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https://www.readbyqxmd.com/read/29048710/correlations-among-ultrasound-guided-diffuse-optical-tomography-microvessel-density-and-breast-cancer-prognosis
#1
Sihua Niu, Qingli Zhu, Yuxin Jiang, Jiaan Zhu, Mengsu Xiao, Shanshan You, Weixun Zhou, Yu Xiao
OBJECTIVES: To investigate the correlation among ultrasound-guided diffuse optical tomography (DOT), microvessel density, and breast cancer prognosis. METHODS: Before surgery, the total hemoglobin (Hb) concentrations of 184 female patients with breast cancer with only a single lesion were measured. During follow-up, 23 patients had recurrence or metastatic disease after surgery. Among these patients, 18 with recurrence or metastatic disease within 3 years after surgery were paired with 18 patients without recurrence or metastatic disease...
October 19, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/29048536/neurobiology-of-female-mate-choice-in-frogs-auditory-filtering-and-valuation
#2
Sabrina S Burmeister
Mate choice is a decision making process with profound implication for the reproductive success of both the sender and the chooser. Preferences for conspecific over heterospecific males and for some conspecifics over others are typically mediated by a female's response to signals produced by males. And although one can experimentally describe a female's preference function, there is relatively little understood about the neural mechanisms mediating these preferences. In anurans, mating preferences have often been explained in terms of sensory biases...
October 1, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29043949/arthroscopic-surgery-for-knee-osteoarthritis-impact-of-health-technology-assessment-in-germany
#3
Naomi Fujita-Rohwerder, Alric Rüther, Stefan Sauerland
OBJECTIVES: This study aims to describe how a negative reimbursement decision-based on the health technology assessment (HTA) report of a nondrug intervention-affects healthcare providers in Germany. METHODS: Knee arthroscopy was chosen as an example, because as of April 2016 this procedure is no longer reimbursed for osteoarthritis, but is still covered for other indications, including meniscal lesions. The exclusion followed an HTA report prepared by the Institute for Quality and Efficiency in Health Care (IQWiG)...
October 18, 2017: International Journal of Technology Assessment in Health Care
https://www.readbyqxmd.com/read/29039725/high-risk-breast-lesions-a-machine-learning-model-to-predict-pathologic-upgrade-and-reduce-unnecessary-surgical-excision
#4
Manisha Bahl, Regina Barzilay, Adam B Yedidia, Nicholas J Locascio, Lili Yu, Constance D Lehman
Purpose To develop a machine learning model that allows high-risk breast lesions (HRLs) diagnosed with image-guided needle biopsy that require surgical excision to be distinguished from HRLs that are at low risk for upgrade to cancer at surgery and thus could be surveilled. Materials and Methods Consecutive patients with biopsy-proven HRLs who underwent surgery or at least 2 years of imaging follow-up from June 2006 to April 2015 were identified. A random forest machine learning model was developed to identify HRLs at low risk for upgrade to cancer...
October 17, 2017: Radiology
https://www.readbyqxmd.com/read/29036751/-diagnosis-and-management-of-vestibular-schwannomas-an-interdisciplinary-challenge
#5
Steffen Rosahl, Christopher Bohr, Michael Lell, Klaus Hamm, Heinrich Iro
Vestibular schwannomas expand slowly in the internal auditory canal, in the cerebellopontine angle, inside the cochlear and the labyrinth. Larger tumors can displace and compress the brainstem. With an annual incidence of 1:100 000 vestibular schwannoma represent 6-7% of all intracranial tumors. In the cerebellopontine angle they are by far the most neoplasm with 90% of all lesions located in this region. Magnetic resonance imaging (MRI), audiometry, and vestibular diagnostics are the mainstays of the clinical workup for patients harboring tumors...
