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https://www.readbyqxmd.com/read/27873388/effects-of-sildenafil-on-cardiac-structure-and-function-cardiopulmonary-exercise-testing-and-health-related-quality-of-life-measures-in-heart-failure-patients-with-preserved-ejection-fraction-and-pulmonary-hypertension
#1
Licette C Y Liu, Yoran M Hummel, Peter van der Meer, Rolf M F Berger, Kevin Damman, Dirk J van Veldhuisen, Adriaan A Voors, Elke S Hoendermis
AIMS: We recently showed that sildenafil did not improve pulmonary pressures and exercise capacity in a cohort of patients with heart failure and preserved ejection fraction (HFpEF) and predominantly postcapillary pulmonary hypertension. Here, we present the effects of sildenafil on cardiac structure and function, cardiopulmonary exercise testing, laboratory parameters and health-related quality of life measures. METHODS AND RESULTS: Fifty-two HFpEF patients with pulmonary hypertension (mean pulmonary artery pressure >25 mmHg; pulmonary artery wedge pressure >15 mmHg) were randomized to sildenafil 60 mg three times a day or placebo and treated for 12 weeks...
November 21, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27823598/serum-potassium-levels-and-outcome-in-acute-heart-failure-data-from-the-protect-and-coach-trials
#2
Jasper Tromp, Jozine M Ter Maaten, Kevin Damman, Christopher M O'Connor, Marco Metra, Howard C Dittrich, Piotr Ponikowski, John R Teerlink, Gad Cotter, Beth Davison, John G F Cleland, Michael M Givertz, Daniel M Bloomfield, Martje H L van der Wal, Tiny Jaarsma, Dirk J van Veldhuisen, Hans L Hillege, Adriaan A Voors, Peter van der Meer
Serum potassium is routinely measured at admission for acute heart failure (AHF), but information on association with clinical variables and prognosis is limited. Potassium measurements at admission were available in 1,867 patients with AHF in the original cohort of 2,033 patients included in the Patients Hospitalized with acute heart failure and Volume Overload to Assess Treatment Effect on Congestion and Renal FuncTion trial. Patients were grouped according to low potassium (<3.5 mEq/l), normal potassium (3...
October 8, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27663098/clinical-correlates-and-prognostic-value-of-pro-enkephalin-in-acute-and-chronic-heart-failure
#3
Yuya Matsue, Jozine M Ter Maaten, Joachim Struck, Marco Metra, Christopher M O'Connor, Piotr Ponikowski, John R Teerlink, Gad Cotter, Beth Davison, John G Cleland, Michael M Givertz, Daniel M Bloomfield, Howard C Dittrich, Dirk J van Veldhuisen, Peter van der Meer, Kevin Damman, Adriaan A Voors
BACKGROUND: Proenkephalin (pro-ENK) has emerged as a novel biomarker associated with both renal function and cardiac function. However, its clinical and prognostic value have not been well evaluated in symptomatic patients with heart failure. METHODS AND RESULTS: The association between pro-ENK and markers of renal function was evaluated in 95 patients with chronic heart failure who underwent renal hemodynamic measurements including renal blood flow (RBF) and glomerular filtration rate (GFR) using(131)I-Hippuran and (125)I-Iothalamate clearances, respectively...
September 20, 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27658757/blood-urea-nitrogen-to-creatinine-ratio-in-the-general-population-and-in-patients-with-acute-heart-failure
#4
Yuya Matsue, Peter van der Meer, Kevin Damman, Marco Metra, Christopher M O'Connor, Piotr Ponikowski, John R Teerlink, Gad Cotter, Beth Davison, John G Cleland, Michael M Givertz, Daniel M Bloomfield, Howard C Dittrich, Ron T Gansevoort, Stephan J L Bakker, Pim van der Harst, Hans L Hillege, Dirk J van Veldhuisen, Adriaan A Voors
OBJECTIVE: The blood urea nitrogen-to-creatinine (BUN/creatinine) ratio has been proposed as a useful parameter in acute heart failure (AHF), but data on the normal range and the added value of the ratio compared with its separate components in patients with AHF are lacking. The aim of this study is to define the normal range of BUN/creatinine ratio and to investigate its clinical significance in patients with AHF. METHODS: In 4484 subjects from the general population without cardiovascular comorbidities, we calculated age-specific and sex-specific normal values of the BUN/creatinine ratio, deriving a higher and lower than normal range of BUN/creatinine ratio (exceeding the 95% prediction intervals)...
