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High Density mapping

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https://www.readbyqxmd.com/read/28086974/ovarian-cancer-density-equalizing-mapping-of-the-global-research-architecture
#1
Dörthe Brüggmann, Katharina Pulch, Doris Klingelhöfer, Celeste Leigh Pearce, David A Groneberg
BACKGROUND: Despite its impact on female health worldwide, no efforts have been made to depict the global architecture of ovarian cancer research and to understand the trends in the related literature. Hence, it was the objective of this study to assess the global scientific performance chronologically, geographically and in regards to economic benchmarks using bibliometric tools and density equalizing map projections. METHODS: The NewQIS platform was employed to identify all ovarian cancer related articles published in the Web of Science since 1900...
January 13, 2017: International Journal of Health Geographics
https://www.readbyqxmd.com/read/28079141/development-of-a-690%C3%A2-k-snp-array-in-catfish-and-its-application-for-genetic-mapping-and-validation-of-the-reference-genome-sequence
#2
Qifan Zeng, Qiang Fu, Yun Li, Geoff Waldbieser, Brian Bosworth, Shikai Liu, Yujia Yang, Lisui Bao, Zihao Yuan, Ning Li, Zhanjiang Liu
Single nucleotide polymorphisms (SNPs) are capable of providing the highest level of genome coverage for genomic and genetic analysis because of their abundance and relatively even distribution in the genome. Such a capacity, however, cannot be achieved without an efficient genotyping platform such as SNP arrays. In this work, we developed a high-density SNP array with 690,662 unique SNPs (herein 690 K array) that were relatively evenly distributed across the entire genome, and covered 98.6% of the reference genome sequence...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28077090/gbs-based-single-dosage-markers-for-linkage-and-qtl-mapping-allow-gene-mining-for-yield-related-traits-in-sugarcane
#3
Thiago Willian Almeida Balsalobre, Guilherme da Silva Pereira, Gabriel Rodrigues Alves Margarido, Rodrigo Gazaffi, Fernanda Zatti Barreto, Carina Oliveira Anoni, Cláudio Benício Cardoso-Silva, Estela Araújo Costa, Melina Cristina Mancini, Hermann Paulo Hoffmann, Anete Pereira de Souza, Antonio Augusto Franco Garcia, Monalisa Sampaio Carneiro
BACKGROUND: Sugarcane (Saccharum spp.) is predominantly an autopolyploid plant with a variable ploidy level, frequent aneuploidy and a large genome that hampers investigation of its organization. Genetic architecture studies are important for identifying genomic regions associated with traits of interest. However, due to the genetic complexity of sugarcane, the practical applications of genomic tools have been notably delayed in this crop, in contrast to other crops that have already advanced to marker-assisted selection (MAS) and genomic selection...
January 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28077071/an-integrated-analysis-of-qtl-mapping-and-rna-sequencing-provides-further-insights-and-promising-candidates-for-pod-number-variation-in-rapeseed-brassica-napus-l
#4
Jiang Ye, Yuhua Yang, Bo Chen, Jiaqin Shi, Meizhong Luo, Jiepeng Zhan, Xinfa Wang, Guihua Liu, Hanzhong Wang
BACKGROUND: As the most important yield component in rapeseed (Brassica napus L.), pod number is determined by a series of successive growth and development processes. Pod number shows extensive variation in rapeseed natural germplasm, which is valuable for genetic improvement. However, the genetic and especially the molecular mechanism for this kind of variation are poorly understood. In this study, we conducted QTL mapping and RNA sequencing, respectively, using the BnaZNRIL population and its two parental cultivars Zhongshuang11 and No...
January 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28077070/scopa-and-meta-scopa-software-for-the-analysis-and-aggregation-of-genome-wide-association-studies-of-multiple-correlated-phenotypes
#5
Reedik Mägi, Yury V Suleimanov, Geraldine M Clarke, Marika Kaakinen, Krista Fischer, Inga Prokopenko, Andrew P Morris
BACKGROUND: Genome-wide association studies (GWAS) of single nucleotide polymorphisms (SNPs) have been successful in identifying loci contributing genetic effects to a wide range of complex human diseases and quantitative traits. The traditional approach to GWAS analysis is to consider each phenotype separately, despite the fact that many diseases and quantitative traits are correlated with each other, and often measured in the same sample of individuals. Multivariate analyses of correlated phenotypes have been demonstrated, by simulation, to increase power to detect association with SNPs, and thus may enable improved detection of novel loci contributing to diseases and quantitative traits...
