keyword
https://read.qxmd.com/read/37950524/involvement-of-microglial-p2x7-receptor-in-pain-modulation
#21
REVIEW
Jing Zhang, Lei Gao, Yaoyuan Zhang, Haozhen Wang, Shukai Sun, Li-An Wu
BACKGROUND: Pain is a rapid response mechanism that compels organisms to retreat from the harmful stimuli and triggers a repair response. Nonetheless, when pain persists for extended periods, it can lead to adverse changes into in the individual's brain, negatively impacting their emotional state and overall quality of life. Microglia, the resident immune cells in the central nervous system (CNS), play a pivotal role in regulating a variety of pain-related disorders. Specifically, recent studies have shed light on the central role that microglial purinergic ligand-gated ion channel 7 receptor (P2X7R) plays in regulating pain...
November 10, 2023: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/37942897/the-role-of-the-purinergic-ligand-gated-ion-channel-7-receptor-in-common-digestive-system-cancers
#22
JOURNAL ARTICLE
Xin Wang, Qingqing Yu, Xue Bai, Xinyu Li, Yanli Sun, Xiaoxiang Peng, Ronglan Zhao
The incidence of digestive malignancies has increased in recent years, including colorectal cancer (CRC), hepatocellular carcinoma (HCC) and pancreatic cancer. Advanced stages of these cancers are prone to metastasis, which seriously reduce the standard of living of patients and lead to decline in the survival rate of patients. So far there are no good specific drugs to stop this phenomenon. It is very important and urgent to find new biomarkers and therapeutic targets. Purinergic ligand-gated ion channel 7 receptor (P2X7R) is ATP-gated and nonselective ion channel receptor involved in many inflammatory processes and cancer progression...
November 6, 2023: European Journal of Cancer Prevention
https://read.qxmd.com/read/37913850/traditional-chinese-medicine-alleviating-neuropathic-pain-targeting-purinergic-receptor-p2-in-purinergic-signaling-a-review
#23
REVIEW
Bo Yang, Nengwei Yu
Past studies have suggested that Chinese herbal may alleviate neuropathic pain, and the mechanism might target the inhibition of purinergic receptor P2. This review discusses whether traditional Chinese medicine target P2 receptors in neuropathic pain and its mechanism in order to provide references for future clinical drug development. The related literatures were searched from Pubmed, Embase, Sinomed, and CNKI databases before June 2023. The search terms included"neuropathic pain", "purinergic receptor P2", "P2", "traditional Chinese medicine", "Chinese herbal medicine", and "herb"...
October 31, 2023: Brain Research Bulletin
https://read.qxmd.com/read/37905866/the-bumpy-road-of-purinergic-inhibitors-to-clinical-application-in-immune-mediated-diseases
#24
JOURNAL ARTICLE
Matthias T Wyss, Christine Heuer, Marina Herwerth
Purinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis. This is also reflected by the widespread expression of two families of purinergic receptors (P1 and P2) with numerous subtypes. In the last few decades, there has been increasing evidence that purinergic signaling plays an important role in the regulation of immune functions. Mainly, signals mediated by P2 receptors have been shown to contribute to immune system-mediated pathologies...
June 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/37871131/enpp1-in-blood-and-bone-skeletal-and-soft-tissue-diseases-induced-by-enpp1-deficiency
#25
REVIEW
Carlos R Ferreira, Thomas O Carpenter, Demetrios T Braddock
The enzyme ectonucleotide pyrophosphatase/phosphodiesterase-1 ( ENPP1 ) codes for a type 2 transmembrane glycoprotein that hydrolyzes extracellular ATP to generate pyrophosphate (PPi ) and adenosine monophosphate, thereby contributing to downstream purinergic signaling pathways. The clinical phenotypes induced by ENPP1 deficiency are seemingly contradictory and include early-onset osteoporosis in middle-aged adults and life-threatening vascular calcifications in the large arteries of infants with generalized arterial calcification of infancy...
