keyword
https://read.qxmd.com/read/38473744/p2x7-receptor-in-dendritic-cells-and-macrophages-implications-in-antigen-presentation-and-t-lymphocyte-activation
#1
REVIEW
Claudio Acuña-Castillo, Alejandro Escobar, Moira García-Gómez, Vivienne C Bachelet, Juan Pablo Huidobro-Toro, Daniela Sauma, Carlos Barrera-Avalos
The P2X7 receptor, a member of the P2X purinergic receptor family, is a non-selective ion channel. Over the years, it has been associated with various biological functions, from modulating to regulating inflammation. However, its emerging role in antigen presentation has captured the scientific community's attention. This function is essential for the immune system to identify and respond to external threats, such as pathogens and tumor cells, through T lymphocytes. New studies show that the P2X7 receptor is crucial for controlling how antigens are presented and how T cells are activated...
February 21, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38447385/cytokine-storm-in-human-monkeypox-a-possible-involvement-of-purinergic-signaling
#2
REVIEW
Gilnei Bruno da Silva, Geórgia de Carvalho Braga, Júlia Leão Batista Simões, Aniela Pinto Kempka, Margarete Dulce Bagatini
Some evidence has indicated that monkeypox can induce a cytokine storm. Purinergic signaling is a cell pathway related to the cytokine storm. However, the precise mechanisms that lead to cytokine storms in monkeypox infections and the possible involvement of purinergic signaling in the immune response to this virus remain unknown. In this review article, we aimed to highlight a body of scientific evidence that consolidates the role of the cytokine storm in monkeypox infection and proposes a new hypothesis regarding the roles of purinergic signaling in this immune-mediated mechanism...
March 5, 2024: Cytokine
https://read.qxmd.com/read/38426088/purinergic-enzymes-on-extracellular-vesicles-immune-modulation-on-the-go
#3
REVIEW
Riekje Winzer, Du Hanh Nguyen, Felix Schoppmeier, Filippo Cortesi, Nicola Gagliani, Eva Tolosa
An increase in the extracellular concentration of ATP as a consequence of cellular stress or cell death results in the activation of immune cells. To prevent inflammation, extracellular ATP is rapidly metabolized to adenosine, which deploys an anti-inflammatory signaling cascade upon binding to P1 receptors on immune cells. The ectonucleotidases necessary for the degradation of ATP and generation of adenosine are present on the cell membrane of many immune cells, and their expression is tightly regulated under conditions of inflammation...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38421486/p2x7-receptors-a-bibliometric-review-from-2002-to-2023
#4
REVIEW
Haiting Tang, Wei Wei, Yu Luo, Xiaoqing Lu, Jun Chen, Shenqiao Yang, Fei Wu, Haiyan Zhou, Wenbin Ma, Xin Yang
For many years, there has been ongoing research on the P2X7 receptor (P2X7R). A comprehensive, systematic, and objective evaluation of the scientific output and status of P2X7R will be instrumental in guiding future research directions. This study aims to present the status and trends of P2X7R research from 2002 to 2023. Publications related to P2X7R were retrieved from the Web of Science Core Collection database. Quantitative analysis and visualization tools were Microsoft Excel, VOSviewer, and CiteSpace software...
February 29, 2024: Purinergic Signalling
https://read.qxmd.com/read/38409828/microbiota-parasite-interaction-implication-of-secretory-immunoglobulin-a-and-p2x7-receptor-signaling
#5
REVIEW
Basma Emad Aboulhoda, Mohamed Abdelfatah, Eman S El-Wakil, Mansour Alghamdi, Emad A Albadawi, Fatma E Hassan, Enas A El Saftawy
The microbiota community is composed of bacteria, fungi, viruses, and protists that exert symbiotic effects within the human body. Unlike microbiota, parasites are characteristically reliant on their hosts to thrive and flourish, producing toxic metabolites that agitate microbiota and disturb homeostasis. The proper management of parasitic infections addresses several important challenges related to low socioeconomic status and emergent resistance. Therefore, understanding the microbiota's role in interactions with hosts and parasites is crucial for managing parasite diseases with fewer economic and adverse effects associated with pharmaceutical interventions...
