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cryoablation atrial fibrillation adenosine

Faraz Khan Luni, Abdur Rahman Khan, Hemindermeet Singh, Haris Riaz, Sonia Ali Malik, Owais Khawaja, Talha Farid, Jennifer Cummings, Mohammed Taleb
BACKGROUND: Ablation is used for treatment of atrial fibrillation (AF) but recurrence is common. Dormant conduction is hypothesized to be responsible for these recurrences, and the role of adenosine in identification and ablation of these pathways is controversial with conflicting results on AF recurrence. MATERIALS AND METHODS: We conducted a meta-analysis for studies evaluating AF ablation and adenosine use. Included in the meta-analysis were human studies that compared ablation using adenosine or adenosine triphosphate (ATP) and reported freedom from AF in patients beyond a minimum follow-up of 6 months...
January 2018: American Journal of the Medical Sciences
Alex J A McLellan, Saurabh Kumar, Catherine Smith, Liang-Han Ling, Sandeep Prabhu, Jonathan M Kalman, Peter M Kistler
AIMS: Adenosine may unmask dormant PV conduction and facilitate consolidation of PV isolation. We performed a meta-analysis to determine the impact of adenosine administration on clinical outcomes in patients undergoing PVI. METHODS: References and electronic databases reporting AF ablation and adenosine following PVI were searched through to 22nd November 2015. The impact of adenosine on freedom from AF was assessed in twenty publications after radiofrequency ablation (RFA), and in four publications after cryoablation to achieve PVI...
June 1, 2017: International Journal of Cardiology
Shinsuke Miyazaki, Hiroshi Taniguchi, Hiroaki Nakamura, Hitoshi Hachiya, Noboru Ichihara, Makoto Araki, Akio Kuroi, Takamitsu Takagi, Jin Iwasawa, Kenzo Hirao, Yoshito Iesaka
BACKGROUND: Adenosine triphosphate (ATP) testing reveals dormant pulmonary vein (PV) conduction after electrical PV isolation (PVI). This study aimed to evaluate the incidence of latent PV conduction after cryothermal PVI. METHODS: Fifty-four consecutive paroxysmal atrial fibrillation patients undergoing cryothermal PVI were prospectively enrolled. PVI was performed with one 28-mm second-generation balloon using a 3-minute freeze technique, and touch-up lesions were created by focal cryothermal applications...
October 2015: Journal of Cardiovascular Electrophysiology
Narendra Kumar, Trang Dinh, Kevin Phan, Carl Timmermans, Suzanne Philippens, Willem Dassen, Nousjka Vranken, Laurent Pison, Jos Maessen, Harry J Crijns
AIMS: Adenosine administration after pulmonary vein (PV) isolation using radiofrequency, laser, and cryoablation can cause acute recovery of conduction to the PVs and predict atrial fibrillation (AF) recurrence. This study evaluates whether ablation of dormant potentials post-adenosine administration following second-generation cryoballoon (CB-2G) ablation may improve the success rate for AF. METHODS AND RESULTS: In 45 of 90 patients after a waiting period of 30 min, a bolus 15-21 mg of adenosine was administered followed by rapid saline flush...
June 2015: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Marieke G Compier, Marta De Riva, Katia Dyrda, Katja Zeppenfeld, Martin J Schalij, Serge A Trines
AIMS: Electrical reconnection after pulmonary vein (PV) isolation is associated with atrial fibrillation (AF) recurrence. Reconnection may already develop within a 30 min waiting period and may only occur as dormant conduction (DC) revealed by adenosine infusion. This study determines incidence and predictors of DC after cryoballoon ablation incorporating a 30 min waiting period and the effect of treating this 'late' DC on 1 year AF-recurrence. METHODS AND RESULTS: Consecutive patients scheduled for a first ablation were prospectively included...
September 2015: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Narendra Kumar, Yuri Blaauw, Carl Timmermans, Laurent Pison, Kevin Vernooy, Harry Crijns
AIMS: Adenosine administration after pulmonary vein (PV) isolation using radiofrequency and cryoablation can cause acute recovery of conduction to the PVs and predicts atrial fibrillation (AF) recurrence. This study evaluated whether adenosine testing after second-generation balloon devices (cryothermal and laser) could reveal dormant PV reconduction and recurrence rate of AF. METHODS: Out of total 60 patients, 20 patients underwent PV isolation using laser balloon and for the remaining patients, the cryoballoon was used...
October 2014: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
J Brian DeVille, J Thomas Svinarich, Dan Dan, Andrew Wickliffe, Charan Kantipudi, Hae W Lim, Lisa Plummer, James Baker, Marcin Kowalski, Hassan Baydoun, Mark Jenkins, Peter Chang-Sing
BACKGROUND: Point-to-point focal radiofrequency (RF) catheter ablation for aberrant pulmonary vein triggers that manifest into atrial fibrillation (AF) is the traditional method for treating symptomatic drug-resistant paroxysmal AF (PAF) when an ablation procedure is warranted. More recently, pulmonary vein isolation (PVI) using the cryoballoon has been demonstrated to be safe and effective (STOP AF clinical trial). Currently, two small studies have reviewed the procedural efficiency when comparing cryoballoon to focal RF catheter ablation procedures; however, no multicenter study has yet reported on this comparison of the two types of ablation catheters...
June 2014: Journal of Invasive Cardiology
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