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early and late neonatal death

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https://www.readbyqxmd.com/read/28329313/single-coronary-artery-and-neonatal-arterial-switch-operation-early-and-long-term-outcomes%C3%A2
#1
Sébastien Gerelli, Margaux Pontailler, Bruno Rochas, Emanuela Angeli, Mathieu Van Steenberghe, Damien Bonnet, Pascal Vouhé, Olivier Raisky
OBJECTIVES: The presence of single coronary artery (CA) in the arterial switch operation (ASO) for neonatal treatment with transposition of the great arteries (TGA) has been reported to be an independent risk factor for early death after surgical repair and late reintervention. The study objective was to evaluate the mortality and the CA stenosis risk at early and long term in neonatal ASO for TGA and single CA. METHODS: Between January 1987 and January 2010, 979 neonates underwent an ASO, of which 73 had a single CA (7...
March 7, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28321847/antenatal-corticosteroids-for-accelerating-fetal-lung-maturation-for-women-at-risk-of-preterm-birth
#2
REVIEW
Devender Roberts, Julie Brown, Nancy Medley, Stuart R Dalziel
BACKGROUND: Respiratory morbidity including respiratory distress syndrome (RDS) is a serious complication of preterm birth and the primary cause of early neonatal mortality and disability. While researching the effects of the steroid dexamethasone on premature parturition in fetal sheep in 1969, Liggins found that there was some inflation of the lungs of lambs born at gestations at which the lungs would be expected to be airless. Liggins and Howie published the first randomised controlled trial in humans in 1972 and many others followed...
March 21, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28302241/neonatal-appendicitis-as-a-rare-cause-of-intestinal-perforation-in-a-preterm-neonate
#3
Seda Yilmaz Semerci, Dilek Kurnaz, Aslan Babayigit, Burcu Cebeci, Gokhan Buyukkale, Merih Cetinkaya, Unal Guvenc, Ozge Kucur
Intestinal perforation or inflammation due to appendicitis is rarely encountered in the neonatal period. The diagnosis may be delayed due to the lack of specific clinical symptoms and its rarity in this patient population. Early surgical treatment is the main treatment strategy with a good prognosis. However, delayed diagnosis may result in complications and even death. Herein, we describe a late preterm female neonate without any risk factors who had a diagnosis of perforated appendicitis at postnatal day 5...
March 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28277909/late-preterm-and-early-term-when-to-induce-a-growth-restricted-fetus-a-population-based-study
#4
Alex Rabinovich, Tehila Tsemach, Lena Novack, Moshe Mazor, Tal Rafaeli-Yehudai, Orna Staretz-Chacham, Ruth Beer Weisel, Vered Klaitman-Mayer, Salvatore A Mastrolia, Offer Erez
PURPOSE: 1) Compare fetal and neonatal morbidity and mortality associated with induction of labor (IOL) vs. expectant management (EM) in women with isolated fetal growth restriction (FGR) between [Formula: see text] - [Formula: see text] weeks; 2) Determine optimal gestational age for delivery of such fetuses. MATERIALS AND METHODS: A retrospective population based cohort study of 2232 parturients with isolated FGR, including two groups: 1) IOL (n = 1428); 2) EM (n= 804)...
March 3, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28241870/trial-of-labour-after-caesarean-section-and-the-risk-of-neonatal-and-infant-death-a-nationwide-cohort-study
#5
Sinéad M O'Neill, Esben Agerbo, Ali S Khashan, Patricia M Kearney, Tine Brink Henriksen, Richard A Greene, Louise C Kenny
BACKGROUND: Caesarean section (CS) rates are increasing worldwide and as a result repeat CS is common. The optimal mode of delivery in women with one previous CS is widely debated and the risks to the infant are understudied. The aim of the current study was to evaluate if women with a trial of labour after caesarean (TOLAC) had an increased odds of neonatal and infant death compared to women with an elective repeat CS (ERCS). METHODS: A population register-based cohort study was conducted in Denmark between 1982 and 2010...