January 11, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/28076338/quantification-of-confounding-factors-in-mri-based-dose-calculations-as-applied-to-prostate-imrt
#6
Matteo Maspero, Peter R Seevinck, Gerald Schubert, Michaela A U Hoesl, Bram van Asselen, Max A Viergever, Jan J W Lagendijk, Gert J Meijer, Cornelis A T van den Berg
Magnetic resonance (MR)-only radiotherapy treatment planning requires pseudo-CT (pCT) images to enable MR-based dose calculations. To verify the accuracy of MR-based dose calculations, institutions interested in introducing MR-only planning will have to compare pCT-based and computer tomography (CT)-based dose calculations. However, interpreting such comparison studies may be challenging, since potential differences arise from a range of confounding factors which are not necessarily specific to MR-only planning...
January 11, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28073759/the-genetic-map-comparator-a-user-friendly-application-to-display-and-compare-genetic-maps
#7
Yan Holtz, Jacques David, Vincent Ranwez
MOTIVATION: Marker-assisted selection strongly relies on genetic maps to accelerate breeding programs. High-density maps are now available for numerous species. Dedicated tools are required to compare several high-density maps on the basis of their key characteristics, while pinpointing their differences and similarities. RESULTS: We developed the Genetic Map Comparator-a web-based application for easy comparison of different maps according to their key statistics and the relative positions of common markers...
January 10, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28070281/multiscale-habitat-relationships-of-snowshoe-hares-lepus-americanus-in-the-mixed-conifer-landscape-of-the-northern-rockies-usa-cross-scale-effects-of-horizontal-cover-with-implications-for-forest-management
#8
Joseph D Holbrook, John R Squires, Lucretia E Olson, Rick L Lawrence, Shannon L Savage
Snowshoe hares (Lepus americanus) are an ecologically important herbivore because they modify vegetation through browsing and serve as a prey resource for multiple predators. We implemented a multiscale approach to characterize habitat relationships for snowshoe hares across the mixed conifer landscape of the northern Rocky Mountains, USA. Our objectives were to (1) assess the relationship between horizontal cover and snowshoe hares, (2) estimate how forest metrics vary across the gradient of snowshoe hare use and horizontal cover, and (3) model and map snowshoe hare occupancy and intensity of use...
January 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28069835/multielectrode-vs-point-by-point-mapping-for-ventricular-tachycardia-substrate-ablation-a-randomized-study
#9
Juan Acosta, Diego Penela, David Andreu, Mario Cabrera, Alicia Carlosena, Francesca Vassanelli, Francisco Alarcón, David Soto-Iglesias, Viatcheslav Korshunov, Roger Borras, Markus Linhart, Mikel Martínez, Juan Fernández-Armenta, Lluis Mont, Antonio Berruezo
AIMS: Ventricular tachycardia (VT) substrate ablation is based on detailed electroanatomical maps (EAM). This study analyses whether high-density multielectrode mapping (MEM) is superior to conventional point-by-point mapping (PPM) in guiding VT substrate ablation procedures. METHODS AND RESULTS: This was a randomized controlled study (NCT02083016). Twenty consecutive ischemic patients undergoing VT substrate ablation were randomized to either group A [n = 10; substrate mapping performed first by PPM (Navistar) and secondly by MEM (PentaRay) ablation guided by PPM] or group B [n = 10; substrate mapping performed first by MEM and second by PPM ablation guided by MEM]...
January 8, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28068919/construction-of-high-resolution-recombination-maps-in-asian-seabass
#10
Le Wang, Bin Bai, Peng Liu, Shu Qing Huang, Zi Yi Wan, Elaine Chua, Baoqing Ye, Gen Hua Yue
BACKGROUND: A high-density genetic map is essential for de novo genome assembly, fine mapping QTL for important complex traits, comparative genomic studies and understanding the mechanisms of genome evolution. Although a number of genomic resources are available in Asian seabass (Lates calcarifer), a high-density linkage map is still lacking. To facilitate QTL mapping for marker-assisted selection and genome assembly, and to understand the genome-wide recombination rates, we constructed high density linkage maps using three families and genotyping by sequencing...
