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https://www.readbyqxmd.com/read/28941390/severe-forms-of-food-allergy
#1
REVIEW
Emanuel Sávio Cavalcanti Sarinho, Maria das Graças Moura Lins
OBJECTIVES: To guide the diagnostic and therapeutic management of severe forms of food allergy. DATA SOURCES: Search in the Medline database using the terms "severe food allergy," "anaphylaxis and food allergy," "generalized urticaria and food allergy," and "food protein-induced enterocolitis syndrome" in the last ten years, searching in the title, abstract, or keyword fields. SUMMARY OF DATA: Food allergy can be serious and life-threatening...
September 20, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28937705/interventions-for-treating-genital-chlamydia-trachomatis-infection-in-pregnancy
#2
REVIEW
Catherine Cluver, Natalia Novikova, David Oa Eriksson, Kevin Bengtsson, Göran K Lingman
BACKGROUND: Genital Chlamydia trachomatis (C.trachomatis) infection may lead to pregnancy complications such as miscarriage, preterm labour, low birthweight, preterm rupture of membranes, increased perinatal mortality, postpartum endometritis, chlamydial conjunctivitis and C.trachomatis pneumonia.This review supersedes a previous review on this topic. OBJECTIVES: To establish the most efficacious and best-tolerated therapy for treatment of genital chlamydial infection in preventing maternal infection and adverse neonatal outcomes...
September 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28936072/alleviating-stress-response-to-tracheal-extubation-in-neurosurgical-patients-a-comparative-study-of-two-infusion-doses-of-dexmedetomidine
#3
Ankur Luthra, Hemanshu Prabhakar, Girija Prasad Rath
BACKGROUND: Tracheal extubation is almost always associated with increase in sympathoadrenal activity may result in hypertension, tachycardia, and arrhythmias. Attempts have been made to oppose the pressor response by the use of various drugs. Dexmedetomidine decreases norepinephrine which reduces the blood pressure and the heart rate (HR). We hypothesize that the infusion of dexmedetomidine may produce more stable hemodynamics during extubation as compared to boluses. MATERIALS AND METHODS: Ninety adult patients aged 18-65 years, the American Society of Anesthesiologists Grade I-II undergoing intracranial surgeries for various neurologic problem at All India Institute of Medical Sciences were enrolled in this randomized controlled trial...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28935935/igg1-memory-b-cells-keep-the-memory-of-ige-responses
#4
Jin-Shu He, Sharrada Subramaniam, Vipin Narang, Kandhadayar Srinivasan, Sean P Saunders, Daniel Carbajo, Tsao Wen-Shan, Nur Hidayah Hamadee, Josephine Lum, Andrea Lee, Jinmiao Chen, Michael Poidinger, Francesca Zolezzi, Juan J Lafaille, Maria A Curotto de Lafaille
The unique differentiation of IgE cells suggests unconventional mechanisms of IgE memory. IgE germinal centre cells are transient, most IgE cells are plasma cells, and high affinity IgE is produced by the switching of IgG1 cells to IgE. Here we investigate the function of subsets of IgG1 memory B cells in IgE production and find that two subsets of IgG1 memory B cells, CD80(+)CD73(+) and CD80(-)CD73(-), contribute distinctively to the repertoires of high affinity pathogenic IgE and low affinity non-pathogenic IgE...
September 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28935176/current-insight-in-the-localized-insulin-derived-amyloidosis-lida-clinico-pathological-characteristics-and-differential-diagnosis
#5
REVIEW
Amir Mehdi Ansari, Lais Osmani, Aerielle E Matsangos, Qing K Li
BACKGROUND: In diabetic patients, subcutaneous insulin injection may cause several types of injection site-related lesions, such as lipoatrophy, insulin-induced cutaneous lipohypertrophy (IICL), allergic reaction, and iatrogenic localized insulin-derived amyloidosis (LIDA). Among these complications, both IICL and LIDA present as tumor-like and slow growing lesions; and they may be confused with one another. The clinical implication and management of IICL and LIDA are different. LIDA causes poor blood glycemic controls due to inadequate absorption of the insulin...
