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https://www.readbyqxmd.com/read/27935641/pinus-contorta-invasions-increase-wildfire-fuel-loads-and-may-create-a-positive-feedback-with-fire
#1
Kimberley T Taylor, Bruce D Maxwell, David B McWethy, Aníbal Pauchard, Martín A Nuñez, Cathy Whitlock
Invasive plant species that have the potential to alter fire regimes have significant impacts on native ecosystems. Concern that pine invasions in the Southern Hemisphere will increase fire activity and severity and subsequently promote further pine invasion prompted us to examine the potential for feedbacks between Pinus contorta invasions and fire in Patagonia and New Zealand. We determined how fuel loads and fire effects were altered by P. contorta invasion. We also examined post-fire plant communities across invasion gradients at a subset of sites to assess how invasion alters the post-fire vegetation trajectory...
December 9, 2016: Ecology
https://www.readbyqxmd.com/read/27935059/rna-polymerase-i-dependent-transcription-coupled-nucleotide-excision-repair-of-uv-induced-dna-lesions-at-transcription-termination-sites-in-saccharomyces-cerevisiae
#2
François Peyresaubes, Carlos Zeledon, Laetitia Guintini, Romain Charton, Alexia Muguet, Antonio Conconi
If not repaired, ultraviolet light induced DNA damage can lead to genome instability. Nucleotide excision repair (NER) of UV photoproducts is generally fast in the coding region of genes, where RNA polymerase-II (RNAP2) arrest at damage sites and trigger transcription-coupled NER (TC-NER). In Saccharomyces cerevisiae there is RNA polymerase-I (RNAP1) dependent TC-NER, but this process remains elusive. Therefore, we wished to characterize TC-NER efficiency in different regions of the rDNA locus: where RNAP1 are present at high density and start transcription elongation, where the elongation rate is slow, and in the transcription terminator where RNAP1 pause, accumulate and then are released...
December 9, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27934969/quantitative-hdl-proteomics-identifies-peroxiredoxin-6-as-a-biomarker-of-human-abdominal-aortic-aneurysm
#3
Elena Burillo, Inmaculada Jorge, Diego Martínez-López, Emilio Camafeita, Luis Miguel Blanco-Colio, Marco Trevisan-Herraz, Iakes Ezkurdia, Jesús Egido, Jean-Baptiste Michel, Olivier Meilhac, Jesús Vázquez, Jose Luis Martin-Ventura
High-density lipoproteins (HDLs) are complex protein and lipid assemblies whose composition is known to change in diverse pathological situations. Analysis of the HDL proteome can thus provide insight into the main mechanisms underlying abdominal aortic aneurysm (AAA) and potentially detect novel systemic biomarkers. We performed a multiplexed quantitative proteomics analysis of HDLs isolated from plasma of AAA patients (N = 14) and control study participants (N = 7). Validation was performed by western-blot (HDL), immunohistochemistry (tissue), and ELISA (plasma)...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934873/high-density-association-mapping-and-interaction-analysis-of-pla2r1-and-hla-regions-with-idiopathic-membranous-nephropathy-in-japanese
#4
Myo Thiri, Kenjiro Honda, Koichi Kashiwase, Akihiko Mabuchi, Hodaka Suzuki, Kimio Watanabe, Masaaki Nakayama, Tsuyoshi Watanabe, Kent Doi, Katsushi Tokunaga, Eisei Noiri
Although recent studies showed anti-PLA2R antibody plays a crucial role in idiopathic membranous nephropathy (IMN), detailed HLA mapping and interaction between the HLA genes and PLA2R1 have not been investigated in IMN. We genotyped across the PLA2R1 gene and the HLA region, using 183 IMN patients and 811 healthy controls. Five SNPs around the PLA2R1 gene were significantly associated with IMN. In addition to the two SNPs previously reported to be strongly associated with IMN, rs3749119 and rs35771982 (OR 3...
