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https://www.readbyqxmd.com/read/27795943/tailored-deep-brain-stimulation-optimization-for-improved-airway-protective-outcomes-in-parkinson-s-disease
#1
Michelle S Troche, Alexandra E Brandimore, Karen W Hegland, Pamela R Zeilman, Kelly D Foote, Michael S Okun
There is no consensus regarding the effects of deep brain stimulation (DBS) surgery on swallowing outcomes in Parkinson's disease (PD). No prospective studies have compared airway protective outcomes following DBS to the subthalamic nucleus (STN) versus globus pallidus interna (GPi). A recent retrospective study described swallowing outcomes pre- and post-STN vs. GPi DBS in a cohort of 34 patients with PD. The results revealed that the patients who received GPi DBS maintained their swallowing function post-DBS, while those in the STN group significantly worsened in swallowing safety...
September 2016: Interdisciplinary Neurosurgery: Advanced Techniques and Case Management
https://www.readbyqxmd.com/read/27662326/acute-hospital-admissions-of-individuals-with-a-known-parkinson-s-disease-diagnosis-in-ireland-2009-2012-a-short-report
#2
Bróna Kelly, Catherine Blake, Olive Lennon
BACKGROUND: The rate of people with Parkinson's disease (PD) is predicted to double by 2030 resulting in an even greater burden to an already struggling Irish health care system. There is a paucity of information regarding hospital utilisation among the PD population in an Irish context. OBJECTIVE: To examine trends of acute hospital in-patient admissions of patients admitted with a secondary diagnosis of PD between 2009 and 2012 in Ireland. METHOD: Data concerning patients, aged over and under 65 years with a previously existing diagnosis of Parkinson's Disease were requested from the HIPE database for the years 2009-2012...
October 19, 2016: Journal of Parkinson's Disease
https://www.readbyqxmd.com/read/27649015/-hospital-mortality-in-parkinson-s-disease-retrospective-analysis-in-a-portuguese-tertiary-centre
#3
Joana Martins, Adriana Rua, Nuno Vila Chã
INTRODUCTION: Parkinson's disease is associated with high hospital mortality. Male gender, late age at onset, higher disability and the coexistence of cognitive impairment or depression have been suggested to be risk factors of death. Pneumonia and cardiovascular diseases are the leading causes of death. OBJECTIVE: To characterize the mortality (causes of hospital admission and death) of Parkinson's disease patients in a tertiary hospital, as well as demographic and clinical characteristics...
May 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/27533053/premotor-symptoms-as-predictors-of-outcome-in-parkinsons-disease-a-case-control-study
#4
Yu-Hsuan Wu, Wei-Ju Lee, Yi-Huei Chen, Ming-Hong Chang, Ching-Heng Lin
BACKGROUND: To evaluate the association between the premotor symptoms and the prognosis of PD. METHODS: A total of 1213 patients who were diagnosed of PD from January 2001 to December 2008 were selected from the Taiwan's National Health Insurance Research Database. Patients were traced back to determine the presence of premotor symptoms, including rapid eye movement sleep behavior disorder (RBD), depression, and constipation. Cox's regression analysis was used to detect the risks between the occurrence of premotor symptoms and the outcome (including death, psychosis, accidental injury, dementia and aspiration pneumonia)...
2016: PloS One
https://www.readbyqxmd.com/read/27532657/effectiveness-of-allied-health-therapy-in-the-symptomatic-management-of-progressive-supranuclear-palsy-a-systematic-review
#5
Erica Tilley, James McLoughlin, Simon A Koblar, Sebastian H Doeltgen, Cindy Stern, Sarahlouise White, Micah D J Peters
BACKGROUND: Progressive supranuclear palsy (PSP) is an adult onset neurodegenerative condition associated with mobility, balance, speech, swallowing, vision and cognitive changes. The condition is diagnosed using the National Institute for Neurological Disorders and Stroke (NINDS) and the Society of Progressive Supranuclear Palsy (SPSP) criteria. Therapeutic interventions for PSP are important, and a healthcare team should include a physiotherapist, occupational therapist and speech therapist...
