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https://www.readbyqxmd.com/read/29123122/identification-of-low-oxygen-tolerating-bacteria-in-prostate-secretions-of-cancer-patients-and-discussion-of-possible-aetiological-significance
#1
Roshni Bhudia, Amar Ahmad, Onyinye Akpenyi, Angela Whiley, Mark Wilks, Tim Oliver
The microaerophylic organism Propionibacterium acnes has shown consistent association with prostate cancer (PC). Studies linking circumcision with reduced PC further support anaerobes involvement as circumcision reduces anaerobe colonisation on the glans penis. A 1988 study linked anaerobes with PC but considered them as opportunists in necrotic tumour. A hypothesis that a "Helicobacter-like" process causes PC justified this pilot study. Active surveillance patients were enrolled. Post-prostate massage urine samples were screened using the Matrix-Assisted Laser Desorption/Ionization Time-of-Flight (MALDI-TOF) technique for bacterial identification after culture in anaerobic and aerobic conditions...
November 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29056081/the-risks-and-benefits-of-cannabis-in-the-dermatology-clinic
#2
Gurbir Dhadwal, Mark G Kirchhof
Cannabis ( Cannabis sativa/indica), also known as marijuana, has been used for medicinal and recreational purposes for millennia. There has been a recent trend to legalize the use of cannabis, as illustrated by the recent legalization votes in numerous states in the United States and legislation in Canada to allow recreational cannabis use. With this increasing consumption of cannabis, dermatologists will see increased pressure to prescribe cannabis and will see the side effects of cannabis use with greater frequency...
October 1, 2017: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/28707712/acne-prevalence-and-associations-with-lifestyle-a-cross-sectional-online-survey-of-adolescents-young-adults-in-7-european-countries
#3
P Wolkenstein, A Machovcová, J C Szepietowski, D Tennstedt, S Veraldi, A Delarue
BACKGROUND: Although acne vulgaris is a common skin disorder, limited epidemiological data exist specifically for European populations. OBJECTIVE: To determine the prevalence of self-reported acne among young people in Europe and evaluate the effect of lifestyle on acne. METHODS: We conducted a cross-sectional population-based online survey in representative samples of individuals aged 15-24 years in Belgium, Czech and Slovak Republics, France, Italy, Poland and Spain (n=10,521), identified by a quota sampling method based on age, geographic location, and socio-professional category...
July 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28609760/epidemiology-of-acne-vulgaris-in-18-year-old-male-army-conscripts-in-a-south-brazilian-city
#4
Rodrigo Pereira Duquia, Iná da Silva Dos Santos, Hiram de Almeida, Paulo Ricardo Martins Souza, Juliano de Avelar Breunig, Christos C Zouboulis
BACKGROUND: Prevalence of acne varies worldwide. Several factors (age, skin color, body fat, diet, and smoking) have been investigated as risk factors. OBJECTIVE: A total of 2,201 18-year-old males living in Pelotas, South Brazil, were evaluated in order to examine the prevalence of acne and associated factors. METHODS: A cross-sectional population-based study was conducted. A dermatologist performed the clinical examination of the face and trunk for identification of acne lesions...
2017: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/28256718/lipocalin-2-is-expressed-by-activated-granulocytes-and-keratinocytes-in-affected-skin-and-reflects-disease-activity-in-acne-inversa-hidradenitis-suppurativa
#5
K Wolk, J Wenzel, A Tsaousi, E Witte-Händel, N Babel, C Zelenak, H-D Volk, W Sterry, S Schneider-Burrus, R Sabat
BACKGROUND: Acne inversa (AI)/hidradenitis suppurativa is a chronic inflammatory disease characterized by painful axillary, inguinal and perianal skin lesions with deep-seated nodules, abscesses and fistulae. OBJECTIVES: This study aimed to identify and characterize the key players in AI pathogenesis. METHODS: Epidemiological and anamnestic data for patients with AI were collected, and blood and skin samples were also taken. Healthy participants and patients with psoriasis served as controls...