September 1, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28934541/contact-dermatitis-reaction-to-2-octyl-cyanoacrylate-following-3-orthopedic-procedures
#6
Nicholas H Lake, Brian T Barlow, James E Toledano, Johannah Valentine, Lucas S McDonald
Two-octyl cyanoacrylate is a popular skin adhesive used for closing surgical incisions. Since Food and Drug Administration approval in 1998, the few reports of adverse reactions following its use have primarily been limited to the nonorthopedic literature. The authors present a case series of contact dermatitis associated with 2-octyl cyanoacrylate following orthopedic surgery and a review of the literature on the diagnosis and treatment of this complication. All 3 patients presented with blistering around their incisions within 2 weeks of surgery and responded to treatment involving removal of the offending agent and use of oral diphenhydramine and hydroxyzine and topical triamcinolone...
September 21, 2017: Orthopedics
https://www.readbyqxmd.com/read/28932345/the-grass-pollen-season-2015-a-proof-of-concept-multi-approach-study-in-three-different-european-cities
#7
Maximilian Kmenta, Katharina Bastl, Uwe Berger, Matthias F Kramer, Matthew D Heath, Sanna Pätsi, Anna-Mari Pessi, Annika Saarto, Barbora Werchan, Matthias Werchan, Reinhard Zetter, Karl-Christian Bergmann
BACKGROUND: Grasses release the most widespread aeroallergens with considerable sensitization rates, while different species produce several pollen concentration peaks throughout the season. This study analyzed the prevalence of grass species in three different European city areas and compared the flowering period of these species with daily pollen concentrations and the symptom loads of grass pollen allergy sufferers. METHODS: The most prevalent grass species in Vienna (Austria), Berlin (Germany) and Turku (Finland) were studied and examined by use of three different approaches: phenology, pollen monitoring and symptom load evaluation...
2017: World Allergy Organization Journal
https://www.readbyqxmd.com/read/28931767/musical-instrument-associated-health-issues-and-their-management
#8
Kae Okoshi, Taro Minami, Masahiro Kikuchi, Yasuko Tomizawa
Playing musical instruments can bring joy to people, but can also cause a wide variety of health issues that range from mild disorders to potentially fatal conditions. Although sports medicine is an established medical subspecialty, relatively few studies have investigated the health issues associated with musical instruments. Here we present an overview of these health issues. These include infections due to microorganisms, allergic reactions, as well as mechanical injuries from sustained high pressures within the oral, mediastinal, thoracic, and abdominal cavities...
2017: Tohoku Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28930780/splinting-after-ear-reconstruction-a-stepwise-and-inexpensive-workflow-protocol
#9
Herman Vercruysse, James I J Green, Gaynor Osman, Brigitte Harrison, Kana Miyagi, Neil W Bulstrode
BACKGROUND: Long-term postoperative splinting plays a role in the prevention of contracture of the grafted skin after a second-stage ear reconstruction. The scar retraction could lead to an unfavorable aesthetic outcome. Splinting could play a role to overcome or prevent the loss of projection and the obliteration of the sulcus. MATERIAL AND METHODS: We have defined the characteristics of an ideal long-term splint and present a stepwise clinical protocol for the fabrication of an ethylene-vinyl acetate splint...
September 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28929692/-metabolomics-of-bovine-serum-albumin-induced-allergic-reactions-based-on-uplc-q-tof-ms
#10
Yuan-Yuan Gu, Dan-Dan Zhang, Cheng Feng, Yu Wang, Da-Zhong Chen, Yan-Hong Wang
The metabonomic techniques were used to study the changes in endogenous metabolites between urines of rats in normal physiological conditions and bovine serum albumin induced allergic reactions, identify potential biomarkers associated with allergic reactions, and then analyze the metabolic pathways and the metabolic mechanisms of allergic reactions. The bovine serum albumin-induced allergic reactions in rats were adopted as a model to detect histamine and tryptase in rat serum and observe the issue morphology of lungs and trachea in rats...
