keyword
MENU ▼
Read by QxMD icon Read
search

NOD1

keyword
https://www.readbyqxmd.com/read/28901890/dietary-l-arginine-inhibits-intestinal-clostridium-perfringens-colonisation-and-attenuates-intestinal-mucosal-injury-in-broiler-chickens
#1
Beibei Zhang, Zengpeng Lv, Huixian Li, Shuangshuang Guo, Dan Liu, Yuming Guo
We investigated the effects of dietary l-arginine level and feeding duration on the intestinal damage of broilers induced by Clostridium perfringens (CP) in vivo, and the antimicrobial effect of its metabolite nitric oxide (NO) in vitro. The in vivo experiment was designed as a factorial arrangement of three dietary treatments×two challenge statuses. Broilers were fed a basal diet (CON) or a high-arginine diet (ARG) containing 1·87 % l-arginine, or CON for the first 8 d and ARG from days 9 to 28 (CON/ARG)...
September 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28878001/nlr-nod1-signaling-promotes-survival-of-bcr-engaged-mature-b-cells-through-up-regulated-nod1-as-a-positive-outcome
#2
Kyoko Hayakawa, Anthony M Formica, Yan Zhou, Daiju Ichikawa, Masanao Asano, Yue-Sheng Li, Susan A Shinton, Joni Brill-Dashoff, Gabriel Núñez, Richard R Hardy
Although B cell development requires expression of the B cell antigen receptor (BCR), it remains unclear whether engagement of self-antigen provides a positive impact for most B cells. Here, we show that BCR engagement by self-ligand during development in vivo results in up-regulation of the Nod-like receptor member Nod1, which recognizes the products of intestinal commensal bacteria. In anti-thymocyte/Thy-1 autoreactive BCR knock-in mice lacking self-Thy-1 ligand, immunoglobulin light chain editing occurred, generating B cells with up-regulated Nod1, including follicular and marginal zone B cells with natural autoreactivity...
September 6, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28854748/pattern-recognition-receptor-genes-expression-profiling-in-indigenous-chickens-of-india-and-white-leghorn
#3
S Haunshi, Arun Kumar Burramsetty, T R Kannaki, K S Raja Ravindra, R N Chatterjee
Pattern recognition receptors (PRR) such as Toll-like receptors, NOD-like receptors, RIG-I helicase receptors, and C-type lectin receptors play a critical role in innate immunity as a first line of defense against invading pathogens through recognition of pathogen and/or damage-associated molecular patterns. Genetic makeup of birds is known to play a role in resistance or susceptibility to various infectious diseases. Therefore, the present study was carried out to elucidate the differential expression of PRR and some of the cytokine genes in peripheral blood mononuclear cells of indigenous chicken breeds such as Ghagus and Nicobari and an exotic chicken breed, White Leghorn (WLH)...
September 1, 2017: Poultry Science
https://www.readbyqxmd.com/read/28829599/nonpyrogenic-molecular-adjuvants-based-on-norabu-muramyldipeptide-and-norabu-glucosaminyl-muramyldipeptide-synthesis-molecular-mechanisms-of-action-biological-activities-in-vitro-and-in-vivo
#4
Roman Effenberg, Pavlína Turánek Knötigová, Daniel Zyka, Hana Čelechovská, Josef Mašek, Eliška Bartheldyová, Frantisek Hubatka, Štěpán Koudelka, Róbert Lukáč, Anna Kovalová, David Saman, Michal Křupka, Lucia Barkocziová, Petr Kosztyu, Marek Šebela, Ladislav Drož, Michal Hučko, Mária Kanásová, Andrew David Miller, Milan Raška, Miroslav Ledvina, Jaroslav Turanek
Apyrogenic fatty acyl analogues of muramyldipeptide (MDP) (abbreviated N-L18norAbuGMDP, N-B30norAbuGMDP, norAbuMDP-Lys(L18), norAbuMDP-Lys(B30), norAbuGMDP-Lys(L18), norAbuGMDP-Lys(B30), (B30)norAbuMDP, (L18)norAbuMDP) were designed and synthesized comprising the normuramyl-L-α-aminobutanoyl (norAbu) structural moiety. All new analogues show depressed pyrogenicity both as free compounds and in liposomal formulations when tested in vivo in rabbits (s.c. and i.v. application). The potency of analogues in selective activation of NOD2 and NLRP3 (inflammasome) receptors in vitro, but not NOD1, is demonstrated using transgenic cell-based detection systems...