October 23, 2023: Annual Review of Pathology
https://read.qxmd.com/read/37868982/degranulation-of-human-mast-cells-modulation-by-p2-receptors-agonists
#26
REVIEW
Edward S Schulman, Haruhisa Nishi, Amir Pelleg
Since the late 1970s, there has been an alarming increase in the incidence of asthma and its morbidity and mortality. Acute obstruction and inflammation of allergic asthmatic airways are frequently caused by inhalation of exogenous substances such as allergens cross-linking IgE receptors expressed on the surface of the human lung mast cells (HLMC). The degree of constriction of human airways produced by identical amounts of inhaled allergens may vary from day to day and even hour to hour. Endogenous factors in the human mast cell (HMC)'s microenvironment during allergen exposure may markedly modulate the degranulation response...
2023: Frontiers in Immunology
https://read.qxmd.com/read/37843749/pharmacological-interaction-and-immune-response-of-purinergic-receptors-in-therapeutic-modulation
#27
REVIEW
Seyed Hossein Kiaie, Zahra Hatami, Mohammad Sadegh Nasr, Pouya Pazooki, Salar Hemmati, Behzad Baradaran, Hadi Valizadeh
Nucleosides and purine nucleotides serve as transmitter and modulator agents that extend their functions beyond the cell. In this context, purinergic signaling plays a crucial role in regulating energy homeostasis and modulating metabolic alterations in tumor cells. Therefore, it is essential to consider the pharmacological targeting of purinergic receptors (PUR), which encompass the expression and inhibition of P1 receptors (metabotropic adenosine receptors) as well as P2 receptors (extracellular ATP/ADP) comprising P2X and P2Y receptors...
October 16, 2023: Purinergic Signalling
https://read.qxmd.com/read/37841931/a-review-of-the-pathophysiology-and-the-role-of-ion-channels-on-bronchial-asthma
#28
REVIEW
Indyra Alencar Duarte Figueiredo, Sarah Rebeca Dantas Ferreira, Jayne Muniz Fernandes, Bagnólia Araújo da Silva, Luiz Henrique César Vasconcelos, Fabiana de Andrade Cavalcante
Asthma is one of the main non-communicable chronic diseases and affects a huge portion of the population. It is a multifactorial disease, classified into several phenotypes, being the allergic the most frequent. The pathophysiological mechanism of asthma involves a Th2-type immune response, with high concentrations of allergen-specific immunoglobulin E, eosinophilia, hyperreactivity and airway remodeling. These mechanisms are orchestrated by intracellular signaling from effector cells, such as lymphocytes and eosinophils...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37828668/purinergic-signaling-and-its-role-in-the-stem-cell-differentiation
#29
JOURNAL ARTICLE
Sumera Zaib, Areeba, Imtiaz Khan
Purinergic signaling is a mechanism in which extracellular purines and pyrimidines interact with specialized cell surface receptors known as purinergic receptors. These receptors are divided into two families of P1 and P2 receptors, each responding to different nucleosides and nucleotides. P1 receptors are activated by adenosine, while P2 receptors are activated by pyrimidine and purines. P2X receptors are ligand-gated ion channels, including seven subunits (P2X1-7). However, P2Y receptors are the G-protein coupled receptors comprising eight subtypes (P2Y1/2/4/6/11/12/13/14)...
October 11, 2023: Mini Reviews in Medicinal Chemistry
https://read.qxmd.com/read/37805959/purinergic-signaling-decoding-its-role-in-covid-19-pathogenesis-and-promising-treatment-strategies
#30
REVIEW
Zahra Shafaghat, Amir-Hossein Khosrozadeh Ghomi, Hossein Khorramdelazad, Elaheh Safari
The pathogenesis of coronavirus disease (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2), is complex and involves dysregulated immune responses, inflammation, and coagulopathy. Purinergic signaling, mediated by extracellular nucleotides and nucleosides, has emerged as a significant player in the pathogenesis of COVID-19. Extracellular adenosine triphosphate (ATP), released from damaged or infected cells, is a danger signal triggering immune responses. It activates immune cells, releasing pro-inflammatory cytokines, contributing to the cytokine storm observed in severe COVID-19 cases...