February 2024: Discovery Medicine
https://read.qxmd.com/read/38400561/alkaline-phosphatase-treatment-of-acute-kidney-injury-an-update
#6
JOURNAL ARTICLE
Thei S Steenvoorden, Janneke A J Rood, Frederike J Bemelman, Roberto Armstrong-Jr, Henri G D Leuvenink, Joost W van der Heijden, Liffert Vogt
Through improved insight in the increasing incidence and detrimental effects of acute kidney injury (AKI), its clinical relevance has become more and more apparent. Although treatment strategies for AKI have also somewhat improved, an adequate remedy still does not exist. Finding one is complicated by a multifactorial pathophysiology and by heterogeneity in the patient population. Alkaline phosphatase (AP) has been suggested as a therapy for sepsis-associated AKI because of its protective effects against lipopolysaccharide (LPS) induced inflammation and kidney injury in animals...
February 23, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38392293/the-purinergic-nature-of-pseudoxanthoma-elasticum
#7
REVIEW
Gilles Kauffenstein, Ludovic Martin, Olivier Le Saux
Pseudoxanthoma Elasticum (PXE) is an inherited disease characterized by elastic fiber calcification in the eyes, the skin and the cardiovascular system. PXE results from mutations in ABCC6 that encodes an ABC transporter primarily expressed in the liver and kidneys. It took nearly 15 years after identifying the gene to better understand the etiology of PXE. ABCC6 function facilitates the efflux of ATP, which is sequentially hydrolyzed by the ectonucleotidases ENPP1 and CD73 into pyrophosphate (PPi) and adenosine, both inhibitors of calcification...
January 26, 2024: Biology
https://read.qxmd.com/read/38375982/the-neurobiological-mechanisms-and-therapeutic-prospect-of-extracellular-atp-in-depression
#8
REVIEW
Kaixin Wang, Shiqian Huang, Daan Fu, Xinxin Yang, Lulin Ma, Tianhao Zhang, Wenjing Zhao, Daling Deng, Yuanyuan Ding, Yanyan Zhang, Li Huang, Xiangdong Chen
BACKGROUND: Depression is a prevalent psychiatric disorder with high long-term morbidities, recurrences, and mortalities. Despite extensive research efforts spanning decades, the cellular and molecular mechanisms of depression remain largely unknown. What's more, about one third of patients do not have effective anti-depressant therapies, so there is an urgent need to uncover more mechanisms to guide the development of novel therapeutic strategies. Adenosine triphosphate (ATP) plays an important role in maintaining ion gradients essential for neuronal activities, as well as in the transport and release of neurotransmitters...
February 2024: CNS Neuroscience & Therapeutics
https://read.qxmd.com/read/38367178/the-impact-of-purine-nucleosides-on-neuroplasticity-in-the-adult-brain
#9
REVIEW
Beatriz Dos Santos, Tetsade Piermartiri, Carla I Tasca
Neuroplasticity refers to the nervous system's ability to adapt and reorganize its cell structures and neuronal networks in response to internal and external stimuli. In adults, this process involves neurogenesis, synaptogenesis, and synaptic and neurochemical plasticity. Several studies have reported the significant impact of the purinergic system on neuroplasticity modulation. And, there is considerable evidence supporting the role of purine nucleosides, such as adenosine, inosine, and guanosine, in this process...
February 17, 2024: Purinergic Signalling
https://read.qxmd.com/read/38363476/hematopoiesis-revolves-around-the-primordial-evolutional-rhythm-of-purinergic-signaling-and-innate-immunity-a-journey-to-the-developmental-roots
#10
JOURNAL ARTICLE
Mariusz Z Ratajczak, Kamila Bujko, Katarzyna Brzezniakiewicz-Janus, Janina Ratajczak, Magdalena Kucia
A cell's most significant existential task is to survive by ensuring proper metabolism, avoiding harmful stimuli, and adapting to changing environments. It explains why early evolutionary primordial signals and pathways remained active and regulate cell and tissue integrity. This requires energy supply and a balanced redox state. To meet these requirements, the universal intracellular energy transporter purine nucleotide-adenosine triphosphate (ATP) became an important signaling molecule and precursor of purinergic signaling after being released into extracellular space...
