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https://www.readbyqxmd.com/read/29444783/mortality-and-quality-of-death-certification-in-a-cohort-of-patients-with-parkinson-s-disease-and-matched-controls-in-north-wales-uk-at-18-years-a-community-based-cohort-study
#1
Peter Hobson, Jolyon Meara
OBJECTIVE: This investigation reports the cause and the quality of death certification in a community cohort of patients with Parkinson's disease (PD) and controls at 18 years. SETTING: Denbighshire North Wales, UK. PARTICIPANTS: The community-based cohorts consisted of 166 patients with PD and 102 matched controls. PRIMARY OUTCOMES: All-cause mortality was ascertained at 18 years by review of hospitals' primary care records and examination of death certificates obtained from the UK General Register Office...
February 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29400144/palliative-care-triggers-in-progressive-neurodegenerative-conditions-an-evaluation-using-a-multi-centre-retrospective-case-record-review-and-principal-component-analysis
#2
Jamilla Hussain, Victoria Allgar, David Oliver
BACKGROUND: The use of specific triggers has been suggested to help identify patients with progressive neurological disease who would benefit from palliative care. AIM: This study aimed to improve the evidence base for the use of triggers for patients with progressive neurological disease. DESIGN: An evaluation of palliative care services was undertaken using a retrospective case note review of the timing and presence of triggers in the last 2 years of life...
February 1, 2018: Palliative Medicine
https://www.readbyqxmd.com/read/29396576/lingual-pressure-as-a-clinical-indicator-of-swallowing-function-in-parkinson-s-disease
#3
Laura L Pitts, Sarah Morales, Julie A G Stierwalt
Purpose: Swallowing impairment, or dysphagia, is a known contributor to reduced quality of life, pneumonia, and mortality in Parkinson's disease (PD). However, the contribution of tongue dysfunction, specifically inadequate pressure generation, to dysphagia in PD remains unclear. Our purpose was to determine whether lingual pressures in PD are (a) reduced, (b) reflect medication state, or are (c) consistent with self-reported diet and swallowing function. Method: Twenty-eight persons with idiopathic PD (PwPD) and 28 age- and sex-matched controls completed lingual pressure tasks with the Iowa Oral Performance Instrument...
February 2, 2018: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29390032/depression-in-parkinson-s-disease-a-case-control-study
#4
Yu-Hsuan Wu, Yi-Huei Chen, Ming-Hong Chang, Ching-Heng Lin
BACKGROUND: To evaluate the association between Parkinson's disease (PD) prognosis and the patient's onset of depression. METHODS: A total of 353 patients with newly-diagnosed PD and a history of depression were enrolled. On the basis of the onset of depression before or after PD diagnosis, we divided participants into PD patients with pre- or post-diagnostic depression. Cox's regression analysis was used to detect risks between the onset of depression and outcomes (including death, accidental injury, dementia, and aspiration pneumonia)...
2018: PloS One
https://www.readbyqxmd.com/read/29246470/effectiveness-and-costs-of-specialised-physiotherapy-given-via-parkinsonnet-a-retrospective-analysis-of-medical-claims-data
#5
Jan H L Ypinga, Nienke M de Vries, Lieke H H M Boonen, Xander Koolman, Marten Munneke, Aeilko H Zwinderman, Bastiaan R Bloem
BACKGROUND: Parkinson's disease is a complex condition that is best managed by specialised professionals. Trials show that specialised allied health interventions are cost-effective, as compared with usual care. We aimed to study the long-term benefits of specialised physiotherapy using the ParkinsonNet approach in real-world practice. METHODS: We did an observational study, retrospectively analysing a database of health insurance claims that included a representative population of Dutch patients with Parkinson's disease, who were followed for up to 3 years (Jan 1, 2013, to Dec 31, 2015)...
December 12, 2017: Lancet Neurology
https://www.readbyqxmd.com/read/29157667/a-case-of-multiple-system-atrophy-parkinsonian-type-with-stuttering-and-palilalia-like-dysfluencies-and-putaminal-atrophy
#6
Yoshikazu Kikuchi, Toshiro Umezaki, Taira Uehara, Hiroo Yamaguchi, Koji Yamashita, Akio Hiwatashi, Motohiro Sawatsubashi, Kazuo Adachi, Yumi Yamaguchi, Daisuke Murakami, Jun-Ichi Kira, Takashi Nakagawa
Both developmental and acquired stuttering are related to the function of the basal ganglia-thalamocortical loop, which includes the putamen. Here, we present a case of stuttering- and palilalia-like dysfluencies that manifested as an early symptom of multiple system atrophy-parkinsonian type (MSA-P) and bilateral atrophy of the putamen. The patient was a 72-year-old man with no history of developmental stuttering who presented with a stutter for consultation with our otorhinolaryngology department. The patient was diagnosed with MSA-P based on parkinsonism, autonomic dysfunction, and bilateral putaminal atrophy revealed by T2-weighted magnetic resonance imaging...