October 8, 2023: Inflammopharmacology
https://read.qxmd.com/read/37762419/the-p2x7-receptor-in-autoimmunity
#31
REVIEW
Fabio Grassi, Gaia Salina
The P2X7 receptor (P2X7R) is an ATP-gated nonselective cationic channel that, upon intense stimulation, can progress to the opening of a pore permeable to molecules up to 900 Da. Apart from its broad expression in cells of the innate and adaptive immune systems, it is expressed in multiple cell types in different tissues. The dual gating property of P2X7R is instrumental in determining cellular responses, which depend on the expression level of the receptor, timing of stimulation, and microenvironmental cues, thus often complicating the interpretation of experimental data in comprehensive settings...
September 14, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37755557/coffee-adenosine-and-the-liver
#32
REVIEW
Jonathan A Dranoff
A variety of observational studies have demonstrated that coffee, likely acting through caffeine, improves health outcomes in patients with chronic liver disease. The primary pharmacologic role of caffeine is to act as an inhibitor of adenosine receptors. Because key liver cells express adenosine receptors linked to liver injury, regeneration, and fibrosis, it is plausible that the biological effects of coffee are explained by effects of caffeine on adenosinergic signaling in the liver. This review is designed to help the reader make sense of that hypothesis, highlighting key observations in the literature that support or dispute it...
September 27, 2023: Purinergic Signalling
https://read.qxmd.com/read/37713157/p2x7-receptors-and-pannexin1-hemichannels-shape-presynaptic-transmission
#33
REVIEW
Nathalia Vitureira, Alberto Rafael, Verónica Abudara
Over the last decades, since the discovery of ATP as a transmitter, accumulating evidence has been reported about the role of this nucleotide and purinergic receptors, in particular P2X7 receptors, in the modulation of synaptic strength and plasticity. Purinergic signaling has emerged as a crucial player in orchestrating the molecular interaction between the components of the tripartite synapse, and much progress has been made in how this neuron-glia interaction impacts neuronal physiology under basal and pathological conditions...
September 15, 2023: Purinergic Signalling
https://read.qxmd.com/read/37697211/pharmacological-characterization-of-p2y-receptor-subtypes-an-update
#34
REVIEW
Ivar von Kügelgen
P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1 , P2Y2 , P2Y4 , P2Y6 , P2Y11 , P2Y12 , P2Y13 , and P2Y14 ). The widely expressed P2Y receptors play important roles in physiology and pathophysiology. This review summarizes the use of pharmacological tools to characterize the P2Y receptor subtypes involved in these responses. MRS2500 is a potent and selective antagonist acting at the P2Y1 receptor. AR-C118925 is useful for the selective antagonism of the P2Y2 receptor...
September 12, 2023: Purinergic Signalling
https://read.qxmd.com/read/37692109/purine-and-purinergic-receptors-in-health-and-disease
#35
REVIEW
Yanling Ai, Hengyi Wang, Lu Liu, Yulin Qi, Shiyun Tang, Jianyuan Tang, Nianzhi Chen
Purines and purinergic receptors are widely distributed throughout the human body. Purine molecules within cells play crucial roles in regulating energy metabolism and other cellular processes, while extracellular purines transmit signals through specific purinergic receptors. The ubiquitous purinergic signaling maintains normal neural excitability, digestion and absorption, respiratory movement, and other complex physiological activities, and participates in cell proliferation, differentiation, migration, and death...