December 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27934803/chronic-vitamin-a-enriched-diet-feeding-regulates-hypercholesterolaemia-through-transcriptional-regulation-of-reverse-cholesterol-transport-pathway-genes-in-obese-rat-model-of-wnin-gr-ob-strain
#5
Shanmugam M Jeyakumar, Alex Sheril, Ayyalasomayajula Vajreswari
BACKGROUND & OBJECTIVES: Hepatic scavenger receptor class B1 (SR-B1), a high-density lipoprotein (HDL) receptor, is involved in the selective uptake of HDL-associated esterified cholesterol (EC), thereby regulates cholesterol homoeostasis and improves reverse cholesterol transport. Previously, we reported in euglycaemic obese rats (WNIN/Ob strain) that feeding of vitamin A-enriched diet normalized hypercholesterolaemia, possibly through hepatic SR-B1-mediated pathway. This study was aimed to test whether it would be possible to normalize hypercholesterolaemia in glucose-intolerant obese rat model (WNIN/GR/Ob) through similar mechanism by feeding identical vitamin A-enriched diet...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934797/small-for-gestational-age-versus-appropriate-for-gestational-age-comparison-of-cord-blood-lipid-profile-insulin-levels-in-term-newborns-saga-act-study
#6
Limmy Loret Lobo, H Uday Kumar, Tejeswita Mishra, Tripura Sundari, Archana Singh, C Vijai Kumar, G Kondal Rao, B Jahangir, Vijay Misale, Poonam Prashant, Nirlep L Gajiwala, Ashok S Thakkar
BACKGROUND & OBJECTIVES: The genesis of atherosclerotic lesions, a major cardiovascular risk factor starts in the early stage of life. If the premature development of cardiovascular risk factors can be anticipated during childhood, cardiovascular events can be prevented effectively by taking appropriate measures. This study was carried out to assess the role of in utero malnutrition in cardiovascular disease development by comparing cord blood lipid profiles and serum insulin levels between small-for-gestational-age (SGA) and appropriate-for-gestational-age (AGA) term newborns...
August 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/27934145/highly-conductive-cu-cu-joint-formation-by-low-temperature-sintering-of-formic-acid-treated-cu-nanoparticles
#7
Jingdong Liu, Hongtao Chen, Hongjun Ji, Mingyu Li
Highly conductive Cu-Cu interconnections of SiC die with Ti/Ni/Cu metallization and direct bonded copper substrate for high-power semiconductor devices are achieved by the low-temperature sintering of Cu nanoparticles with a formic acid treatment. The Cu-Cu joints formed via a long-range sintering process exhibited good electrical conductivity and high strength. When sintered at 260 °C, the Cu nanoparticle layer exhibited a low resistivity of 5.65 μΩ·cm and the joints displayed a high shear strength of 43...
December 7, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27934088/biomimetic-light-harvesting-antenna-based-on-the-self-assembly-of-conjugated-polyelectrolytes-embedded-within-lipid-membranes
#8
Christina F Calver, Kirk S Schanze, Gonzalo Cosa
Here we report a biomimetic light-harvesting antenna based on negatively charged poly(phenylene ethynylene) conjugated polyelectrolytes assembled within a positively charged lipid membrane scaffold constructed by the lipid 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP). Light harvested by the polymers was transferred via through-space mechanisms to a lipophilic energy acceptor (the cyanine dye DiI) whose effective molar absorption was enhanced by up to 18-fold due to the antenna effect. Absorption amplification of DiI was found to be due primarily to direct energy transfer from polymers...
November 22, 2016: ACS Nano
https://www.readbyqxmd.com/read/27933201/association-between-metabolic-syndrome-and-liver-histology-among-nafld-patients-without-diabetes
#9
Pushpjeet Kanwar, James E Nelson, Katherine Yates, David E Kleiner, Aynur Unalp-Arida, Kris V Kowdley
BACKGROUND: Metabolic syndrome (MetS) and obesity are associated with non-alcoholic fatty liver disease (NAFLD). The aim of this observational study was to examine the relationship of MetS and a diagnosis of non-alcoholic steatohepatitis (NASH) in patients without diabetes in the NASH Clinical Research Network (CRN). METHODS: Clinical, demographic, histological, laboratory and anthropometric data were collected on 356 adult patients without diabetes with NAFLD. Obesity was defined as body mass index ≥30...
2016: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/27932940/retraction-the-improvement-of-large-high-density-lipoprotein-hdl-particle-levels-and-presumably-hdl-metabolism-depend-on-effects-of-low-carbohydrate-diet-and-weight-loss
#10
C Finelli, P Crispino, S Gioia, N La Sala, L D'amico, M La Grotta, O Miro, D Colarusso
[This retracts the article DOI: 10.17179/excli2015-642.].
