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https://www.readbyqxmd.com/read/29458220/incidence-of-autoimmune-and-related-disorders-after-resolution-of-endogenous-cushing-syndrome-in-children
#1
Christina Tatsi, Meg Keil, Charalampos Lyssikatos, Elena Belyavskaya, Constantine A Stratakis, Maya B Lodish
Glucocorticoids are widely used for immunosuppression in autoimmune diseases. After the resolution of hypercortisolemia, the immune system recovers allowing for autoimmune diseases to manifest. Here we investigated the presence of autoimmune and related diseases that developed after cure of endogenous Cushing syndrome (CS) in children. We identified 129 children who were diagnosed and successfully treated for endogenous CS at the National Institutes of Health from 1997 until 2017, and who were followed for at least 6 months after treatment...
February 19, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
https://www.readbyqxmd.com/read/29456039/exposure-to-dogs-but-not-cats-is-associated-to-a-decrease-in-the-prevalence-in-atopic-dermatitis-amongst-school-children
#2
M Bedolla-Barajas, J Morales-Romero, T I Bedolla-Pulido, T R Bedolla-Pulido, C Meza-López, N A Pulido-Guillén
INTRODUCTION: The association regarding the exposure to pets, especially cats and dogs, and the prevalence of allergic diseases is inconsistent. OBJECTIVE: We analyzed the role played by early exposure to dogs or cats in the prevalence of allergic diseases amongst school-aged children. METHOD: Through a cross-sectional study, we examined 756 children, aged 6-7; these candidates were selected through cluster sampling. We inquired about the exposure that these children had had to dogs and cats, and whether these pets spent most of their time indoors or outdoors during the first year of the child's life...
February 15, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29455359/eosinophilic-esophagitis-an-important-comorbid-condition-of-asthma
#3
REVIEW
Sandy R Durrani, Vincent A Mukkada, Theresa W Guilbert
Eosinophilic esophagitis and asthma are frequently found as comorbid conditions in children and adults along with other manifestations of atopic diathesis. These two conditions have similar T helper 2 responses-driven pathophysiology and share common management strategies such as using systemic corticosteroids and targeted anti-cytokine biologic therapies. Review of the literature finds that asthma is often a comorbid condition in eosinophilic esophagitis in both children and adults; however, the EoE-asthma relationship remains poorly characterized mechanistically and clinically...
February 18, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29454096/jak-stat-inhibitors-and-other-small-molecule-cytokine-antagonists-for-the-treatment-of-allergic-disease
#4
REVIEW
Michael D Howell, Carolyn Fitzsimons, Paul Smith
OBJECTIVE: To provide an overview of janus kinase (JAK), chemoattractant receptor-homologous molecule expressed on T-helper 2 cells (CRTH2), and phosphodiesterase 4 (PDE4) inhibitors in allergic disorders. DATA SOURCES: PubMed literature review. STUDY SELECTIONS: Articles included in this review discuss the emerging mechanism of action of small molecule inhibitors and their utilization in atopic dermatitis (AD), asthma, and allergic rhinitis (AR)...
February 14, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29452068/glycyrrhizin-attenuates-histamine-mediated-muc5ac-upregulation-inflammatory-cytokine-production-and-aquaporin-5-downregulation-through-suppressing-the-nf-%C3%AE%C2%BAb-pathway-in-human-nasal-epithelial-cells
#5
Haixia Li, Dandan Guo, Liangran Zhang, Xiao Feng
Allergic rhinitis (AR) is a chronic respiratory inflammatory disease. Glycyrrhizin is a main bioactive component of the licorice root extract and exhibits anti-inflammatory activity. However, the role of glycyrrhizin in AR has not been studied. The aim of the present study was to investigate the effect of glycyrrhizin on histamine-induced human nasal epithelial cells (HNEpCs). Here, we found that glycyrrhizin (20 or 40 μM) inhibited histamine-induced the mRNA expression and secretion of mucin 5 subtype AC (MUC5AC), interleukin (IL)-6 and IL-8 in HNEpCs...
