
Anza Khader, Mary Vineetha, Mamatha George, Shiny Padinjarayil Manakkad, Sunitha Balakrishnan, Uma Rajan
Neurolymphomatosis (NL) refers to nerve infiltration by neurotropic neoplastic cells in the setting of a known or an unknown hematological malignancy. It typically presents as painful or painless peripheral mononeuropathy, mononeuritis multiplex, polyneuropathy, polyradiculopathy, or cranial neuropathy. A 32-year-old male presented with a hyperpigmented hypoesthetic plaque over the anterolateral aspect of the right leg with thickening of the right common peroneal nerve and foot drop clinically diagnosed as Hansen's disease...
May 2017: Indian Journal of Dermatology
https://www.readbyqxmd.com/read/28502935/two-cases-of-neurolymphomatosis-with-fatal-bilateral-vocal-cord-paralysis-that-were-diagnosed-with-18-f-fluorodeoxyglucose-positron-emission-tomography-fdg-pet-ct
#8
Yuichiro Ono, Yasuhiro Kazuma, Yotaro Ochi, Ryosuke Matsuoka, Yukihiro Imai, Takayuki Ishikawa
Neurolymphomatosis is a rare entity defined as nerve infiltration by neurotropic abnormal lymphocytes which can lead to the development of neuropathy, with typical presentations including pain, hypoesthesia, paresthesis and palsy. We herein report two cases where critical bilateral vocal cord paralysis due to neurolymphomatosis in recurrent nerves occurred in refractory Burkitt lymphoma and adult T-cell lymphoma patients. High-dose methotrexate and intrathecal chemotherapy injection for the nervous lesions were ineffective, and the patients died...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28482727/diagnosis-of-secondary-peripheral-neurolymphomatosis-a-multi-center-experience
#9
Ja Min Byun, Ki Hwan Kim, Miso Kim, Tae Min Kim, Yoon Kyung Jeon, Jeong Hwan Park, Jin Ho Paik, Jung Min Lee, Ho-Young Lee, Jong Seok Lee, Dae Seog Heo, Jeong-Ok Lee
Here, we describe our experience with secondary neurolymphomatosis (NL) in non-Hodgkin lymphoma patients, with the emphasis on the diagnosis process. A retrospective chart review of 12 patients from 3 tertiary academic centers between January 2005 and December 2015 was conducted. Secondary NL was diagnosed within a median interval of 10 months (range 5-41 months) after initial diagnosis of NHL. Painful neuropathy was present in 66.7%, but the diagnosis of NL was delayed in nine out of 12 patients (75.0%) by median of 2 months...
May 9, 2017: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/28288046/fdg-pet-ct-in-pediatric-neurolymphomatosis
#10
Carole de Vaugelade, Henri de Clermont-Gallerande, Marie Meyer, Aude My Duyen Tiphaine, Alice Benjamin, Stephane Ducassou, Jean-François Chateil, Philippe Fernandez
An 8-year-old girl presented with back and leg pain and left arm and leg paresis. Lumbar puncture was suggestive of lymphocytic meningitis without identified organism. A second lumbar puncture demonstrated a large number of lymphoid B cells, with positive immunohistochemical staining for CD20 and CD25, proving the diagnosis of neurolymphomatosis. Brain and spine MRI demonstrated involvement of cervical and lumbosacral nerve roots. FDG PET/CT showed multiple bone metastases in addition to nerve involvement. Postchemotherapy FDG PET/CT demonstrated complete metabolic response...
May 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28245733/targeted-fascicular-biopsy-of-the-brachial-plexus-rationale-and-operative-technique
#11
Pierre Laumonerie, Stepan Capek, Kimberly K Amrami, P James B Dyck, Robert J Spinner
OBJECTIVE Nerve biopsy is useful in the management of neuromuscular disorders and is commonly performed in distal, noncritical cutaneous nerves. In general, these procedures are diagnostic in only 20%-50%. In selected cases in which preoperative evaluation points toward a more localized process, targeted biopsy would likely improve diagnostic yield. The authors report their experience with targeted fascicular biopsy of the brachial plexus and provide a description of the operative technique. METHODS All cases of targeted biopsy of the brachial plexus biopsy performed between 2003 and 2015 were reviewed...
March 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/28242998/18f-fdg-pet-ct-mri-fusion-images-showing-cranial-and-peripheral-nerve-involvement-in-neurolymphomatosis
#12
Ana Carolina Trevisan, Fernanda Borges Ribeiro, Emerson Nobuyuki Itikawa, Leonardo Santos Alexandre, Felipe Arriva Pitella, Antonio Carlos Santos, Belinda Pinto Simões, Lauro Wichert-Ana
We report a 56-year-old female patient with non-Hodgkin's diffuse large B cell lymphoma (NHL) who, on magnetic resonance imaging (MRI) with a T1 weighted and gadolinium-enhanced imaging, was found to have thickening and infiltration in 75% of peripheral nerves of the patient and enlargements of cranial nerves, possibly related to lymphomatous infiltration. Subsequent positron emission tomography/computed tomography (PET/CT) using (18)F-labeled 2-deoxy-2-fluoro-d-glucose ((18)F-FDG) showed widespread active involvement of the cervical plexus, bilateral peripheral nerves, right femoral nerve, the parasellar region of the skull, and marked hypermetabolism in the left trigeminal ganglia...
