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https://www.readbyqxmd.com/read/29453165/endoscopic-submucosal-dissection-for-the-diagnosis-and-therapy-of-pedunculated-gastric-cancer-with-prolapse-into-the-duodenal-bulb-a-case-report
#1
Norihiko Suzuki, Masashi Yoshida, Hironori Ohdaira, Tomonori Imakita, Nobuhiro Tsutsui, Yasunobu Kobayashi, Junji Takahashi, Shinya Okada, Masaki Kitajima, Yutaka Suzuki
INTRODUCTION: Preoperative diagnosis of gastric cancer invasion is not always sufficiently accurate. Diagnostic endoscopic submucosal dissection (ESD) can be performed for the purpose of accurate decision making and to avoid partial treatment vs aggressive over-treatment. We present a patient with the gastric cancer with indeterminate pre-operative diagnosis for depth of the invasion. CASE PRESENTATION: A 70-year-old man presented at our hospital because both anti-Helicobacter pylori (Hp) IGG antibody and serum pepsinogen (PG) levels were classified as positive...
February 9, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29447887/thirty-day-perioperative-outcomes-in-resection-of-cervical-lymphatic-malformations
#2
Ashoke Khanwalkar, John Carter, Bharat Bhushan, Jeff Rastatter, John Maddalozzo
INTRODUCTION: Limited information exists regarding short-term morbidity in the resection of lymphatic malformations. In order to make informed collaborative medical decisions, clinicians and families would benefit from information on 30-day outcomes and the expected course associated with surgical excision of lymphatic malformations. METHODS: A retrospective chart review was conducted to develop a case series of patients who underwent resection of lymphatic malformation at a pediatric tertiary care center between June 1, 2007 and September 30, 2016...
March 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29433986/surgical-and-oncological-outcomes-in-patients-after-vascularised-flap-reconstruction-for-locoregionally-advanced-penile-cancer
#3
Sarah R Ottenhof, Andrew Leone, Rosa S Djajadiningrat, Mounsif Azizi, Kamran Zargar, Laura C Kidd, Gregory Diorio, Gerard Mosiello, Niels M Graafland, Philippe E Spiess, Simon Horenblas
BACKGROUND: Treatment of locoregionally advanced penile squamous cell carcinoma (LAPSCC) is challenging. The exact role (in terms of oncological benefit) of extensive surgery is not well established. Moreover, surgery invariably leads to large defects requiring reconstructive surgery. Rectus abdominis myocutaneous (RAM) and abdominal advancement flaps have an independent and constant blood supply, are easily harvested, and provide substantial skin coverage and soft tissue. OBJECTIVE: To determine the surgical and oncological outcomes in patients with LAPSCC undergoing surgical resection with RAM flaps...
February 9, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29420255/development-and-translational-application-of-a-minimal-physiologically-based-pharmacokinetic-mpbpk-model-for-a-monoclonal-antibody-mab-against-interleukin-23-il-23-in-il-23-induced-psoriasis-like-psl-mice
#4
Xi Chen, Xiling Jiang, Rajitha Janssen R D Doddareddy, Brian Geist, Thomas McIntosh, William J Jusko, Honghui Zhou, Weirong Wang
The IL-23/Th17/IL-17 immune pathway has been identified to play an important role in the pathogenesis of psoriasis. Many therapeutic proteins targeting IL-23 or IL-17 are currently under development for the treatment of psoriasis. In the present study, a mechanistic PK/PD study was conducted to assess the target-binding and disposition kinetics of a monoclonal antibody (mAb), CNTO 3723, and its soluble target, mouse IL-23, in an IL-23-induced psoriasis-like (PsL) mouse model. A minimal physiologically-based pharmacokinetic (mPBPK) model with target-mediated drug disposition (TMDD) features was developed to quantitatively assess the kinetics and interrelationship between CNTO 3723 and exogenously administered, recombinant mouse IL-23 (rmIL-23) in both serum and lesional skin site...
February 2, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29418009/multidisciplinary-approach-in-a-case-of-hand-sch%C3%A3-ller-christian-disease-with-maxillary-involvement
#5
Angela Pia Cazzolla, Nunzio Francesco Testa, Gianfranco Favia, Maria Grazia Lacaita, Domenico Ciavarella, Khrystyna Zhurakivska, Giuseppe Troiano, Lorenzo Lo Muzio
Langerhans cell histiocytosis (LCH) is a childhood pathology with a peak of incidence ranging from 1 to 4 years of age, though diagnosis is often made in adult age. LCH is clinically classified into three types: eosinophilic granuloma, Hand-Schuller-Christian disease and Abt-Letterer-Siwe disease. We report a case of Hand-Schüller-Christian disease with diabetes insipidus, skull and maxillary involvement in a 16-year-old boy referred to our observation for gradual increase in mobility of the teeth and subsequent gradual loss of the second premolars and the first molars of the upper jaw...
