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https://www.readbyqxmd.com/read/29236331/reduction-of-histone-marks-h3k9me3-and-h3k27me3-by-epidrug-induces-neuroendocrine-differentiation-in-prostate-cancer
#1
Eunsohl Lee, Jingcheng Wang, Younghun Jung, Frank C Cackowski, Russell S Taichman
Neuroendocrine prostate cancer (NE PCa) is an aggressive malignancy, often presenting with advanced metastasis. We previously reported that reduction of histone marks regulated by DNMT1 following epidrug (5-Azacitidine, 5-Aza) treatment controls induction of epithelial to mesenchymal (EMT) and a cancer stem cell (CSC) phenotype, which facilitates tumorigenesis in PCa cells. Here, we use the epidrug 5-Aza as a model for how histone marks may regulate the reprogramming of prostate adenocarcinoma into NE phenotypic cells...
December 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29235994/pressure-induced-structural-change-in-liquid-gei-sub-4-sub
#2
Kazuhiro Fuchizaki, Hironori Nishimura, Takaki Hase, Hiroyuki Saitoh
The similarity in the shape of the melting curve of GeI<sub>4</sub> to that of SnI<sub>4</sub> suggests that a liquid-liquid transition as observed in liquid SnI<sub>4</sub> is also expected to occur in liquid GeI<sub>4</sub>. Because the slope of the melting curve of GeI<sub>4</sub> abruptly changes at around 3 GPa, in situ synchrotron diffraction measurements were conducted to examine closely the structural changes upon compression at around 3 GPa...
December 13, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29235659/effect-of-metabolic-syndrome-on-late-life-depression-associations-with-disease-severity-and-treatment-resistance
#3
John S Mulvahill, Ginger E Nicol, David Dixon, Eric J Lenze, Jordan F Karp, Charles F Reynolds, Daniel M Blumberger, Benoit H Mulsant
BACKGROUND/OBJECTIVES: Metabolic syndrome (MetS) is the co-occurrence of obesity and metabolic derangements. Prior research implicates MetS in prolongation of the course of depression in older adults, but its effect on antidepressant response is unknown in this population. The objective was to determine whether MetS and related metabolic dyscrasias are associated with decreased rate of remission from depression in older adults treated pharmacologically for depression. DESIGN: Secondary analysis of a randomized controlled trial...
December 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/29235396/brain-derived-neurotrophic-factor-bdnf-serum-level-in-women-with-first-episode-depression-correlation-with-clinical-and-metabolic-parameters
#4
Maria Skibinska, Pawel Kapelski, Aleksandra Rajewska-Rager, Joanna Pawlak, Aleksandra Szczepankiewicz, Beata Narozna, Joanna Twarowska-Hauser, Monika Dmitrzak-Weglarz
BACKGROUND: Brain-derived neurotrophic factor (BDNF) influences neuron differentiation during development, as well as the synaptic plasticity and neuron survival in adulthood. BDNF has been implicated in the pathogenesis of psychiatric disorders and its serum level is a potential biomarker for depression. The aim of this study was to examine serum levels of BDNF in first-episode depression and its correlation with clinical and metabolic parameters. MATERIALS AND METHODS: The study was performed on a group of 60 women: 30 diagnosed with a first-episode of depression and 30 healthy controls...
December 13, 2017: Nordic Journal of Psychiatry
https://www.readbyqxmd.com/read/29235180/the-effects-of-hypoglycemia-and-weight-loss-of-total-lignans-from-fructus-arctii-in-kkay-mice-and-its-mechanisms-of-the-activity
#5
Yingying Gao, Chenchen Gu, Kai Wang, Haiying Wang, Kefeng Ruan, Zhaohui Xu, Yi Feng
Fructus Arctii (great burdock achene) is the dried ripe fruit of Arctium lappa L. (family Asteraceae) and is included in the Chinese pharmacopoeia. It has been reported that the clinical use of Fructus Arctii resulted in a satisfactory hypoglycemic effect in diabetic patients. This study aimed to investigate antidiabetic activity and mechanism of total lignans from Fructus Arctii (TLFA) in KKAy mice, a spontaneous Type 2 diabetic rodent model that exhibits marked obesity. In this study, KKAy mice were gavaged once daily with solvents (0...
