Senem Ceren Ozen, Ulkü Dagli, Mesut Yalin Kiliç, Murat Törüner, Yasemin Celik, Muhip Ozkan, Irfan Soykan, Hülya Cetinkaya, Aysel Ulker, Ali Ozden, A Mithat Bozdayi
PURPOSE: The genetic susceptibility of people with certain NOD2/CARD15, NOD1/CARD4, and ICAM-1 gene variants to inflammatory bowel disease is still under investigation. The aim of this study was to investigate polymorphisms in the NOD2/CARD15 (R702W, G908R, and 3020insC), NOD1/CARD4 (E266K, D372N), and ICAM-1 (G241R, K469E) genes, which are known to be associated with inflammation, in Turkish patients with inflammatory bowel disease and healthy control groups. METHODS: The genotypes of 70 patients with endoscopically and histopathologically diagnosed Crohn's disease (38 men, 32 women; mean age, 38...
April 2006: Journal of Gastroenterology