2016: EXCLI journal
https://www.readbyqxmd.com/read/27932762/-correlations-between-lipid-ratio-oxidative-stress-status-in-copd-patients-and-pulmonary-hypertension-%C3%A2-as-well-as-prognosis
#11
Chunzhi Li, Li Yan, Jinwei Xu
To investigate the correlations between lipid ratio/oxidative stress status in chronic obstructive pulmonary disease (COPD) patients and pulmonary hypertension as well as the prognosis.
 Methods: A total of 120 patients with COPD were randomly selected and served as the COPD group and 30 healthy persons were selected as the control group. The ratios of low density lipoprotein (LDL)/high-density lipoprotein (HDL), triglyceride (TG)/HDL and total cholesterol (TC)/HDL were measured. The superoxide dismutase (SOD) activity, malondialdehyde (MDA) content and total antioxidant capacity (T-AOC) level in the control group and COPD patients were detected...
November 28, 2016: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/27932499/genetic-variation-in-one-carbon-metabolism-and-changes-in-metabolic-parameters-in-first-episode-schizophrenia-patients
#12
Błażej Misiak, Łukasz Łaczmański, Natalia Kinga Słoka, Elżbieta Szmida, Ryszard Ślęzak, Patryk Piotrowski, Andrzej Kiejna, Dorota Frydecka
BACKGROUND: In this study, we aimed to investigate the effects of polymorphisms in genes encoding 1-carbon metabolism enzymes on differential development of metabolic parameters during 12 weeks of treatment with second-generation antipsychotics in first-episode schizophrenia patients. METHODS: The following polymorphisms in 1-carbon metabolism genes were genotyped: MTHFR (C677T and A1298C), MTHFD1 (G1958A), MTRR (A66G), and BHMT (G742A). A broad panel of metabolic parameters including body mass index, waist circumference, total cholesterol low and high density lipoproteins, triglycerides, homocysteine, folate, and vitamin B12 was determined...
December 8, 2016: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27931543/efficacy-and-safety-of-the-intensive-dose-of-rosuvastatin-40mg-day-in-patients-with-acute-coronary-syndrome-and-at-high-risk-of-cardiovascular-disease-rosuvees-2
#13
Chetan P Shah, Bhaskar P Shah, Sameer I Dani, B B Channa, S S Lakshmanan, N C Krishnamani, Ashwani Mehta, P Moorthy
BACKGROUND: Randomized clinical trials have established the benefits of statin therapy in acute coronary syndromes (ACS) via their pleiotropic effects. AIM OF THE STUDY: This was a 12-week, open-label, multicenter, postmarketing observational study evaluating the efficacy and safety of rosuvastatin 40 mg/day in very high-risk or high-risk Indian patients according to NCEP ATP III guidelines. METHODOLOGY: One hundred and sixty two patients (age: 30 to 69 years) with evidence of coronary artery disease, hospitalized with chest pain with/without electrocardiogram changes and with non-ST segment elevation ACS and ST segment elevation ACS who received optimal reperfusion therapy were enrolled...
November 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27931267/western-diet-in-the-perinatal-period-promotes-dysautonomia-in-the-offspring-of-adult-rats
#14
R Vidal-Santos, F N Macedo, M N S Santana, V U De Melo, J L de Brito Alves, M R V Santos, L C Brito, E Nascimento, J H Costa-Silva, V J Santana-Filho
The present study investigated the impact of a western diet during gestation and lactation on the anthropometry, serum biochemical, blood pressure and cardiovascular autonomic control on the offspring. Male Wistar rats were divided into two groups according to their mother's diet received: control group (C: 18% calories of lipids) and westernized group (W: 32% calories of lipids). After weaning both groups received standard diet. On the 60th day of life, blood samples were collected for the analysis of fasting glucose and lipidogram...
December 9, 2016: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/27931194/serum-albumin-to-globulin-ratio-is-related-to-cognitive-decline-via-reflection-of-homeostasis-a-nested-case-control-study
#15
Teruhide Koyama, Nagato Kuriyama, Etsuko Ozaki, Daisuke Matsui, Isao Watanabe, Fumitaro Miyatani, Masaki Kondo, Aiko Tamura, Takashi Kasai, Yoichi Ohshima, Tomokatsu Yoshida, Takahiko Tokuda, Ikuko Mizuta, Shigeto Mizuno, Kei Yamada, Kazuo Takeda, Sanae Matsumoto, Masanori Nakagawa, Toshiki Mizuno, Yoshiyuki Watanabe
BACKGROUND: Recent research suggests that several pathogenetic factors, including aging, genetics, inflammation, dyslipidemia, diabetes, and infectious diseases, influence cognitive decline (CD) risk. However, no definitive candidate causes have been identified. The present study evaluated whether certain serum parameters predict CD. METHODS: A total of 151 participants were assessed for CD using the Mini-Mental State Examination (MMSE), and 34 participants were identified as showing CD...
