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Cardiovascular review

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https://www.readbyqxmd.com/read/29232703/knowledge-and-awareness-of-and-perception-towards-cardiovascular-disease-risk-in-sub-saharan-africa-a-systematic-review
#1
Daniel Boateng, Frederick Wekesah, Joyce L Browne, Charles Agyemang, Peter Agyei-Baffour, Ama de-Graft Aikins, Henriette A Smit, Diederick E Grobbee, Kerstin Klipstein-Grobusch
INTRODUCTION: Cardiovascular diseases (CVDs) are the most common cause of non-communicable disease mortality in sub-Saharan African (SSA) countries. Gaps in knowledge of CVD conditions and their risk factors are important barriers in effective prevention and treatment. Yet, evidence on the awareness and knowledge level of CVD and associated risk factors among populations of SSA is scarce. This review aimed to synthesize available evidence of the level of knowledge of and perceptions towards CVDs and risk factors in the SSA region...
2017: PloS One
https://www.readbyqxmd.com/read/29232562/tm6sf2-a-novel-target-for-plasma-lipid-regulation
#2
REVIEW
Ting-Ting Li, Tao-Hua Li, Juan Peng, Bei He, Lu-Shan Liu, Dang-Heng Wei, Zhi-Sheng Jiang, Xi-Long Zheng, Zhi-Han Tang
Transmembrane 6 superfamily 2 (TM6SF2), a gene identified at the locus 19p12, has been recognized to regulate plasma lipids. Here, we provide an overview of the roles of TM6SF2 as a novel target for plasma lipid regulation. We first review the association of TM6SF2 variant with plasma lipid traits, cardiovascular disease (CVD) and non-alcoholic fatty liver disease (NAFLD). Then, we present an overview about the in vivo validation of TM6SF2 as a regulator of plasma lipid levels using mice, with overexpression or knockdown/knockout of TM6SF2...
December 1, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29232276/contemporary-protease-inhibitors-and-cardiovascular-risk
#3
Jens Lundgren, Amanda Mocroft, Lene Ryom
PURPOSE OF REVIEW: To review the evidence linking use of HIV protease inhibitors with excess risk of cardiovascular disease (CVD) in HIV+ populations. RECENT FINDINGS: For the two contemporary most frequently used protease inhibitors, darunavir and atazanavir [both pharmacologically boosted with ritonavir (/r)], darunavir/r has been shown to be associated with increased CVD risk. The effect is cumulative with longer exposure increasing risk and an effect size comparable to what has been observed for previously developed protease inhibitors...
December 9, 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/29232261/long-chain-omega-3-fatty-acids-and-cancer-any-cause-for-concern
#4
Simona Serini, Gabriella Calviello
PURPOSE OF REVIEW: Recently, concerns have been raised with regard to the recommended doses of marine long-chain omega-3 polyunsaturated fatty acids (LC-omega-3 PUFAs) especially in relation to cancer risk and treatment. There is urgent need to clarify this point. This review considers the most recent evidence related to the potential risk of developing cancer with high LC-omega-3 PUFA intakes, and possible research strategies to better elucidate this matter. RECENT FINDINGS: The latest published recommendations have still highlighted the usefulness of an increased dietary intake of LC-omega-3 PUFAs for the prevention of some cardiovascular diseases...
December 11, 2017: Current Opinion in Clinical Nutrition and Metabolic Care
https://www.readbyqxmd.com/read/29231904/protective-effects-of-%C3%AF-3-pufa-in-anthracycline-induced-cardiotoxicity-a-critical-review
#5
REVIEW
Simona Serini, Renata Ottes Vasconcelos, Renata Nascimento Gomes, Gabriella Calviello
It has been demonstrated that ω-3 polyunsaturated fatty acids (ω-3 PUFA) may exert a beneficial role as adjuvants in the prevention and treatment of many disorders, including cardiovascular diseases and cancer. Particularly, several in vitro and in vivo preclinical studies have shown the antitumor activity of ω-3 PUFA in different kinds of cancers, and several human studies have shown that ω-3 PUFA are able to decrease the risk of a series of cardiovascular diseases. Several mechanisms have been proposed to explain their pleiotropic beneficial effects...
