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Keywords
nephrology, renal transplant, ...
nephrology, renal transplant, dialysis, chronic kidney disease, glomerular disease
#21
JOURNAL ARTICLE
Ziman Chen, Yingli Wang, Michael Tin Cheung Ying, Zhongzhen Su
BACKGROUND: Non-invasive renal fibrosis assessment is critical for tailoring personalized decision-making and managing follow-up in patients with chronic kidney disease (CKD). We aimed to exploit machine learning algorithms using clinical and elastosonographic features to distinguish moderate-severe fibrosis from mild fibrosis among CKD patients. METHODS: A total of 162 patients with CKD who underwent shear wave elastography examinations and renal biopsies at our institution were prospectively enrolled...
February 5, 2024: Journal of Nephrology
#22
JOURNAL ARTICLE
Simon Nusinovici, Hengtong Li, Crystal Chong, Marco Yu, Ida Maria Hjelm Sørensen, Line Stattau Bisgaard, Christina Christoffersen, Susanne Bro, Sylvia Liu, Jian-Jun Liu, Lim Su Chi, Tien-Yin Wong, Gavin S W Tan, Ching-Yu Cheng, Charumathi Sabanayagam
BACKGROUND: The prevalence of chronic kidney disease (CKD) is high. Identification of cases with CKD or at high risk of developing it is important to tailor early interventions. The objective of this study was to identify blood metabolites associated with prevalent and incident severe CKD, and to quantify the corresponding improvement in CKD detection and prediction. METHODS: Data from four cohorts were analyzed: Singapore Epidemiology of Eye Diseases (SEED) (n = 8802), Copenhagen Chronic Kidney Disease (CPH) (n = 916), Singapore Diabetic Nephropathy (n = 714), and UK Biobank (UKBB) (n = 103,051)...
February 3, 2024: Journal of Nephrology
#23
JOURNAL ARTICLE
Mehmet Kanbay, Sidar Copur, Cicek N Bakir, Adrian Covic, Alberto Ortiz, Katherine R Tuttle
The global burden of chronic kidney disease (CKD) is high and increasing. Early diagnosis and intervention are key to improve outcomes. Single nephron glomerular hyperfiltration is an early pathophysiologic manifestation of CKD that may result in absolute glomerular hyperfiltration, i.e. a high glomerular filtration rate (GFR) or be associated with normal or low GFR because of nephron loss (relative glomerular hyperfiltration). Even though compensatory glomerular hyperfiltration may contribute to maintain kidney function after loss of kidney mass, the associated increased glomerular capillary pressure and glomerular and podocyte size drive podocyte loss, albuminuria and proximal tubular overload, contributing to CKD progression...
February 2, 2024: Nephrology, Dialysis, Transplantation
#24
JOURNAL ARTICLE
Omosomi Enilama, Kevin Yau, Lee Er, Mohammad Atiquzzaman, Matthew J Oliver, Marc G Romney, Jerome A Leis, Kento T Abe, Freda Qi, Karen Colwill, Anne-Claude Gingras, Michelle A Hladunewich, Adeera Levin
BACKGROUND: Chronic kidney disease (CKD) is associated with a lower serologic response to vaccination compared to the general population. There is limited information regarding the serologic response to coronavirus disease 2019 (COVID-19) vaccination in the non-dialysis-dependent CKD (NDD-CKD) population, particularly after the third dose and whether this response varies by estimated glomerular filtration rate (eGFR). METHODS: The NDD-CKD (G1-G5) patients who received 3 doses of mRNA COVID-19 vaccines were recruited from renal clinics within British Columbia and Ontario, Canada...
2024: Canadian Journal of Kidney Health and Disease
#25
JOURNAL ARTICLE
Hajime Nagasawa, Seiji Ueda, Hitoshi Suzuki, Celia Jenkinson, Yusuke Fukao, Maiko Nakayama, Tomoyuki Otsuka, Teruyuki Okuma, Wilmelenne Clapper, Kai Liu, Mai Nguyen, Radko Komers, Yusuke Suzuki
BACKGROUND: The mechanism leading to the development of IgA nephropathy (IgAN) remains to be completely understood. Endothelin-1 (ET-1) as well as angiotensin II (AngII) promote glomerular injury, tubulointerstitial inflammation, and fibrosis leading to chronic kidney disease. Sparsentan, a dual endothelin angiotensin receptor antagonist (DEARA), recently received accelerated approval in United States for the reduction of proteinuria in adults with IgAN at high risk of disease progression...