October 2023: MedComm
https://read.qxmd.com/read/37688412/glomerular-microcirculation-implications-for-diabetes-preeclampsia-and-kidney-injury
#36
REVIEW
Michael S Goligorsky
This review outlines the features of tandem regulation of glomerular microcirculation by autoregulatory mechanisms and intraglomerular redistribution of blood flow. Multiple points of cooperation exist between autoregulatory and distributional mechanisms. Mutual interactions between myogenic and tubuloglomerular feedback (TGF) mechanisms regulating the inflow are briefly discussed. In addition to this, TGF operation involving purinergic, autocoid, and NO signaling affects, however, not only afferent arteriolar tone, but mesangial cell tone as well...
September 9, 2023: Acta Physiologica
https://read.qxmd.com/read/37685963/adenosine-receptors-as-potential-therapeutic-analgesic-targets
#37
REVIEW
Mansour Haddad, Federica Cherchi, Mohammad Alsalem, Yousef M Al-Saraireh, Saba Madae'en
Pain represents an international burden and a major socio-economic public health problem. New findings, detailed in this review, suggest that adenosine plays a significant role in neuropathic and inflammatory pain, by acting on its metabotropic adenosine receptors (A1 AR, A2A AR, A2B AR, A3 AR). Adenosine receptor ligands have a practical translational potential based on the favorable efficacy and safety profiles that emerged from clinical research on various agonists and antagonists for different pathologies...
August 24, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37678839/mechanisms-of-acupuncture-electroacupuncture-on-inflammatory-pain
#38
JOURNAL ARTICLE
Qingxiang Zhang, Mengmeng Zhou, Mingzhu Huo, Yuxin Si, Youlin Zhang, Yuxin Fang, Di Zhang
Acupuncture, as a traditional treatment, has been extensively used in China for thousands of years. According to the World Health Organization (WHO), acupuncture is recommended for the treatment of 77 diseases. And sixteen of these diseases are related to inflammatory pain. As a combination of traditional acupuncture and modern electrotherapy, electroacupuncture (EA) has satisfactory analgesic effects on various acute and chronic pain. Because of its good analgesic effects and no side effects, acupuncture has been widely accepted all over the world...
September 7, 2023: Molecular Pain
https://read.qxmd.com/read/37638395/autophagy-may-protect-the-brain-against-prolonged-consequences-of-headache-attacks-a-narrative-hypothesis-review
#39
REVIEW
Michal Fila, Elzbieta Pawlowska, Joanna Szczepanska, Janusz Blasiak
OBJECTIVE: To assess the potential of autophagy in migraine pathogenesis. BACKGROUND: The interplay between neurons and microglial cells is important in migraine pathogenesis. Migraine-related effects, such as cortical spreading depolarization and release of calcitonin gene-related peptide, may initiate adenosine triphosphate (ATP)-mediating pro-nociceptive signaling in the meninges causing headaches. Such signaling may be induced by the interaction of ATP with purinergic receptor P2X 7 (P2X7R) on microglial cells leading to a Ca2+ -mediated pH increase in lysosomes and release of autolysosome-like vehicles from microglial cells indicating autophagy impairment...
September 2023: Headache
https://read.qxmd.com/read/37592949/non-canonical-pathways-in-the-pathophysiology-and-therapeutics-of-bipolar-disorder
#40
REVIEW
Rodrigo Machado-Vieira, Alan C Courtes, Carlos A Zarate, Ioline D Henter, Husseini K Manji
Bipolar disorder (BD) is characterized by extreme mood swings ranging from manic/hypomanic to depressive episodes. The severity, duration, and frequency of these episodes can vary widely between individuals, significantly impacting quality of life. Individuals with BD spend almost half their lives experiencing mood symptoms, especially depression, as well as associated clinical dimensions such as anhedonia, fatigue, suicidality, anxiety, and neurovegetative symptoms. Persistent mood symptoms have been associated with premature mortality, accelerated aging, and elevated prevalence of treatment-resistant depression...
2023: Frontiers in Neuroscience
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