February 8, 2018: Special Care in Dentistry
https://www.readbyqxmd.com/read/29416964/arthroscopic-rotator-cuff-repair-with-mini-open-subpectoral-biceps-tenodesis
#6
Nicholas I Kennedy, George Sanchez, Sandeep Mannava, Márcio B Ferrari, Salvatore J Frangiamore, Matthew T Provencher
With a range of tear characteristics such as chronicity, degree of fatty atrophy, and number of tendons involved as well as varying patient-specific characteristics including age, injury mechanism, and expectations after treatment to consider, proper and successful treatment of a rotator cuff tear is multifactorial and, consequently, challenging. Although conservative management of a rotator cuff tear may be successful, a more severe tear with involvement of more tendons may warrant surgical intervention. Furthermore, additional pathology including biceps tendinopathy may result in greater patient morbidity and an even more complex treatment decision-making process and surgical technique...
October 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29406341/femoral-version-abnormalities-significantly-outweigh-effect-of-cam-impingement-on-hip-internal-rotation
#7
Matthew J Kraeutler, Vivek Chadayammuri, Tigran Garabekyan, Omer Mei-Dan
BACKGROUND: The purpose of this study was to investigate the effects of femoral version, cam-type femoroacetabular impingement (FAI), and the combination of the 2 on the passive hip range of motion (ROM). METHODS: We prospectively analyzed a consecutive cohort of 220 patients (440 hips) who presented with unilateral or bilateral hip pain. The passive hip ROM was measured bilaterally with the patient in prone, supine, and lateral positions. Femoral version was measured and the presence of cam-type deformity was determined on preoperative computed tomography (CT) scans...
February 7, 2018: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29405770/liquid-biopsy-and-its-role-in-an-advanced-clinical-trial-for-lung-cancer
#8
Donald J Johann, Mathew Steliga, Ik J Shin, Donghoon Yoon, Konstantinos Arnaoutakis, Laura Hutchins, Meeiyueh Liu, Jason Liem, Karl Walker, Andy Pereira, Mary Yang, Susanne K Jeffus, Erich Peterson, Joshua Xu
Liquid biopsy methodologies, for the purpose of plasma genotyping of cell-free DNA (cfDNA) of solid tumors, are a new class of novel molecular assays. Such assays are rapidly entering the clinical sphere of research-based monitoring in translational oncology, especially for thoracic malignancies. Potential applications for these blood-based cfDNA assays include: (i) initial diagnosis, (ii) response to therapy and follow-up, (iii) tumor evolution, and (iv) minimal residual disease evaluation. Precision medicine will benefit from cutting-edge molecular diagnostics, especially regarding treatment decisions in the adjuvant setting, where avoiding over-treatment and unnecessary toxicity are paramount...
February 2018: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29404260/microsurgical-resection-of-lateral-tuberculum-sellae-meningioma-operative-video
#9
Duarte N C Cândido, Paulo E H Nakashima, Jean Gonçalves de Oliveira, Luis A B Borba
Tuberculum Sellae Meningiomas (TSMs) are lesions dramatically related to the optic apparatus once the principal clinical complain remains on visual alterations. This is the main picture on decision making to evaluate the best time, risk-benefit, and surgical approaches to the patient treatment. In this video, we present a 65 years old female with 30 days complaint of unilateral (right) complete blindness and complete impaired right eye field test. On physical examination, there were normal pupillary function to light tests...
February 2018: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29392926/diagnosis-and-kidney-sparing-treatments-for-upper-tract-urothelial-carcinoma-state-of-the-art
#10
Angelo Territo, Bear Foerster, Shahrokh F Shariat, Morgan Rouprêt, Jose M Gaya, Joan Palou, Alberto Breda
INTRODUCTION: Conservative management of upper tract urothelial cancer (UTUC) is becoming increasingly popular: the key to success is correct selection of patients with low-risk UTUC based on size (≤ 2 cm), focality (single lesion), stage (< T2), and grade (low grade). Despite the recent growing interest in the conservative approach to UTUC, the diagnostic process is still a challenge, and kidney-sparing surgery (KSS) is traditionally reserved for patients with contraindications to radical nephroureterectomy...
February 1, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29390906/comparison-of-the-symptoms-and-localisation-of-endometriosis-involvement-according-to-fertility-status-of-endometriosis-patients
#11
Fatemeh Aliani, Mahnaz Ashrafi, Arezoo Arabipoor, Ensieh Shahrokh-Tehraninejad, Shahideh Jahanian Sadatmahalleh, Mohammad Reza Akhond
This cross-sectional study aimed to assess the prevalence of endometriosis in women who were referred for Diagnostic Laparoscopy Unit due to infertility or pelvic pain between January 2012 and January 2013 and compare the symptoms and laparoscopic signs among the three groups according to the fertility status. Four hundred and thirteen women were evaluated; of these, 383 patients for infertility and 30 patients for pelvic pain and/or cyst. Endometriosis symptoms were compared between fertile and infertile women with primary and secondary infertility...