November 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28929666/-32-546-intensive-hospital-monitoring-cases-of-shuxuetong-injection
#11
Jun-Jie Jiang, Yan-Ming Xie, Yin Zhang, Zhi-Xin Yang, Dan-Hui Yi
This study adopted multi-center and large sample design to understand the incidence, characteristics and other information about adverse reaction of Shuxuetong injection. In 54 medical institutions, use of Shuxuetong injection of entire treatment period was monitored, including patients' general information, diagnostic information, medication, adverse reaction/event information, etc. Sixty four cases of adverse reactions in 32 546 patients was monitored, adverse rate was 0.197%, mainly characterized by skin itching, rash, flu-like, dyspnea, palpitations, headache, chest tightness and other allergic reactions...
October 2016: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28928989/an-unusual-case-of-recurrent-hypersensitivity-reaction-associated-with-kounis-like-acute-coronary-syndrome
#12
Shanker Kundumadam, Vivek Reddy, Sagar Mallikethi Reddy, Pradeep Kathi, Aiden Abidov
There have been multiple reports of allergic reactions associated with acute coronary syndromes. This has been classically described as Kounis syndrome. We present an unusual case of 70-year-old male with multiple prior hypersensitivity reactions and history of coronary artery bypass grafting who presented recurrent episode of severe angioedema and anaphylaxis. He responded to epinephrine but subsequently developed a non-ST elevation myocardial infarction with worsening heart failure. Our case is unique in that, unlike classic Kounis syndrome, the acute coronary event in this case did not present concurrently with the allergic reaction; rather it took nearly 48 hours to present...
2017: Case Reports in Cardiology
https://www.readbyqxmd.com/read/28928455/polydatin-inhibits-mast-cell-mediated-allergic-inflammation-by-targeting-pi3k-akt-mapk-nf-%C3%AE%C2%BAb-and-nrf2-ho-1-pathways
#13
Jing Ye, Hongmei Piao, Jingzhi Jiang, Guangyu Jin, Mingyu Zheng, Jinshi Yang, Xiang Jin, Tianyi Sun, Yun Ho Choi, Liangchang Li, Guanghai Yan
Polydatin(PD) shows anti-allergic inflammatory effect, and this study investigated its underlying mechanisms in in vitro and in vivo models. IgE-mediated passive cutaneous anaphylaxis (PCA) and passive systemic anaphylaxis (PSA) models were used to confirm PD effect in vivo. Various signaling pathway proteins in mast cell were examined. RT-PCR, ELISA and western blotting were applied when appropriate. Activity of Lyn and Fyn kinases in vitro was measured using the Kinase Enzyme System. PD dose-dependently reduced the pigmentation of Evans blue in the PCA model and decreased the concentration of serum histamine in PSA model, and attenuated the degranulation of mast cells without generating cytotoxicity...
September 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28926504/acute-upper-extremity-edema-in-a-10-year-old-girl-as-presenting-symptom-of-a-rare-cancer
#14
Tracy Elizabeth McCallin, Sheila Thampi, Stephanie Michelle Eighmy, Timothy Cameron Griffin, April Deon Sorrell
Acute onset upper extremity edema can pose a diagnostic challenge for the emergency physician, with conditions ranging from mild local allergic reactions to deep venous thrombosis to underlying life threatening conditions. We discuss a case of a 10-year-old female with upper extremity edema and the diagnostic considerations, which ultimately led to uncovering a malignant etiology. This case represents a rare presentation of her underlying diagnosis, anaplastic large cell lymphoma.
September 18, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28925724/pistachio-nut-allergy-an-updated-overview
#15
Joana Costa, Isa Silva, António A Vicente, M Beatriz P P Oliveira, Isabel Mafra
Pistachio nut (Pistacia vera) is highly appreciated for its organoleptic characteristics and potential health benefits. However, this tree nut is also responsible for triggering moderate to severe IgE-mediated reactions in allergic individuals. Currently, pistachio nut allergy has gained some special attention, mainly due to its intrinsic relation with cashew nut allergy. Like for other nuts, the prevalence of pistachio nut allergy seems to be increasing at a global scale. Until now, there are five allergenic proteins officially listed for pistachio nut (Pis v 1, Pis v 2, Pis v 3, Pis v 4 and Pis v 5)...
