Youngjoo Lee, Arijita Sarkar, Jade Tassey, Jonathan N Levi, Siyoung Lee, Nancy Q Liu, Andrew C Drake, Jenny Magallanes, Una Stevic, Jinxiu Lu, Dawei Ge, Hanhan Tang, Tadiwanashe Mkaratigwa, Fangzhou Bian, Ruzanna Shkhyan, Michael Bonaguidi, Denis Evseenko
Interleukin-6 (IL-6) is a major pro-inflammatory cytokine for which the levels in plasma demonstrate a robust correlation with age and body mass index (BMI) as part of the senescence-associated secretory phenotype. IL-6 cytokines also play a crucial role in metabolic homeostasis and regenerative processes, primarily via the canonical STAT3 pathway. Thus, selective modulation of IL-6 signaling may offer a unique opportunity for therapeutic interventions. Recently, we discovered that a non-canonical signaling pathway downstream of tyrosine (Y) 814 within the intracellular domain of gp130, the IL-6 co-receptor, is responsible for the recruitment and activation of SRC family of kinases (SFK)...
April 11, 2024: bioRxiv