February 1, 2018: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/29387630/usefulness-of-plaque-magnetic-resonance-imaging-in-identifying-high-risk-carotid-plaques-irrespective-of-the-degree-of-stenosis
#12
Jinseong Lee, Jinsang Kil, Dae-Won Kim, Sung-Don Kang
Objective: Measurement of the degree of stenosis is not enough to decide on the treatment strategy for patients with carotid stenosis. Plaque morphology examination is needed for such a decision-making. Thus, we evaluated the usefulness of plaque magnetic resonance imaging (MRI) to decide on the modality of treatment for patients with carotid atherosclerotic plaques. Materials and Methods: Fifteen patients presenting with carotid stenosis between 2014 and 2016 were included...
December 2017: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/29384877/acute-appendicitis-complicated-with-necrotizing-fasciitis-in-a-patient-with-adult-onset-still-s-disease-a-case-report
#13
Zheng-Hao Huang, Yu-Chen Chiu, Li-Lu Ho, Hsiu-Lung Fan, Chun-Chi Lu
RATIONALE: Adult-onset Still disease (AOSD) is a rare systemic inflammatory disease of unknown etiology characterized by evanescent salmon-pink rash, spiking fever, arthralgia/ arthritis, and lymphadenopathy. AOSD sometimes was fatal when it is complicated by macrophage activation syndrome (MAS) or hemophagocytic lymphohistiocytosis (HLH). Nonetheless, the literature provides no recommendations for treatment of AOSD patients with severe sepsis. PATIENT CONCERNS: A previously healthy 65-year-old man with history of AOSD was referred to our hospital for persistent right lower quadrant abdominal pain for 2 days...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383713/prognostic-factors-for-soft-tissue-sarcoma-patients-with-lung-metastases-only-who-are-receiving-first-line-chemotherapy-an-exploratory-retrospective-analysis-of-the-european-organization-for-research-and-treatment-of-cancer-soft-tissue-and-bone-sarcoma-group
#14
Lars H Lindner, Saskia Litière, Stefan Sleijfer, Charlotte Benson, Antoine Italiano, Bernd Kasper, Christina Messiou, Hans Gelderblom, Eva Wardelmann, Axel Le Cesne, Jean-Yves Blay, Sandrine Marreaud, Nadia Hindi, Ingrid M E Desar, Alessandro Gronchi, Winette T A van der Graaf
The prognosis of adult soft tissue sarcoma (STS) patients with metastases is generally poor. As little is known about the impact of the involvement of different metastatic sites and the extent of pulmonary lesions on the outcome for patients receiving first-line chemotherapy, we aimed to establish prognostic factors for STS patients with lung metastases only. A retrospective, exploratory analysis was performed on 2913 metastatic STS patients who received first-line chemotherapy. Detailed information from 580 patients who had lung metastases only, was used for prognostic factor analysis...
January 31, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29383479/magnetic-resonance-imaging-as-an-adjunct-diagnostic-tool-in-computed-tomography-defined-bosniak-iif-iii-renal-cysts-a-multicenter-study
#15
Tomas Pitra, Kristyna Pivovarcikova, Radek Tupy, Reza Alaghehbandan, Tana Barakova, Ivan Travnicek, Kristyna Prochazkova, Tobias Klatte, Piotr Chlosta, Ondrej Hes, Milan Hora
INTRODUCTION: CT imaging is the standard examination for renal cystic lesions and defines the Bosniak category, which dictates further management. Given that Bosniak II/IIF/III renal cystic lesions can potentially harbor renal cell carcinoma (RCC), additional diagnostic modalities may be required in management decision making. AIM: To determine the value of additional magnetic resonance imaging in CT-defined Bosniak IIF-III renal cystic lesions. MATERIALS AND METHODS: This a multicenter retrospective study of 46 consecutive patients, diagnosed with cystic renal lesions between 2009 and 2016...
January 30, 2018: World Journal of Urology
https://www.readbyqxmd.com/read/29378389/limits-of-endoscopic-endonasal-surgery-for-craniopharyngioma
#16
Douglas A Hardesty, Alaa S Montaser, André Beer-Furlan, Ricardo L Carrau, Daniel M Prevedello
Craniopharyngiomas represent one of the most challenging brain tumors for the neurosurgeon. For most of the 20th century, these parasellar lesions have been approached via the classic open approaches of neurosurgery such as pterional, frontobasal, interhemispheric, and transpetrosal craniotomies. The endoscopic endonasal approach to these tumors, rather than craniotomy, has risen in popularity over the last two decades. Regardless of approach, a detailed knowledge of surgical anatomy and careful preoperative surgical planning are essential to achieve good clinical results; iatrogenic morbidity can potentially be severe due to hypothalamus, optic apparatus, and/or vascular injuries...