December 12, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29231052/efficacy-and-safety-of-ranolazine-in-diabetic-patients-a-systematic-review-and-meta-analysis
#6
Xiaofang Zeng, Yinyin Zhang, Jianhui Lin, Haikuo Zheng, Jie Peng, Wei Huang
BACKGROUND: Recent studies have discovered that the antiangina agent ranolazine exerts a glucometabolic effect. OBJECTIVE: This systematic review and meta-analysis aimed to further understand the efficacy and safety profile of ranolazine in patients with diabetes. METHODS: Randomized controlled trials (RCTs) were searched in PubMed, Cochrane, and EMBASE databases and in ClinicalTrials.gov up to July 2017. Efficacy end points were defined as the change in hemoglobin A1C (A1C) and fasting serum glucose (FSG) levels...
December 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29231011/-research-progress-of-the-relationship-between-sunds-and-osahs
#7
REVIEW
Y D Wu, L Y Zhang, J D Cheng
Sudden unexplained nocturnal death syndrome (SUNDS) is always a difficulty in forensic medicine researches. Although the development of molecular genetics promotes the etiologic study of SUNDS, the pathogenesis of most such cases is still unclear. Sleep apnea syndrome (SAS) is one of the common forms of sleep disorders, and obstructive sleep apnea hypopnea syndrome (OSAHS) is the most common. In recent years, some domestic and international researches show that OSAHS is related to the development of cardiovascular disease, which may cause cardiac arrhythmia, even sudden death...
February 2017: Fa Yi Xue za Zhi
https://www.readbyqxmd.com/read/29230714/obesity-phenotypes-depot-differences-in-adipose-tissue-and-their-clinical-implications
#8
REVIEW
Valeria Guglielmi, Paolo Sbraccia
Obesity, defined as excess fat mass, increases risks for multiple chronic diseases, such as type 2 diabetes, cardiovascular disease, and several types of cancer. Beyond adiposity per se, the pattern of fat distribution, android or truncal as compared to gynoid or peripheral, has a profound influence on systemic metabolism and hence risk for obesity complications. Not only factors as genetics, environment, gender, and age account for the apparent compartmentalization of white adipose tissue (WAT) in the body...
December 11, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29230653/environmental-exposure-to-cadmium-a-risk-for-health-of-the-general-population-in-industrialized-countries-and-preventive-strategies
#9
Magdalena Mezynska, Malgorzata M Brzóska
Cadmium (Cd) is a heavy metal belonging to the group of the main chemical pollutants of the natural and occupational environment in economically developed countries. The forecasts indicate that contamination of the environment with this toxic metal, and thus the exposure of the general population, will increase. Food (particularly plant products) is the main source of the general population exposure to this element. Moreover, an important, and often the main, source of intoxication with Cd is habitual tobacco smoking...