February 27, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28241253/a-quantitative-risk-based-approach-to-the-management-of-neonatal-early-onset-sepsis
#6
Michael W Kuzniewicz, Karen M Puopolo, Allen Fischer, Eileen M Walsh, Sherian Li, Thomas B Newman, Patricia Kipnis, Gabriel J Escobar
Importance: Current algorithms for management of neonatal early-onset sepsis (EOS) result in medical intervention for large numbers of uninfected infants. We developed multivariable prediction models for estimating the risk of EOS among late preterm and term infants based on objective data available at birth and the newborn's clinical status. Objectives: To examine the effect of neonatal EOS risk prediction models on sepsis evaluations and antibiotic use and assess their safety in a large integrated health care system...
February 20, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28151493/surfactant-reduced-the-mortality-of-neonates-with-birth-weight-%C3%A2-1500%C3%A2-g-and-hypoxemic-respiratory-failure-a-survey-from-an-emerging-nicu-network
#7
H Wang, X Gao, C Liu, C Yan, X Lin, Y Dong, B Sun
OBJECTIVE: We evaluated the efficacy of surfactant therapy and assisted ventilation on morbidity and mortality of neonates with birth weight (BW) ⩾1500 g and hypoxemic respiratory failure (HRF). STUDY DESIGN: We retrospectively analyzed 5650 patients with BW ⩾1500 g for incidence, management and outcome of HRF, defined as acute hypoxemia requiring mechanical ventilation and/or nasal continuous positive airway pressure ⩾24 h. The patients were allocated into groups of moderate preterm (1735, 30...
February 2, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28118360/the-world-health-organization-fetal-growth-charts-a-multinational-longitudinal-study-of-ultrasound-biometric-measurements-and-estimated-fetal-weight
#8
Torvid Kiserud, Gilda Piaggio, Guillermo Carroli, Mariana Widmer, José Carvalho, Lisa Neerup Jensen, Daniel Giordano, José Guilherme Cecatti, Hany Abdel Aleem, Sameera A Talegawkar, Alexandra Benachi, Anke Diemert, Antoinette Tshefu Kitoto, Jadsada Thinkhamrop, Pisake Lumbiganon, Ann Tabor, Alka Kriplani, Rogelio Gonzalez Perez, Kurt Hecher, Mark A Hanson, A Metin Gülmezoglu, Lawrence D Platt
BACKGROUND: Perinatal mortality and morbidity continue to be major global health challenges strongly associated with prematurity and reduced fetal growth, an issue of further interest given the mounting evidence that fetal growth in general is linked to degrees of risk of common noncommunicable diseases in adulthood. Against this background, WHO made it a high priority to provide the present fetal growth charts for estimated fetal weight (EFW) and common ultrasound biometric measurements intended for worldwide use...
January 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28078861/interleukin-6-and-interleukin-8-in-diagnosing-neonatal-septicemia
#9
LETTER
Y Q Wu, J Shen, Q L Zhou, H W Zhao, L R Liu, X Liu
Neonatal septicemia (NS) is a common cause of death of newborn infants, hence early diagnosis and treatment are of the utmost importance. However, lack of specific clinical symptoms and late detection delay a correct diagnosis. It is therefore of great importance to establish auxiliary indexes for the early diagnosis of NS. To evaluate the value of interleukin (IL-6 and IL-8) in the diagnosis of NS, a prospective study was carried out. Seventy-five newborns who developed septicemia and received treatment in our hospital from January 2013 to December 2014 were selected as research subjects; also, 50 healthy newborns were set as a control group...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28077109/cause-of-neonatal-deaths-in-northern-ethiopia-a-prospective-cohort-study
#10
Hayelom Gebrekirstos Mengesha, Berhe W Sahle
BACKGROUND: Despite the significant reduction in childhood mortality, neonatal mortality has shown little or no concomitant decline worldwide. The dilemma arises in that the lack of documentation of cause of death in developing countries, where registration of vital events is virtually nonexistent. Understanding of the causes of death in neonates is important to guide public health interventions. The present study identifies the common causes of neonatal death in Ethiopia. METHODS: A prospective cohort study was conducted among neonates born between April 2014 and July 2014 in seven hospitals, in Tigray region, Ethiopia...
