keyword
MENU ▼
Read by QxMD icon Read
search

NOD1

keyword
https://www.readbyqxmd.com/read/27917621/association-of-nucleotide-binding-oligomerization-domain-receptors-with-peptic-ulcer-and-gastric-cancer
#1
Rajeeh Mohammadian Amiri, Mohsen Tehrani, Shirin Taghizadeh, Javad Shokri-Shirvani, Hafez Fakheri, Abolghasem Ajami
Host innate immunity can affect the clinical outcomes of Helicobacter pylori infection, including gastritis, gastric ulcer, gastric adenocarcinoma, and MALT lymphoma. Nucleotide binding oligomerization domain (NOD)-1 and -2 are two molecules of innate immunity which are involved in the host defense against H. pylori. This study aimed to evaluate the effect of the expression level of NOD1 and NOD2 on the susceptibility to gastric cancer as well as peptic ulcer in individuals with H. pylori infection. The gene expression levels of these molecules were compared in three groups of non-ulcer dyspepsia (NUD) as a control group (n=52); peptic ulcer disease (PUD), (n=53); and gastric cancer (GC), (n=39)...
October 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27893720/a-functional-atg16l1-t300a-variant-is-associated-with-necrotizing-enterocolitis-in-premature-infants
#2
Venkatesh Sampath, Vineet Bhandari, Jessica Berger, Daniel Merchant, Liyun Zhang, Mihoko Ladd, Heather Menden, Jeffery Garland, Namasivayam Ambalavanan, Neil Mulrooney, Michael Quasney, John Dagle, Pascal M Lavoie, Pippa Simpson, Mary Dahmer
BACKGROUND: The genetic basis of dysfunctional immune responses in necrotizing enterocolitis (NEC) remains unknown. We hypothesized that variants in Nucleotide binding and Oligomerization Domain (NOD)-Like Receptors (NLRs) and Autophagy (ATG) genes modulate vulnerability to NEC. METHODS: We genotyped a multi-center cohort of premature infants with and without NEC for NOD1, NOD2, ATG16L1, CARD8 and NLRP3 variants. Chi-square tests and logistic regression were used for statistical analysis...
November 28, 2016: Pediatric Research
https://www.readbyqxmd.com/read/27885704/effects-of-genetic-variations-in-the-genes-encoding-nod1-and-nod2-on-type-2-diabetes-mellitus-and-insulin-resistance
#3
C Ozbayer, H Kurt, M N Kebapci, H V Gunes, E Colak, I Degirmenci
WHAT IS KNOWN AND OBJECTIVE: Nucleotide-binding oligomerization domain (NOD) 1 and NOD 2 are members of the NOD-like receptor (NLR) family and contain a caspase recruitment domain. NLRs are located in the cytosol, bind bacterial and viral ligands and play a key role in the realization of innate and adaptive immune response, inflammation, apoptosis and reactive oxygen species generation. Insulin resistance (IR) is a leading cause of type 2 diabetes mellitus (T2DM) and associated with obesity, inflammation and pro-inflammatory responses...
November 25, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27856764/role-of-nucleotide-binding-oligomerization-domain-1-nod1-and-its-variants-in-human-cytomegalovirus-control-in-vitro-and-in-vivo
#4
Yi-Hsin Fan, Sujayita Roy, Rupkatha Mukhopadhyay, Arun Kapoor, Priya Duggal, Genevieve L Wojcik, Robert F Pass, Ravit Arav-Boger
Induction of nucleotide-binding oligomerization domain 2 (NOD2) and downstream receptor-interacting serine/threonine-protein kinase 2 (RIPK2) by human cytomegalovirus (HCMV) is known to up-regulate antiviral responses and suppress virus replication. We investigated the role of nucleotide-binding oligomerization domain 1 (NOD1), which also signals through RIPK2, in HCMV control. NOD1 activation by Tri-DAP (NOD1 agonist) suppressed HCMV and induced IFN-β. Mouse CMV was also inhibited through NOD1 activation...
November 29, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27853874/comparative-expression-profile-of-nod1-2-and-certain-acute-inflammatory-cytokines-in-thermal-stressed-cell-culture-model-of-native-and-crossbred-cattle
#5
V Bhanuprakash, Umesh Singh, Gyanendra Singh Sengar, T V Raja, Basavraj Sajjanar, Rani Alex, Sushil Kumar, R R Alyethodi, Ashish Kumar, Ankur Sharma, Suresh Kumar, Bharat Bhusan, Rajib Deb
Thermotolerance depends mainly on the health and immune status of the animals. The variation in the immune status of the animals may alter the level of tolerance of animals exposed to heat or cold stress. The present study was conducted to investigate the expression profile of two important nucleotide binding and oligomerization domain receptors (NLRs) (NOD1 and NOD2) and their central signalling molecule RIP2 gene during in vitro thermal-stressed bovine peripheral blood mononuclear cells (PBMCs) of native (Sahiwal) and crossbred (Sahiwal X HF) cattle...