February 13, 2018: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29447897/pattern-of-allergic-rhinitis-among-children-in-ekiti-nigeria
#6
Waheed Atilade Adegbiji, Gabriel Toye Olajide, Anthony Oyebanji Olajuyin, Shuaib Kayode Aremu, Akanbi Ganiyu Olusola
BACKGROUND: Allergic rhinitis is a chronic and recurrent nasal condition. It is often neglected in children with late presentation. This study aimed at determining the prevalence, sociodemographic features, comorbid illnesses, complications and quality of life in children with allergic rhinitis in the study institution. MATERIALS AND METHODS: This is a prospective hospital based study of children with allergic rhinitis in Ekiti state university teaching hospital, Ado Ekiti...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29446153/eating-fish-and-farm-life-reduce-allergic-rhinitis-at-the-age-of-twelve
#7
Styliana Vasileiadou, Göran Wennergren, Frida Strömberg Celind, Nils Åberg, Rolf Pettersson, Bernt Alm, Emma Goksör
BACKGROUND: The prevalence of allergic rhinitis has increased, but the cause of this rise is partly unknown. Our aim was to analyse the prevalence, risk factors and protective factors for allergic rhinitis in 12-year-old Swedish children. METHODS: Data were collected from a prospective, longitudinal cohort study of children born in western Sweden in 2003. The parents answered questionnaires when the children were six months to 12 years. The response rate at 12 years was 76% (3,637/4,777) of the questionnaires distributed...
February 15, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29446105/occupational-allergic-rhinitis-and-contact-urticaria-caused-by-gum-arabic-in-a-candy-factory-worker
#8
Paolo Romita, Tamara Bufano, Annarita Antelmi, Caterina Foti
No abstract text is available yet for this article.
February 15, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29444346/prenatal-vitamin-d-status-and-respiratory-and-allergic-outcomes-in-childhood-a-meta-analysis-of-observational-studies
#9
REVIEW
Rosa M Pacheco-González, Luis García-Marcos, Eva Morales
Prenatal vitamin D status may influence offspring's respiratory and allergic outcomes; however, evidence is inconclusive. A systematic review and meta-analysis was conducted on the association between 25-hydroxyvitamin D [25(OH)D] levels in maternal blood in pregnancy or cord blood at birth with the risk of offspring's respiratory and allergic conditions. Two independent researchers conducted systematic searches for observational studies published until May 2017 using defined keywords on vitamin D and health outcomes, including respiratory tract infections (RTIs), wheeze, asthma, atopic eczema, allergic rhinitis, allergic sensitization, and lung function...
February 14, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29440045/impact-of-acupuncture-on-antihistamine-use-in-patients-suffering-seasonal-allergic-rhinitis-secondary-analysis-of-results-from-a-randomised-controlled-trial
#10
Daniela Adam, Linus Grabenhenrich, Miriam Ortiz, Sylvia Binting, Thomas Reinhold, Benno Brinkhaus
BACKGROUND: Seasonal allergic rhinitis (SAR) is a common disease that has detrimental effects on the quality of life (QoL) of affected individuals. Approximately 18% of patients try to alleviate their symptoms through acupuncture. The ACUSAR (ACUpuncture in Seasonal Allergic Rhinitis) study (ClinicalTrials.gov registration no. NCT00610584) assessed the impact of acupuncture on SAR, showing significant improvements in rhinitis-specific QoL (RQoL) and in rescue medication (RM) use. OBJECTIVE: A secondary analysis of SAR patients' use of antihistamine...
February 10, 2018: Acupuncture in Medicine: Journal of the British Medical Acupuncture Society
https://www.readbyqxmd.com/read/29439692/automated-chart-review-utilizing-natural-language-processing-algorithm-for-asthma-predictive-index
#11
Harsheen Kaur, Sunghwan Sohn, Chung-Il Wi, Euijung Ryu, Miguel A Park, Kay Bachman, Hirohito Kita, Ivana Croghan, Jose A Castro-Rodriguez, Gretchen A Voge, Hongfang Liu, Young J Juhn
BACKGROUND: Thus far, no algorithms have been developed to automatically extract patients who meet Asthma Predictive Index (API) criteria from the Electronic health records (EHR) yet. Our objective is to develop and validate a natural language processing (NLP) algorithm to identify patients that meet API criteria. METHODS: This is a cross-sectional study nested in a birth cohort study in Olmsted County, MN. Asthma status ascertained by manual chart review based on API criteria served as gold standard...
