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Daniel W Abbott, Kenneth D Friedman, Matthew S Karafin
BACKGROUND: Thrombotic thrombocytopenic purpura (TTP) is a microangiopathic hemolytic anemia that requires emergent treatment with plasma exchange and is one of the most important conditions for which apheresis service professionals are consulted. Careful interpretation of initial laboratory values and the peripheral blood smear is a critical first step to determining the need for plasma exchange because other conditions can show deceptively similar red cell morphology, and ADAMTS13 levels are often not rapidly available...
September 28, 2016: Transfusion and Apheresis Science
Thomas Forbes, Atul Malhotra, Michael Fahey, Chris Smith
No abstract text is available yet for this article.
October 2016: Journal of Paediatrics and Child Health
(no author information available yet)
No abstract text is available yet for this article.
October 2016: Journal of Paediatrics and Child Health
M A Thenganatt, J Jankovic
Psychogenic parkinsonism (PP), although often quite disabling, is one of the least commonly reported subtypes of psychogenic movement disorders. There are certain features that help distinguish PP from idiopathic Parkinson's disease, such as abrupt onset, early disability, bilateral shaking and slowness, nondecremental slowness when performing repetitive movements, voluntary resistance against passive movement without cogwheel rigidity, distractibility, "give-way" weakness, stuttering speech, bizarre gait, and a variety of behavioral symptoms...
2017: Handbook of Clinical Neurology
A Carson, M Hallett, J Stone
We describe an overall approach and structure to the clinical assessment of the patient with a functional neurologic disorder. Whilst the primary purpose of the assessment is to make a diagnosis and develop a treatment plan, we believe the assessment also plays a key role in treatment in its own right, as it sets a tone and context for future clinical interactions. We aim to set up an atmosphere of collaboration based on taking the patient's problems seriously, and emphasizing that all facets of the patient's presentation - physical, psychologic, and social - are of importance...
2017: Handbook of Clinical Neurology
Lazaro D Causil, Romy Ames, Paulo Puac, Mauricio Castillo
Some brain tumors results are interesting due to their rarity at presentation and overwhelming imaging characteristics, posing a diagnostic challenge in the eyes of any experienced neuroradiologist. This article focuses on the most important features regarding epidemiology, location, clinical presentation, histopathology, and imaging findings of cases considered "bizarre." A review of the most recent literature dealing with these unusual tumors and pseudotumors is presented, highlighting key points related to the diagnosis, treatments, outcomes, and differential diagnosis...
November 2016: Neuroimaging Clinics of North America
Gregory S Day, David F Tang-Wai, Michel C F Shamy
We review the case of a young man who developed a constellation of symptoms and signs-bizarre behavior, seizures, abnormal movements, and autonomic instability-that evaded diagnosis at the time of presentation. We use this case to explore the way medical knowledge changes over time. Despite the dramatic advances in our understanding of neurological diseases in recent decades, physicians tend to approach diseases and diagnoses as if they were immutable. Our case reinforces how the diagnosis and treatment of disease are determined by an ever-changing historical context driven by the rapid expansion of medical knowledge...
October 2016: Neurohospitalist
Shanigarn Thiravit, Sukanya Lapatikarn, Kobkun Muangsomboon, Voraparee Suvannarerg, Phakphoom Thiravit, Pornpim Korpraphong
OBJECTIVES: To retrospectively review the MRI findings of placenta percreta and identify those helpful for differentiation from non-placenta percreta. MATERIALS AND METHODS: The MRI images of 21 patients with a preliminary diagnosis of placental adhesive disorder scanned between 2005 and 2014 were evaluated. Radiologists blinded to the final diagnosis evaluated six previously described MRI findings of placenta adhesive disorder. The sensitivity, specificity, accuracy, negative predictive value (NPV), and positive predictive value (PPV) of MRI for the diagnosis of placenta percreta were also calculated...
September 20, 2016: La Radiologia Medica
Eiichi Ohnuki, Shinya Asayama, Tomoko Asayama, Kazuo Nakamichi, Masayuki Saijo, Satoru Kosaka
An 83-year-old man with chronic renal failure was referred to our hospital because of subacute progressive right hemiparesis. A brain MRI showed high-intensity lesions in bilateral middle cerebellar peduncles and white matter of the left frontal lobe on T2-weighted images. The lesions increased gradually, so we suspected a brain tumor because (1)H-MRS images showed elevated Cho and decreased NAA, and also pathologic findings of the brain biopsy suggested glioblastoma. However, JC virus (JCV) in cerebrospinal fluid was revealed highly positive by PCR...
September 16, 2016: Rinshō Shinkeigaku, Clinical Neurology
Emelie Glenne, Hanna Leek, Magnus Klarqvist, Jörgen Samuelsson, Torgny Fornstedt
In supercritical fluid chromatography (SFC) the mobile phase comprises of carbon dioxide (CO2) as main solvent and smaller amounts of an organic polar solvent (often an alcohol) as co-solvent. The co-solvent is considered to function by changing the overall polarity of the eluent, i.e. by acting as a "modifier". However, recent studies indicate that the co-solvent methanol can also adsorb to some common SFC stationary phases. Hence, the co-solvent should also be able to function as an "adsorbing additive", i...