December 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29230264/prevalence-and-risk-factors-of-intra-dialytic-hypotension-a-5-year-retrospective-report-from-a-single-nigerian-centre
#10
Ogochukwu Chinedum Okoye, Henry Enyinmisan Slater, Nilum Rajora
Introduction: Intra-dialytic hypotension (IDH) is a common complication of haemodialysis that impacts negatively on the patient's quality of life and can induce serious cardiovascular events. Methods: Records of all adults who had haemodialysis treatments from Jan 2012-Jan 2016 were reviewed. Socio-demographic data, health status of patient, aetiology of renal disease, clinical and biochemical parameters such as systolic and diastolic blood pressures (SBP and DBP), packed cell volume, were collated using Microsoft Excel...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29230179/transplacental-nutrient-transport-mechanisms-of-intrauterine-growth-restriction-in-rodent-models-and-humans
#11
REVIEW
Elke Winterhager, Alexandra Gellhaus
Although the causes of intrauterine growth restriction (IUGR) have been intensively investigated, important information is still lacking about the role of the placenta as a link from adverse maternal environment to adverse pregnancy outcomes of IUGR and preterm birth. IUGR is associated with an increased risk of cardiovascular, metabolic, and neurological diseases later in life. Determination of the most important pathways that regulate transplacental transport systems is necessary for identifying marker genes as diagnostic tools and for developing drugs that target the molecular pathways...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/29229723/prospective-study-of-fasting-blood-glucose-and-intracerebral-hemorrhagic-risk
#12
Cheng Jin, Guohong Li, Kathryn M Rexrode, Mahmut E Gurol, Xiaodong Yuan, Ying Hui, Chunyu Ruan, Anand Vaidya, Yanxiu Wang, Shouling Wu, Xiang Gao
BACKGROUND AND PURPOSE: Although diabetes mellitus is an established independent risk factor for ischemic stroke, the association between fasting blood glucose and intracerebral hemorrhage (ICH) is limited and inconsistent. The objective of the current study was to examine the potential impact of long-term fasting blood glucose concentration on subsequent risk of ICH. METHODS: This prospective study included 96 110 participants of the Kailuan study, living in Kailuan community, Tangshan city, China, who were free of cardiovascular diseases and cancer at baseline (2006)...
December 11, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29229570/medicinal-plants-used-for-hypertension-treatment-by-folk-healers-in-songkhla-province-thailand
#13
Oratai Neamsuvan, Panadda Komonhiran, Kamonvadee Boonming
ETHNOPHARMACOLOGICAL RELEVANCE: Hypertension is the most dominant risk factor for the development of cardiovascular, kidney, and eye diseases. In Thailand, illness and hospitalisation in the modern public health system due to high blood pressure is increasing. However, some Thai people have turned their attention to the use of herbal medicines for healthcare. Therefore, this study aimed (1) to study the folk knowledge of hypertension treatment and (2) to study plant utilisation in the treatment of high blood pressure by Songkhla folk healers...
December 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29229563/osteoarthritis-year-in-review-2017-clinical
#14
REVIEW
Amanda E Nelson
This review is based on a systematic review of the literature relevant to clinical topics in osteoarthritis (OA) performed for the time period February 22, 2016 to April 1, 2017. A PubMed search using the terms "osteoarthritis" and "treatment or epidemiology" returned over 800 papers, of which 57 are reviewed here, with inclusion primarily based on relevance to clinical OA. Epidemiologic studies in this time frame focused on the incidence and prevalence of OA, comorbidities and mortality in relation to OA (particularly obesity and cardiovascular disease), and multiple joint involvement...
December 8, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29229313/emerging-role-of-adipocytokines-in-type-2-diabetes-as-mediators-of-insulin-resistance-and-cardiovascular-disease
#15
REVIEW
Ravindran Jaganathan, Rajeswari Ravindran, Sugapriya Dhanasekaran
Adipose tissue is an enormously active endocrine organ, secreting various hormones, such as adiponectin, leptin, resistin and visfatin, together with classical cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6). All these adipocytokines plays significant roles in the regulation of energy metabolism, glucose and lipid metabolism, reproduction, cardiovascular function and immunity. Adipocytokines are significantly regulated by nutritional status and can directly influence other organ systems, including brain, liver and skeletal muscle...
December 8, 2017: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29229170/care-of-the-pediatric-patient-on-chronic-dialysis
#16
REVIEW
Annabelle N Chua, Bradley A Warady
Optimal care of the pediatric end-stage renal disease (ESRD) patient on chronic dialysis is complex and requires multidisciplinary care as well as patient/caregiver involvement. The dialysis team, along with the family and patient, should all play a role in choosing the dialysis modality which best meets the patient's needs, taking into account special considerations and management issues that may be particularly pertinent to children who receive peritoneal dialysis or hemodialysis. Meticulous attention to dialysis adequacy in terms of solute and fluid removal, as well as to a variety of clinical manifestations of ESRD, including anemia, growth and nutrition, chronic kidney disease-mineral bone disorder, cardiovascular health, and neurocognitive development, is essential...