January 26, 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29375902/fine-needle-versus-core-needle-biopsy-which-one-to-choose-in-preoperative-assessment-of-focal-lesions-in-the-breasts-literature-review
#17
REVIEW
Ewa Łukasiewicz, Agnieszka Ziemiecka, Wiesław Jakubowski, Jelena Vojinovic, Magdalena Bogucevska, Katarzyna Dobruch-Sobczak
Aim: The aim of the study was to review two techniques that can be used to verify focal lesions in the breasts: fine-needle aspiration biopsy and core-needle biopsy. Material and methods: Fifty-five articles (original papers and reviews), half of them published within the past 5 years, were included in the analysis. The authors also took their own experience into account. Results: Pre-operative assessment of focal lesions in the breasts is crucial in the planning of further therapeutic management...
December 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/29374055/circulating-tumor-cells-with-stem-like-phenotypes-for-diagnosis-prognosis-and-therapeutic-response-evaluation-in-hepatocellular-carcinoma
#18
Jia Fan, Wei Guo, Yun-Fan Sun, Minna Shen, Xiao-Lu Ma, Jiong Wu, Chunyan Zhang, Yan Zhou, Yang Xu, Bo Hu, Min Zhang, Gang Wang, Wei-Qin Chen, Lin Guo, Renquan Lu, Chao-Hui Zhou, Xin Zhang, Ying-Hong Shi, Shuang-Jian Qiu, Bai-Shen Pan, Ya Cao, Jian Zhou, Xin-Rong Yang
PURPOSE: In present study, we assessed the clinical value of circulating tumor cells (CTCs) with stem-like phenotypes for diagnosis, prognosis and surveillance in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) by an optimized QPCR-based detection platform. EXPERIMENTAL DESIGN: Differing subsets of CTCs were investigated, and a multimarker diagnostic CTC panel was constructed in a multicenter-patient study with independent validation (total n=1006), including healthy individuals, patients with chronic hepatitis B infection (CHB), liver cirrhosis (LC), benign hepatic lesion (BHL) and HBV-related HCC, with area under the receiver operating characteristic curve (AUC-ROC) reflecting diagnostic accuracy...
January 26, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29363175/seborrheic-keratoses-mimicking-melanoma-unveiled-by-in-vivo-reflectance-confocal-microscopy
#19
C Pezzini, V D Mandel, F Persechino, S Ciardo, S Kaleci, J Chester, N De Carvalho, S Persechino, G Pellacani, F Farnetani
BACKGROUND: Seborrheic keratoses (SebK) with atypical dermoscopy presentation are increasingly reported. These lesions do not exhibit typical dermoscopy features of SebK and sometimes mimic melanoma, thus complicating the differential diagnosis. Reflectance confocal microscopy (RCM) is a non-invasive tool, which allows an in vivo imaging of the skin. The study objectives were to evaluate the agreement between RCM classification and histological diagnoses, and the reliability of well-known RCM criteria for SebK in the identification of SebK with atypical dermoscopy presentation...
January 24, 2018: Skin Research and Technology
https://www.readbyqxmd.com/read/29361435/safety-and-effectiveness-of-sgm-101-a-fluorescent-antibody-targeting-carcinoembryonic-antigen-for-intraoperative-detection-of-colorectal-cancer-a-dose-escalation-pilot-study
#20
Leonora S F Boogerd, Charlotte E S Hoogstins, Dennis P Schaap, Miranda Kusters, Henricus J M Handgraaf, Maxime J M van der Valk, Denise E Hilling, Fabian A Holman, Koen C M J Peeters, J Sven D Mieog, Cornelis J H van de Velde, Arantza Farina-Sarasqueta, Ineke van Lijnschoten, Bérénice Framery, André Pèlegrin, Marian Gutowski, Simon W Nienhuijs, Ignace H J T de Hingh, Grard A P Nieuwenhuijzen, Harm J T Rutten, Francoise Cailler, Jacobus Burggraaf, Alexander L Vahrmeijer
BACKGROUND: Tumour-targeted fluorescence imaging has the potential to advance current practice of oncological surgery by selectively highlighting malignant tissue during surgery. Carcinoembryonic antigen (CEA) is overexpressed in 90% of colorectal cancers and is a promising target for colorectal cancer imaging. We aimed to assess the tolerability of SGM-101, a fluorescent anti-CEA monoclonal antibody, and to investigate the feasibility to detect colorectal cancer with intraoperative fluorescence imaging...
January 17, 2018: Lancet. Gastroenterology & Hepatology
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