November 16, 2016: International Journal of Biometeorology
https://www.readbyqxmd.com/read/27848953/immunopathogenesis-of-pancreatitis
#6
REVIEW
T Watanabe, M Kudo, W Strober
The conventional view of the pathogenesis of acute and chronic pancreatitis is that it is due to a genetic- or environment-based abnormality of intracellular acinar trypsinogen activation and thus to the induction of acinar cell injury that, in turn, sets in motion an intra-pancreatic inflammatory process. More recent studies, reviewed here, present strong evidence that while such trypsinogen activation is likely a necessary first step in the inflammatory cascade underlying pancreatitis, sustained pancreatic inflammation is dependent on damage-associated molecular patterns-mediated cytokine activation causing the translocation of commensal (gut) organisms into the circulation and their induction of innate immune responses in acinar cells...
November 16, 2016: Mucosal Immunology
https://www.readbyqxmd.com/read/27836539/negative-regulation-of-nod1-mediated-angiogenesis-by-ppar%C3%AE-regulated-mir-125a
#7
Hyesoo Kang, Youngsook Park, Aram Lee, Hyemin Seo, Min Jung Kim, Jihea Choi, Ha-Neul Jo, Ha-Neul Jeong, Jin Gu Cho, Woochul Chang, Myeong-Sok Lee, Raok Jeon, Jongmin Kim
Infection with pathogens activates the endothelial cell and its sustained activation may result in impaired endothelial function. Endothelial dysfunction contributes to the pathologic angiogenesis that is characteristic of infection-induced inflammatory pathway activation. Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a protein receptor which recognizes bacterial molecules and stimulates an immune reaction in various cells; however, the underlying molecular mechanisms in the regulation of inflammation-triggered angiogenesis are not fully understood...
November 9, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27830761/delayed-development-of-systemic-immunity-in-preterm-pigs-as-a-model-for-preterm-infants
#8
Duc Ninh Nguyen, Pingping Jiang, Hanne Frøkiær, Peter M H Heegaard, Thomas Thymann, Per T Sangild
Preterm neonates are highly sensitive to systemic infections in early life but little is known about systemic immune development following preterm birth. We hypothesized that preterm neonates have immature systemic immunity with distinct developmental trajectory for the first several weeks of life, relative to those born at near-term or term. Using pigs as a model, we characterized blood leukocyte subsets, antimicrobial activities and TLR-mediated cytokine production during the first weeks after preterm birth...
November 10, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27830463/lrrk2-enhances-nod1-2-mediated-inflammatory-cytokine-production-by-promoting-rip2-phosphorylation
#9
Ruiqing Yan, Zhihua Liu
The innate immune system is critical for clearing infection, and is tightly regulated to avert excessive tissue damage. Nod1/2-Rip2 signaling, which is essential for initiating the innate immune response to bacterial infection and ER stress, is subject to many regulatory mechanisms. In this study, we found that LRRK2, encoded by a gene implicated in Crohn's disease, leprosy and familial Parkinson's disease, modulates the strength of Nod1/2-Rip2 signaling by enhancing Rip2 phosphorylation. LRRK2 deficiency markedly reduces cytokine production in macrophages upon Nod2 activation by muramyl dipeptide (MDP), Nod1 activation by D-gamma-Glu-meso-diaminopimelic acid (iE-DAP) or ER stress...
November 9, 2016: Protein & Cell
https://www.readbyqxmd.com/read/27806943/hmgb1-induces-an-inflammatory-response-in-the-chorioamniotic-membranes-that-is-partially-mediated-by-the-inflammasome
#10
Olesya Plazyo, Roberto Romero, Ronald Unkel, Amapola Balancio, Tara N Mial, Yi Xu, Zhong Dong, Sonia S Hassan, Nardhy Gomez-Lopez
Spontaneous preterm labor occurs in two subsets of patients with sterile intra-amniotic inflammation, which is induced by alarmins such as high-mobility group box-1 (HMGB1). Inflammasomes are also implicated in the process of spontaneous preterm labor with acute chorioamnionitis. Therefore, we investigated whether HMGB1 initiates an inflammasome-associated inflammatory response in the chorioamniotic membranes. Incubation of the chorioamniotic membranes with HMGB1: 1) induced the release of mature IL-1beta and IL-6; 2) upregulated the mRNA expression of the pro-inflammatory mediators NFKB1, IL6, TNF, IL1A, IFNG, and HMGB1 receptors RAGE and TLR2; 3) upregulated the mRNA expression of the inflammasome components NLRP3 and AIM2, and NOD proteins (NOD1 and NOD2); 4) increased the protein concentrations of NLRP3 and NOD2; 5) increased the concentration of caspase-1 and the quantity of its active form (p20); and 6) upregulated the mRNA expression and active form of MMP-9...
