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https://www.readbyqxmd.com/read/29335537/a-bony-crested-jurassic-dinosaur-with-evidence-of-iridescent-plumage-highlights-complexity-in-early-paravian-evolution
#1
Dongyu Hu, Julia A Clarke, Chad M Eliason, Rui Qiu, Quanguo Li, Matthew D Shawkey, Cuilin Zhao, Liliana D'Alba, Jinkai Jiang, Xing Xu
The Jurassic Yanliao theropods have offered rare glimpses of the early paravian evolution and particularly of bird origins, but, with the exception of the bizarre scansoriopterygids, they have shown similar skeletal and integumentary morphologies. Here we report a distinctive new Yanliao theropod species bearing prominent lacrimal crests, bony ornaments previously known from more basal theropods. It shows longer arm and leg feathers than Anchiornis and tail feathers with asymmetrical vanes forming a tail surface area even larger than that in Archaeopteryx...
January 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29332133/fumarate-hydratase-fh-deficiency-in-uterine-leiomyomas-recognition-by-histological-features-versus-blind-immunoscreening
#2
Lisa Siegler, Ramona Erber, Stefanie Burghaus, Tobias Brodkorb, David Wachter, Nafisa Wilkinson, James Bolton, Helen Stringfellow, Florian Haller, Matthias W Beckmann, Arndt Hartmann, Abbas Agaimy
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) syndrome is a rare autosomal dominant disease caused by germline mutations in the fumarate hydratase (FH) gene. Affected individuals develop cutaneous and uterine leiomyomas and aggressive RCC. To date, only few publications described the frequency and morphology of FH-deficient uterine leiomyomas. We reviewed 22 cases collected over 8 years from routine and consultation files based on distinctive histological features. In addition, we screened 580 consecutive uterine leiomyomas from 484 patients, 23 extra-uterine and 8 uterine leiomyosarcomas, and 6 leiomyomas with bizarre nuclei for FH loss using immunohistochemistry (IHC) on tissue microarrays (TMAs)...
January 13, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29326297/current-status-and-future-directions-of-l%C3%A3-vy-walk-research
#3
REVIEW
Andy M Reynolds
Lévy walks are a mathematical construction useful for describing random patterns of movement with bizarre fractal properties that seem to have no place in biology. Nonetheless, movement patterns resembling Lévy walks have been observed at scales ranging from the microscopic to the ecological. They have been seen in the molecular machinery operating within cells during intracellular trafficking, in the movement patterns of T cells within the brain, in DNA, in some molluscs, insects, fish, birds and mammals, in the airborne flights of spores and seeds, and in the collective movements of some animal groups...
January 11, 2018: Biology Open
https://www.readbyqxmd.com/read/29324524/ect-and-pronounced-impairment-in-spatial-cognition-the-fallacy-of-drawing-conclusions-from-a-single-case
#4
Chittaranjan Andrade, Yameni Prasad, Aathira Devaraj, Ekta Franscina Pinto, Lekhansh Shukla
INTRODUCTION: Electroconvulsive therapy (ECT) is associated with memory deficits on neuropsychological assessment. The association of ECT with nonmemory cognitive deficits has been poorly studied. METHODS: We present a 40-year-old woman who showed a bizarre form of spatial cognition impairment on a subtest of the Tactual Performance Test (TPT) after recovering from depression with 6 alternate day, thrice-weekly, inpatient ECT treatments. This woman was part of a naturalistic, nonblind study that examined nonmemory cognitive deficits in antidepressant-treated depressed patients who did and did not receive ECT...
January 11, 2018: Journal of ECT
https://www.readbyqxmd.com/read/29311003/common-bite-bizarre-rash
#5
Simant Singh Thapa, Buddha Basnyat
No abstract text is available yet for this article.
January 5, 2018: Wilderness & Environmental Medicine
https://www.readbyqxmd.com/read/29258902/the-selected-biomarker-analysis-in-five-types-of-uterine-smooth-muscle-tumors
#6
Qing Zhang, Margaux Jenna Kanis, Julianne Ubago, Dachao Liu, Denise M Scholtens, Anna E Strohl, John R Lurain, Shohreh Shahabi, Beihua Kong, Jian-Jun Wei
Uterine smooth muscle tumors (USMT) consist of a group of histologically heterogeneous and clinically diverse diseases ranging from malignant leiomyosarcoma (LMS) to benign leiomyoma (ULM). The genetic alterations in LMS are complex with some genetic alterations present in both LMS and other atypical histologic variants of USMT. In this study we reviewed 119 USMT with a diagnosis of LMS, STUMP (smooth muscle tumor of uncertain malignant potential), ALM/LM-BN (atypical leiomyomas/leiomyoma with bizarre nuclei) and CLM (cellular leiomyoma) as well as 46 ULM and 60 myometrial controls...