March 3, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28225954/frequency-severity-and-related-factors-of-androgenetic-alopecia-in-dermatology-outpatient-clinic-hospital-based-cross-sectional-study-in-turkey
#6
Kubra Esen Salman, Ilknur Kivanc Altunay, Nihal Asli Kucukunal, Asli Aksu Cerman
BACKGROUND: Androgenetic alopecia (AGA) is a patterned hair loss occurring due to systemic androgen and genetic factors. It is the most common cause of hair loss in both genders. In recent years, many studies investigating the relation between systemic diseases and androgenetic alopecia presented controversial results. OBJECTIVES: In this study we aimed to investigate the frequency of androgenetic alopecia, the presence of accompanying systemic diseases, the relation between body mass index and androgenetic alopecia severity and the association of hyperandrogenemia signs with androgenetic alopecia in patients who referred to our outpatient clinic...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28195077/effects-of-air-pollution-on-the-skin-a-review
#7
REVIEW
Poonam Puri, Shashi Kumar Nandar, Sushruta Kathuria, V Ramesh
The increase in air pollution over the years has had major effects on the human skin. Various air pollutants such as ultraviolet radiation, polycyclic aromatic hydrocarbons, volatile organic compounds, oxides, particulate matter, ozone and cigarette smoke affect the skin as it is the outermost barrier. Air pollutants damage the skin by inducing oxidative stress. Although human skin acts as a biological shield against pro-oxidative chemicals and physical air pollutants, prolonged or repetitive exposure to high levels of these pollutants may have profound negative effects on the skin...
July 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/28110842/biomarkers-in-patients-admitted-to-the-emergency-department-after-exposure-to-acrylonitrile-in-a-major-railway-incident-involving-bulk-chemical-material
#8
Sebastiaan Colenbie, Walter Buylaert, Christophe Stove, Ellen Deschepper, Koenraad Vandewoude, Tom De Smedt, Michael Bader, Thomas Göen, An Van Nieuwenhuyse, Peter De Paepe
BACKGROUND: A railway incident with victims of exposure to the cyanogenic substance acrylonitrile (ACN). AIMS: We retrospectively (i)built an inventory of the clinical characteristics of individuals admitted to surrounding emergency departments (ED's) and (ii)studied the correlation between N-2-cyanoethylvaline (CEV), a biomarker used in a population study for evaluating exposure to ACN, with lactate and thiocyanate (SCN), biomarkers determined during emergency care...
March 2017: International Journal of Hygiene and Environmental Health
https://www.readbyqxmd.com/read/28060687/adult-acne-prevalence-and-portrayal-in-primary-healthcare-patients-in-the-greater-porto-area-portugal
#9
Diogo Semedo, Filipa Ladeiro, Mariana Ruivo, Carlos D'Oliveira, Filipa De Sousa, Mariana Gayo, Clara Lima, Frederico Magalhães, Rui Brandão, Maria Branco, Isabel Da Silva, Joana Batista, João Amado, António Massa, João Neves-Amado
INTRODUCTION: Though typically found in adolescents, acne frequently affects the adult population. In Portugal, no representative studies about acne prevalence in greater populational areas are known. This study had the following objectives: calculate acne prevalence in primary healthcare patients; its characteristics, including risk factors for onset and worsening; collect information concerning selfmedication and/or prescribed treatment. MATERIAL AND METHODS: Application of a questionnaire and physical examination into a convenience sample, composed by adults from20 - 60 years old that visited, in random days, five primary healthcare centers of the Greater Porto area...
September 2016: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28012211/derivation-and-validation-of-a-risk-scoring-model-to-predict-advanced-colorectal-neoplasm-in-adults-of-all-ages
#10
Hyo-Joon Yang, Sungkyoung Choi, Soo-Kyung Park, Yoon Suk Jung, Kyu Yong Choi, Taesung Park, Ji Yeon Kim, Dong Il Park
BACKGROUND AND AIMS: Little is known about how to include adults < 50 years in colonoscopy screening. This study aimed to derive a risk-scoring model incorporating laboratory indicators for metabolic risks to predict advanced colorectal neoplasia (ACN) in asymptomatic Korean adults both younger and older than 50 years. METHODS: In this cross-sectional study, 70 812 consecutive adult recipients of a screening colonoscopy in a single health check-up center in Korea between 2003 and 2012 were enrolled...