November 2, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27803247/nod1-activation-in-cardiac-fibroblasts-induces-myocardial-fibrosis-in-a-murine-model-of-type-2-diabetes
#11
Almudena Val-Blasco, Patricia Prieto-Chinchilla, Silvia Gonzalez-Ramos, Gemma Benito, María Teresa Vallejo-Cremades, Ivette Pacheco, María Pilar González-Peramato, Noelia Agra, Verónica Terrón, Carmen Delgado, Paloma Martín-Sanz, Lisardo Boscá, María Fernández-Velasco
Cardiac fibrosis and chronic inflammation are common complications in type 2 diabetes mellitus (T2D). Since nucleotide oligomerization-binding domain 1 (NOD1), an innate immune receptor, is involved in the pathogenesis of insulin resistance and diabetes outcomes, we sought to investigate its involvement in cardiac fibrosis. Here we show that selective staining of cardiac fibroblasts from T2D ( db/db;db ) mice exhibit up-regulation and activation of the NOD1 pathway, resulting in enhanced NF-kB and TGF-β signalling...
November 1, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27799160/sensing-of-the-microbiota-by-nod1-in-mesenchymal-stromal-cells-regulates-murine-hematopoiesis
#12
Chiaki Iwamura, Nicolas Bouladoux, Yasmine Belkaid, Alan Sher, Dragana Jankovic
The microbiota are known to influence the generation of hematopoietic progenitors although the pathways underlying this process are still poorly understood. NOD1 and NOD2 are intracellular sensors for both Gram-positive and negative bacteria, but their role in steady-state hematopoiesis has never been characterized. We observed that stimulation with NOD1 or NOD2 ligand had no effect on the survival/proliferation of hematopoietic precursors. Nonetheless, NOD1 but not NOD2 ligand induced expression of multiple hematopoietic cytokines (IL-7, Flt3L, SCF, ThPO and IL-6) from bone marrow mesenchymal stromal cells (MSC) in vitro...
October 31, 2016: Blood
https://www.readbyqxmd.com/read/27747243/functional-roles-of-nod1-in-odontoblasts-on-dental-pulp-innate-immunity
#13
Yuki Hosokawa, Kouji Hirao, Hiromichi Yumoto, Ayako Washio, Tadashi Nakanishi, Daisuke Takegawa, Chiaki Kitamura, Takashi Matsuo
Caries-related pathogens are first recognized by odontoblasts and induce inflammatory events that develop to pulpitis. Generally, initial sensing of microbial pathogens is mediated by pattern recognition receptors, such as Toll-like receptor and nucleotide-binding oligomerization domain (NOD); however, little is known about NODs in odontoblasts. In this study, the levels of NODs expressed in rat odontoblastic cell line, KN-3, were assessed by flow cytometry and the levels of chemokines in NOD-specific ligand-stimulated KN-3 cells were analyzed by real-time PCR and ELISA...
2016: BioMed Research International
https://www.readbyqxmd.com/read/27742759/bacterial-peptidoglycan-with-amidated-meso-diaminopimelic-acid-evades-nod1-recognition-an-insight-on-nod1-structure-recognition-study
#14
Sukhithasri Vijayrajratnam, Anju Choorakottayil Pushkaran, Aathira Balakrishnan, Anilkumar Vasudevan, Raja Biswas, Chethampadi Gopi Mohan
Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is an intracellular pattern recognition receptor that recognizes bacterial peptidoglycan (PG) containing meso -diaminopimelic acid ( meso DAP) and activates the innate immune system. Interestingly, few pathogenic and commensal bacteria modify their PG stem peptide by amidation of meso DAP ( meso DAPNH2). In this study, NOD1 stimulation assays were performed using bacterial PG containing meso DAP (PGDAP) and meso DAPNH2 (PGDAPNH2) to understand the differences in their biomolecular recognition mechanism...
October 14, 2016: Biochemical Journal
https://www.readbyqxmd.com/read/27726775/multifaceted-functions-of-nod-like-receptor-proteins-in-myeloid-cells-at-the-intersection-of-innate-and-adaptive-immunity
#15
Thomas A Kufer, Giulia Nigro, Philippe J Sansonetti
NOD-like receptor (NLR) proteins, as much as Toll-like receptor proteins, play a major role in modulating myeloid cells in their immune functions. There is still, however, limited knowledge on the expression and function of several of the mammalian NLR proteins in myeloid lineages. Still, the function of pyrin domain-containing NLR proteins and NLRC4/NAIP as inflammasome components that drive interleukin-1β (IL-1β) and IL-18 maturation and secretion upon pathogen stimulation is well established. NOD1, NOD2, NLRP3, and NLRC4/NAIP act as bona fide pattern recognition receptors (PRRs) that sense microbe-associated molecular patterns (MAMPs) but also react to endogenous danger-associated molecular patterns (DAMPs)...