December 16, 2017: Human Pathology
https://www.readbyqxmd.com/read/29248882/-mutiny-on-the-crown-two-cases-of-rare-cephalic-malformations
#7
Kashish Khanna, Minu Bajpai, Alisha Gupta, Prabudh Goel
The presentation and management of two bizarre congenital cephalic curiosities at the two extremes of the clinical spectrum are discussed herewith. Case 1: presented to us as a neonate with a scalp swelling mirror-imaging her head and face. The journey from clinics to wards and to the operation theatre and to her home is introspected. Case 2: presented to us as dicephalous dibrachius dipus parapagus conjoined twins. The detailed work-up of individual organ systems, the multidisciplinary approach to management and the final outcome are discussed...
December 15, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29243259/a-unique-anomaly-of-the-ear-oculo-auriculo-vertebral-spectrum-or-an-isolated-disruption
#8
Eleonoor A R Theunissen, Isabella C M Hoogslag, Erik van Spronsen, Roelof J Oostra, Fenna A Ebbens
We present a rare case of a neonate with an isolated congenital condition of his right ear involving the outer ear, middle ear, eustachian tube, and the facial nerve, with an external opening into the skull that connects to the oropharynx. Taking this bizarre aspect of the exterior lesion and the oropharyngeal communication into account, we consider the condition presented here, which to our knowledge is the first of its kind to have resulted from a vascular disruption. Laryngoscope, 2017.
December 15, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29242790/surgical-retrieval-of-an-impaled-tapestry-needle-from-the-true-pelvic-cavity-of-a-child-an-unusual-case-report
#9
Nirmal Raj Gopinathan, Rakesh John, Himanshu Kanwat, Pebam Sudesh
Introduction: Impalement injuries of pelvis have been reported in children but are uncommon. Impalement could be associated with injuries to deep organs, wound contamination, crush injuries, and in certain instances, can even be fatal. Case Report: We present a bizarre case of a 2-year-old female child who presented to us with a tapestry needle embedded in the true pelvic cavity after a history of fall on the buttock while playing at home. The impaled needle was eventually successfully extracted surgically using the modified Stoppa's approach and the post-operative period was uneventful...
September 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/29237665/intermittent-catatonia-and-complex-automatisms-caused-by-frontal-lobe-epilepsy-in-dementia
#10
Robynne George, Alex Langford
An 82-year-old man was admitted to the emergency department following bizarre behaviour. Police had noticed him driving erratically through his village. He did not stop when instructed, drove slowly home and appeared 'vacant' on questioning. While in hospital, he had approximately 15 episodes of catatonia, involving rigidity, negativism, mutism except echolalia and perseveration, automatic obedience and utilisation phenomena, lasting 2-20 min each. Between episodes, he was amnestic but otherwise well. Electroencephalography demonstrated bifrontal slowing with left-sided emphasis, and captured two focal onset partial seizures with the clinical correlate of the syndrome described above...
December 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29235251/the-score-distribution-and-factor-structure-of-the-community-assessment-of-psychic-experiences-positive-scale-cape-p15-in-a-canadian-sample
#11
Mashal K Haque, Jill A Jacobson, Christopher R Bowie, Kevin G Munhall
AIM: Psychotic-like experiences (PLEs) share several risk factors with psychotic disorders and confer greater risk of developing a psychotic disorder. Thus, individuals with PLEs not only comprise a valuable population in which to study the aetiology and premorbid changes associated with psychosis, but also represent a high-risk population that could benefit from clinical monitoring or early intervention efforts. METHOD: We examined the score distribution and factor structure of the current 15-item Community Assessment of Psychic Experiences-Positive Scale (CAPE-P15) in a Canadian sample...
December 13, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/29224226/bizarre-appearance-of-chronic-cutaneous-lupus-erythematosus-of-face-mimicking-factitial-dermatitis
#12
Ružica Jurakić Tončić, Branka Marinović, Anamaria Balić, Borna Pavičić, Suzana Ljubojević Hadžavdić, Mirna Bradamant
Old dermatological wisdom says that syphilis and lupus are great imitators. Cutaneous manifestations of lupus erythematosus (LE) are usually characteristic, however, some patients may present with a less typical clinical picture. Correct diagnosis of cutaneous lupus erythematosus (CLE) requires a high level of clinical suspicion and understanding of broad differential diagnosis. Early lesions of CLE are sometimes difficult to diagnose, both clinically and histopathologically. This article is protected by copyright...
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29218275/outcomes-of-surgical-excision-and-brachytherapy-in-intractable-keloids
#13
Ahmadreza Taheri, Hojjat Molaei, Mehdi Aghili, Naser Rahmanpanah, Atefeh Mirmohseni
BACKGROUND: Keloids as unusual scars are injury remnants characterized by bizarre cosmetics and painful itching. This study assessed outcomes of surgical excision and brachytherapy in intractable keloids. METHODS: Six patients with 10 keloid lesions were followed up. Surgical excision was done with 1-2 mm margin, and then radiotherapy was undertaken in 3 divided fractions on days 0, 1 and 2 after surgery. Scar improvement was evaluated by patients and observer with scar assessment scale (POSAS)...