June 2016: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/27462817/a-novel-excitatory-network-for-the-control-of-breathing
#6
Tatiana M Anderson, Alfredo J Garcia, Nathan A Baertsch, Julia Pollak, Jacob C Bloom, Aguan D Wei, Karan G Rai, Jan-Marino Ramirez
Breathing must be tightly coordinated with other behaviours such as vocalization, swallowing, and coughing. These behaviours occur after inspiration, during a respiratory phase termed postinspiration. Failure to coordinate postinspiration with inspiration can result in aspiration pneumonia, the leading cause of death in Alzheimer's disease, Parkinson's disease, dementia, and other neurodegenerative diseases. Here we describe an excitatory network that generates the neuronal correlate of postinspiratory activity in mice...
August 4, 2016: Nature
https://www.readbyqxmd.com/read/27461481/reflex-cough-and-disease-duration-as-predictors-of-swallowing-dysfunction-in-parkinson-s-disease
#7
Michelle S Troche, Beate Schumann, Alexandra E Brandimore, Michael S Okun, Karen W Hegland
Patients with Parkinson's disease (PD) have progressive and pervasive disorders of airway protection. Recent work has highlighted the relationship between reflex and voluntary cough and swallowing safety. The goal of this study was to test the sensitivity and specificity of several airway protective and disease-specific factors for predicting swallowing safety outcomes in PD. Sixty-four participants (44 males) completed measures of voluntary and reflex cough, and swallowing safety. Clinical predictors included disease severity and duration, and cough airflow and sensitivity measures...
July 26, 2016: Dysphagia
https://www.readbyqxmd.com/read/27446780/the-functional-dysphagia-scale-is-a-useful-tool-for-predicting-aspiration-pneumonia-in-patients-with-parkinson-disease
#8
Jong Hwa Lee, Kyeong Woo Lee, Sang Beom Kim, Sook Joung Lee, Sang Myung Chun, Sung Moon Jung
OBJECTIVE: To describe the correlation between the functional dysphagia scale and aspiration pneumonia and which characteristics influence the occurrence of aspiration pneumonia in patients with idiopathic Parkinson disease. METHODS: Fifty-three patients with idiopathic Parkinson disease were prospectively evaluated in this study. Disease severity and functional status were measured by modified Hoehn and Yahr (H&Y) staging, Schwab and England activities of daily living (S-E ADL) scale and Korean version of Mini-Mental State Examination (K-MMSE)...
June 2016: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/27321989/risk-and-prognostic-factors-for-pneumonia-and-choking-amongst-parkinson-s-disease-patients-with-dysphagia
#9
Kwang-Hwee Goh, Sanchalika Acharyya, Samuel Yong-Ern Ng, Jasmine Pei-Ling Boo, Amanda Hui-Juan Kooi, Hwee-Lan Ng, Wei Li, Kay-Yaw Tay, Wing-Lok Au, Louis Chew-Seng Tan
OBJECTIVE: To evaluate the time to hospitalisation and baseline factors associated with pneumonia/choking in Parkinson's Disease (PD) patients. BACKGROUND: Although dysphagia and pneumonia are common problems in PD, scarce research has been performed. METHODS: A total of 194 PD patients who underwent a VFS evaluation were retrospectively selected. The mode of feeding and admissions for pneumonia/choking were analyzed. Baseline clinical and demographic variables were compared between feeding groups...
August 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/27299944/-dysphagia-in-parkinson-s-disease-pathophysiology-diagnosis%C3%A2-and-therapy
#10
I Suttrup, T Warnecke
Oropharyngeal and esophageal dysphagia are a frequent, but seldom diagnosed symptom of Parkinson's disease (PD). More than 80 % of patients with PD develop dysphagia during the course of their disease leading to a reduced quality of life, complicated medication intake, malnutrition and aspiration pneumonia, which is a major cause of death in PD. The underlying pathophysiology is poorly understood. Impaired dopaminergic and non-dopaminergic mechanisms of the cortical swallowing network as well as peripheral neuromuscular involvement have been suggested to contribute to its multifactorial genesis...