February 13, 2018: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/29438602/international-consensus-statement-on-allergy-and-rhinology-allergic-rhinitis
#12
Sarah K Wise, Sandra Y Lin, Elina Toskala, Richard R Orlandi, Cezmi A Akdis, Jeremiah A Alt, Antoine Azar, Fuad M Baroody, Claus Bachert, G Walter Canonica, Thomas Chacko, Cemal Cingi, Giorgio Ciprandi, Jacquelynne Corey, Linda S Cox, Peter Socrates Creticos, Adnan Custovic, Cecelia Damask, Adam DeConde, John M DelGaudio, Charles S Ebert, Jean Anderson Eloy, Carrie E Flanagan, Wytske J Fokkens, Christine Franzese, Jan Gosepath, Ashleigh Halderman, Robert G Hamilton, Hans Jürgen Hoffman, Jens M Hohlfeld, Steven M Houser, Peter H Hwang, Cristoforo Incorvaia, Deborah Jarvis, Ayesha N Khalid, Maritta Kilpeläinen, Todd T Kingdom, Helene Krouse, Desiree Larenas-Linnemann, Adrienne M Laury, Stella E Lee, Joshua M Levy, Amber U Luong, Bradley F Marple, Edward D McCoul, K Christopher McMains, Erik Melén, James W Mims, Gianna Moscato, Joaquim Mullol, Harold S Nelson, Monica Patadia, Ruby Pawankar, Oliver Pfaar, Michael P Platt, William Reisacher, Carmen Rondón, Luke Rudmik, Matthew Ryan, Joaquin Sastre, Rodney J Schlosser, Russell A Settipane, Hemant P Sharma, Aziz Sheikh, Timothy L Smith, Pongsakorn Tantilipikorn, Jody R Tversky, Maria C Veling, De Yun Wang, Marit Westman, Magnus Wickman, Mark Zacharek
BACKGROUND: Critical examination of the quality and validity of available allergic rhinitis (AR) literature is necessary to improve understanding and to appropriately translate this knowledge to clinical care of the AR patient. To evaluate the existing AR literature, international multidisciplinary experts with an interest in AR have produced the International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR). METHODS: Using previously described methodology, specific topics were developed relating to AR...
February 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29438600/international-consensus-statement-on-allergy-and-rhinology-allergic-rhinitis-executive-summary
#13
Sarah K Wise, Sandra Y Lin, Elina Toskala
BACKGROUND: The available allergic rhinitis (AR) literature continues to grow. Critical evaluation and understanding of this literature is important to appropriately utilize this knowledge in the care of AR patients. The International Consensus statement on Allergy and Rhinology: Allergic Rhinitis (ICAR:AR) has been produced as a multidisciplinary international effort. This Executive Summary highlights and summarizes the findings of the comprehensive ICAR:AR document. METHODS: The ICAR:AR document was produced using previously described methodology...
February 2018: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/29436772/asthma-and-its-related-socioeconomic-factors-the-shiraz-adult-respiratory-disease-study-2015
#14
Seyed Masoom Masoompour, Hamideh Mahdaviazad, Seiyed Mohammad Ali Ghayumi
OBJECTIVE: This study aimed to explore the association between the prevalence of asthma and socio-economic factors using data from the Shiraz Adult Respiratory Disease Study, 2015(SARDS). METHODS: The SARDS was conducted from June to October 2015 among adult subjects of the general population of Shiraz, Iran. Current asthma was defined as the presence of at least one of the following factors in the preceding 12 months: 1) being awakened by an attack of shortness of breath, coughing, or chest tightness without any identifiable cause; 2) having an asthma attack; 3) currently using medication for asthma; or 4) having wheezing or whistling in the chest not associated with a cold or the flu...
February 13, 2018: Clinical Respiratory Journal
https://www.readbyqxmd.com/read/29436586/amelioration-of-inflammatory-responses-by-socheongryong-tang-a-traditional-herbal-medicine-in-raw-264-7%C3%A2-cells-and-rats
#15
Sang Mi Park, Tae Hoon Lee, Rongjie Zhao, Youn Sook Kim, Ji Yun Jung, Chung A Park, Kyung Hwan Jegal, Sae Kwang Ku, Jae Kwang Kim, Chul Won Lee, Young Woo Kim, Il Je Cho, Won G An, Sang Chan Kim
Socheongryong-Tang (SCRT) is a natural medicine prescription that has been mainly used in East Asia for the treatment of inflammatory disorders, including asthma and allergic rhinitis. The present study evaluated the anti-inflammatory effects of SCRT on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and in a rat model of carrageenan (CA)-induced paw edema. Levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6 and prostaglandin E2 (PGE2) in the culture supernatant were quantified and nitric oxide (NO) production was monitored...