January 11, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28056166/nitric-oxide-for-respiratory-failure-in-infants-born-at-or-near-term
#11
REVIEW
Keith J Barrington, Neil Finer, Thomas Pennaforte, Gabriel Altit
BACKGROUND: Nitric oxide (NO) is a major endogenous regulator of vascular tone. Inhaled nitric oxide (iNO) gas has been investigated as treatment for persistent pulmonary hypertension of the newborn. OBJECTIVES: To determine whether treatment of hypoxaemic term and near-term newborn infants with iNO improves oxygenation and reduces rate of death and use of extracorporeal membrane oxygenation (ECMO), or affects long-term neurodevelopmental outcomes. SEARCH METHODS: We used the standard search strategy of the Cochrane Neonatal Review Group to search the Cochrane Central Register of Controlled Trials (CENTRAL; 2016, Issue 1), MEDLINE via PubMed (1966 to January 2016), Embase (1980 to January 2016) and the Cumulative Index to Nursing and Allied Health Literature (CINAHL; 1982 to January 2016)...
January 5, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27983995/n-terminal-pro-b-type-natriuretic-peptide-and-angiogenic-biomarkers-in-the-prognosis-of-adverse-outcomes-in-women-with-suspected-preeclampsia
#12
Indira Álvarez-Fernández, Belén Prieto, Verónica Rodríguez, Yolanda Ruano, Ana I Escudero, Francisco V Álvarez
BACKGROUND: This study compares the performance of the soluble fms-like tyrosine kinase 1 to placental growth factor (sFlt-1/PlGF) ratio and the cardiac biomarker N-terminal pro-B type natriuretic peptide (NT-proBNP) in the prediction of adverse outcomes in women with suspicion of PE. METHODS: A retrospective cohort study was conducted on women admitted at triage with signs and/or symptoms of PE (n=340). Serum levels of sFlt-1, PlGF and NT-proBNP were determined by an electrochemiluminescence immunoassay (Roche Diagnostics)...
December 1, 2016: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/27941983/underreporting-of-congenital-syphilis-as-a-cause-of-fetal-and-infant-deaths-in-northeastern-brazil
#13
Ana Rita Paulo Cardoso, Maria Alix Leite Araújo, Roumayne Fernandes Vieira Andrade, Valéria Saraceni, Angelica E Miranda, Maria Inês Costa Dourado
INTRODUCTION: Of all syphilis-related pregnancy outcomes, fetal death is certainly the most common one, being directly related to the availability, accessibility and quality of prenatal care. The present study aimed to analyze the underreporting of fetal and infant deaths and other maternal factors associated with congenital syphilis (CS) death. METHODS: This cross-sectional study integrated data of infants that were diagnosed and/or died of CS from the Sistema de Informação de Agravos de Notificação-Sinan (Notifiable Diseases Information System) and the Sistema de Informação de Mortalidade-SIM (Mortality Information System) in Fortaleza, Northeastern Brasil to identify unreported cases of congenital syphilis...
2016: PloS One
https://www.readbyqxmd.com/read/27924107/newborn-healthcare-in-urban-india
#14
REVIEW
J Sharma, D Osrin, B Patil, S B Neogi, M Chauhan, R Khanna, R Kumar, V K Paul, S Zodpey
The rapid population growth in urban India has outpaced the municipal capacity to build essential infrastructures that make life in cities safe and healthy. Local and national governments alike are grappling with the challenges of urbanization with thousands migrating from villages to cities. Thus, urbanization in India has been accompanied by a concentration of poverty and urban public healthcare has emerged as one of the most pressing priorities facing our country. Newborn mortality rates in urban settings are lower than rural areas, early neonatal deaths account for greater proportion than late neonatal deaths...
December 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27924104/state-of-newborn-health-in-india
#15
REVIEW
M J Sankar, S B Neogi, J Sharma, M Chauhan, R Srivastava, P K Prabhakar, A Khera, R Kumar, S Zodpey, V K Paul
About 0.75 million neonates die every year in India, the highest for any country in the world. The neonatal mortality rate (NMR) declined from 52 per 1000 live births in 1990 to 28 per 1000 live births in 2013, but the rate of decline has been slow and lags behind that of infant and under-five child mortality rates. The slower decline has led to increasing contribution of neonatal mortality to infant and under-five mortality. Among neonatal deaths, the rate of decline in early neonatal mortality rate (ENMR) is much lower than that of late NMR...