September 22, 2016: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/27638233/progression-of-renal-impairment-and-chronic-kidney-disease-in-chronic-heart-failure
#5
Kevin Damman, Serge Masson, Donata Lucci, Marco Gorini, Renato Urso, Aldo P Maggioni, Luigi Tavazzi, Luigi Tarantini, Gianni Tognoni, Adriaan Voors, Roberto Latini
BACKGROUND: Data on the natural change in renal function in patients with chronic heart failure (HF) is limited. METHODS AND RESULTS: Estimated glomerular filtration rate (eGFR) was assessed over 36 months in 6934 patients included in the GISSI-HF study. Association between baseline, changes in renal function and occurrence of Cardiovascular Death or HF hospitalization was assessed. Mean age was 67 years, mainly males (78%) and mean eGFR was 68 mL/min/1.73m(2). Change in eGFR in the first year was -1...
September 13, 2016: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/27507112/hypochloremia-diuretic-resistance-and-outcome-in-patients-with-acute-heart-failure
#6
Jozine M Ter Maaten, Kevin Damman, Jennifer S Hanberg, Michael M Givertz, Marco Metra, Christopher M O'Connor, John R Teerlink, Piotr Ponikowski, Gad Cotter, Beth Davison, John G Cleland, Daniel M Bloomfield, Hans L Hillege, Dirk J van Veldhuisen, Adriaan A Voors, Jeffrey M Testani
BACKGROUND: Chloride plays a role in renal salt sensing, neurohormonal activation, and regulation of diuretic targets, and hypochloremia predicts mortality in acute heart failure (AHF). AHF therapies, such as diuretics, alter chloride homeostasis. We studied the association between (changes in) chloride levels and diuretic responsiveness, decongestion, and mortality in patients with AHF. METHODS AND RESULTS: Patients hospitalized for AHF in the PROTECT trial (n=2033) with serum chloride levels within 24 hours of admission and 14 days later were studied (n=1960)...
August 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/27427441/worsening-renal-function-and-outcome-in-heart-failure-patients-with-reduced-and-preserved-ejection-fraction-and-the-impact-of-angiotensin-receptor-blocker-treatment-data-from-the-charm-study-programme
#7
Kevin Damman, Scott D Solomon, Marc A Pfeffer, Karl Swedberg, Salim Yusuf, James B Young, Jean L Rouleau, Christopher B Granger, John J V McMurray
AIMS: We investigated the association between worsening renal function (WRF) that occurs during renin-angiotensin-aldosterone system inhibition initation and outcome in heart failure (HF) patients with preserved ejection fraction (HFPEF) and compared this with HF patients with reduced ejection fraction (HFREF). METHODS AND RESULTS: We examined changes in estimated glomerular filtration rate (GFR) and the relationship between WRF (defined as ≥26.5 µmol/L and ≥25% increase in serum creatinine from baseline to 6 weeks) and outcome, according to randomized treatment, in patients with HFREF (EF <45%; n = 1569) and HFPEF (EF ≥45%; n = 836) in the CHARM programme...
December 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27266853/combining-diuretic-response-and-hemoconcentration-to-predict-rehospitalization-after-admission-for-acute-heart-failure
#8
Jozine M Ter Maaten, Mattia A E Valente, Kevin Damman, John G Cleland, Michael M Givertz, Marco Metra, Christopher M O'Connor, John R Teerlink, Piotr Ponikowski, Daniel M Bloomfield, Gadi Cotter, Beth Davison, Haris Subacius, Dirk J van Veldhuisen, Peter van der Meer, Hans L Hillege, Mihai Gheorghiade, Adriaan A Voors
BACKGROUND: Both diuretic response and hemoconcentration are indicators of decongestion and have individually been found to predict rehospitalization after admission for acute heart failure (HF). This study examines the value of combining diuretic response and hemoconcentration to better predict patients at low risk for rehospitalization after admission for acute HF. METHODS AND RESULTS: Diuretic response (defined as weight change per 40 mg of furosemide on day 4 after admission) and hemoconcentration (change in hemoglobin at discharge or day 7) were tested both individually and combined to predict the risk of HF and cardiovascular rehospitalization 60 days after hospitalization for acute HF...
