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High Density mapping

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https://www.readbyqxmd.com/read/29341322/isthmus-sites-identified-by-ripple-mapping-are-usually-anatomically-stable-a-novel-method-to-guide-atrial-substrate-ablation
#1
Vishal Luther, Norman Qureshi, Phang Boon Lim, Michael Koa-Wing, Shahnaz Jamil-Copley, Fu Siong Ng, Zachary Whinnett, D Wyn Davies, Nicholas S Peters, Prapa Kanagaratnam, Nick Linton
BACKGROUND: Post ablation reentrant ATs depend upon conducting isthmuses bordered by scar. Bipolar voltage maps highlight scar as sites of low voltage, but the voltage amplitude of an electrogram depends upon the myocardial activation sequence. Furthermore, a voltage threshold that defines atrial scar is unknown. We used Ripple Mapping (RM) to test whether these isthmuses were anatomically fixed between different activation vectors and atrial rates. METHODS: We studied post-AF ablation ATs where > 1 rhythm was mapped...
January 17, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29340501/accidents-involving-motorcycles-and-potential-years-of-life-lost-an-ecological-and-exploratory-study
#2
Drielle Rezende Pavanitto, Renata Armani de Moura Menezes, Luiz Fernando Costa Nascimento
CONTEXT AND OBJECTIVE: Traffic accidents have gained prominence as one of the modern epidemics that plague the world. The objective of this study was to identify the spatial distribution of potential years of life lost (PYLL) due to accidents involving motorcycles in the state of São Paulo, Brazil. DESIGN AND SETTING: Ecological and exploratory study conducted in São Paulo. METHODS: Data on deaths among individuals aged 20-39 years due to motorcycle accidents (V20-V29 in the International Classification of Diseases, 10th revision) in the state of São Paulo in the years 2007-2011 were obtained from DATASUS...
January 15, 2018: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/29339835/obtaining-high-quality-transcriptome-data-from-formalin-fixed-paraffin-embedded-diagnostic-prostate-tumor-specimens
#3
Liesel M FitzGerald, Chol-Hee Jung, Ee Ming Wong, JiHoon E Joo, Jodee A Gould, Vivien Vasic, Julie K Bassett, Neil O'Callaghan, Tim Nottle, John Pedersen, Graham G Giles, Melissa C Southey
Prognostic genomic biomarkers that can be measured at diagnosis to aid choice of treatment options are unavailable for most common cancers. This is due in part to the poor quality and quantity of available diagnostic specimens for discovery research and to limitations in genomic technologies. Recent technical advances now enable high-density molecular analyses using suboptimal biological specimens. Here we describe the optimization of a transcriptome-specific protocol for use with formalin-fixed, paraffin-embedded (FFPE) diagnostic prostate cancer (PrCa) specimens...
January 16, 2018: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/29339742/slaf-based-high-density-genetic-map-construction-and-qtl-mapping-for-major-economic-traits-in-sea-urchin-strongylocentrotus-intermedius
#4
Yaqing Chang, Jun Ding, Yuhui Xu, Dan Li, Weijie Zhang, Lei Li, Jian Song
Sea urchin (Strongylocentrotus intermedius) has long been a model species for developmental and evolutionary research, but only a few studies have focused on gene mapping. Here, we reported a high-density genetic map containing 4,387 polymorphism specific-length amplified fragment (SLAF) markers spanning 21 linkage groups (LG) for sea urchin. Based on this genetic map and phenotyping data for eight economic traits, 33 potentially significant QTLs were detected on ten different LGs with explanations ranging from 9...
January 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29339525/pulsating-dissolution-of-crystalline-matter
#5
Cornelius Fischer, Andreas Luttge
Fluid-solid reactions result in material flux from or to the solid surface. The prediction of the flux, its variations, and changes with time are of interest to a wide array of disciplines, ranging from the material and earth sciences to pharmaceutical sciences. Reaction rate maps that are derived from sequences of topography maps illustrate the spatial distribution of reaction rates across the crystal surface. Here, we present highly spatially resolved rate maps that reveal the existence of rhythmic pulses of the material flux from the crystal surface...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29335602/in-situ-single-shot-diffractive-fluence-mapping-for-x-ray-free-electron-laser-pulses
#6
Michael Schneider, Christian M Günther, Bastian Pfau, Flavio Capotondi, Michele Manfredda, Marco Zangrando, Nicola Mahne, Lorenzo Raimondi, Emanuele Pedersoli, Denys Naumenko, Stefan Eisebitt
Free-electron lasers (FELs) in the extreme ultraviolet (XUV) and X-ray regime opened up the possibility for experiments at high power densities, in particular allowing for fluence-dependent absorption and scattering experiments to reveal non-linear light-matter interactions at ever shorter wavelengths. Findings of such non-linear effects are met with tremendous interest, but prove difficult to understand and model due to the inherent shot-to-shot fluctuations in photon intensity and the often structured, non-Gaussian spatial intensity profile of a focused FEL beam...