August 2016: Microbiology Spectrum
https://www.readbyqxmd.com/read/27706808/understanding-the-regulation-of-pattern-recognition-receptors-in-inflammatory-diseases-a-nod-in-the-right-direction
#16
REVIEW
Claire L Feerick, Declan P McKernan
Nucleotide-binding oligomerization domain (NOD) -like receptors (NLRs) are a family of 23 receptors known as pattern recognition receptors; they are expressed in many cell types and play a key role in the innate immune response. The NLRs are activated by pathogen-associated molecular patterns, which include structurally conserved molecules present on the surfaces of bacteria. The activation of these NLRs by pathogens results in the downstream activation of signalling kinases and transcription factors, culminating in the transcription of genes coding for pro-inflammatory factors...
October 5, 2016: Immunology
https://www.readbyqxmd.com/read/27622570/cardiopulmonary-bypass-down-regulates-nod-signaling-and-inflammatory-response-in-children-with-congenital-heart-disease
#17
Qinghua Yang, Jianyi Liao, Jie Huang, Yi Ping Li, Shungen Huang, Huiting Zhou, Yi Xie, Jian Pan, Yanhong Li, Jiang Huai Wang, Jian Wang
In the present study, we aimed to examine the impact of cardiopulmonary bypass (CPB) on expression and function of NOD1 and NOD2 in children with congenital heart disease (CHD), in an attempt to clarify whether NOD1 and NOD2 signaling is involved in the modulation of host innate immunity against postoperative infection in pediatric CHD patients. Peripheral blood samples were collected from pediatric CHD patients at five different time points: before CPB, immediately after CPB, and 1, 3, and 7 days after CPB...
2016: PloS One
https://www.readbyqxmd.com/read/27610390/metainflammation-in-diabetic-coronary-artery-disease-emerging-role-of-innate-and-adaptive-immune-responses
#18
REVIEW
Vivekanandhan Aravindhan, Haridoss Madhumitha
Globally, noncommunicable chronic diseases such as Type-2 Diabetes Mellitus (T2DM) and Coronary Artery Disease (CAD) are posing a major threat to the world. T2DM is known to potentiate CAD which had led to the coining of a new clinical entity named diabetic CAD (DM-CAD), leading to excessive morbidity and mortality. The synergistic interaction between these two comorbidities is through sterile inflammation which is now being addressed as metabolic inflammation or metainflammation, which plays a pivotal role during both early and late stages of T2DM and also serves as a link between T2DM and CAD...
2016: Journal of Diabetes Research
https://www.readbyqxmd.com/read/27605548/role-of-nod2-and-rip2-in-host-microbe-interactions-with-gram-negative-bacteria-insights-from-the-periodontal-disease-model
#19
Joao Ac Souza, Marcell C Medeiros, Fernanda Rg Rocha, Sabrina G de Aquino, Mario J Ávila-Campos, Luis C Spolidorio, Dario S Zamboni, Dana T Graves, Carlos Rossa
NOD2 is a member of the NLR family of proteins that participate in the activation of the innate immune response. RIP2 is a downstream kinase activated by both NOD1 and NOD2. There is scarcity of information regarding the relevance of NOD2 in periodontitis, a chronic inflammatory condition characterized by inflammatory bone resorption. We used NOD2-KO and RIP2-KO mice in a model of microbial-induced periodontitis. Heat-killed Aggregatibacter actinomycetemcomitans was injected in the gingival tissues three times/wk for 4 wk...
September 7, 2016: Innate Immunity
https://www.readbyqxmd.com/read/27601373/identification-of-indole-scaffold-based-dual-inhibitors-of-nod1-and-nod2
#20
Kaja Keček Plešec, Dunja Urbančič, Martina Gobec, Aleksandra Pekošak, Tihomir Tomašič, Marko Anderluh, Irena Mlinarič-Raščan, Žiga Jakopin
NOD1 and NOD2 are important members of the pattern recognition receptor family and play a crucial role within the context of innate immunity. However, overactivation of NODs, especially of NOD1, has also been implicated in a number of diseases. Surprisingly, NOD1 remains a virtually unexploited target in this respect. To gain additional insight into the structure-activity relationships of NOD1 inhibitors, a series of novel analogs has been designed and synthesized and then screened for their NOD1-inhibitory activity...
November 1, 2016: Bioorganic & Medicinal Chemistry
keyword
keyword
111552
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"