June 2016: Circulation. Heart Failure
https://www.readbyqxmd.com/read/26861140/connecting-heart-failure-with-preserved-ejection-fraction-and-renal-dysfunction-the-role-of-endothelial-dysfunction-and-inflammation
#9
REVIEW
Jozine M Ter Maaten, Kevin Damman, Marianne C Verhaar, Walter J Paulus, Dirk J Duncker, Caroline Cheng, Loek van Heerebeek, Hans L Hillege, Carolyn S P Lam, Gerjan Navis, Adriaan A Voors
Renal dysfunction in heart failure with preserved ejection fraction (HFpEF) is common and is associated with increased mortality. Impaired renal function is also a risk factor for developing HFpEF. A new paradigm for HFpEF, proposing a sequence of events leading to myocardial remodelling and dysfunction in HFpEF, was recently introduced, involving inflammatory, microvascular, and cardiac components. The kidney might play a key role in this systemic process. Renal impairment causes metabolic and systemic derangements in circulating factors, causing an activated systemic inflammatory state and endothelial dysfunction, which may lead to cardiomyocyte stiffening, hypertrophy, and interstitial fibrosis via cross-talk between the endothelium and cardiomyocyte compartments...
June 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/26693947/loop-diuretics-renal-function-and-clinical-outcome-in-patients-with-heart-failure-and-reduced-ejection-fraction
#10
Kevin Damman, John Kjekshus, John Wikstrand, John G F Cleland, Michel Komajda, Hans Wedel, Finn Waagstein, John J V McMurray
AIM: We aimed to study the relationships of loop diuretic dose with renal function and clinical outcomes in patients with chronic heart failure (HF). METHODS AND RESULTS: Loop diuretic dose at baseline was recorded in patients included in the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA). The relationship to change in estimated glomerular filtration rate (eGFR) over time and to the first occurrence of the composite outcome of cardiovascular (CV) death or hospitalization owing to HF was examined in propensity score matched cohorts...
March 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/26543046/biomarkers-of-renal-injury-and-function-diagnostic-prognostic-and-therapeutic-implications-in-heart-failure
#11
REVIEW
Dirk J van Veldhuisen, Luis M Ruilope, Alan S Maisel, Kevin Damman
Heart failure guidelines suggest evaluating renal function as a routine work-up in every patient with heart failure. Specifically, it is advised to calculate glomerular filtration rate and determine blood urea nitrogen. The reason for this is that renal impairment and worsening renal function (WRF) are common in heart failure, and strongly associate with poor outcome. Renal function, however, consists of more than glomerular filtration alone, and includes tubulointerstitial damage and albuminuria. For each of these renal entities, different biomarkers exist that have been investigated in heart failure...
September 1, 2016: European Heart Journal
https://www.readbyqxmd.com/read/26511274/plasma-kidney-injury-molecule-1-in-heart-failure-renal-mechanisms-and-clinical-outcome
#12
Johanna E Emmens, Jozine M Ter Maaten, Yuya Matsue, Marco Metra, Christopher M O'Connor, Piotr Ponikowski, John R Teerlink, Gad Cotter, Beth Davison, John G Cleland, Michael M Givertz, Daniel M Bloomfield, Howard C Dittrich, John Todd, Dirk J van Veldhuisen, Hans L Hillege, Kevin Damman, Peter van der Meer, Adriaan A Voors
AIMS: Urinary kidney injury molecule-1 (KIM-1) is a marker of tubular damage and associated with worse outcome in heart failure (HF). Plasma KIM-1 has not been described in HF. METHODS AND RESULTS: In a renal mechanistic cohort of 120 chronic HF patients, we established the association between plasma KIM-1, renal invasive haemodynamic parameters {renal blood flow ([(131) I]hippuran clearance) and measured glomerular filtration rate (GFR; [(125) I]iothalamate)} and urinary tubular damage markers...