April 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29034318/mediodorsal-thalamic-neurons-mirror-the-activity-of-medial-prefrontal-neurons-responding-to-movement-and-reinforcement-during-a-dynamic-dnmtp-task
#6
Rikki L A Miller, Miranda J Francoeur, Brett M Gibson, Robert G Mair
The mediodorsal nucleus (MD) interacts with medial prefrontal cortex (mPFC) to support learning and adaptive decision-making. MD receives driver (layer 5) and modulatory (layer 6) projections from PFC and is the main source of driver thalamic projections to middle cortical layers of PFC. Little is known about the activity of MD neurons and their influence on PFC during decision-making. We recorded MD neurons in rats performing a dynamic delayed nonmatching to position (dDNMTP) task and compared results to a previous study of mPFC with the same task (Onos et al...
September 2017: ENeuro
https://www.readbyqxmd.com/read/29032158/location-affects-the-management-of-liver-haemangioma-a-retrospective-cohort-study
#7
Xiaolei Liu, Zhiying Yang, Haidong Tan, Li Xu, Liguo Liu, Jia Huang, Shuang Si, Yongliang Sun
BACKGROUND: The location of liver haemangioma may affect surgical decisions, but no study has ever examined this issue. METHODS: A retrospective study was performed on 338 liver haemangioma patients who visited at clinic. The collected data included demographics, location, symptoms and whether surgical treatment was performed. For patients with surgical treatment, the collected data included radiologic characteristics, surgical procedures, surgical variables, postoperative stay, morbidity, and mortality...
October 12, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/29028764/the-prognostic-value-of-mri-in-moderate-and-severe-traumatic-brain-injury-a-systematic-review-and-meta-analysis
#8
Hourmazd Haghbayan, Amélie Boutin, Mathieu Laflamme, François Lauzier, Michèle Shemilt, Lynne Moore, Ryan Zarychanski, Vincent Douville, Dean Fergusson, Alexis F Turgeon
OBJECTIVES: Traumatic brain injury is a major cause of death and disability, yet many predictors of outcome are not precise enough to guide initial clinical decision-making. Although increasingly used in the early phase following traumatic brain injury, the prognostic utility of MRI remains uncertain. We thus undertook a systematic review and meta-analysis of studies evaluating the predictive value of acute MRI lesion patterns for discriminating clinical outcome in traumatic brain injury...
October 12, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/29027859/quantitative-cerebral-blood-flow-using-xenon-enhanced-ct-after-decompressive-craniectomy-in-traumatic-brain-injury
#9
Aditya Vedantam, Claudia S Robertson, Shankar P Gopinath
OBJECTIVE Few studies have reported on changes in quantitative cerebral blood flow (CBF) after decompressive craniectomy and the impact of these measures on clinical outcome. The aim of the present study was to evaluate global and regional CBF patterns in relation to cerebral hemodynamic parameters in patients after decompressive craniectomy for traumatic brain injury (TBI). METHODS The authors studied clinical and imaging data of patients who underwent xenon-enhanced CT (XeCT) CBF studies after decompressive craniectomy for evacuation of a mass lesion and/or to relieve intractable intracranial hypertension...
October 13, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29020853/blood-based-protein-biomarkers-for-the-management-of-traumatic-brain-injuries-in-adults-presenting-with-mild-head-injury-to-emergency-departments-a-living-systematic-review-and-meta-analysis
#10
Stefania Mondello, Abayomi Sorinola, Endre Czeiter, Zoltán Vámos, Krisztina Amrein, Anneliese Synnot, Emma L Donoghue, János Sándor, Kevin K W Wang, Ramon Diaz-Arrastia, Ewout W Steyerberg, David Menon, Andrew Maas, Andras Buki
Accurate diagnosis of traumatic brain injury (TBI) is critical to effective management and intervention, but can be challenging in patients with mild TBI. A substantial number of studies have reported the use of circulating biomarkers as signatures for TBI, capable of improving diagnostic accuracy and clinical decision-making beyond current practice standards. We performed a systematic review and meta-analysis to comprehensively and critically evaluate the existing body of evidence for the use of blood protein biomarkers (S100B, GFAP, NSE, UCH-L1, Tau and Neurofilament proteins) for diagnosis of intracranial lesions on CT following mild TBI...