September 19, 2017: Critical Reviews in Food Science and Nutrition
https://www.readbyqxmd.com/read/28925060/current-food-allergenic-risk-assessment-is-it-fit-for-novel-foods-status-quo-and-identification-of-gaps
#16
REVIEW
Gabriel Mazzucchelli, Thomas Holzhauser, Tanja Cirkovic-Velickovic, Araceli Diaz-Perales, Elena Molina, Paola Roncada, Pedro Rodrigues, Kitty Verhoeckx, Karin Hoffmann-Sommergruber
Food allergies are recognised as a global health concern. In order to protect allergic consumers from severe symptoms, allergenic risk assessment for well known foods and foods containing genetically modified ingredients was installed. However, population is steadily growing and there is a rising need to provide adequate protein-based foods, including novel sources, not yet used for human consumption. In this context safety issues such as a potential increased allergenic risk need to be assessed before marketing novel food sources...
September 19, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28924447/passive-blood-anaphylaxis-subcutaneous-immunoglobulins-are-a-cause-of-ongoing-passive-anaphylactic-reaction
#17
Przemyslaw Zdziarski, Andrzej Gamian, Jacek Majda, Agnieszka Korzeniowska-Kowal
BACKGROUND: Allergic, especially anaphylactic, reactions during immunoglobulin replacement therapy are rare, but their pathophysiology and classification remain ambiguous. Recent findings show positive results of skin tests with commercially available immunoglobulins, but target antigens and responsible compounds of the tested immunoglobulins have not been strictly identified. CASE DESCRIPTION AND FINDINGS: Four adult patients with recently diagnosed common variable immunodeficiency qualified for standard subcutaneous immunoglobulin replacement therapy regimen...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28924280/antibiotics-use-and-misuse-in-upper-respiratory-tract-infection-patients-knowledge-attitude-and-practice-analysis-in-university-hospital-saudi-arabia
#18
Waseem Hajjar, Sami Alnassar, Sara Al-Khelb, Sarah Al-Mutairi, Norah Al-Refayi, Sultan Ayoub Meo
OBJECTIVE: To assess the awareness and causes of antibiotics use and misuse in patients with upper respiratory tract infections. METHODS: This cross-sectional study was conducted at King Saud University, Riyadh, Saudi Arabia, from January 2014 to December 2015, and comprised patients suffering from upper respiratory tract infections. A well-established, self-administrated questionnaire was randomly distributed to the patients. The questionnaire consisted of 3 parts: demographic variables, knowledge, and beliefs, and behaviour towards antibiotic use and misuse...
September 2017: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/28923036/safety-of-intravenously-applied-mistletoe-extract-results-from-a-phase-i-dose-escalation-study-in-patients-with-advanced-cancer
#19
Roman Huber, Dietrich Schlodder, Carola Effertz, Sabine Rieger, Wilfried Tröger
BACKGROUND: Mistletoe extracts have anti-tumor properties and are approved for subcutaneous use in cancer patients. Data on Intravenous application are limited. METHODS: An aqueous extract from pine-mistletoe was used to investigate maximum tolerable dose (MTD) and safety of intravenous application. It was infused once weekly for 3 weeks in patients with advanced cancer. Any type of cancer was included; relevant exclusion criteria were concurrent chemo- or radiation therapy...
September 18, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28921918/proteomic-response-of-human-umbilical-vein-endothelial-cells-to-histamine-stimulation
#20
Pelin Esma Emirbayer, Ankit Sinha, Vladimir Ignatchenko, Stefanie Hoyer, Jan Dörrie, Niels Schaft, Monika Pischetsrieder, Thomas Kislinger
The histamine receptors (HRs) represent a subclass of G protein-coupled receptors (GPCRs) and comprise four subtypes. Due to their numerous physiological and pathological effects, HRs are popular drug targets for the treatment of allergic reactions or the regulation of gastric acid secretion. Hence, an understanding of the functional selectivity of HR ligands has gained importance. These ligands can bind to specific GPCRs and selectively activate defined pathways. Supporting the activation of a therapeutically necessary pathway without the activation of other signaling cascades can result in drugs with more specific activity and fewer side effects...
September 18, 2017: Proteomics
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