January 25, 2024: Nephrology, Dialysis, Transplantation
#26
JOURNAL ARTICLE
Maximilian Brockmeyer, Claudio Parco, Kris Gregory Vargas, Ralf Westenfeld, Christian Jung, Malte Kelm, Michael Roden, Cihan Akbulut, Sabrina Schlesinger, Georg Wolff, Oliver Kuss
BACKGROUND: Absolute treatment benefits-expressed as numbers needed to treat-of the glucose lowering and cardiovascular drugs, glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose transporter 2 (SGLT2) inhibitors on renal outcomes remain uncertain. With the present meta-analysis of digitalized individual patient data, we aimed to display and compare numbers needed to treat of both drugs on a composite renal outcome. METHODS: From Kaplan-Meier plots of major cardiovascular outcome trials of GLP-1 receptor agonists and SGLT2 inhibitors vs...
January 18, 2024: Journal of Nephrology
#27
JOURNAL ARTICLE
Agnès Oude Engberink, Guillaume Tessier, Ilham Kamil, Gérard Bourrel, Olivier Moranne
BACKGROUND: In high-income countries, chronic kidney disease (CKD) affects over 10% of the population. Identifying these patients early is a priority, especially as new treatments are available to reduce the risk of cardiovascular and renal morbidity. We aimed at understanding the management and care pathway of patients with early-to-moderate CKD defined as an estimated glomerular filtration rate (eGFR) ≥ 45 mL/min/1.73 m2 (CKD-EPI), by analyzing the experience of general practitioners in a region in France...
January 16, 2024: Journal of Nephrology
#28
JOURNAL ARTICLE
Katharina Rohner, Matko Marlais, Yo Han Ahn, Alaa Ali, Abrar Alsharief, Anja Blejc Novak, Marta Brambilla, Evrim Kargin Cakici, Cengiz Candan, Nur Canpolat, Eugene Yu-Hin Chan, Stéphane Decramer, Madeleine Didsbury, Filipa Durao, Anne M Durkan, Ali Düzova, Thomas Forbes, Valentina Gracchi, Tulin Güngör, Tomoko Horinouchi, Belde Kasap Demir, Yasuko Kobayashi, Mikael Koskela, Eda Didem Kurt-Sukur, Claudio La Scola, Dean Langan, Xiaozhong Li, Gabriele Malgieri, Antonio Mastrangelo, Jeesu Min, Malgorzata Mizerska-Wasiak, Nabila Moussaoui, Aytul Noyan, Matti Nuutinen, Jennifer O'Gormon, Takayuki Okamoto, Louise Oni, Michiel Oosterveld, Malgorzata Pańczyk-Tomaszewska, Gonul Parmaksiz, Andrea Pasini, Pornpimol Rianthavorn, Joris Roelofs, Yunyan Shen, Rajiv Sinha, Rezan Topaloglu, Diletta Domenica Torres, Tomohiro Udagawa, Martin Wennerström, Yok Chin Yap, Kjell Tullus
BACKGROUND AND HYPOTHESIS: IgA vasculitis with nephritis (IgAVN) is the most common vasculitis in children. Treatment recommendations are, due to a lack of evidence, based on expert opinion resulting in variation. The aim of this study was to describe clinical presentation, treatment and outcome of an extremely large cohort of children with biopsy proven IgAVN to identify prognostic risk factors and signals of treatment efficacy. METHODS: Retrospective data were collected on 1148 children with biopsy proven IgAVN between 2005 and 2019 from 41 international paediatric nephrology centres across 25 countries and analyzed using multivariate analysis...
January 11, 2024: Nephrology, Dialysis, Transplantation
#29
JOURNAL ARTICLE
Anne H S Vestergaard, Simon K Jensen, Uffe Heide-Jørgensen, Line E Frederiksen, Henrik Birn, Dorte E Jarbøl, Jens Søndergaard, Frederik Persson, Reimar W Thomsen, Christian F Christiansen
BACKGROUND: Chronic kidney disease (CKD) is a growing global health concern. Identifying individuals in routine clinical care with new onset CKD at high risk of rapid progression of the disease is imperative to guide allocation of prophylactic interventions, but community-based data are limited. We aimed to examine the risk of rapid progression, kidney failure, hospitalisation and death among adults with incident CKD stage G3 and to clarify the association between predefined risk markers and rapid CKD progression...