August 22, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28813514/the-helicobacter-pylori-type-iv-secretion-system-promotes-il-8-synthesis-in-a-model-of-pediatric-airway-epithelium-via-p38-map-kinase
#5
Myra G Dela Pena-Ponce, Monica T Jimenez, Lori M Hansen, Jay V Solnick, Lisa A Miller
Epidemiologic studies have reported an inverse relationship between childhood Helicobacter pylori infection and development of allergic asthma. Because lung epithelium plays an important role in allergic asthma pathogenesis, we hypothesized that H. pylori may directly influence airway epithelial cell innate immune function, particularly in early childhood. To test our hypothesis, we established an in vitro H. pylori infection model using primary tracheobronchial epithelial cell cultures derived from infant, juvenile and adult rhesus monkeys...
2017: PloS One
https://www.readbyqxmd.com/read/28811347/tifa-signaling-in-gastric-epithelial-cells-initiates-the-cag-type-4-secretion-system-dependent-innate-immune-response-to-helicobacter-pylori-infection
#6
Alevtina Gall, Ryan G Gaudet, Scott D Gray-Owen, Nina R Salama
Helicobacter pylori is a bacterial pathogen that colonizes the human stomach, causing inflammation which, in some cases, leads to gastric ulcers and cancer. The clinical outcome of infection depends on a complex interplay of bacterial, host genetic, and environmental factors. Although H. pylori is recognized by both the innate and adaptive immune systems, this rarely results in bacterial clearance. Gastric epithelial cells are the first line of defense against H. pylori and alert the immune system to bacterial presence...
August 15, 2017: MBio
https://www.readbyqxmd.com/read/28768269/a-potential-role-for-the-nod1-variant-rs6958571-in-gram-positive-blood-stream-infection-in-elbw-infants
#7
Venkatesh Sampath, Neil Mulrooney, Aloka L Patel, Jonathan Cohen, Liyun Zhang, Jeffery Garland, Pascal M Lavoie, John Dagle, Pippa Simpson
BACKGROUND: The genetic basis of sepsis susceptibility in preterm infants remains understudied. Herein, we investigated the nucleotide binding-oligomerization domain (NOD)-like receptor (NLR) family of immune receptors as putative loci for preterm sepsis susceptibility. OBJECTIVE: To determine whether single nucleotide polymorphisms (SNPs) in NLR genes are associated with blood stream infections (BSI) in premature infants. METHODS: An international cohort of infants with gestational age (GA) <35 weeks were genotyped for SNPs in the ATG16L1, CARD8, NLRP3, NOD2, and NOD1 genes...
August 3, 2017: Neonatology
https://www.readbyqxmd.com/read/28736992/microbiota-metabolome-and-immune-alterations-in-obese-mice-fed-a-high-fat-diet-containing-type-2-resistant-starch
#8
Javad Barouei, Zach Bendiks, Alice Martinic, Darya Mishchuk, Dustin Heeney, Yu-Hsin Hsieh, Dorothy Kieffer, Jose Zaragoza, Roy Martin, Carolyn Slupsky, Maria L Marco
SCOPE: We examined the intestinal and systemic responses to incorporating a type 2 resistant starch (RS) into a high fat diet fed to obese mice. METHODS AND RESULTS: Diet-induced obese, C57BL/6J male mice were fed an HF diet without or with 20% (by weight) high-amylose maize resistant starch (HF-RS) for 6 weeks. Serum adiponectin levels were higher with RS consumption, but there were no differences in weight gain and adiposity. With HF-RS, the expression levels of ileal TLR2 and Reg3g and cecal occludin, TLR2, TLR4, NOD1 and NOD2 were induced; whereas colonic concentrations of the inflammatory cytokine IL-17A declined...