February 16, 2024: Stem cell reviews and reports
https://read.qxmd.com/read/38329708/targeting-adenosine-a-2a-receptors-for-early-intervention-of-retinopathy-of-prematurity
#11
REVIEW
Xuhao Chen, Xiaoting Sun, Yuanyuan Ge, Xuzhao Zhou, Jiang-Fan Chen
Retinopathy of prematurity (ROP) continues to pose a significant threat to the vision of numerous children worldwide, primarily owing to the increased survival rates of premature infants. The pathologies of ROP are mainly linked to impaired vascularization as a result of hyperoxia, leading to subsequent neovascularization. Existing treatments, including anti-vascular endothelial growth factor (VEGF) therapies, have thus far been limited to addressing pathological angiogenesis at advanced ROP stages, inevitably leading to adverse side effects...
February 8, 2024: Purinergic Signalling
https://read.qxmd.com/read/38310082/recent-progress-in-understanding-the-intracellular-domain-s-gating-and-functional-roles-in-trimeric-ligand-gated-ion-channels
#12
JOURNAL ARTICLE
Yan Lu, Yi Yu Lin, Jin Wang
Ligand-gated ion channels are a large category of essential ion channels, whose superfamily members may modulate their state by binding to specific ligands, allowing specific ions to pass through the cell membrane. Purinergic ligand- gated ion channel(P2X)and ASIC (acid-sensitive ion channel) are representative members of trimeric ligand-gated ion channels. Recent studies have shown that structural differences in the intracellular domain of P2X receptors (P2XR) may determine the desensitization process. The lateral fenestrations of P2XR potentially serve as a pathway for ion conduction and play a decisive role in ion selectivity...
February 2, 2024: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://read.qxmd.com/read/38246970/molecular-insights-into-p2x-signalling-cascades-in-acute-kidney-injury
#13
REVIEW
Swati Mishra, Vishwadeep Shelke, Neha Dagar, Maciej Lech, Anil Bhanudas Gaikwad
Acute kidney injury (AKI) is a critical health issue with high mortality and morbidity rates in hospitalized individuals. The complex pathophysiology and underlying health conditions further complicate AKI management. Growing evidence suggests the pivotal role of ion channels in AKI progression, through promoting tubular cell death and altering immune cell functions. Among these channels, P2X purinergic receptors emerge as key players in AKI pathophysiology. P2X receptors gated by adenosine triphosphate (ATP), exhibit increased extracellular levels of ATP during AKI episodes...
January 22, 2024: Purinergic Signalling
https://read.qxmd.com/read/38211839/how-is-the-p2x7-receptor-signaling-pathway-involved-in-epileptogenesis
#14
REVIEW
Caichuan Wei, Miaoying Fu, Haiju Zhang, Baozhen Yao
Epilepsy, a condition characterized by spontaneous recurrent epileptic seizures, is among the most prevalent neurological disorders. This disorder is estimated to affect approximately 70 million people worldwide. Although antiseizure medications are considered the first-line treatments for epilepsy, most of the available antiepileptic drugs are not effective in nearly one-third of patients. This calls for the development of more effective drugs. Evidence from animal models and epilepsy patients suggests that strategies that interfere with the P2X7 receptor by binding to adenosine triphosphate (ATP) are potential treatments for this patient population...
January 9, 2024: Neurochemistry International
https://read.qxmd.com/read/38153366/update-on-vascular-control-of-central-chemoreceptors
#15
REVIEW
Thiago S Moreira, Daniel K Mulkey, Ana C Takakura
At least four mechanisms have been proposed to elucidate how neurons in the retrotrapezoid (RTN) region sense changes in CO2 /H+ to regulate breathing (i.e., function as respiratory chemosensors). These mechanisms include: (1) intrinsic neuronal sensitivity to H+ mediated by TASK-2 and GPR4; (2) paracrine activation of RTN neurons by CO2 -responsive astrocytes (via a purinergic mechanism); (3) enhanced excitatory synaptic input or disinhibition; and (4) CO2 -induced vascular contraction. Although blood flow can influence tissue CO2 /H+ levels, there is limited understanding of how control of vascular tone in central CO2 chemosensitive regions might contribute to respiratory output...