July 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/27276074/-perioperative-management-of-pd-patients
#11
H Reichmann
Both patients and caregivers but also treating physicians are concerned about complications along with surgical interventions. A major problem is abrupt cessation of anti-Parkinson medication, which leads to manifold disturbances, sometimes even to an akinetic crisis. There are several means to guarantee continuous dopaminergic stimulation even in patients that are not allowed to take medication orally before they undergo surgery. Amongst others rectally applied levodopa, amantadine infusions, and especially the use of a rotigotine patch are good means to overcome oral intake...
July 2016: Fortschritte der Neurologie-Psychiatrie
https://www.readbyqxmd.com/read/27269197/swallowing-disorders-in-parkinson-s-disease
#12
Sandra Mamolar Andrés, María Liliana Santamarina Rabanal, Carla María Granda Membiela, María José Fernández Gutiérrez, Paloma Sirgo Rodríguez, César Álvarez Marcos
INTRODUCTION: Parkinson's disease is a type of chronic neurodegenerative pathology with a typical movement pattern, as well as different, less studied symptoms such as dysphagia. Disease-related disorders in efficacy or safety in the process of swallowing usually lead to malnutrition, dehydration or pneumonias. The aim of this study was identifying and analyzing swallowing disorders in Parkinson's disease. SUBJECTS AND METHODS: The initial sample consisted of 52 subjects with Parkinson's disease to whom the specific test for dysphagia SDQ was applied...
June 3, 2016: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/27242063/epidemiology-of-inpatient-stay-in-parkinson-s-disease-in-the-united-states-insights-from-the-nationwide-inpatient-sample
#13
Abhimanyu Mahajan, Poojitha Balakrishnan, Achint Patel, Ioannis Konstantinidis, Dominic Nistal, Narender Annapureddy, Priti Poojary, Girish N Nadkarni, Christos Sidiropoulos
The total number of people living with Parkinson's disease (PD) worldwide is expected to double by 2030. The risk factors for emergency department visits in PD patients have been described before, however, there is limited data on inpatient hospitalizations of PD patients. We derived our study cohort from the Nationwide Inpatient Sample (NIS) database from 2002-2011. The NIS is a stratified 20% sample of discharges from all U.S. hospitals. We extracted causes of hospitalization using International Classification of Diseases, 9th revision, Clinical Modification (ICD-9-CM) codes and calculated inpatient mortality, length of stay and cost...
September 2016: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/27195055/the-role-of-geographical-ecological-studies-in-identifying-diseases-linked-to-uvb-exposure-and-or-vitamin-d
#14
REVIEW
William B Grant
Using a variety of approaches, researchers have studied the health effects of solar ultraviolet (UV) radiation exposure and vitamin D. This review compares the contributions from geographical ecological studies with those of observational studies and clinical trials. Health outcomes discussed were based on the author's knowledge and include anaphylaxis/food allergy, atopic dermatitis and eczema, attention deficit hyperactivity disorder, autism, back pain, cancer, dental caries, diabetes mellitus type 1, hypertension, inflammatory bowel disease, lupus, mononucleosis, multiple sclerosis, Parkinson disease, pneumonia, rheumatoid arthritis, and sepsis...
January 2016: Dermato-endocrinology
https://www.readbyqxmd.com/read/27175081/risk-factors-for-pneumonia-among-patients-with-parkinson-s-disease-a-taiwan-nationwide-population-based-study
#15
Yang-Pei Chang, Chih-Jen Yang, Kai-Fang Hu, A-Ching Chao, Yu-Han Chang, Kun-Pin Hsieh, Jui-Hsiu Tsai, Pei-Shan Ho, Shen-Yang Lim
OBJECTIVE: Pneumonia is the leading cause of death in patients with Parkinson's disease (PD). However, few studies have been performed to explore the risk factors for pneumonia development in patients with PD. METHODS: We conducted a nationwide population-based cohort study of patients with PD to identify the risk factors for these patients developing pneumonia. Participants with newly diagnosed PD between 2000 and 2009 were enrolled from the 2000-2010 National Health Insurance Research Database in Taiwan...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27157001/-use-of-gastrostomies-in-patients-over-75-years-old
#16
María Elena Baeza-Monedero, Beatriz Montero-Errasquín, Juan Sánchez-Corral, Alfonso J Cruz-Jentoft
OBJECTIVE: To describe the indications of insertion of a percutaneous gastrostomy (PG) in older patients in a university hospital, as well as patient characteristics, short and long term complications, and mortality. METHODS: Retrospective descriptive study of all patients over 75 years who had a PG inserted during a three year period by the Interventional Radiology Department. The indication of the procedure was reviewed, and the incidence of complications and mortality during a 36 months follow-up period were assessed through electronic medical records...