July 24, 2017: Molecular Nutrition & Food Research
https://www.readbyqxmd.com/read/28671993/epithelial-cells-detect-functional-type-iii-secretion-system-of-enteropathogenic-escherichia-coli-through-a-novel-nf-%C3%AE%C2%BAb-signaling-pathway
#9
Yael Litvak, Shir Sharon, Meirav Hyams, Li Zhang, Simi Kobi, Naama Katsowich, Shira Dishon, Gabriel Nussbaum, Na Dong, Feng Shao, Ilan Rosenshine
Enteropathogenic Escherichia coli (EPEC), a common cause of infant diarrhea, is associated with high risk of mortality in developing countries. The primary niche of infecting EPEC is the apical surface of intestinal epithelial cells. EPEC employs a type three secretion system (TTSS) to inject the host cells with dozens of effector proteins, which facilitate attachment to these cells and successful colonization. Here we show that EPEC elicit strong NF-κB activation in infected host cells. Furthermore, the data indicate that active, pore-forming TTSS per se is necessary and sufficient for this NF-κB activation, regardless of any specific effector or protein translocation...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28655577/nod1-is-the-innate-immune-receptor-for-ie-dap-and-can-activate-nf-%C3%AE%C2%BAb-pathway-in-teleost-fish
#10
Dekun Bi, Yunhang Gao, Qing Chu, Junxia Cui, Tianjun Xu
The innate immune system is the first line for organisms defense against microbial infection, and NOD-like receptors (NLRs) protein family is an important member of innate immunity effector molecules. It has been proved that NLRs are located in the endochylema and can senses of microbial products. NOD1 is one of the representatives of this family, it has been proved that in mammals, NOD1 can distinguish a specific muropeptide (G-d-glutamyl-meso-diaminopimelic acid, iE-DAP) which was derived from bacterial peptidoglycans...
June 24, 2017: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/28652394/lack-of-both-nucleotide-binding-oligomerization-domain-containing-proteins-1-and-2-primes-t-cells-for-activation-induced-cell-death
#11
Sashi G Kasimsetty, Alana A Shigeoka, Andrew A Scheinok, Amanda L Gavin, Richard J Ulevitch, Dianne B McKay
Nucleotide-binding oligomerization domain (Nod)-containing proteins Nod1 and Nod2 play important roles in the innate immune response to pathogenic microbes, but mounting data suggest these pattern recognition receptors might also play key roles in adaptive immune responses. Targeting Nod1 and Nod2 signaling pathways in T cells is likely to provide a new strategy to modify inflammation in a variety of disease states, particularly those that depend on Ag-induced T cell activation. To better understand how Nod1 and Nod2 proteins contribute to adaptive immunity, this study investigated their role in alloantigen-induced T cell activation and asked whether their absence might impact in vivo alloresponses using a severe acute graft versus host disease model...
August 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28651476/molecular-mechanisms-of-intrauterine-growth-restriction
#12
Rao Gurugubelli Krishna, B Vishnu Bhat
Intrauterine growth restriction (IUGR) is a pregnancy specific disease characterized by decreased growth rate of fetus than the normal growth potential at particular gestational age. In the current scenario it is a leading cause of fetal and neonatal morbidity and mortality. In the last decade exhilarating experimental studies from several laboratories have provided fascinating proof for comprehension of molecular basis of IUGR. Atypical expression of enzymes governed by TGFβ causes the placental apoptosis and altered expression of TGFβ due to hyper alimentation causes impairment of lung function...