October 12, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/29016425/diagnostic-value-of-99mtc-ubiquicidin-scintigraphy-in-differentiation-between-osteomyelitis-and-bone-tumors
#11
Narjess Ayati, Mohammad Norouzi, Ramin Sadeghi, Mostafa Erfani, Mohammad Gharedaghi, Kamran Aryana
AIM: The differentiation of osteomyelitis from bone tumors is of great importance in clinical decision-making; however, the features of both osteomyelitis and bone tumors are noncontributory. Tc-ubiquicidin scintigraphy is a new promising method with the ability to specifically localize the infection site by bacterial cell membrane binding. This study aimed to evaluate the ability of this radiopeptide for the differentiation of these two entities. PATIENTS AND METHODS: Thirty consecutive patients (mean age=20...
November 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28993874/prognosis-of-patients-with-primary-malignant-brain-tumors-admitted-to-the-intensive-care-unit-a-two-decade-experience
#12
Maxens Decavèle, Nicolas Weiss, Isabelle Rivals, Hélène Prodanovic, Ahmed Idbaih, Julien Mayaux, Thomas Similowski, Alexandre Demoule
The purpose of this study is to describe the reasons for ICU admission and to evaluate the outcome and prognostic factors of patients with primary malignant brain tumors (PMBT) admitted to the intensive care unit (ICU). This is a retrospective observational cohort study of 196 PMBT patients admitted to two ICUs over a 19-year period. Acute respiratory failure was the main reason for ICU admission (45%) followed by seizures (25%) and non-epileptic coma (14%). Seizures were more common in patients with glial lesions (84 vs...
October 9, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28991133/pleuropulmonary-blastoma-a-single-center-case-series-of-6-patients
#13
Janie M Pierce, Priscilla LaCroix, Kenneth Heym, William P Bowman, Linda Margraf, Jose Iglesias, Anish Ray
Pleuropulmonary blastoma (PPB) is a rare malignancy of childhood which when left untreated often shows pathologic progression resulting in a more aggressive neoplasm with an increasingly poor prognosis. Because of this it is important to diagnose and initiate treatment early. However, early stage PPB can appear as a cystic lung lesion on imaging and can be easily misdiagnosed given the rarity of the malignancy. Moreover, current therapeutic guidelines for these lesions are not well established, making treatment decisions and management difficult for clinicians...
October 4, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28988351/management-of-complex-anterior-shoulder-instability-a-case-based-approach
#14
REVIEW
Nathan Olszewski, Michael Gustin, Emily J Curry, Xinning Li
PURPOSE OF THE REVIEW: The goal of this review is to provide a guide on surgical decision-making options for complex anterior shoulder instability using a case-based approach. RECENT FINDINGS: Arthroscopic Bankart repair is well documented for having successful outcomes in patients with isolated labral tear involvement with minimal bone loss. Latarjet is a generally accepted procedure in patients with 20-30% glenoid bone loss. When bone loss exceeds that which cannot be managed through Latarjet, a range of options exist and are highly dependent upon the extent of osseous deficiency on both the glenoid and humeral sides, surgeon experience, and patient-specific factors...
October 7, 2017: Current Reviews in Musculoskeletal Medicine
https://www.readbyqxmd.com/read/28987685/sub-differentiating-equivocal-pi-rads-3-lesions-in-multiparametric-magnetic-resonance-imaging-of-the-prostate-to-improve-cancer-detection
#15
N L Hansen, B C Koo, A Y Warren, C Kastner, T Barrett
PURPOSE: To evaluate sub-differentiation of PI-RADS-3 prostate lesions using pre-defined T2- and diffusion-weighted (DWI) MRI criteria, to aid the biopsy decision process. METHODS: 143 patients with PIRADS-3 index lesions on MRI underwent targeted transperineal-MR/US fusion biopsy. Radiologists with 2 and 7-years experience performed blinded retrospective second-reads using set criteria and assigned biopsy recommendations. Inter-reader agreement, Gleason score (GS), positive (PPV) predictive values (±95% confidence intervals) were calculated and compared by Fisher's exact test with Bonferroni-Hom correction...