February 6, 2018: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29434763/correlation-between-upper-and-lower-airway-inflammations-in-patients-with-combined-allergic-rhinitis-and-asthma-syndrome-a-comparison-of-patients-initially-presenting-with-allergic-rhinitis-and-those-initially-presenting-with-asthma
#16
Shu Xia, Zheng Zhu, Wei-Jie Guan, Yan-Qing Xie, Jia-Ying An, Tao Peng, Rong-Chang Chen, Jin-Ping Zheng
Allergic rhinitis (AR) and asthma often coexist. The terminology combined allergic rhinitis and asthma syndrome (CARAS) was introduced to describe patients with combined AR and asthma. The aim of the present study was to evaluate the correlation between eosinophilic inflammation in the upper and lower airways of patients with CARAS. Stable patients with CARAS initially presenting with AR or asthma were recruited. Healthy subjects and patients with AR alone were recruited as controls. Clinical characteristics, including disease history, lung function, nasal airway inspiratory resistance and upper and lower airway eosinophilic inflammation were evaluated and compared...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29434524/the-control-of-allergic-rhinitis-in-real-life-a-multicenter-cross-sectional-italian-study
#17
Federica Gani, Carlo Lombardi, Laura Barrocu, Massimo Landi, Erminia Ridolo, Massimo Bugiani, Giovanni Rolla, Gianenrico Senna, Giovanni Passalacqua
Background: Allergic Rhinitis (AR) is a high-prevalence disease. In Europe about 25% of the general population is affected, and in Italy the prevalence is estimated to be 19.8%. The Allergic Rhinitis and its Impact on Asthma (ARIA) international document underlined that the prevalence of severe or refractory or overlapping rhinitis is increasing and represents a non-negligible socio-economic burden. In general, despite the social healthcare costs, allergic rhinitis remains underestimated, not sufficiently controlled and often undertreated...
2018: Clinical and Molecular Allergy: CMA
https://www.readbyqxmd.com/read/29432967/lack-of-effect-of-grastek%C3%A2-on-birch-pollen-induced-allergic-rhinoconjunctivitis-in-the-environmental-exposure-unit
#18
Anne K Ellis, Mark W Tenn, Lisa M Steacy, Daniel E Adams, Andrew G Day, Terry J Walker, Hendrik Nolte
BACKGROUND: Grastek® is a standardized sublingual immunotherapy tablet(SLIT-T) approved for the treatment of grass pollen-induced allergic rhinitis(AR) and conjunctivitis. Many grass-allergic patients are also co-sensitized to birch pollen. Whether Grastek® can confer symptomatic benefits for birch pollen-induced AR symptoms is unknown. OBJECTIVE: To evaluate the treatment effect of Grastek® for birch pollen-induced AR in participants sensitized to both grass and birch pollen using the Environmental Exposure Unit(EEU)...
February 9, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29432965/repeatability-of-nasal-allergen-challenge-results-further-validation-of-the-allergic-rhinitis-clinical-investigator-collaborative-ar-cic-protocols
#19
Mena Soliman, Lisa M Steacy, Jenny Thiele, Dan E Adams, Helen L Neighbour, Anne K Ellis
BACKGROUND: Nasal Allergen Challenge(NAC) models have been used to study allergic rhinitis and new therapies. Symptoms and biological samples can be evaluated at time points following allergen exposure. OBJECTIVE: Verification of protocol repeatability and adequate interval between allergen exposures. METHODS: 10 ragweed allergic participants were exposed to incrementally increasing dosages of ragweed allergen intra-nasally until they achieved a Total Nasal Symptom Score(TNSS) of 8/12 and a Peak Nasal Inspiratory Flow(PNIF) >=50% reduction from baseline...
February 9, 2018: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/29432042/relationship-between-upper-airway-diseases-exhaled-nitric-oxide-and-bronchial-hyperresponsiveness-to-methacholine
#20
Marina Lluncor, Pilar Barranco, Emerson-Daniel Amaya, Javier Domínguez-Ortega, Valentín López-Carrasco, Isabel Coman, Santiago Quirce
OBJECTIVE: The "united airway disease" concept is based on the bidirectional interaction between asthma and rhinitis. The aim of this study was to determine the relationship between upper airway diseases and bronchial hyperresponsiveness (BHR), as well as their association with the fractional concentration of exhaled nitric oxide (FeNO) and atopy in patients with persistent symptoms suggestive of asthma requiring methacholine challenge testing (MCT) to confirm asthma diagnosis. METHODS: A cross-sectional prospective study was carried out in adult patients with persistent asthma-like symptoms and negative bronchodilator testing...
February 12, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
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