July 10, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28640392/calcineurin-inhibitors-exacerbate-coronary-arteritis-via-the-myd88-signalling-pathway-in-a-murine-model-of-kawasaki-disease
#13
K Murata, Y Motomura, T Tanaka, S Kanno, T Yano, M Onimaru, A Shimoyama, H Nishio, Y Sakai, M Oh-Hora, H Hara, K Fukase, H Takada, S Masuda, S Ohga, S Yamasaki, T Hara
Calcineurin inhibitors (CNIs) have been used off-label for the treatment of refractory Kawasaki disease (KD). However, it remains unknown whether CNIs show protective effects against the development of coronary artery lesions in KD patients. To investigate the effects of CNIs on coronary arteries and the mechanisms of their actions on coronary arteritis in a mouse model of KD, we performed experiments with FK565, a ligand of nucleotide-binding oligomerization domain-containing protein 1 (NOD1) in wild-type, severe combined immunodeficiency (SCID), caspase-associated recruitment domain 9 (CARD9)(-/-) and myeloid differentiation primary response gene 88 (MyD88)(-/-) mice...
October 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28615462/posttranslational-modification-as-a-critical-determinant-of-cytoplasmic-innate-immune-recognition
#14
REVIEW
Paul J Baker, Dominic De Nardo, Fiona Moghaddas, Le Son Tran, Annabell Bachem, Tan Nguyen, Thomas Hayman, Hazel Tye, James E Vince, Sammy Bedoui, Richard L Ferrero, Seth L Masters
Cell surface innate immune receptors can directly detect a variety of extracellular pathogens to which cytoplasmic innate immune sensors are rarely exposed. Instead, within the cytoplasm, the environment is rife with cellular machinery and signaling pathways that are indirectly perturbed by pathogenic microbes to activate intracellular sensors, such as pyrin, NLRP1, NLRP3, or NLRC4. Therefore, subtle changes in key intracellular processes such as phosphorylation, ubiquitination, and other pathways leading to posttranslational protein modification are key determinants of innate immune recognition in the cytoplasm...
July 1, 2017: Physiological Reviews
https://www.readbyqxmd.com/read/28614830/expression-of-tlr2-nod1-and-nod2-and-the-nlrp3-inflammasome-in-renal-tubular-epithelial-cells-of-male-versus-female-mice
#15
Sean E DeWolf, Alana A Shigeoka, Andrew Scheinok, Sashi G Kasimsetty, Alexander K Welch, Dianne B McKay
BACKGROUND: Gender-biased outcomes are associated with acute kidney injury (AKI) and human and animal studies have shown that females are preferentially protected from renal ischemia. However, the reason for this is not known. One clue might lie with pattern recognition receptors (PRRs), which are triggers of ischemic injury when ligated by molecules in the ischemic milieu. Several PRR families are expressed by renal tubular epithelial cells (RTEs) and incite cell death signaling and production of pro-inflammatory molecules...
2017: Nephron
https://www.readbyqxmd.com/read/28611823/genetic-variability-as-a-regulator-of-tlr4-and-nod-signaling-in-response-to-bacterial-driven-dna-damage-response-ddr-and-inflammation-focus-on-the-gastrointestinal-gi-tract
#16
REVIEW
Evagelia Spanou, Polyxeni Kalisperati, Ioannis S Pateras, Alexandros Papalampros, Alexandra Barbouti, Athanasios G Tzioufas, Athanassios Kotsinas, Stavros Sougioultzis
The fundamental role of human Toll-like receptors (TLRs) and NOD-like receptors (NLRs), the two most studied pathogen recognition receptors (PRRs), is the protection against pathogens and excessive tissue injury. Recent evidence supports the association between TLR/NLR gene mutations and susceptibility to inflammatory, autoimmune, and malignant diseases. PRRs also interfere with several cellular processes, such as cell growth, apoptosis, cell proliferation, differentiation, autophagy, angiogenesis, cell motility and migration, and DNA repair mechanisms...