January 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/28240665/fdg-pet-to-diagnose-neurolymphomatosis-in-a-case-of-triple-hit-b-cell-lymphoma
#13
Caroline Bund, Céline Heimburger, Philippe Trensz, Cécile Fohrer, Stéphane Kremer, Izzie-Jacques Namer
A 46-year-old man with stage IV triple-hit B-cell lymphoma diagnosed in February 2016 was treated with chemotherapy. He was followed classically with FDG PET/CT, which assessed the complete metabolic response in June 2016. In July 2016, he had autologous stem cell transplantation. Two months later, he underwent an FDG PET/CT for revaluation. It showed intense FDG uptake in the medullary canal from cervical 4 to thoracic 4, bilateral cervical 7 to thoracic 8, and right thoracic 9 to 12 nerve roots, leading to the diagnosis of neurolymphomatosis...
June 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28205463/peripheral-nerve-lymphomatosis
#14
Tun-Lin Foo, Ryan Yak, Mark E Puhaindran
Lymphoma involvement of peripheral nerves is rare and it may mimic benign neurogenic tumors or neuropraxic injury. This study presents three patterns of presentations in four patients with neurolymphomatous involvement of their peripheral nerves. We reviewed the clinical records of four patients who underwent exploratory brachial plexus surgery (n = 1), pronator tunnel decompression (n = 1) and peripheral nerve exploration (n = 2) and subsequently found to have neurolymphomatosis (NL). Histological diagnoses were diffuse large B-cell lymphoma (n = 3) and NK/T-cell lymphoma (n = 1)...
March 2017: Journal of Hand Surgery Asian-Pacific Volume
https://www.readbyqxmd.com/read/28202873/neurolymphomatosis-appeared-following-primary-central-nervous-system-lymphoma
#15
Masakuni Tanimizu, Keita Kobayashi
No abstract text is available yet for this article.
2017: Internal Medicine
https://www.readbyqxmd.com/read/27980756/diagnostic-and-response-assessment-fdg-pet-ct-in-neurolymphomatosis
#16
David Bruce, Helen Eagleton, Manil Subesinghe
FDG PET-CT is a useful imaging tool in the diagnosis and response assessment of neurolymphomatosis, especially in cases of otherwise unexplained neuropathy following conventional diagnostic work-up including lumbar puncture, CT, and MRI. The use of a novel PET reconstruction algorithm improves image quality and lesion detection through increased signal-to-noise ratio.
December 2016: Clinical Case Reports
https://www.readbyqxmd.com/read/27687936/distribution-of-feline-lymphoma-in-the-central-and-peripheral-nervous-systems
#17
REVIEW
Maria Teresa Mandara, Luca Motta, Pietro Calò
In cats, lymphoma (lymphosarcoma) is the most common neoplasm affecting the spinal cord and the second most common intracranial tumour. Although lymphoma commonly develops in the spinal cord as a part of a multicentric process, a primary form may occur. Lymphoma can exhibit a wide range of morphological patterns, including intraparenchymal brain mass, lymphomatosis cerebri, intravascular lymphoma, lymphomatous choroiditis and meningitis, extradural, intradural-extramedullary or intramedullary lymphoma in the spinal cord, or neurolymphomatosis in the peripheral nerves...
October 2016: Veterinary Journal
https://www.readbyqxmd.com/read/27686620/neurolymphomatosis-as-a-relapse-of-primary-cerebral-nervous-system-lymphoma
#18
Loïc Le Guennec, Thierry Maisonobe, Sylvain Choquet, Audrey Massein, Arièle Azoulay-Cayla, Nicolas Villain, Frederique Archambaud, Khe Hoang-Xuan, Ahmed Idbaih
No abstract text is available yet for this article.
August 9, 2016: Leukemia & Lymphoma
https://www.readbyqxmd.com/read/27651745/an-extremely-rare-intersection-neurolymphomatosis-in-a-patient-with-burkitt-lymphoma-detected-by-18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#19
Ali Ozan Oner, Kursat Okuyucu, Engin Alagoz, Bilal Battal, Nuri Arslan
Neurolymphomatosis (NL) is a rarely seen neurologic involvement of the systematic lymphoma. Its diagnosis is challenging, and requires biopsy. In cases where biopsy is not appropriate, 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) may aid in diagnosis. Here, we present a 54-year old male patient diagnosed with Burkitt lymphoma who underwent FDG-PET/CT in order to evaluate the treatment response after chemotherapy and radiotherapy. On viewing PET/CT images of the patient who complained of pain and weakness in his upper extremities after therapy, linear FDG uptake was observed in bilateral cervical 5 (C5), left cervical 6 (C6), bilateral cervical 7 (C7), and right lumbar 4 (L4) nerve roots...
September 2016: World Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/27636384/neurolymphomatosis-of-the-peripheral-nervous-system-a-case-report-and-review-of-the-literature
#20
REVIEW
Panagiotis A Sideras, John Matthews, S M Nazmus Sakib, Franka Ofikwu, Vadim Spektor
Neurolymphomatosis is a rare neurological syndrome in lymphomas. It is reported as infiltration of peripheral nerves by lymphoma. It is important to distinguish neurolymphomatosis from other types of neuropathies, particularly infectious and inflammatory conditions. However, it is difficult to isolate a cancer-related inflammatory vasculitis and mononeuritis multiplex without definitive histopathologic examination. In this report, we describe a case of non-Hodgkin's lymphoma involving the peroneal nerve and presenting as neurolymphomatosis...
November 2016: Clinical Imaging
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