July 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27865981/srb1-as-a-new-redox-target-of-cigarette-smoke-in-human-sebocytes
#11
Ilaria Crivellari, Claudia Sticozzi, Giuseppe Belmonte, Ximena M Muresan, Franco Cervellati, Alessandra Pecorelli, Carlotta Cavicchio, Emanuela Maioli, Christos C Zouboulis, Mascia Benedusi, Carlo Cervellati, Giuseppe Valacchi
For its critical location, the skin represents the major interface between the body and the environment, therefore is one of the major biological barriers against the outdoor environmental stressors. Among the several oxidative environmental stressors, cigarette smoke (CS) has been associated with the development and worsening of many skin pathologies such as acne, dermatitis, delayed wound healing, aging and skin cancer. In our previous work we have demonstrated that CS is able to affect genes involved in skin cholesterol trafficking, among which SRB1, a receptor involved in the uptake of cholesterol from HDL, seems to be very susceptible to the oxidative stress induced by CS...
January 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/27819279/concurrent-profiling-of-polar-metabolites-and-lipids-in-human-plasma-using-hilic-ftms
#12
Xiaoming Cai, Ruibin Li
Blood plasma is the most popularly used sample matrix for metabolite profiling studies, which aim to achieve global metabolite profiling and biomarker discovery. However, most of the current studies on plasma metabolite profiling focused on either the polar metabolites or lipids. In this study, a comprehensive analysis approach based on HILIC-FTMS was developed to concurrently examine polar metabolites and lipids. The HILIC-FTMS method was developed using mixed standards of polar metabolites and lipids, the separation efficiency of which is better in HILIC mode than in C5 and C18 reversed phase (RP) chromatography...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27817838/noncontraceptive-use-of-oral-combined-hormonal-contraceptives-in-polycystic-ovary-syndrome-risks-versus-benefits
#13
REVIEW
Anuja Dokras
The use of steroid sex hormones for noncontraceptive benefits has been endorsed by several medical societies. In women with polycystic ovary syndrome (PCOS), hormonal contraceptives are first-line therapy for concurrent treatment of menstrual irregularity, acne, and hirsutism. The association of PCOS with obesity, diabetes, and dyslipidemia frequently brings up the debate regarding risks versus benefits of hormonal contraceptives in this population. In women with PCOS, the lack of large-scale studies evaluating the risks with varying doses of ethinyl estradiol, types of progestins, and presence of confounding factors such as obesity, smoking, and other cardiometabolic comorbidities is a significant limitation in these deliberations...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27749646/epidemiology-of-acne-vulgaris-in-adolescent-male-students-in-arar-kingdom-of-saudi-arabia
#14
Nagah M Abo El-Fetoh, Naif G Alenezi, Nasser G Alshamari, Omar G Alenezi
BACKGROUND: Acne vulgaris is the most common cutaneous disorder affecting adolescents and young adults. Small, noninflamed acne lesions may not be more than a slight nuisance, but, in individuals with more severe inflammatory disease, pain, social embarrassment, and both physical and psychological scarring can be life altering. Despite its high prevalence, no previous community-based studies have been conducted in Arar, northern border of Kingdom of Saudi Arabia, addressing this issue...
September 2016: Journal of the Egyptian Public Health Association
https://www.readbyqxmd.com/read/27509079/acne-during-adolescence-did-not-predict-skin-rash-reaction-to-cetuximab
#15
Gil Bar-Sela, Sharon Avgush, Orit Kaidar-Person, Alex Beny, Valeriya Semenisty, Yael Liel, Reuven Bergman, Ziad Khamaysi
Cetuximab, a monoclonal antibody, is a part of the treatment for metastatic colorectal cancer. The most common side effect of cetuximab is skin rash, which has a similar distribution to acne vulgaris and some overlapping pathophysiological mechanisms. The aim of the current study was to determine whether acne vulgaris in adolescence (AinA) is predictive of a cetuximab-related rash to better understand the pathogenesis of this side effect and explore potential preventive actions. From July 2013 to June 2015, patients with metastatic colorectal cancer planned for treatment with cetuximab were enrolled in the study...
