Inge Sutanto, Amin Soebandrio, Lenny L Ekawati, Krisin Chand, Rintis Noviyanti, Ari Winasti Satyagraha, Decy Subekti, Yulia Widya Santy, Chelzie Crenna-Darusallam, Instiaty Instiaty, Waras Budiman, Catur Bidik Prasetya, Soroy Lardo, Iqbal Elyazar, Stephan Duparc, Eve Cedar, Katie Rolfe, Disala Fernando, Alessandro Berni, Siôn Jones, Jörg-Peter Kleim, Kim Fletcher, Hema Sharma, Ana Martin, Maxine Taylor, Navin Goyal, Justin A Green, Lionel K Tan, J Kevin Baird
BACKGROUND: Tafenoquine, co-administered with chloroquine, is approved for the radical cure (prevention of relapse) of Plasmodium vivax malaria. In areas of chloroquine resistance, artemisinin-based combination therapies are used to treat malaria. This study aimed to evaluate tafenoquine plus the artemisinin-based combination therapy dihydroartemisinin-piperaquine for the radical cure of P vivax malaria. METHODS: In this double-blind, double-dummy, parallel group study, glucose-6-phosphate dehydrogenase-normal Indonesian soldiers with microscopically confirmed P vivax malaria were randomly assigned by means of a computer-generated randomisation schedule (1:1:1) to dihydroartemisinin-piperaquine alone, dihydroartemisinin-piperaquine plus a masked single 300-mg dose of tafenoquine, or dihydroartemisinin-piperaquine plus 14 days of primaquine (15 mg)...
May 23, 2023: Lancet Infectious Diseases