Job A J Verdonschot, Mark R Hazebroek, Ingrid P C Krapels, Michiel T H M Henkens, Anne Raafs, Ping Wang, Jort J Merken, Godelieve R F Claes, Els K Vanhoutte, Arthur van den Wijngaard, Stephane R B Heymans, Han G Brunner
BACKGROUND: Genetic analysis is a first-tier test in dilated cardiomyopathy (DCM). Electrical phenotypes are common in genetic DCM, but their exact contribution to the clinical course and outcome is unknown. We determined the prevalence of pathogenic gene variants in a large unselected DCM population and determined the role of electrical phenotypes in association with outcome. METHODS: This study included 689 patients with DCM from the Maastricht Cardiomyopathy Registry, undergoing genetic evaluation using a 48 cardiomyopathy-associated gene-panel, echocardiography, endomyocardial biopsies, and Holter monitoring...
October 2020: Circulation. Genomic and Precision Medicine