December 13, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/29235048/serum-lipid-enzyme-and-hematological-responses-of-broilers-fed-acacia-angustissima-leaf-meal-based-diets
#6
Sharai Ncube, Petronella Tapiwa Saidi, Musavengana Tapera Tivapasi, Venancio Edward Imbayarwo-Chikosi, Tinyiko Edward Halimani
The objective of the study was to determine serum lipid, enzyme, and hematological responses of broilers to Acacia angustissima leaf meal. Acacia angustissima leaves were harvested at mid maturity, ground into a leaf meal, and included in broiler diets at 0, 5, and 10%. One hundred and fifty-day-old chicks of 41.7 ± 1.560 g were randomly allocated to 15 groups of the three diets. Feed and water were provided ad libitum throughout the trial. At days 14, 28, and 42, 4 ml of blood were collected from the jugular vein in plain vacutainer tubes for alanine aminotransferase (ALT), alkaline phosphatase (ALP), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and total cholesterol (TC) analyses...
December 12, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/29235017/oral-treatment-with-a-rattlesnake-native-polypeptide-crotamine-efficiently-inhibits-the-tumor-growth-with-no-potential-toxicity-for-the-host-animal-and-with-suggestive-positive-effects-on-animal-metabolic-profile
#7
Joana D Campeiro, Marcelo P Marinovic, Fernando Cintra Carapeto, Caroline Dal Mas, Gabriela Guilherme Monte, Lucas Carvalho Porta, Marcela B Nering, Eduardo B Oliveira, Mirian A F Hayashi
The efficacy of crotamine as antitumoral was first demonstrated by daily intraperitoneal (IP) injections of low doses of this toxin in an animal model bearing melanoma tumors. Significant inhibition of tumor growth and increased lifespan of mice bearing tumor was also noticed after 21 consecutive days of this daily IP administration of crotamine. However, due to the limited acceptance of treatments by IP route in clinical conditions, herein, we evaluated the antitumor effect of this native polypeptide employing the oral route...
December 12, 2017: Amino Acids
https://www.readbyqxmd.com/read/29235010/metabolic-changes-up-to-10%C3%A2-years-after-gastric-bypass
#8
Daniela Vicinansa Mônaco-Ferreira, Vânia Aparecida Leandro-Merhi, Nilton César Aranha, Andre Brandalise, Nelson Ary Brandalise
OBJECTIVE: The aim of this study was to investigate the lipid and glycemic profiles of patients up to 10 years after Roux-en-Y gastric bypass. METHOD: A retrospective, longitudinal study was conducted at a multidisciplinary center for the treatment of obesity in the state of São Paulo, Brazil. The study included 150 patients submitted to unbanded laparoscopic Roux-en-Y gastric bypass. The metabolic profile included total cholesterol and fractions, triglycerides, and fasting glucose...
December 12, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/29234908/characterization-of-type-iv-antifreeze-gene-in-nile-tilapia-oreochromis-niloticus-and-influence-of-cold-and-hot-weather-on-its-expression-and-some-immune-related-genes
#9
Asmma Y Ammar, Abeer F El Nahas, Shawky Mahmoud, Mohamed E Barakat, Asmaa M Hassan
The aim of this work is to study the effect of the thermal stress of ambient temperature during winter and summer on the expression of type IV antifreeze gene (ANF IV) in different tissues of Nile tilapia (Oreochromis niloticus) as well as some immune-related genes. At first, genomic ANF IV gene was characterized from one fish; 124 amino acids were identified with 92.7% similarity with that on the gene bank. Expression of ANF IV and immune-related genes were done twice, once at the end of December (winter sample, temperature 14 °C) and the other at August (summer sample, temperature 36 °C)...