January 15, 2018: Nature Communications
https://www.readbyqxmd.com/read/29335595/mapping-the-epidemic-changes-and-risks-of-hemorrhagic-fever-with-renal-syndrome-in-shaanxi-province-china-2005-2016
#7
Weifeng Liang, Xu Gu, Xue Li, Kangjun Zhang, Kejian Wu, Miaomiao Pang, Jianhua Dong, Hunter R Merrill, Tao Hu, Kun Liu, Zhongjun Shao, Hong Yan
Hemorrhagic fever with renal syndrome (HFRS) is a major rodent-borne zoonosis. Each year worldwide, 60,000-100,000 HFRS human cases are reported in more than seventy countries with almost 90% these cases occurring in China. Shaanxi Province in China has been among the most seriously affected areas since 1955. During 2009-2013, Shaanxi reported 11,400 human cases, the most of all provinces in China. Furthermore, the epidemiological features of HFRS have changed over time. Using long-term data of HFRS from 2005 to 2016, we carried out this retrospective epidemiological study combining ecological assessment models in Shaanxi...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330432/developing-genome-wide-snps-and-constructing-an-ultrahigh-density-linkage-map-in-oil-palm
#8
Bin Bai, Le Wang, Ying Jun Zhang, May Lee, Rahmadsyah Rahmadsyah, Yuzer Alfiko, Bao Qing Ye, Sigit Purwantomo, Antonius Suwanto, Nam-Hai Chua, Gen Hua Yue
Oil palm (Elaeis guineensis Jacq.) is the leading oil-producing crops and the most important edible oil resource worldwide. DNA markers and genetic linkage maps are essential resources for marker-assisted selection to accelerate genetic improvement. We conducted RAD-seq on an Illumina NextSeq500 to discover genome-wide SNPs, and used the SNPs to construct a linkage map for an oil palm (Tenera) population derived from a cross between a Deli Dura and an AVROS Pisifera. The RAD-seq produced 1,076 million single-end reads across the breeding population containing 155 trees...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29328157/talbot-lau-x-ray-deflectometry-phase-retrieval-methods-for-electron-density-diagnostics-in-high-energy-density-experiments
#9
Maria Pia Valdivia, Dan Stutman, Christian Stoeckl, Chad Mileham, Ildar A Begishev, Jake Bromage, Sean P Regan
Talbot-Lau x-ray interferometry uses incoherent x-ray sources to measure refraction index changes in matter. These measurements can provide accurate electron density mapping through phase retrieval. An adaptation of the interferometer has been developed in order to meet the specific requirements of high-energy density experiments. This adaptation is known as a moiré deflectometer, which allows for single-shot capabilities in the form of interferometric fringe patterns. The moiré x-ray deflectometry technique requires a set of object and reference images in order to provide electron density maps, which can be costly in the high-energy density environment...
January 10, 2018: Applied Optics
https://www.readbyqxmd.com/read/29328079/high-resolution-coherent-x-ray-diffraction-imaging-of-metal-coated-polymer-microspheres
#10
Eirik T B Skjønsfjell, David Kleiven, Nilesh Patil, Yuriy Chushkin, Federico Zontone, Alain Gibaud, Dag W Breiby
Coherent x-ray diffraction imaging (CXDI) is becoming an important 3D quantitative microscopy technique, allowing structural investigation of a wide range of delicate mesoscale samples that cannot be imaged by other techniques like electron microscopy. Here we report high-resolution 3D CXDI performed on spherical microcomposites consisting of a polymer core coated with a triple layer of nickel-gold-silica. These composites are of high interest to the microelectronics industry, where they are applied in conducting adhesives as fine-pitch electrical contacts-which requires an exceptional degree of uniformity and reproducibility...