December 8, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27930524/dietary-protein-and-fat-intake-in-relation-to-risk-of-colorectal-adenoma-in-korean
#16
Sun Young Yang, Young Sun Kim, Jung Eun Lee, Jueun Seol, Ji Hyun Song, Goh Eun Chung, Jeong Yoon Yim, Sun Hee Lim, Joo Sung Kim
Consumption of red meat and alcohol are known risk factors for colorectal cancer, but associations for dietary fat remain unclear. We investigated the associations of dietary fat, protein, and energy intake with prevalence of colorectal adenoma.We performed a prospective cross-sectional study on asymptomatic persons who underwent a screening colonoscopy at a single center during a routine health check-up from May to December 2011. Dietary data were obtained via a validated Food Frequency Questionnaire (FFQ), assisted by a registered dietician...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27930484/are-hospital-workers-healthy-a-study-of-cardiometabolic-behavioral-and-psychosocial-factors-associated-with-obesity-among-hospital-workers
#17
Shreela V Sharma, Mudita Upadhyaya, Mandar Karhade, William B Baun, William B Perkison, Lisa A Pompeii, Henry S Brown, Deanna M Hoelscher
OBJECTIVE: This study evaluated the cardiometabolic, behavioral, and psychosocial factors associated with weight status among hospital employees. METHODS: A total of n = 924 employees across the six hospitals in Texas participated in this cross-sectional study, 2012 to 2013. Association between weight status and waist circumference, blood pressure, biomarkers, diet, physical activity, sedentary behaviors, and psychosocial factors was assessed. RESULTS: About 78...
December 2016: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/27929470/high-density-electroencephalographic-acquisition-in-a-rodent-model-using-low-cost-and-open-source-resources
#18
Andrzej Z Wasilczuk, Alexander Proekt, Max B Kelz, Andrew R McKinstry-Wu
Advanced electroencephalographic analysis techniques requiring high spatial resolution, including electrical source imaging and measures of network connectivity, are applicable to an expanding variety of questions in neuroscience. Performing these kinds of analyses in a rodent model requires higher electrode density than traditional screw electrodes can accomplish. While higher-density electroencephalographic montages for rodents exist, they are of limited availability to most researchers, are not robust enough for repeated experiments over an extended period of time, or are limited to use in anesthetized rodents...
November 26, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27929461/isolation-of-high-density-lipoproteins-for-non-coding-small-rna-quantification
#19
Danielle L Michell, Ryan M Allen, Stuart R Landstreet, Shilin Zhao, Cynthia L Toth, Quanhu Sheng, Kasey C Vickers
The diversity of small non-coding RNAs (sRNA) is rapidly expanding and their roles in biological processes, including gene regulation, are emerging. Most interestingly, sRNAs are also found outside of cells and are stably present in all biological fluids. As such, extracellular sRNAs represent a novel class of disease biomarkers and are likely involved in cell signaling and intercellular communication networks. To assess their potential as biomarkers, sRNAs can be quantified in plasma, urine, and other fluids...
November 28, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/27929136/an-integrated-genomic-approach-for-the-study-of-mandibular-prognathism-in-the-european-seabass-dicentrarchus-labrax
#20
Massimiliano Babbucci, Serena Ferraresso, Marianna Pauletto, Rafaella Franch, Chiara Papetti, Tomaso Patarnello, Paolo Carnier, Luca Bargelloni
Skeletal anomalies in farmed fish are a relevant issue affecting animal welfare and health and causing significant economic losses. Here, a high-density genetic map of European seabass for QTL mapping of jaw deformity was constructed and a genome-wide association study (GWAS) was carried out on a total of 298 juveniles, 148 of which belonged to four full-sib families. Out of 298 fish, 107 were affected by mandibular prognathism (MP). Three significant QTLs and two candidate SNPs associated with MP were identified...
December 8, 2016: Scientific Reports
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