December 12, 2017: Fish Physiology and Biochemistry
https://www.readbyqxmd.com/read/29234897/potential-influence-of-the-phthalates-on-normal-liver-function-and-cardiometabolic-risk-in-males
#10
Nataša Milošević, Nataša Milić, Dragana Živanović Bosić, Ivana Bajkin, Ivanka Perčić, Ludovico Abenavoli, Milica Medić Stojanoska
Phthalates are ubiquitous environmental contaminants, massively used in industry as plasticizers and additives in cosmetics, which may impair the human endocrine system inducing fertility problems, respiratory diseases, obesity, and neuropsychological disorders. The aim of this study was to examine the influence of the monoethyl phthalate (MEP) and mono-(2-ethylhexyl) phthalate (MEHP) on the liver function and cardiometabolic risk factors in males. In this research, 102 male participants (51 normal weight and 51 overweight/obese) were enrolled and examined for phthalate metabolites exposure in urine samples after 12 h of fasting...
December 13, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29234464/production-of-isoprene-one-of-the-high-density-fuel-precursors-from-peanut-hull-using-the-high-efficient-lignin-removal-pretreatment-method
#11
Sumeng Wang, Zhaobao Wang, Yongchao Wang, Qingjuan Nie, Xiaohua Yi, Wei Ge, Jianming Yang, Mo Xian
Background: Isoprene as the feedstock can be used to produce renewable energy fuels, providing an alternative to replace the rapidly depleting fossil fuels. However, traditional method for isoprene production could not meet the demands for low-energy consumption and environment-friendliness. Moreover, most of the previous studies focused on biofuel production out of lignocellulosic materials such as wood, rice straw, corn cob, while few studies concentrated on biofuel production using peanut hull (PH)...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29234430/antidyslipidemic-anti-inflammatory-and-antioxidant-activities-of-aqueous-leaf-extract-of-dioscoreophyllum-cumminsii-stapf-diels-in-high-fat-diet-fed-rats
#12
O B Ibitoye, U M Ghali, J B Adekunle, J N Uwazie, T O Ajiboye
Dioscoreophyllum cumminsii (Stapf) Diels leaves are widely used in the treatment of diabetes, obesity, and cardiovascular related complications in Nigeria. This study investigates the anti-inflammatory and antiobesity effect of aqueous extract of Dioscoreophyllum cumminsii leaves in high-fat diet- (HFD-) induced obese rats. HFD-fed rats were given 100, 200, and 400 mgkg-1 body weight of aqueous extract of Dioscoreophyllum cumminsii leaves for 4 weeks starting from 9th week of HFD treatment. D. cumminsii leaves aqueous extract reversed HFD-mediated decrease in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glucose 6-phosphate dehydrogenase...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29234331/rna-seq-profiling-shows-divergent-gene-expression-patterns-in-arabidopsis-grown-under-different-densities
#13
Di Guo, Xiaoming Song, Min Yuan, Zhenyi Wang, Weina Ge, Li Wang, Jinpeng Wang, Xiyin Wang
Plants growing under high-density (HD) conditions experience increased competition for water, nutrients, and light, possibly leading to changes in size, biomass, morphology, and productivity. However, no research has focused on the relationship between whole-genome expression patterns and growth density. Here, we performed whole-genome RNA sequencing to examine the gene expression patterns in Arabidopsis grown under low and high densities. Of the 20,660 detected genes, the expression levels of 98 were enhanced and 107 were repressed under HD growth...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29234157/spatial-genetic-structure-in-american-black-bears-ursus-americanus-female-philopatry-is-variable-and-related%C3%A2-to-population-history
#14
Thea V Kristensen, Emily E Puckett, Erin L Landguth, Jerrold L Belant, John T Hast, Colin Carpenter, Jaime L Sajecki, Jeff Beringer, Myron Means, John J Cox, Lori S Eggert, Don White, Kimberly G Smith
Previously, American black bears (Ursus americanus) were thought to follow the pattern of female philopatry and male-biased dispersal. However, recent studies have identified deviations from this pattern. Such flexibility in dispersal patterns can allow individuals greater ability to acclimate to changing environments. We explored dispersal and spatial genetic relatedness patterns across ten black bear populations-including long established (historic), with known reproduction >50 years ago, and newly established (recent) populations, with reproduction recorded <50 years ago-in the Interior Highlands and Southern Appalachian Mountains, United States...