October 14, 2016: Journal of Chromatography. A
I Weng Lao, Lin Yu, Jian Wang
AIMS: We describe an additional series of superficial CD34-positive fibroblastic tumor, a newly described neoplasm, to enhance the recognition of an emerging novel entity. METHODS AND RESULTS: The clinicopathological features and immunophenotypes of 11 cases of superficial CD34-positive fibroblastic tumor were studied. There were 8 males and 3 females with a median age of 36 years. Tumor occurred in the thigh (n=4), buttock (n=3), shoulder (n=2), upper arm (n=1) and waist (n=1)...
September 16, 2016: Histopathology
Kenneth S Kendler
Importance: This article aims to determine the degree to which modern operationalized diagnostic criteria for schizophrenia reflect the main clinical features of the disorder as described historically by diagnostic experts. Observations:, the National Library of Medicine, and were searched for articles written or translated into English from 1900 to 1960. Clinical descriptions of schizophrenia or dementia praecox appearing in 16 textbooks or review articles published between 1899 and 1956 were reviewed and compared with the criteria for schizophrenia from 6 modern US operationalized diagnostic systems...
October 1, 2016: JAMA Psychiatry
De-Yao Zhou, Li-Zhen Li
Horaeomorphus bicornis sp. n., a remarkable species with strongly modified head from Yunnan, Southwest China is described. A distinctly different female from the same locality is also recorded, its identity remains unconfirmed until associated males become available. The previously unknown female of H. hujiayaoi Zhou & Zhang, 2016, is discovered, with its spermatheca and female terminalia illustrated. Horaeomorphus punctatissimus Franz, 1992 is newly recorded from Mount Trus Madi, Malaysia. Two females of H...
2016: Zootaxa
M Archer, S J Hand, K H Black, R M D Beck, D A Arena, L A B Wilson, S Kealy, T-T Hung
No abstract text is available yet for this article.
2016: Scientific Reports
Ashvini Shekhar, Rasika Hendahewa, Mahesh Jayanna, Sujith Ratnayake
No abstract text is available yet for this article.
August 25, 2016: ANZ Journal of Surgery
C Hartog, V Centmaier-Molnar, R Patzwahl, D Pfofe, M Wiewiorski
A bizarre parosteal osteochondromatous proliferation (BPOP), also known as a Nora lesion, is a rare benign bone formation. It emanates mainly from the intact cortex of the metaphysis of short tubular bones (hands or feet). Conventional radiographs should be complemented using cross-sectional imaging modalities (CT/MRI). In the absence of symptoms a non-operative regime with radiological and clinical controls is possible. If symptomatic, excision biopsy is the treatment of choice, though a high recurrence rate has been reported...
October 2016: Der Orthopäde
Filipa Gomes Vieira, Clarissa Canella, Flavia Martins Costa, Silvana Mendonça, Edson Marchiori
No abstract text is available yet for this article.
September 2016: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
Christa Einspieler, Michael Freilinger, Peter B Marschik
The dynamic course of Rett syndrome (RTT) is still said to begin with a period of apparently normal development although there is mounting evidence that individuals with RTT show behavioural peculiarities and abnormalities during their infancy. Their spontaneous general movements are abnormal from birth onwards. Normal cooing vocalisation and canonical babbling (if at all required) are interspersed with abnormalities such as proto-vowel and proto-consonant alternations produced on ingressive airstream, breathy voice characteristics, and pressed or high-pitched vocalisations...
September 2016: Wiener Medizinische Wochenschrift
Tomer Fekete, Cees van Leeuwen, Shimon Edelman
A computational theory of consciousness should include a quantitative measure of consciousness, or MoC, that (i) would reveal to what extent a given system is conscious, (ii) would make it possible to compare not only different systems, but also the same system at different times, and (iii) would be graded, because so is consciousness. However, unless its design is properly constrained, such an MoC gives rise to what we call the boundary problem: an MoC that labels a system as conscious will do so for some-perhaps most-of its subsystems, as well as for irrelevantly extended systems (e...
2016: Frontiers in Psychology
Gerri Kaufman
Adverse drug reactions (ADRs) are increasingly common and are a significant cause of morbidity and mortality. Historically, ADRs have been classified as type A or type B. Type A reactions are predictable from the known pharmacology of a drug and are associated with high morbidity and low mortality. Type B reactions are idiosyncratic, bizarre or novel responses that cannot be predicted from the known pharmacology of a drug and are associated with low morbidity and high mortality. Not all ADRs fit into type A and type B categories; therefore, additional categories have been developed...
August 10, 2016: Nursing Standard
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