May 5, 2016: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/27118763/post-encephalitic-parkinsonism-and-sleep-disorder-responsive-to-immunological-treatment-a-case-report
#17
Valerio Brunetti, Elisa Testani, Raffaele Iorio, Giovanni Frisullo, Marco Luigetti, Daniela Di Giuda, Giacomo Della Marca
We describe a 70-year-old man who, after a viral encephalitis associated with pneumonia, progressively developed a parkinsonism associated with lethargy. Encephalitis manifested with persistent hiccups, seizures and impairment of consciousness. After 2 weeks, the initial neurologic symptoms subsided and the patient progressively developed movement disorders (rigidity and bradykinesia, resistant to L-DOPA), lethargy and behavioral hypersomnia. Magnetic resonance imaging showed thalamic and hippocampal signal abnormalities, immunohistochemistry on a mouse brain substrate revealed serum autoantibodies binding to the brainstem neuropil...
April 25, 2016: Clinical EEG and Neuroscience: Official Journal of the EEG and Clinical Neuroscience Society (ENCS)
https://www.readbyqxmd.com/read/27030949/long-term-peg-j-tube-safety-in-patients-with-advanced-parkinson-s-disease
#18
Michael Epstein, David A Johnson, Robert Hawes, Nathan Schmulewitz, Arvydas D Vanagunas, E Roderich Gossen, Weining Z Robieson, Susan Eaton, Jordan Dubow, Krai Chatamra, Janet Benesh
OBJECTIVES: The objectives of this study were to present procedure- and device-associated adverse events (AEs) identified with long-term drug delivery via percutaneous endoscopic gastrojejunostomy (PEG-J). Levodopa-carbidopa intestinal gel (LCIG, also known in US as carbidopa-levodopa enteral suspension, CLES) is continuously infused directly to the proximal small intestine via PEG-J in patients with advanced Parkinson's disease (PD) to overcome slow and erratic gastric emptying and treat motor fluctuations that are not adequately controlled by oral or other pharmacological therapy...
March 31, 2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27015218/outcomes-after-non-neurological-surgery-in-patients-with-parkinson-s-disease-a-nationwide-matched-cohort-study
#19
Yu-Feng Huang, Yi-Chun Chou, Chun-Chieh Yeh, Chaur-Jong Hu, Yih-Giun Cherng, Ta-Liang Chen, Chien-Chang Liao
Patients with Parkinson disease (PD) were known to have increased risk of complications during hospitalization. The purpose of this study is to validate the global features of postoperative adverse outcomes for patients with PD.Using reimbursement claims from Taiwan's National Health Insurance Research Database, we conducted a nationwide retrospective cohort study of 6455 patients with preoperative PD receiving major surgery during 2008 to 2012. With a propensity score matching procedure, 12,910 surgical patients without PD were selected for comparison...
March 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/26970760/a-systematic-review-of-the-prevalence-of-oropharyngeal-dysphagia-in-stroke-parkinson-s-disease-alzheimer-s-disease-head-injury-and-pneumonia
#20
Claire Takizawa, Elizabeth Gemmell, James Kenworthy, Renée Speyer
Oropharyngeal dysphagia is a common condition after stroke, Parkinson's disease (PD), and Alzheimer's disease (AD), and can cause serious complications including malnutrition, aspiration pneumonia, and premature mortality. Despite its high prevalence among the elderly and associated serious complications, dysphagia is often overlooked and under-diagnosed in vulnerable patient populations. This systematic review aimed to improve understanding and awareness of the prevalence of dysphagia in susceptible patient populations...
June 2016: Dysphagia
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