December 13, 2017: Heredity
https://www.readbyqxmd.com/read/29234106/first-demonstration-of-coherent-cherenkov-radiation-matched-to-circular-plane-wave
#15
Norihiro Sei, Toshiharu Takahashi
We observed coherent Cherenkov radiation matched to a circular plane wave (CCR-MCP) for the first time using a hollow conical dielectric made of a high-density polyethylene. The refractive index and the absorption coefficient of the dielectric were evaluated to be 1.537 ± 0.004 and 0.006 ± 0.028 by measuring the pulse formed by the interference between the CCR-MCP and the coherent diffraction radiation. These values were consistent with the values shown in a reference for the high-density polyethylene...
December 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29234039/forming-quasicrystals-by-monodisperse-soft-core-particles
#16
Mengjie Zu, Peng Tan, Ning Xu
In traditional approaches to form quasicrystals, multiple competing length scales involved in particle size, shape, or interaction potential are believed to be necessary. It is unexpected that quasicrystals can be formed by monodisperse, isotropic particles interacting via a simple potential that does not contain explicit multiple length scales to stabilize quasicrystals. Here, we report the surprising finding of the formation of such quasicrystals in high-density systems of soft-core particles. Although there are length scales naturally introduced in our model systems, they do not establish the quasicrystalline order...
December 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/29233945/resource-limitation-prevents-the-emergence-of-drug-resistance-by-intensifying-within-host-competition
#17
Nina Wale, Derek G Sim, Matthew J Jones, Rahel Salathe, Troy Day, Andrew F Read
Slowing the evolution of antimicrobial resistance is essential if we are to continue to successfully treat infectious diseases. Whether a drug-resistant mutant grows to high densities, and so sickens the patient and spreads to new hosts, is determined by the competitive interactions it has with drug-susceptible pathogens within the host. Competitive interactions thus represent a good target for resistance management strategies. Using an in vivo model of malaria infection, we show that limiting a resource that is disproportionately required by resistant parasites retards the evolution of drug resistance by intensifying competitive interactions between susceptible and resistant parasites...
December 12, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29233668/expression-of-hmgb1-in-maternal-exposure-to-fine-particulate-air-pollution-induces-lung-injury-in-rat-offspring-assessed-with-micro-ct
#18
Wenting Tang, Suran Huang, Lili Du, Wen Sun, Zhiqiang Yu, Yanmei Zhou, Jingsi Chen, Xiuying Li, Xiaomei Li, Bolan Yu, Dunjin Chen
OBJECTIVES: Maternal particulate matter with less than 2.5 μm in diameter (PM2.5) is associated with an increased risk for acute lower respiratory infections and allergic airway inflammation; however, its effect on the developing lung remains unclear. The aim of this study is to determine the effect of maternal PM2.5 during pregnancy on lung development in offspring. METHODS: Timed pregnant Sprague-Dawley rats were treated with PM2.5 (0.1, 0.5, 2.5, or 7.5 mg/kg) once every 3 days from day 0-18 of pregnancy and delivered at term...
December 9, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/29232947/spin-control-induced-by-molecular-charging-in-a-transport-junction
#19
Sujoy Karan, Carlos Garcia, Michael Karolak, David Jacob, Nicolas Lorente, Richard Berndt
The ability of molecules to maintain magnetic multistability in nanoscale-junctions will determine their role in downsizing spintronic devices. While spin-injection from ferromagnetic leads gives rise to magnetoresistance in metallic nano-contacts, nonmagnetic leads probing the magnetic states of the junction itself have been considered as an alternative. Extending this experimental approach to molecular junctions, which are sensitive to chemical parameters, we demonstrate that the electron affinity of a molecule decisively influences its spin transport...
December 12, 2017: Nano Letters
https://www.readbyqxmd.com/read/29232707/genetic-mapping-of-qtl-for-maize-leaf-width-combining-ril-and-if2-populations
#20
Ruixiang Liu, Qingchang Meng, Fei Zheng, Lingjie Kong, Jianhua Yuan, Thomas Lübberstedt
Leaf width is an important component of plant architecture that affects light capture during photosynthesis and wind circulation under dense planting conditions. To improve understanding of the genetic mechanisms involved in leaf width at different positions, a comprehensive evaluation using the RIL (Recombinant Inbred Line) and IF2 (Immortalized F2) populations and a subsequent meta-analysis were performed. Forty-seven QTL associated with leaf width at different positions below the tassel were detected. The individual effects of QTL explained 3...
2017: PloS One
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