November 14, 2017: Journal of Fluency Disorders
https://www.readbyqxmd.com/read/29133570/activity-of-simulated-human-dosage-regimens-of-meropenem-and-vaborbactam-against-carbapenem-resistant-enterobacteriaceae-in-an-in-vitro-hollow-fiber-model
#7
Mojgan Sabet, Ziad Tarazi, Debora Rubio-Aparicio, Thomas G Nolan, Jonathan Parkinson, Olga Lomovskaya, Michael N Dudley, David C Griffith
The objective of these studies was to evaluate the exposures of meropenem and vaborbactam that would produce antibacterial activity and prevent resistance development in carbapenem-resistant, Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae strains when tested at an inocula of 108 CFU/mL. Thirteen K. pneumoniae isolates, three Enterobacter cloacae isolates, and one Escherichia coli isolate were examined in an in vitro hollow fiber model over 32 hours. Simulated dosage regimens of meropenem 1-2 g with vaborbactam 1-2 g, meropenem administered every 8 hours by 3 hour infusion based on Phase 1 or Phase 3 patient pharmacokinetic data were studied in the model...
November 13, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28805570/swallowing-dysfunctions-in-parkinson-s-disease
#8
Janine A Simons
Dysphagia is a very frequent and highly relevant symptom in Parkinson's disease (PD) for quality of life, morbidity, and remaining lifetime, which is unfortunately widely underdiagnosed and underestimated regarding patients' centered care. Especially in early stages, the causal association between disease and swallowing disabilities remains unnoticed, which may be accounted for by the inability of caregivers and physicians to detect subtle swallowing problems and by the low self-awareness among PD patients...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28781200/outcome-of-gastrostomy-in-parkinsonism-a-retrospective-study
#9
Clémence Marois, Maria Del Mar Amador, Christine Payan, Lucette Lacomblez, Anne-Marie Bonnet, Bertrand Degos, Jean-Christophe Corvol, Marie Vidailhet, Nadine Le Forestier, Valérie Mesnage, David Grabli
OBJECTIVE: To investigate the indications and the outcomes of gastrostomy tube insertion in patients with parkinsonian syndromes. METHODS: Consecutive patients with Parkinson's disease or atypical parkinsonism, seen in two French tertiary referral movement disorders centers, that received gastrostomy tube insertion (GTI) for feeding between 2008 and 2014 were included in this retrospective study. Data regarding clinical status, indications and outcomes were retrieved from medical files...
June 23, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28739426/incorporating-oral-health-into-interprofessional-care-teams-for-patients-with-parkinson-s-disease
#10
REVIEW
Natalia S Rozas, June M Sadowsky, Deborah J Jones, Cameron B Jeter
Parkinson's disease (PD) is a progressive neurodegenerative disorder that primarily affects the motor system. However, non-motor symptoms such as cognitive, autonomic, sleep-related and sensory dysfunctions are often reported. A subgroup of non-motor symptoms, oropharyngeal problems, also affects these patients in ways that greatly deteriorate quality of life. Each patient may develop a different set of non-motor symptoms, making interprofessional collaboration among health care providers a must to treat patients with PD...
July 17, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28714426/suicide-following-acute-admissions-for-physical-illnesses-across-england-and-wales
#11
S E Roberts, A John, U Kandalama, J G Williams, R A Lyons, K Lloyd
BACKGROUND: The study aim was to establish and quantify suicide risk following acute admissions for all major physical illnesses, for confirmatory purposes, from two independent information sources from different countries. METHODS: Record linkage of inpatient and death certificate data for 11 004 389 acute admissions for physical illnesses in England and 713 496 in Wales. The main outcome measure was standardised mortality ratios (SMRs) for suicide at 1 year following discharge from hospital...
July 17, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28690533/dysphagia-in-perry-syndrome-pharyngeal-pressure-in-two-cases
#12
George Umemoto, Yoshio Tsuboi, Hirokazu Furuya, Takayasu Mishima, Shinsuke Fujioka, Naoki Fujii, Hajime Arahata, Miwa Sugahara, Mitsuaki Sakai
BACKGROUND: To investigate the impact of dysphagia in Perry syndrome (PS), an autosomal dominant parkinsonism caused by mutation of DCTN1, which is associated with hypoventilation, depression, and weight loss. CASE PRESENTATION: We used tongue pressure measurements and manofluorography to investigate swallowing function in 2 patients with PS. Case 1, a 60-year-old male showing parkinsonism, and case 2, a 49-year-old male admitted with pneumonia, were diagnosed as having PS based on the DCTN1 gene analysis...
May 2017: Case Reports in Neurology
https://www.readbyqxmd.com/read/28652714/the-safety-issues-and-hardware-related-complications-of-deep-brain-stimulation-therapy-a-single-center-retrospective-analysis-of-478-patients-with-parkinson-s-disease
#13
Jing Zhang, Tao Wang, Chen-Cheng Zhang, Kristina Zeljic, Shikun Zhan, Bo-Min Sun, Dian-You Li
INTRODUCTION: Deep brain stimulation (DBS) is a well-established therapy for the treatment of advanced Parkinson's disease (PD) in patients experiencing motor fluctuations and medication-refractory tremor. Despite the relative tolerability and safety of this procedure, associated complications and unnatural deaths are still unavoidable. METHODS: In this study, hardware-related complications and the causes of unnatural death were retrospectively analyzed in 478 patients with PD who were treated with DBS...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28560917/caring-for-patients-with-parkinson-s-disease-in-general-hospital-settings
#14
Vicky Queen
Parkinson's disease (PD) is a common progressive neurological condition. There are 127,000 people with the disease in the UK, that is, one in every 500 of the population. In 2014-15 there were 14,000 hospital admissions of people with PD in England. However, PD is often not the primary cause of admission. Urinary tract infections and pneumonia, for example, are frequent causes of hospital admission for people with PD. Therefore, nurses on general medical and surgical wards will often care for people with PD...