January 1, 2018: Journal of the Optical Society of America. A, Optics, Image Science, and Vision
https://www.readbyqxmd.com/read/29327365/millimeter-spatial-resolution-in-vivo-sodium-mri-of-the-human-eye-at-7-t-using-a-dedicated-radiofrequency-transceiver-array
#11
Daniel Wenz, Andre Kuehne, Till Huelnhagen, Armin M Nagel, Helmar Waiczies, Oliver Weinberger, Celal Oezerdem, Oliver Stachs, Soenke Langner, Erdmann Seeliger, Bert Flemming, Russell Hodge, Thoralf Niendorf
PURPOSE: The aim of this study was to achieve millimeter spatial resolution sodium in vivo MRI of the human eye at 7 T using a dedicated six-channel transceiver array. We present a detailed description of the radiofrequency coil design, along with electromagnetic field and specific absorption ratio simulations, data validation, and in vivo application. METHODS: Electromagnetic field and specific absorption ratio simulations were performed. Transmit field uniformity was optimized by using a multi-objective genetic algorithm...
January 12, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29325965/genome-wide-association-mapping-for-seed-protein-and-oil-contents-using-a-large-panel-of-soybean-accessions
#12
Dongmei Li, Xue Zhao, Yingpeng Han, Wenbin Li, Futi Xie
Soybean is globally cultivated primarily for its protein and oil. The protein and oil contents of the seeds are quantitatively inherited traits determined by the interaction of numerous genes. In order to gain a better understanding of the molecular foundation of soybean protein and oil content for the marker-assisted selection (MAS) of high quality traits, a population of 185 soybean germplasms was evaluated to identify the quantitative trait loci (QTLs) associated with the seed protein and oil contents. Using specific length amplified fragment sequencing (SLAF-seq) technology, a total of 12,072 single nucleotide polymorphisms (SNPs) with a minor allele frequency (MAF) ≥ 0...
January 8, 2018: Genomics
https://www.readbyqxmd.com/read/29325559/pangenome-analyses-of-the-wheat-pathogen-zymoseptoria-tritici-reveal-the-structural-basis-of-a-highly-plastic-eukaryotic-genome
#13
Clémence Plissonneau, Fanny E Hartmann, Daniel Croll
BACKGROUND: Structural variation contributes substantially to polymorphism within species. Chromosomal rearrangements that impact genes can lead to functional variation among individuals and influence the expression of phenotypic traits. Genomes of fungal pathogens show substantial chromosomal polymorphism that can drive virulence evolution on host plants. Assessing the adaptive significance of structural variation is challenging, because most studies rely on inferences based on a single reference genome sequence...
January 11, 2018: BMC Biology
https://www.readbyqxmd.com/read/29323885/unraveling-hidden-mg-mn-h-phase-relations-at-high-pressures-and-temperatures-by-in-situ-synchrotron-diffraction
#14
Kristina Spektor, Wilson A Crichton, Sumit Konar, Stanislav Filippov, Johan Klarbring, Sergei I Simak, Ulrich Häussermann
The Mg-Mn-H system was investigated by in situ high pressure studies of reaction mixtures MgH2-Mn-H2. The formation conditions of two complex hydrides with composition Mg3MnH7 were established. Previously known hexagonal Mg3MnH7 (h-Mg3MnH7) formed at pressures 1.5-2 GPa and temperatures between 480 and 500 °C, whereas an orthorhombic form (o-Mg3MnH7) was obtained at pressures above 5 GPa and temperatures above 600 °C. The crystal structures of the polymorphs feature octahedral [Mn(I)H6]5- complexes and interstitial H-...