December 28, 2023: Experimental Physiology
https://read.qxmd.com/read/38103231/resident-immune-responses-to-spinal-cord-injury-role-of-astrocytes-and-microglia
#16
JOURNAL ARTICLE
Sydney Brockie, Cindy Zhou, Michael G Fehlings
Spinal cord injury can be traumatic or non-traumatic in origin, with the latter rising in incidence and prevalence with the aging demographics of our society. Moreover, as the global population ages, individuals with co-existent degenerative spinal pathology comprise a growing number of traumatic spinal cord injury cases, especially involving the cervical spinal cord. This makes recovery and treatment approaches particularly challenging as age and comorbidities may limit regenerative capacity. For these reasons, it is critical to better understand the complex milieu of spinal cord injury lesion pathobiology and the ensuing inflammatory response...
August 1, 2024: Neural Regeneration Research
https://read.qxmd.com/read/38069224/energy-regulation-in-inflammatory-sarcopenia-by-the-purinergic-system
#17
REVIEW
Miguel Marco-Bonilla, Maria Fresnadillo, Raquel Largo, Gabriel Herrero-Beaumont, Aránzazu Mediero
The purinergic system has a dual role: the maintenance of energy balance and signaling within cells. Adenosine and adenosine triphosphate (ATP) are essential for maintaining these functions. Sarcopenia is characterized by alterations in the control of energy and signaling in favor of catabolic pathways. This review details the association between the purinergic system and muscle and adipose tissue homeostasis, discussing recent findings in the involvement of purinergic receptors in muscle wasting and advances in the use of the purinergic system as a novel therapeutic target in the management of sarcopenia...
November 29, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38068897/ion-channel-disturbances-in-migraine-headache-exploring-the-potential-role-of-the-kynurenine-system-in-the-context-of-the-trigeminovascular-system
#18
REVIEW
Eleonóra Spekker, Gábor Nagy-Grócz, László Vécsei
Migraine is a primary headache disorder, which is an enormous burden to the healthcare system. While some aspects of the pathomechanism of migraines remain unknown, the most accepted theory is that activation and sensitization of the trigeminovascular system are essential during migraine attacks. In recent decades, it has been suggested that ion channels may be important participants in the pathogenesis of migraine. Numerous ion channels are expressed in the peripheral and central nervous systems, including the trigeminovascular system, affecting neuron excitability, synaptic energy homeostasis, inflammatory signaling, and pain sensation...
November 21, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/38052270/purinergic-p2x7-receptor-as-a-potential-therapeutic-target-in-depression
#19
REVIEW
Wang Qi, Xiang Jin, Wei Guan
The elaborate mechanisms of depression have always been a research hotspot in recent years, and the pace of research has never ceased. The P2X7 receptor (P2X7R) belongs to one of the adenosine triphosphates (ATP)-gated cation channels that exist widely in brain tissues and play a prominent role in the regulation of depression-related pathology. To date, the role of purinergic P2X7R in the mechanisms underlying depression is not fully understood. In this review, we conclude that the purinergic receptor P2X7 is a potential therapeutic target for depression based on research results published over the past 5 years in Google Scholar and the National Library of Medicine (PubMed)...
December 3, 2023: Biochemical Pharmacology
https://read.qxmd.com/read/38038801/purinergic-signaling-in-the-battlefield-of-viral-infections
#20
REVIEW
Nayara Carvalho-Barbosa, Julianna Dias Zeidler, Luiz Eduardo Baggio Savio, Robson Coutinho-Silva
Purinergic signaling has been associated with immune defenses against pathogens such as bacteria, protozoa, fungi, and viruses, acting as a sentinel system that signals to the cells when a threat is present. This review focuses on the roles of purinergic signaling and its therapeutic potential for viral infections. In this context, the purinergic system may play potent antiviral roles by boosting interferon signaling. In other cases, though, it can contribute to a hyperinflammatory response and disease severity, resulting in poor outcomes, such as during flu and potentially COVID-19...
December 1, 2023: Purinergic Signalling
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