May 31, 2017: Nursing Older People
https://www.readbyqxmd.com/read/28473650/a-descriptive-study-of-lewy-body-dementia-with-functional-imaging-support-in-a-chinese-population-a-preliminary-study
#15
Y F Shea, L W Chu, S C Lee
INTRODUCTION: Lewy body dementia includes dementia with Lewy bodies and Parkinson's disease dementia. There have been limited clinical studies among Chinese patients with Lewy body dementia. This study aimed to review the presenting clinical features and identify risk factors for complications including fall, dysphagia, aspiration pneumonia, pressure sores, and mortality in Chinese patients with Lewy body dementia. We also wished to identify any difference in clinical features of patients with Lewy body dementia with and without an Alzheimer's disease pattern of functional imaging...
May 5, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/28447217/swallowing-disorders-in-schizophrenia
#16
REVIEW
Deepika P Kulkarni, Vandan D Kamath, Jonathan T Stewart
Disorders of swallowing are poorly characterized but quite common in schizophrenia. They are a source of considerable morbidity and mortality in this population, generally as a result of either acute asphyxia from airway obstruction or more insidious aspiration and pneumonia. The death rate from acute asphyxia may be as high as one hundred times that of the general population. Most swallowing disorders in schizophrenia seem to fall into one of two categories, changes in eating and swallowing due to the illness itself and changes related to psychotropic medications...
August 2017: Dysphagia
https://www.readbyqxmd.com/read/28253409/enhancing-care-for-hospitalized-patients-with-parkinson-s-disease-development-of-a-formal-educational-program-for-nursing-staff
#17
Mary C DiBartolo
Although not generally a primary admission diagnosis, Parkinson's disease (PD) can be a significant comorbidity during hospitalization. Hospitalized individuals with PD can experience a variety of complications, such as confusion, pneumonia, and urinary infections. More than 20% of patients experience deterioration in symptoms and hospital stays are extended by an average of 4 days. Late, omitted, or inappropriate medications are frequent culprits leading to serious consequences, including falls and aspiration...
May 1, 2017: Journal of Gerontological Nursing
https://www.readbyqxmd.com/read/27795943/tailored-deep-brain-stimulation-optimization-for-improved-airway-protective-outcomes-in-parkinson-s-disease
#18
Michelle S Troche, Alexandra E Brandimore, Karen W Hegland, Pamela R Zeilman, Kelly D Foote, Michael S Okun
There is no consensus regarding the effects of deep brain stimulation (DBS) surgery on swallowing outcomes in Parkinson's disease (PD). No prospective studies have compared airway protective outcomes following DBS to the subthalamic nucleus (STN) versus globus pallidus interna (GPi). A recent retrospective study described swallowing outcomes pre- and post-STN vs. GPi DBS in a cohort of 34 patients with PD. The results revealed that the patients who received GPi DBS maintained their swallowing function post-DBS, while those in the STN group significantly worsened in swallowing safety...
September 2016: Interdisciplinary Neurosurgery: Advanced Techniques and Case Management
https://www.readbyqxmd.com/read/27662326/acute-hospital-admissions-of-individuals-with-a-known-parkinson-s-disease-diagnosis-in-ireland-2009-2012-a-short-report
#19
Bróna Kelly, Catherine Blake, Olive Lennon
BACKGROUND: The rate of people with Parkinson's disease (PD) is predicted to double by 2030 resulting in an even greater burden to an already struggling Irish health care system. There is a paucity of information regarding hospital utilisation among the PD population in an Irish context. OBJECTIVE: To examine trends of acute hospital in-patient admissions of patients admitted with a secondary diagnosis of PD between 2009 and 2012 in Ireland. METHOD: Data concerning patients, aged over and under 65 years with a previously existing diagnosis of Parkinson's Disease were requested from the HIPE database for the years 2009-2012...
October 19, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27649015/-hospital-mortality-in-parkinson-s-disease-retrospective-analysis-in-a-portuguese-tertiary-centre
#20
Joana Martins, Adriana Rua, Nuno Vila Chã
INTRODUCTION: Parkinson's disease is associated with high hospital mortality. Male gender, late age at onset, higher disability and the coexistence of cognitive impairment or depression have been suggested to be risk factors of death. Pneumonia and cardiovascular diseases are the leading causes of death. OBJECTIVE: To characterize the mortality (causes of hospital admission and death) of Parkinson's disease patients in a tertiary hospital, as well as demographic and clinical characteristics...
May 2016: Acta Médica Portuguesa
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