January 2, 2024: Nephrology, Dialysis, Transplantation
#30
REVIEW
Rafael Dos Santos Borges, Gustavo de Oliveira Almeida, Vinícius Freire Costa Alves, Thiago Faraco Nienkotter, Edmundo Damiani Bertoli, Ana Cristina Simões E Silva
BACKGROUND: Sotagliflozin is a dual sodium-glucose co-transporter 1 and 2 inhibitor that increases glucosuria and natriuresis in patients with type 2 diabetes mellitus (T2DM). However, the safety and efficacy in patients with concomitant chronic kidney disease (CKD) remains unclear. Therefore, we aimed to conduct a meta-analysis to evaluate the current evidence in this regard. METHODS: We searched PubMed, Embase, Cochrane, and Web of Science for randomized controlled clinical trials on the safety and efficacy of Sotagliflozin in patients with T2DM and CKD compared with placebo...
December 23, 2023: Journal of Nephrology
#31
JOURNAL ARTICLE
Hongshan Chen, Youxia Liu, Li Wei, He Wang, Zhenfeng Zheng, Tiekun Yan, Junya Jia, Dong Li
BACKGROUND: To explore the clinicopathologic features and outcomes of IgAN patients who presented with fibrinoid necrosis (FN) lesions or not and the effect of immunosuppressive (IS) treatment in IgAN patients with FN lesions as well. METHODS: This was a retrospective cohort study with 665 patients diagnosed with primary IgAN from January 2010 to December 2020 in Tianjin Medical University General Hospital and having detailed baseline and follow-up characteristics...
December 11, 2023: BMC Nephrology
#32
JOURNAL ARTICLE
Jialin Han, Yinshan Zhao, Mark Canney, Mohammad Atiquzzaman, Paul Keown, Adeera Levin, Sean Barbour
Over the past decade, several observational studies and case series have provided evidence suggesting a connection between glomerular diseases (GN) and the development of malignancies, with an estimated risk ranging from 5%-11%. These malignancies include solid organ tumors as well as hematologic malignancies such as lymphoma and leukemia. However, these risk estimates are subject to several sources of bias, including unmeasured confounding from inadequate exploration of risk factors, inclusion of GN cases that were potentially secondary to an underlying malignancy, misclassification of GN type, and ascertainment bias arising from an increased likelihood of physician encounters compared to the general population...
December 9, 2023: Nephrology, Dialysis, Transplantation
#33
JOURNAL ARTICLE
Eduardo Gallego-Valcarce, Amir Shabaka, Ana María Tato-Ribera, Eugenia Landaluce-Triska, Mariana León-Poo, Deborah Roldan, Enrique Gruss
BACKGROUND: The Kidney Failure Risk Equation (KFRE) is a 2- and 5-year kidney failure prediction model that is applied in chronic kidney disease (CKD) G3 + . The Grams model predicts kidney failure and death at 2 and 4 years in CKD G4 + . There are limited external validations of the Grams model, especially for predicting mortality before kidney failure. METHODS: We performed an external validation of the Grams and Kidney Failure Risk Equation prediction models in incident patients with CKD G4 + at Hospital Universitario Fundación Alcorcón, Spain, between 1/1/2014 and 31/12/2018, ending follow-up on 30/09/2023...
December 7, 2023: Journal of Nephrology
#34
JOURNAL ARTICLE
Hélène Levassort, Julie Boucquemont, Natalia Alencar de Pinho, Oriane Lambert, Catherine Helmer, Marie Metzger, Laurent Teillet, Luc Frimat, Christian Combe, Denis Fouque, Maurice Laville, Christian Jacquelinet, Sophie Liabeuf, Bénédicte Stengel, Ziad A Massy, Marion Pépin
BACKGROUND AND HYPOTHESIS: Chronic kidney disease (CKD) is associated with an elevated risk of neurocognitive disorders (NCDs). It remains unclear whether CKD-related NCDs have specific cognitive pattern or are earlier-onset phenotypes of the main NCDs (vascular NCDs and Alzheimer's disease). METHODS: We used the Mini Mental State Examination score (MMSE) to assess cognitive pattern in 3003 CKD patients (stage 3 to 4) followed up over 5 years in the Chronic Kidney Disease-Renal Epidemiology and Information Network (CKD-REIN) cohort...