2017: Frontiers in Genetics
https://www.readbyqxmd.com/read/28592872/nod1-deficiency-impairs-cd44a-lck-as-well-as-pi3k-akt-pathway
#17
Yi Wei Hu, Xiao Man Wu, Shi Si Ren, Lu Cao, Pin Nie, Ming Xian Chang
Pattern recognition receptors (PRRs) are crucial for host defense and tissue homeostasis against infecting pathogens. PRRs are highly conserved cross species, suggesting their key roles in fundamental biological processes. Though much have been learned for NOD1 receptor in the innate and adaptive immune responses, the roles of NOD1 during embryonic and larval stages remain poorly understood. Here, we report that NOD1 is necessary for the modulation of PI3K-Akt pathway and larval survival in zebrafish. Transcriptome analysis revealed that the significantly enriched pathways in NOD1 (-/-) zebrafish larvae were mainly involved in metabolism and immune system processes...
June 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28578011/homology-modeling-and-in-silico-prediction-of-ulcerative-colitis-associated-polymorphisms-of-nod1
#18
Ishani Majumdar, Isha Nagpal, Jaishree Paul
Cytosolic pattern recognition receptors play key roles in innate immune response. Nucleotide binding and oligomerisation domain containing protein 1 (NOD1) belonging to the Nod-like receptor C (NLRC) sub-family of Nod-like receptors (NLRs) is important for detection and clearance of intra-cellular Gram negative bacteria. NOD1 is involved in activation of pro-inflammatory pathways. Limited structural data is available for NOD1. Using different templates for each domain of NOD1, we determined the full-length homology model of NOD1...
May 31, 2017: Molecular and Cellular Probes
https://www.readbyqxmd.com/read/28576260/regulation-of-bone-mass-by-the-gut-microbiota-is-dependent-on-nod1-and-nod2-signaling
#19
Claes Ohlsson, Giulia Nigro, Ivo Gomperts Boneca, Fredrik Bäckhed, Philippe Sansonetti, Klara Sjögren
Germ-free (GF) mice have increased bone mass that is normalized by colonization with gut microbiota (GM) from conventionally raised (CONV-R) mice. To determine if innate immune signaling pathways mediated the effect of the GM, we studied the skeleton of GF and CONV-R mice with targeted inactivation of MYD88, NOD1 or NOD2. In contrast to WT and Myd88(-/-) mice, cortical bone thickness in mice lacking Nod1 or Nod2 was not increased under GF conditions. The expression of Tnfα and the osteoclastogenic factor Rankl in bone was reduced in GF compared to CONV-R WT mice but not in Nod1(-/-) or Nod2(-/-) mice indicating that the effect of the GM to increase Tnfα and Rankl in bone and to reduce bone mass is dependent on both NOD1 and NOD2 signaling...
July 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28545134/structures-of-the-inactive-and-active-states-of-rip2-kinase-inform-on-the-mechanism-of-activation
#20
Erika Pellegrini, Luca Signor, Saurabh Singh, Elisabetta Boeri Erba, Stephen Cusack
Innate immune receptors NOD1 and NOD2 are activated by bacterial peptidoglycans leading to recruitment of adaptor kinase RIP2, which, upon phosphorylation and ubiquitination, becomes a scaffold for downstream effectors. The kinase domain (RIP2K) is a pharmaceutical target for inflammatory diseases caused by aberrant NOD2-RIP2 signalling. Although structures of active RIP2K in complex with inhibitors have been reported, the mechanism of RIP2K activation remains to be elucidated. Here we analyse RIP2K activation by combining crystal structures of the active and inactive states with mass spectrometric characterization of their phosphorylation profiles...
2017: PloS One
keyword
keyword
111552
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"