June 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/26482378/effect-of-metformin-on-renal-function-after-primary-percutaneous-coronary-intervention-in-patients-without-diabetes-presenting-with-st-elevation-myocardial-infarction-data-from-the-gips-iii-trial
#13
Rene A Posma, Chris P H Lexis, Erik Lipsic, Maarten W N Nijsten, Kevin Damman, Daan J Touw, Dirk Jan van Veldhuisen, Pim van der Harst, Iwan C C van der Horst
PURPOSE: The association between metformin use and renal function needs further to be elucidated since data are insufficient whether metformin affects renal function in higher risk populations such as after ST-elevation myocardial infarction (STEMI). METHODS: We studied 379 patients included in the GIPS-III trial in which patients without diabetes or renal dysfunction, who underwent primary percutaneous coronary interventions (PCI) for STEMI, were randomized to metformin 500 mg or placebo twice daily for four months...
October 2015: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/26299229/diuretic-response-in-acute-heart-failure-an-analysis-from-ascend-hf
#14
RANDOMIZED CONTROLLED TRIAL
Jozine M ter Maaten, Allison M Dunning, Mattia A E Valente, Kevin Damman, Justin A Ezekowitz, Robert M Califf, Randall C Starling, Peter van der Meer, Christopher M O'Connor, Phillip J Schulte, Jeffrey M Testani, Adrian F Hernandez, W H Wilson Tang, Adriaan A Voors
BACKGROUND: Diuretic unresponsiveness often occurs during hospital admission for acute heart failure (AHF) and is associated with adverse outcome. This study aims to investigate determinants, clinical outcome, and the effects of nesiritide on diuretic response early after admission for AHF. METHODS: Diuretic response, defined as weight loss per 40 mg of furosemide or equivalent, was examined from hospital admission to 48 hours in 4,379 patients from the ASCEND-HF trial...
August 2015: American Heart Journal
https://www.readbyqxmd.com/read/26280875/a-combined-clinical-and-biomarker-approach-to-predict-diuretic-response-in-acute-heart-failure
#15
MULTICENTER STUDY
Jozine M ter Maaten, Mattia A E Valente, Marco Metra, Noemi Bruno, Christopher M O'Connor, Piotr Ponikowski, John R Teerlink, Gad Cotter, Beth Davison, John G Cleland, Michael M Givertz, Daniel M Bloomfield, Howard C Dittrich, Dirk J van Veldhuisen, Hans L Hillege, Kevin Damman, Adriaan A Voors
BACKGROUND: Poor diuretic response in acute heart failure is related to poor clinical outcome. The underlying mechanisms and pathophysiology behind diuretic resistance are incompletely understood. We evaluated a combined approach using clinical characteristics and biomarkers to predict diuretic response in acute heart failure (AHF). METHODS AND RESULTS: We investigated explanatory and predictive models for diuretic response--weight loss at day 4 per 40 mg of furosemide--in 974 patients with AHF included in the PROTECT trial...
February 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/26123828/long-term-changes-in-renal-function-and-perfusion-in-heart-failure-patients-with-reduced-ejection-fraction
#16
Nicolas F Schroten, Kevin Damman, Mattia A E Valente, Tom D Smilde, Dirk J van Veldhuisen, Gerjan Navis, Carlo A Gaillard, Adriaan A Voors, Hans L Hillege
INTRODUCTION: Little is known about the natural course of renal function and renal hemodynamics in heart failure patients with reduced ejection fraction (HFREF). METHODS AND RESULTS: We prospectively studied effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) in 73 HFREF patients with (125)I-iothalamate/(131)I-hippuran clearances with a mean follow-up of 34.6 ± 4.4 months. Fifteen percent were female, with age 58 ± 12 years and left ventricular ejection fraction (LVEF) 29 ± 10%...
January 2016: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/26071975/%C3%AE-blocker-therapy-is-not-associated-with-reductions-in-angina-or-cardiovascular-events-after-coronary-artery-bypass-graft-surgery-insights-from-the-imagine-trial
#17
RANDOMIZED CONTROLLED TRIAL
Harmen G Booij, Kevin Damman, J Wayne Warnica, Jean L Rouleau, Wiek H van Gilst, B Daan Westenbrink
PURPOSE: To evaluate whether β-blockers were associated with a reduction in cardiovascular events or angina after Coronary Artery Bypass Graft (CABG) surgery, in otherwise stable low-risk patients during a mid-term follow-up. METHODS: We performed a post-hoc analysis of the IMAGINE (Ischemia Management with Accupril post-bypass Graft via Inhibition of angiotensin coNverting Enzyme) trial, which tested the effect of Quinapril in 2553 hemodynamically stable patients with left ventricular ejection fraction (LVEF) >40 %, after scheduled CABG...