November 9, 2023: Nephrology, Dialysis, Transplantation
#35
JOURNAL ARTICLE
Pierre Delanaye, Hans Pottel, Etienne Cavalier, Martin Flamant, Thomas Stehlé, Christophe Mariat
Creatinine-based estimated GFR (eGFR) is imprecise at individual level, due to non-GFR-related serum creatinine determinants, including atypical muscle mass. Cystatin C has the advantage of being independent on muscle mass, a feature that led to the development of race- and sex-free equations. Yet, cystatin C-based equations do not perform better than creatinine-based equations to estimate GFR, unless both variables are included together. The new race-free Chronic Kidney Disease Epidemiology (CKD-EPI) equation, had slight opposite biases between Black and Non-Black subjects in USA, but performs poorer than that the previous version in European populations...
November 9, 2023: Nephrology, Dialysis, Transplantation
#36
JOURNAL ARTICLE
Shir Frydman, Ophir Freund, Lior Zornitzki, Haytham Abu Katash, Shmuel Banai, Yacov Shacham
INTRODUCTION: Acute kidney injury (AKI) is a clinically relevant and common complication among patients with acute coronary syndrome. Neutrophil gelatinase-associated lipocalin (NGAL), secreted from different cells including renal tubules, has been widely studied as an early marker for kidney injury. However, chronic kidney disease (CKD) could impact NGAL levels and alter their predictive performance. Some studies attempted to address this issue by setting different cutoff values for patients with CKD, with limited success to date...
November 2, 2023: Journal of Nephrology
#37
JOURNAL ARTICLE
Lilia Belarif, Sophie Girerd, Frédéric Jaisser, Xavier Lepage, Ludovic Merckle, Kevin Duarte, Nicolas Girerd, Philippe Guerci
INTRODUCTION: Ischaemia/reperfusion injuries (IRIs) are associated with poorer survival of kidney grafts from expanded criteria donors. Preclinical studies have shown that mineralocorticoid receptor antagonists (MRAs) prevent acute and chronic post-ischaemic renal dysfunction by limiting IRI. However, data concerning the safety of MRAs in brain-dead donor patients are scarce. We seek to investigate the tolerance of MRAs on the haemodynamics in this population. METHODS AND ANALYSIS: CANREO-PMO is a randomised, controlled, single-centre, double-blind study...
October 11, 2023: BMJ Open
#38
JOURNAL ARTICLE
Edouard L Fu, Andrew S Levey, Josef Coresh, Morgan E Grams, Anne-Laure Faucon, Carl-Gustaf Elinder, Friedo W Dekker, Pierre Delanaye, Lesley A Inker, Juan-Jesus Carrero
BACKGROUND AND HYPOTHESIS: New equations to estimate GFR based on creatinine (eGFRcr), cystatin C (eGFRcys) or both (eGFRcr-cys) have been developed by the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and the European Kidney Function Consortium (EKFC). There is a need to evaluate the performance of these equations in diverse European settings to inform implementation decisions, especially among people with key comorbid conditions. METHODS: We performed a cross-sectional study including 6174 adults referred for single-point plasma clearance of iohexol in Stockholm, Sweden, with 9579 concurrent measurements of creatinine and cystatin C...
October 9, 2023: Nephrology, Dialysis, Transplantation
#39
JOURNAL ARTICLE
Michael Chiu, Samuel A Silver, Laura Berall, Isabelle Ethier, Claire Harris, Keigan More, Annie-Claire Nadeau-Fredette, Karthik Tennankore, Jay Hingwala
BACKGROUND: Estimated glomerular filtration rate (eGFR) at dialysis initiation is increasingly recognized as a key quality indicator (QI) for patients with end-stage kidney disease (ESKD). Specifically, guidelines recommend assessing deferral of dialysis initiation until symptoms arise or if the eGFR is ≤6 mL/min/1.73 m2 . Despite the recognition of the importance of this QI, how eGFR at the time of dialysis initiation is defined, collected, and tracked at dialysis centers across Canada remains unknown...
2023: Canadian Journal of Kidney Health and Disease
#40
JOURNAL ARTICLE
J van der Weijden, P A De Hoogt, M M E Leufkens, A A Keijbeck, H van Goor, M C van den Heuvel, J P M Cleutjens, C Moers, M G Snoeijs, G J Navis, M van Londen, I M Nolte, S P Berger, M H De Borst, C J Peutz-Kootstra
BACKGROUND: Peritubular capillary rarefaction plays an important role in the progression of chronic kidney disease. Little is known about the relation between peritubular capillary density, glomerular volume and filtration rate in the healthy kidney. METHODS: In this single-center study, we included 69 living kidney donors who donated between 2005 and 2008 and had representative renal biopsies available. In all donors, glomerular filtration rate was measured using 125 I-Iothalamate before donation and at five years after donation...
September 28, 2023: Journal of Nephrology
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