January 11, 2018: Inorganic Chemistry
https://www.readbyqxmd.com/read/29321632/genome-wide-association-study-in-asia-adapted-tropical-maize-reveals-novel-and-explored-genomic-regions-for-sorghum-downy-mildew-resistance
#15
Zerka Rashid, Pradeep Kumar Singh, Hindu Vemuri, Pervez Haider Zaidi, Boddupalli Maruthi Prasanna, Sudha Krishnan Nair
Globally, downy mildews are among the important foliar diseases of maize that cause significant yield losses. We conducted a genome-wide association study for sorghum downy mildew (SDM; Peronosclerospora sorghi) resistance in a panel of 368 inbred lines adapted to the Asian tropics. High density SNPs from Genotyping-by-sequencing were used in GWAS after controlling for population structure and kinship in the panel using a single locus mixed model. The study identified a set of 26 SNPs that were significantly associated with SDM resistance, with Bonferroni corrected P values ≤ 0...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29320477/a-global-map-of-travel-time-to-cities-to-assess-inequalities-in-accessibility-in-2015
#16
D J Weiss, A Nelson, H S Gibson, W Temperley, S Peedell, A Lieber, M Hancher, E Poyart, S Belchior, N Fullman, B Mappin, U Dalrymple, J Rozier, T C D Lucas, R E Howes, L S Tusting, S Y Kang, E Cameron, D Bisanzio, K E Battle, S Bhatt, P W Gething
The economic and man-made resources that sustain human wellbeing are not distributed evenly across the world, but are instead heavily concentrated in cities. Poor access to opportunities and services offered by urban centres (a function of distance, transport infrastructure, and the spatial distribution of cities) is a major barrier to improved livelihoods and overall development. Advancing accessibility worldwide underpins the equity agenda of 'leaving no one behind' established by the Sustainable Development Goals of the United Nations...
January 10, 2018: Nature
https://www.readbyqxmd.com/read/29318634/high-density-contact-and-non-invasive-mapping-of-focal-atrial-tachycardia-evidence-of-dual-endocardial-exits-from-an-epicardial-focus
#17
Seigo Yamashita, Darren A Hooks, Ghassen Cheniti, Pierre Jais
We report a case of recurrent focal atrial tachycardia (AT) which mechanisms could be resolved by using non-invasive electrocardiographic imaging (ECGI) reconstructing epicardial potentials and rapid high-density endocardial contact mapping (Rhythmia™). ECGI demonstrated focal activity from the anterior of the left superior pulmonary vein antrum, although Rhythmia™ showed focal activity from the high anterior left atrium with the 2nd focus originating from the site where identical to the focus on the ECGI map with slightly delay (by 8 ms)...
January 10, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29317972/high-density-mapping-in-ventricular-tachycardia-ablation-a-pentaray%C3%A2-study
#18
Petra Maagh, Arnd Christoph, Henning Dopp, Markus Sebastian Mueller, Gunnar Plehn, Axel Meissner
Background: High-density mapping of ventricular tachycardia (VT) with PentaRay® (Biosense-Webster) provides high resolution with discrimination of local abnormal electrograms and slow conducting channels. We evaluate the feasibility of PentaRay® to characterize the anatomical substrate and assume an influence of the outcome despite limitations. Methods: Over a 24-month period, 26 endocardial and four epicardial maps were obtained of 26 VT patients (18 ischemic cardiomyopathy (ICM, 69...
December 2017: Cardiology Research
https://www.readbyqxmd.com/read/29315991/efficacy-of-catheter-ablation-of-focal-sources-in-persistent-atrial-fibrillation
#19
Yoshihide Takahashi, Syu Yamashita, Masahito Suzuki, Kento Yabe, Kenzo Hirao
INTRODUCTION: Recent studies suggest that atrial fibrillation (AF) is maintained by electrical activity arising from focal sources. We sought to test whether catheter ablation that targets focal sources can improve on current ablation protocols for persistent AF. METHODS AND RESULTS: In patients with persistent AF whose AF did not terminate with pulmonary vein isolation, the left atrium was mapped with a 20-pole high-density mapping catheter using CARTO®3 navigation...
January 9, 2018: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/29312815/satellite-tagging-highlights-the-importance-of-productive-mozambican-coastal-waters-to-the-ecology-and-conservation-of-whale-sharks
#20
Christoph A Rohner, Anthony J Richardson, Fabrice R A Jaine, Michael B Bennett, Scarla J Weeks, Geremy Cliff, David P Robinson, Katie E Reeve-Arnold, Simon J Pierce
The whale shark Rhincodon typus is an endangered, highly migratory species with a wide, albeit patchy, distribution through tropical oceans. Ten aerial survey flights along the southern Mozambican coast, conducted between 2004-2008, documented a relatively high density of whale sharks along a 200 km stretch of the Inhambane Province, with a pronounced hotspot adjacent to Praia do Tofo. To examine the residency and movement of whale sharks in coastal areas around Praia do Tofo, where they may be more susceptible to gill net entanglement, we tagged 15 juveniles with SPOT5 satellite tags and tracked them for 2-88 days (mean = 27 days) as they dispersed from this area...
2018: PeerJ
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