December 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27922501/an-overview-of-congenital-myopathies
#16
Jean K Mah, Jeffrey T Joseph
PURPOSE OF REVIEW: This article uses a case-based approach to highlight the clinical features as well as recent advances in molecular genetics, muscle imaging, and pathophysiology of the congenital myopathies. RECENT FINDINGS: Congenital myopathies refer to a heterogeneous group of genetic neuromuscular disorders characterized by early-onset muscle weakness, hypotonia, and developmental delay. Congenital myopathies are further classified into core myopathies, centronuclear myopathies, nemaline myopathies, and congenital fiber-type disproportion based on the key pathologic features found in muscle biopsies...
December 2016: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/27894129/isolated-fetal-ascites-neonatal-outcome-in-51-cases-observed-in-a-tertiary-referral-center
#17
Vincenzo Davide Catania, Alessia Muru, Marcella Pellegrino, Erika Adalgisa De Marco, Filomena Valentina Paradiso, Carlo Manzoni, Lorenzo Nanni, Lucia Masini
Introduction Prenatal detection of isolated ascites is a rare finding on ultrasound, usually suggestive of an underlying pathology that may negatively impact on the pregnancy and neonatal outcome. The purpose of the present study was to evaluate the outcome of primary isolated ascites in relation to gestational age (GA) at diagnosis. Materials and Methods Data were prospectively collected for fetuses with ascites that have been followed in our center of prenatal diagnosis and therapy from 2004 to 2014. Patients have been divided in group I when ascites was detected before the 24th week of GA and group II if it was noticed later...
February 2017: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27851719/the-correlation-between-serum-vitamin-d-deficiency-and-preterm-birth
#18
Lixia Yang, Shilei Pan, Yufeng Zhou, Xiaoyang Wang, Aikai Qin, Yuxin Huang, Suxia Sun
BACKGROUND Preterm birth is an important cause of death and developmental disorder in neonates. Vitamin D deficiency has been shown to regulate body inflammatory factor levels that stimulate elevation of uterine contraction hormones, such as prostaglandin, thus causing preterm birth. However, current observations regarding the relationship between vitamin D and preterm birth are inconsistent. We performed a nested case-control study to investigate the effect of vitamin D on preterm birth. MATERIAL AND METHODS A prospective cohort study included 200 cases of pregnant women in our hospital from May 2013 to May 2015...
November 16, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27823995/analysis-of-in-hospital-neonatal-death-in-the-tertiary-neonatal-intensive-care-unit-in-china-a-multicenter-retrospective-study
#19
MULTICENTER STUDY
Chen-Hong Wang, Li-Zhong Du, Xiao-Lu Ma, Li-Ping Shi, Xiao-Mei Tong, Hong Liu, Guo-Fang Ding, Bin Yi, Xin-Nian Pan, Dan-Ni Zhong, Ling Liu, Mei Li, Cui-Qing Liu, Shi-Wen Xia, Hong-Yun Wang, Ling He, Kun Liang, Xiao-Yu Zhou, Shu-Ping Han, Qin Lyu, Yin-Ping Qiu, Ruo-Bing Shan, De-Zhi Mu, Xiao-Hong Liu, Si-Qi Zhuang, Jing Guo, Li Liu, Jia-Jun Zhu, Hong Xiong
BACKGROUND: Globally, the proportion of child deaths that occur in the neonatal period remains a high level of 37-41%. Differences of cause in neonate death exist in different regions as well as in different economic development countries. The specific aim of this study was to investigate the causes, characteristics, and differences of death in neonates during hospitalization in the tertiary Neonatal Intensive Care Unit (NICU) of China. METHODS: All the dead neonates admitted to 26 NICUs were included between January l, 2011, and December 31, 2011...
2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27784756/three-decades-of-inequality-in-neonatal-and-early-childhood-mortality-in-singleton-births-in-scotland
#20
A Kershenbaum, B Fu, R Gilbert
BACKGROUND: Socioeconomic inequality in child mortality highlights opportunities for policies to reduce child deaths. METHODS: We used singleton birth, death and maternity records from Scotland, 1981-2011, to examine mortality rate differences by age across deprivation quintiles over time. We measured the difference between the most and least deprived quintiles (Q5-Q1) and the slope index of inequality (SII) across all quintiles-measures of the absolute deprivation gap, providing an indication of the public health impact...
October 26, 2016: Journal of Public Health
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