November 2016: Anti-cancer Drugs
https://www.readbyqxmd.com/read/27495143/comorbidities-treatment-and-outcome-in-severe-anogenital-inverse-acne-hidradenitis-suppurativa-a-15-year-single-center-report
#16
Uwe Wollina, Dana Langner, Birgit Heinig, Andreas Nowak
BACKGROUND: Acne inversa (hidradentitis suppurativa; AI) is a severe chronic relapsing inflammatory skin disease of unknown cause. Anogenital AI has the strongest negative impact on quality of life and causes great disability. OBJECTIVES: We analyzed patients, comorbities, outcome of extensive surgery, and possible adverse effects. PATIENTS AND METHODS: We included patients from January 2000 to March 2015 with anogenital AI Hurley grade III...
January 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/27473418/magnetic-solid-phase-extraction-based-on-oleic-acid-coated-fe3o4-for-the-determination-of-benzo-%C3%AE-pyrene-in-cigarette-smoke-coupled-with-high-performance-liquid-chromatography
#17
Shouai Feng, Kang Wei, Zhaofu Tian, Xiaolan Li, Dongling Meng, Wenlong Liao, Mingming Miao, Yaling Yang
In this work, a simple and effective method based on magnetic solid-phase extraction combined with high-performance liquid chromatography was developed for the determination of benzo[α]pyrene (BaP) in cigarette smoke. Oleic acid coated Fe3O4 (Fe3O4-OA) was synthesized and directly used as an efficient sorbent for the first time in magnetic solid-phase extraction (MSPE) procedure for the clean-up of BaP in cigarette smoke extracts. The synthesized Fe3O4-OA was characterized by transmission electron microscopy, X-ray diffraction and Fourier transformed infrared spectroscopy...
July 29, 2016: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/27468217/favorable-lifestyle-before-diagnosis-associated-with-lower-risk-of-screen-detected-advanced-colorectal-neoplasia
#18
Markus D Knudsen, Thomas de Lange, Edoardo Botteri, Dung-Hong Nguyen, Helge Evensen, Chloé B Steen, Geir Hoff, Tomm Bernklev, Anette Hjartåker, Paula Berstad
AIM: To investigate the association between adherence to health recommendations and detection of advanced colorectal neoplasia (ACN) in colorectal cancer (CRC) screening. METHODS: A total of 14832 women and men were invited to CRC screening, 6959 in the fecal immunochemical test arm and 7873 in the flexible sigmoidoscopy arm. These were also sent a self-reported lifestyle questionnaire to be completed prior to their first CRC screening. A lifestyle score was created to reflect current adherence to healthy behaviors in regard to smoking, body mass index, physical activity, alcohol consumption and food consumption, and ranged from zero (poorest) to six (best)...
July 21, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27459457/epidemiological-assessments-of-skin-outcomes-in-the-nurses-health-studies
#19
REVIEW
Wen-Qing Li, Eunyoung Cho, Martin A Weinstock, Hasan Mashfiq, Abrar A Qureshi
OBJECTIVES: To review the contribution of the Nurses' Health Studies (NHSs) to identifying epidemiological factors associated with multiple skin diseases, including skin cancer, psoriasis, and other inflammatory and autoimmune skin diseases. METHODS: We carried out a narrative review of NHS articles published between 1976 and 2016. RESULTS: The NHSs have identified environmental and lifestyle factors related to psoriasis, supporting obesity and smoking as psoriasis risk factors; associations between psoriasis and diabetes, myocardial infarction, and Crohn's disease, supporting psoriasis as a systemic disorder; and associations of pigmentary traits, ultraviolet radiation, and lifestyle factors such as citrus consumption with risk of skin cancer...
September 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27438194/acne-scars-in-18-year-old-male-adolescents-a-population-based-study-of-prevalence-and-associated-factors
#20
Fernanda Tcatch Lauermann, Hiram Larangeira de Almeida, Rodrigo Pereira Duquia, Paulo Ricardo Martins de Souza, Juliano de Avelar Breunig
BACKGROUND: Acne vulgaris is a pilosebaceous follicle disorder affecting over 85% of adolescents to some degree. It frequently causes psychological distress that may persist into adulthood due to scarring. Little information about post-acne scarring epidemiology is available. OBJECTIVES: To describe prevalence, distribution patterns and associated factors of acne scarring in young males, drawing on a representative population sample from a southern Brazilian city...
May 2016: Anais Brasileiros de Dermatologia
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