January 10, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28068339/effect-of-climatic-factors-and-population-density-on-the-distribution-of-dengue-in-sri-lanka-a-gis-based-evaluation-for-prediction-of-outbreaks
#11
Pdnn Sirisena, Faseeha Noordeen, Harithra Kurukulasuriya, Thanuja Alar Romesh, LakKumar Fernando
Dengue is one of the major hurdles to the public health in Sri Lanka, causing high morbidity and mortality. The present study focuses on the use of geographical information systems (GIS) to map and evaluate the spatial and temporal distribution of dengue in Sri Lanka from 2009 to 2014 and to elucidate the association of climatic factors with dengue incidence. Epidemiological, population and meteorological data were collected from the Epidemiology Unit, Department of Census and Statistics and the Department of Meteorology of Sri Lanka...
2017: PloS One
https://www.readbyqxmd.com/read/28067433/plasmonic-imaging-of-the-interfacial-potential-distribution-on-bipolar-electrodes
#12
Meisam Hasheminejad, Yimin Fang, Meng Li, Yingyan Jiang, Wei Wang, Hong-Yuan Chen
Bipolar electrochemistry is based on the gradient distribution of free-electron density along an electrically isolated electrode, which causes a positive electrode potential at one end and a negative potential at the other, allowing for wide applications in analytical chemistry and materials science. To take full advantage of its wireless and high-throughput features, various types of optical probes, such as pH indicators and fluorescence and electrochemiluminescence reagents, have often been used to indirectly monitor the interfacial electron transfer through chromogenic or fluorogenic reactions...
January 9, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28067331/observation-of-transient-overcritical-currents-in-ybco-thin-films-using-high-speed-magneto-optical-imaging-and-dynamic-current-mapping
#13
Frederick S Wells, Alexey V Pan, Igor A Golovchanskiy, Sergey A Fedoseev, Anatoly Rozenfeld
The dynamics of transient current distributions in superconducting YBa2Cu3O7-δ thin films were investigated during and immediately following an external field ramp, using high-speed (real-time) Magneto-Optical Imaging and calculation of dynamic current profiles. A number of qualitatively unique and previously unobserved features are seen in this novel analysis of the evolution of supercurrent during penetration. As magnetic field ramps up from zero, the dynamic current profile is characterized by strong peaks, the magnitude of which exceed the conventional critical current density (as determined from static current profiles)...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28063269/novel-mapping-technique-for-localization-of-focal-and-reentrant-activation-during-atrial-fibrillation
#14
Yoshihide Takahashi, Shinsuke Iwai, Syu Yamashita, Mayumi Masumura, Masahito Suzuki, Kento Yabe, Yasuhiro Sato, Kenzo Hirao, Mitsuaki Isobe
INTRODUCTION: Identification of wavefront propagation pattern during AF remains challenging in ablation procedures. We sought to test a novel combination of a new mapping technology called Ripple Map and high density mapping to distinguish focal and reentrant activation during atrial fibrillation (AF). METHODS AND RESULTS: Subjects were patients undergoing ablation for persistent AF. If AF remained after isolation of the pulmonary veins, the left atrium (LA) was mapped by a high-density mapping catheter for later analysis, after which ablation was continued using a conventional stepwise approach...
January 7, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28061813/construction-of-a-high-density-genetic-map-using-specific-locus-amplified-fragments-in-sorghum
#15
Guisu Ji, Qingjiang Zhang, Ruiheng Du, Peng Lv, Xue Ma, Shu Fan, Suying Li, Shenglin Hou, Yucui Han, Guoqing Liu
BACKGROUND: Sorghum is mainly used as a human food and beverage source, playing an important role in the production of ethanol and other bio-industrial products. Thus it is regarded as a model crop for energy plants. Genetic map construction is the foundation for marker-assisted selection and gene cloning. So far several sorghum linkage maps have been reported using different kinds of molecular markers. However marker numbers and chromosome coverage are limited. As a result, it is difficult to get consistent results and the maps are hard to unify...