October 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28986230/machine-learning-and-neurosurgical-outcome-prediction-a-systematic-review
#16
REVIEW
Joeky T Senders, Patrick C Staples, Aditya V Karhade, Mark M Zaki, William B Gormley, Marike L D Broekman, Timothy R Smith, Omar Arnaout
OBJECTIVE: Accurate measurement of surgical outcomes is highly desirable to optimize surgical decision-making. An important element of surgical decision making is identification of the patient cohort that will benefit from surgery prior to the intervention. Machine learning (ML) enables computers to learn from previous data to make accurate predictions on new data. In this systematic review, we evaluate the potential of ML for neurosurgical outcome prediction. METHODS: A systematic search in the Pubmed and Embase databases was performed to identify all potential relevant studies up to January 1, 2017...
October 3, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28981566/the-impact-of-executive-functions-and-emotional-intelligence-on-iowa-gambling-task-performance-focus-on-right-frontal-lobe-damage
#17
Oksana Zinchenko, Elena Enikolopova
Objective: Decision-making in the Iowa Gambling Task (IGT) has been intensively studied regarding both the "hot" and "cold" components. The ventromedial prefrontal cortex is a key region involved in processing somatic marker information, though recent findings suggest dorsolateral regions are also important. The dorsolateral prefrontal cortex is also known as a substrate of executive functions-the cold component of decision-making. However, there is contradictory evidence about the role of executive functions, as well as the hot component of decision-making-emotional intelligence...
July 19, 2017: Archives of Clinical Neuropsychology: the Official Journal of the National Academy of Neuropsychologists
https://www.readbyqxmd.com/read/28974246/surgical-repair-and-reconstruction-of-aortic-arch-in-debakey-type-i-aortic-dissection-recent-advances-and-single-center-experience-in-the-application-of-branched-stent-graft
#18
Qian Zhang, Xiaochun Ma, Wenlong Zhang, Zhengjun Wang, Haizhou Zhang, Xiaofeng Zhang, Jian Song, Chengwei Zou
BACKGROUND: Aortic dissection (AD) represents a clinically uncommon aortic pathology which predicts a dismal prognosis if not promptly treated. In acute Debakey type I AD (ADIAD), aortic lesion extends from aortic root to even distal abdominal aorta among which aortic arch and its three main branches still remain a great surgical challenge for repair and reconstruction. Several decades have witnessed the painstaking efforts of cardiovascular surgeons across the globe for optimizing the surgical procedures, from total or hemi-arch replacement, "elephant trunk" technique to branched stent graft...
October 3, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28973000/temporal-similarity-perfusion-mapping-a-standardized-and-model-free-method-for-detecting-perfusion-deficits-in-stroke
#19
Sunbin Song, Reinoud P H Bokkers, Marie Luby, Matthew A Edwardson, Tyler Brown, Shreyansh Shah, Robert W Cox, Ziad S Saad, Richard C Reynolds, Daniel R Glen, Leonardo G Cohen, Lawrence L Latour
INTRODUCTION: Interpretation of the extent of perfusion deficits in stroke MRI is highly dependent on the method used for analyzing the perfusion-weighted signal intensity time-series after gadolinium injection. In this study, we introduce a new model-free standardized method of temporal similarity perfusion (TSP) mapping for perfusion deficit detection and test its ability and reliability in acute ischemia. MATERIALS AND METHODS: Forty patients with an ischemic stroke or transient ischemic attack were included...
2017: PloS One
https://www.readbyqxmd.com/read/28966138/human-lesion-studies-of-ventromedial-prefrontal-cortex
#20
REVIEW
Brett Schneider, Michael Koenigs
Studies of neurological patients with focal lesions involving ventromedial prefrontal cortex (vmPFC) have demonstrated a critical role for this brain area in various aspects of cognition, emotion, and behavior. In this article, we review the key themes, methods, and findings from neuropsychological research on vmPFC lesion patients. Early case studies demonstrated profound disruptions in personality and behavior following vmPFC damage, including blunted affect, poor decision-making, and inappropriate social behavior...
September 28, 2017: Neuropsychologia
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