June 2015: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/25999021/recommendations-on-pre-hospital-early-hospital-management-of-acute-heart-failure-a-consensus-paper-from-the-heart-failure-association-of-the-european-society-of-cardiology-the-european-society-of-emergency-medicine-and-the-society-of-academic-emergency-medicine
#18
REVIEW
Alexandre Mebazaa, M Birhan Yilmaz, Phillip Levy, Piotr Ponikowski, W Frank Peacock, Said Laribi, Arsen D Ristic, Ekaterini Lambrinou, Josep Masip, Jillian P Riley, Theresa McDonagh, Christian Mueller, Christopher deFilippi, Veli-Pekka Harjola, Holger Thiele, Massimo F Piepoli, Marco Metra, Aldo Maggioni, John McMurray, Kenneth Dickstein, Kevin Damman, Petar M Seferovic, Frank Ruschitzka, Adelino F Leite-Moreira, Abdelouahab Bellou, Stefan D Anker, Gerasimos Filippatos
Acute heart failure is a fatal syndrome. Emergency physicians, cardiologists, intensivists, nurses and other health care providers have to cooperate to provide optimal benefit. However, many treatment decisions are opinion-based and few are evidenced-based. This consensus paper provides guidance to practicing physicians and nurses to manage acute heart failure in the pre-hospital and hospital setting. Criteria of hospitalization and of discharge are described. Gaps in knowledge and perspectives in the management of acute heart failure are also detailed...
June 2015: European Journal of Heart Failure
https://www.readbyqxmd.com/read/25998514/recommendations-on-pre-hospital-and-early-hospital-management-of-acute-heart-failure-a-consensus-paper-from-the-heart-failure-association-of-the-european-society-of-cardiology-the-european-society-of-emergency-medicine-and-the-society-of-academic-emergency
#19
REVIEW
Alexandre Mebazaa, M Birhan Yilmaz, Phillip Levy, Piotr Ponikowski, W Frank Peacock, Said Laribi, Arsen D Ristic, Ekaterini Lambrinou, Josep Masip, Jillian P Riley, Theresa McDonagh, Christian Mueller, Christopher deFilippi, Veli-Pekka Harjola, Holger Thiele, Massimo F Piepoli, Marco Metra, Aldo Maggioni, John J V McMurray, Kenneth Dickstein, Kevin Damman, Petar M Seferovic, Frank Ruschitzka, Adelino F Leite-Moreira, Abdelouahab Bellou, Stefan D Anker, Gerasimos Filippatos
No abstract text is available yet for this article.
August 7, 2015: European Heart Journal
https://www.readbyqxmd.com/read/25965717/effect-of-additive-renin-inhibition-with-aliskiren-on-renal-blood-flow-in-patients-with-chronic-heart-failure-and-renal-dysfunction-additive-renin-inhibition-with-aliskiren-on-renal-blood-flow-and-neurohormonal-activation-in-patients-with-chronic-heart-failure
#20
RANDOMIZED CONTROLLED TRIAL
Nicolas F Schroten, Kevin Damman, Marc H Hemmelder, Adriaan A Voors, Gerjan Navis, Carlo A J M Gaillard, Dirk J van Veldhuisen, Wiek H Van Gilst, Hans L Hillege
AIMS: We examined the effect of the renin inhibitor, aliskiren, on renal blood flow (RBF) in patients with heart failure with reduced ejection fraction (HFREF) and decreased glomerular filtration rate (GFR). Renal blood flow is the main determinant of GFR in HFREF patients. Both reduced GFR and RBF are associated with increased mortality. Aliskiren can provide additional renin-angiotensin-aldosterone system inhibition and increases RBF in healthy individuals. METHODS AND RESULTS: Patients with left ventricular ejection fraction ≤45% and estimated GFR 30 to 75 mL/min per 1...
May 2015: American Heart Journal
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