September 2017: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29201327/stiff-person-case-misdiagnosed-as-conversion-disorder-a-case-report
#14
Saeed Razmeh, Amir Hasan Habibi, Farzad Sina, Elham Alizadeh, Monireh Eslami
Background: Stiff person syndrome (SPS) is a rare neurological disease resulting in stiffness and spasm of muscles. It initially affects the axial muscles and then spread to limb muscles. Emotional stress exacerbated the symptoms and signs of the disease. The pathophysiology of the disease is caused by the decreased level of the glutamic acid decarboxylase (GAD) activity due to an autoantibody against GAD that decreases the level of gamma-aminobutyric acid (GABA). In this paper, we present a case of atypical presentation of SPS with lower limb stiffness misdiagnosed as conversion disorder...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/29191620/genetic-alterations-in-primary-acral-melanoma-and-acral-melanocytic-nevus-in-korea-common-mutated-genes-show-distinct-cytomorphological-features
#15
Ki Rang Moon, Yoo Duk Choi, Jung Min Kim, Suna Jin, Min-Ho Shin, Hyun-Jeong Shim, Jee-Bum Lee, Sook Jung Yun
Acral melanoma occurring on the palms, soles, and nails is the most common subtype of cutaneous melanoma in Asians. Genetic alterations in acral melanoma and acral melanocytic nevus are not well known. We performed next-generation sequencing and evaluated the correlations between genetic information and the clinicopathologic characteristicsfrom 85 Korean patients with acral melanocytic neoplasms. Of the 64 patients with acral melanoma, most had ≥ T2 stage, and the heel was the most common anatomical site of melanoma (n = 34, 53...
November 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29181194/physiological-roles-of-dna-double-strand-breaks
#16
REVIEW
Farhaan A Khan, Syed O Ali
Genomic integrity is constantly threatened by sources of DNA damage, internal and external alike. Among the most cytotoxic lesions is the DNA double-strand break (DSB) which arises from the cleavage of both strands of the double helix. Cells boast a considerable set of defences to both prevent and repair these breaks and drugs which derail these processes represent an important category of anticancer therapeutics. And yet, bizarrely, cells deploy this very machinery for the intentional and calculated disruption of genomic integrity, harnessing potentially destructive DSBs in delicate genetic transactions...
2017: Journal of Nucleic Acids
https://www.readbyqxmd.com/read/29169623/endocardial-peripheral-nerve-sheath-tumour-with-features-of-a-benign-schwannoma-in-a-donkey
#17
G Paraschou, A Suárez-Bonnet, V Grove, S L Priestnall
A peripheral nerve sheath tumour, with features of a benign schwannoma and arising from the endocardium of the right ventricle, was found incidentally during routine post-mortem examination of a 28-year-old gelding donkey. Macroscopically, five round to oval, white to grey and red, firm masses, firmly attached to the endocardium were identified. Microscopically, the endocardium and adjacent subendocardium were infiltrated by a variably demarcated, non-encapsulated mesenchymal neoplasm with features of a benign schwannoma, including concurrent presence of Antoni A and Antoni B areas, nuclear palisading, neoplastic cells with enlarged bizarre nuclei ('ancient change') and the formation of Verocay-like bodies...
November 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/29159525/hepatic-tumors-of-vascular-origin-imaging-appearances
#18
Eric C Ehman, Michael S Torbenson, Michael L Wells, Brian T Welch, Scott M Thompson, Ishan Garg, Sudhakar K Venkatesh
A number of benign and malignant neoplasms may arise from the vascular elements within the liver parenchyma. Lesions discussed in this article include angiosarcoma, epithelioid hemangioendothelioma, solitary fibrous tumor (hemangiopericytoma), infantile, and cavernous hemangiomas. Despite a common theme of vascular origin, the pathologic and imaging appearance of these entities can be heterogeneous. Angiosarcomas are bizarrely enhancing, highly aggressive tumors, which often present with metastatic disease...
November 20, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29154448/significance-of-bizarre-cells-in-cervical-screening-liquid-based-cytology-a-prospective-study-of-15-cases
#19
O Ondič, R Ferko, J Kičinová, J Bouda, I Kinkorová-Luňáčková, L Kupcová, M Zůchová, J Chytra, T Waloschek, M Tůmová Bartošková, R Alaghehbandan, J Němcová
OBJECTIVE: The aim of this study was to assess the significance of bizarre cells (cells of squamous origin with a superficial squamous cell-type cytoplasm and characterised by multinucleation that produces bizarre nuclear shapes) in liquid-based cytology (LBC) Papanicoaou (pap) smears with clinical and histological follow-up correlation. METHODS: Fifteen patients, all with LBC samples containing bizarre cells, were identified in routine ThinPrep® LBC workload. HPV testing was performed in each case using residual LBC material...
November 20, 2017: Cytopathology: Official Journal of the British Society for Clinical Cytology
https://www.readbyqxmd.com/read/29153818/expect-the-unexpected-a-bizarre-lookalike-of-left-atrial-tumor
#20
Federico Cammertoni, Piergiorgio Bruno, Christian Colizzi, Biagio Merlino, Natalia Pavone, Marialisa Nesta, Massimo Massetti
No abstract text is available yet for this article.
December 2017: Annals of Thoracic Surgery
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