January 7, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28060782/high-density-emg-reveals-novel-evidence-of-altered-masseter-muscle-activity-during-symmetrical-and-asymmetrical-bilateral-jaw-clenching-tasks-in-people-with-chronic-nonspecific-neck-pain
#16
Marco Testa, Tommaso Geri, Leonardo Gizzi, Deborah Falla
OBJECTIVES: To characterize the distribution of masseter muscle activity and force control during bilateral jaw clenching tasks in people with chronic nonspecific neck pain, without an associated temporomandibular disorder. METHODS: Twelve volunteers with nonspecific neck pain and 12 age-matched and sex-matched healthy individuals participated. Submaximal symmetrical and asymmetrical bilateral jaw clenching was performed with and without visual feedback of force...
February 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28059971/geographical-information-system-evaluation-and-trends-of-nonaccidental-trauma-at-a-level-i-trauma-center-pilot-study
#17
Michael Robert Smith, Robert Lee Davis, Patricia Anne Phillips, Tatyana Shvilkina, Kamalijit Kaur, Heather Katrina Tabolt, Matthew Krause, Vincent Galdi
PREMISE: Although trauma may be considered a random act, geographical patterns of trauma potentially emerge. Our institution is unique in that it rests at an intersection of two of the highest areas of poverty and assault in New York City and has adequate data to analyze these patterns. METHODS: We review the incident reports logged by emergency medical services (EMS) technicians arriving with intentionally injured trauma patients from January 1 to December 31, 2013 at a single institution...
February 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28059371/plenoptic-mapping-for-imaging-and-retrieval-of-the-complex-field-amplitude-of-a-laser-beam
#18
Chensheng Wu, Jonathan Ko, Christopher C Davis
The plenoptic sensor has been developed to sample complicated beam distortions produced by turbulence in the low atmosphere (deep turbulence or strong turbulence) with high density data samples. In contrast with the conventional Shack-Hartmann wavefront sensor, which utilizes all the pixels under each lenslet of a micro-lens array (MLA) to obtain one data sample indicating sub-aperture phase gradient and photon intensity, the plenoptic sensor uses each illuminated pixel (with significant pixel value) under each MLA lenslet as a data point for local phase gradient and intensity...
December 26, 2016: Optics Express
https://www.readbyqxmd.com/read/28056726/community-mapping-of-sex-work-criminalization-and-violence-impacts-on-hiv-treatment-interruptions-among-marginalized-women-living-with-hiv-in-vancouver-canada
#19
Shira M Goldenberg, Kathleen Deering, Ofer Amram, Silvia Guillemi, Paul Nguyen, Julio Montaner, Kate Shannon
Despite the high HIV burden faced by sex workers, data on access and retention in antiretroviral therapy (ART) are limited. Using an innovative spatial epidemiological approach, we explored how the social geography of sex work criminalization and violence impacts HIV treatment interruptions among sex workers living with HIV in Vancouver over a 3.5-year period. Drawing upon data from a community-based cohort (AESHA, 2010-2013) and linked external administrative data on ART dispensation, GIS mapping and multivariable logistic regression with generalized estimating equations to prospectively examine the effects of spatial criminalization and violence near women's places of residence on 2-day ART interruptions...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28053035/a-high-resolution-in-vivo-atlas-of-the-human-brain-s-serotonin-system
#20
Vincent Beliveau, Melanie Ganz, Ling Feng, Brice Ozenne, Liselotte Højgaard, Patrick M Fisher, Claus Svarer, Douglas N Greve, Gitte M Knudsen
: The serotonin (5-hydroxytryptamine, 5-HT) system modulates many important brain functions and is critically involved in many neuropsychiatric disorders. Here, we present a high-resolution, multidimensional, in vivo atlas of four of the human brain's 5-HT receptors (5-HT1A, 5-HT1B, 5-HT2A, and 5-HT4) and the 5-HT transporter (5-HTT). The atlas is created from molecular and structural high-resolution neuroimaging data consisting of positron emission tomography (PET) and magnetic resonance imaging (MRI) scans acquired in a total of 210 healthy individuals...
January 4, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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