November 2017: Advances in Chronic Kidney Disease
https://www.readbyqxmd.com/read/29228975/prediabetes-and-cardiovascular-complications-study-paccs-international-collaboration-4%C3%A2-years-summary-and-future-direction
#17
E U Nwose, R S Richards, P T Bwititi, E O Igumbor, E J Oshionwu, K Okolie, I C Onyia, A Pokhrel, P Gyawali, J N Okuzor, V M Oguoma, F W Gardiner, L Wang
OBJECTIVE: The prediabetes and cardiovascular complications studies proposes to develop a screening protocol for diabetes cardiovascular risk, and strategies for holistic management amongst others. Over 500 participants were recruited in the first 2 years of rural community research screening. Specific for this report, various published findings were reviewed. The objective is to summarize research outcomes and itemize limitations as they constitute basis of future directions. RESULTS: Affordability and availability are major confounding behavioural change wheel factors in the rural community...
December 11, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29228916/physical-and-psychosomatic-health-outcomes-in-people-bereaved-by-suicide-compared-to-people-bereaved-by-other-modes-of-death-a-systematic-review
#18
Ailbhe Spillane, Celine Larkin, Paul Corcoran, Karen Matvienko-Sikar, Fiona Riordan, Ella Arensman
BACKGROUND: Little research has been conducted into the physical health implications of suicide bereavement compared to other causes of death. There is some evidence that suicide bereaved parents have higher morbidity, particularly in terms of chronic illness. This systematic review aims to examine the physical and psychosomatic morbidities of people bereaved by a family member's suicide and compare them with family members bereaved by other modes of death. METHODS: MEDLINE, EMBASE, CINAHL, and PsycINFO were searched from 1985 to February 2016...
December 12, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29228887/can-whole-body-vibration-exercises-affect-growth-hormone-concentration-a-systematic-review
#19
Laisa Liane Paineiras-Domingos, Danúbia da Cunha de Sá-Caputo, Eloá Moreira-Marconi, Danielle Soares Morel, Carla da Fontoura Dionello, Cintia Renata Sousa-Gonçalves, Éric Heleno Freire Ferreira Frederico, Pedro Jesus Marín, Sofia Tamini, Alessandro Sartorio, Mario Bernardo-Filho
Whole body vibration (WBV) has been recognized as an effective alternative exercise modality to resistance exercise for its ability in enhancing force and power, generating capacity in skeletal muscle, increasing bone mass and improving cardiovascular function. Since the effect of WBV exercises on growth hormone (GH) levels has been never compared and discussed, the aim of this study was to review systematically the literature to verify the WBV effects on GH concentration. By using PubMed, Scopus and PEDRo databases with the keywords 'growth hormone' or GH and 'whole body vibration' or WBV, we found and analysed 12 papers (182 subjects recruited), verifying their level of evidence (National Health and Medical Research Council hierarchy of evidence) and the methodological quality (PEDRo scale)...
October 2017: Growth Factors
https://www.readbyqxmd.com/read/29228855/effects-of-telephone-call-intervention-on-cardiovascular-risk-factors-in-type-2-diabetes-mellitus-a-meta-analysis
#20
Junping Wei, Huijuan Zheng, Liansheng Wang, Qiuhong Wang, Fan Wei, Litao Bai
Background Mobile health interventions utilising telephone calls are promising tools for diabetes management. However, there is still a lack of convincing evidence demonstrating their beneficial effects on cardiovascular risk factors. The aim of this meta-analysis of randomised controlled trials was to assess the effect of telephone calls on glycaemic control and other cardiovascular risk factors in type 2 diabetes mellitus patients. Methods Two independent reviewers searched three online databases (PubMed, the Cochrane Library and EMBASE) to identify relevant English-language randomised controlled trials up to September 2017...
January 1, 2017: Journal of Telemedicine and Telecare
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