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https://www.readbyqxmd.com/read/28431417/the-occurrence-of-single-and-multiple-organ-dysfunction-in-pediatric-electrical-versus-other-thermal-burns
#1
Gabriel Hundeshagen, Paul Wurzer, Abigail A Forbes, Charles D Voigt, Vanessa N Collins, Janos Cambiaso-Daniel, Celeste C Finnerty, David N Herndon, Ludwik K Branski
BACKGROUND: Multiple organ failure (MOF) is a major contributor to morbidity and mortality in burned children. While various complications induced by electrical injuries have been described, the incidence and severity of single organ failure (SOF) and MOF associated with this type of injury are unknown. The study was undertaken to compare the incidence and severity of SOF and MOF as well as other complications between electrically and thermally burned children. PATIENTS AND METHODS: Between 2001 and 2016, 288 pediatric patients with electrical burns (EB; n = 96) or thermal burns (CTR; n = 192) were analyzed in this study...
May 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28425226/a-review-of-pediatric-pulmonary-hypertension-with-new-guidelines
#2
Serdar Kula, Ayhan Pektaş
This study aims to review pediatric pulmonary hypertension (PH) by comparing the guidelines of the European Society of Cardiology (ESC)/European Respiratory Society (ERS), the American Heart Association (AHA)/American Thoracic Society (ATS), and the European Pediatric Pulmonary Vascular Disease Network (EPPVDN). All three sets of guidelines define PH as having a mean pulmonary artery pressure of ≥25 mmHg and accept the validity of the World Health Organization (WHO) classification system. Every child with a high index of suspicion for PH should undergo an initial work-up of chest X-rays, electrocardiography, and echocardiography...
April 18, 2017: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28420358/healthcare-utilization-in-older-patients-using-personal-emergency-response-systems-an-analysis-of-electronic-health-records-and-medical-alert-data-brief-description-a-longitudinal-retrospective-analyses-of-healthcare-utilization-rates-in-older-patients-using
#3
Stephen Agboola, Sara Golas, Nils Fischer, Mariana Nikolova-Simons, Jorn Op den Buijs, Linda Schertzer, Joseph Kvedar, Kamal Jethwani
BACKGROUND: Personal Emergency Response Systems (PERS) are traditionally used as fall alert systems for older adults, a population that contributes an overwhelming proportion of healthcare costs in the United States. Previous studies focused mainly on qualitative evaluations of PERS without a longitudinal quantitative evaluation of healthcare utilization in users. To address this gap and better understand the needs of older patients on PERS, we analyzed longitudinal healthcare utilization trends in patients using PERS through the home care management service of a large healthcare organization...
April 18, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28417024/new-classification-for-heart-failure-with-mildly-reduced-ejection-fraction-greater-clarity-or-more-confusion
#4
Sunil Nadar
The latest European Society of Cardiology (ESC) guidelines for the diagnosis and management of heart failure include a new patient group for those with heart failure with mildly reduced ejection fraction (HFmrEF). By defining this group of patients as a separate entity, the ESC hope to encourage more research focusing on patients with HFmrEF. Previously, patients with this condition were caught between two classifications-heart failure with reduced ejection fraction and heart failure with preserved ejection fraction...
February 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28411107/pulmonary-hypertension-due-to-left-heart-disease
#5
REVIEW
Emmanuelle Berthelot, Minh Tam Bailly, Safwane El Hatimi, Ingrid Robard, Hatem Rezgui, Amir Bouchachi, David Montani, Olivier Sitbon, Denis Chemla, Patrick Assayag
Pulmonary hypertension due to left heart disease, also known as group 2 pulmonary hypertension according to the European Society of Cardiology/European Respiratory Society classification, is the most common cause of pulmonary hypertension. In patients with left heart disease, the development of pulmonary hypertension favours right heart dysfunction, which has a major impact on disease severity and outcome. Over the past few years, this condition has been considered more frequently. However, epidemiological studies of group 2 pulmonary hypertension are less exhaustive than studies of other causes of pulmonary hypertension...
April 11, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28405987/cardiorenal-syndrome-clinical-outcome-study
#6
H R Shah, N P Singh, N P Aggarwal, D Singhania, A Kumar
BACKGROUND: Over recent years, the field of medicine has been challenged by the twin epidemic of heart failure and renal insufficiency. The coexistence of the two problems in the same patient, referred to as cardiorenal syndrome (CRS), is defined as 'disorders of the heart and kidneys whereby acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other. The mechanisms underlying this interaction are complex and multifactorial in nature. OBJECTIVE OF STUDY: Identify and classify patients admitted with cardiorenal syndrome into various subtypes and assess clinical outcome at discharge and at three months...
December 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28403428/maternal-and-fetal-outcomes-of-admission-for-delivery-in-women-with-congenital-heart-disease
#7
Robert M Hayward, Elyse Foster, Zian H Tseng
Background: Women with congenital heart disease (CHD) may be at increased risk for adverse events during pregnancy and delivery. Objective: To compare delivery outcomes between women with and without CHD. Design, Setting, and Participants: This retrospective study of inpatient delivery admissions in the Healthcare Cost and Utilization Project's California State Inpatient Database compared maternal and fetal outcomes between women with and without CHD by using multivariate logistic regression...
April 12, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28399043/different-estimation-methods-of-spontaneous-baroreflex-sensitivity-have-different-predictive-value-in-heart-failure-patients
#8
Gian Domenico Pinna, Alberto Porta, Roberto Maestri, Beatrice De Maria, Laura Adelaide Dalla Vecchia, Maria Teresa La Rovere
OBJECTIVE: Several methods have been developed so far to estimate cardiac baroreflex sensitivity (BRS) through the analysis of spontaneous fluctuations of systolic arterial pressure (SAP) and R-R interval. Their relative performance in predicting cardiac mortality in heart failure patients is not known. The aim of this study was to compare the prognostic value of a set of representative indexes of spontaneous BRS in these patients. METHODS: We studied 228 stable, moderate-to-severe heart failure patients with reduced ejection fraction, in sinus rhythm, who underwent an 8-min supine recording of ECG, arterial blood pressure and respiration during paced breathing (15 breaths/min)...
April 10, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28398917/emotion-regulation-and-perceptions-of-illness-coherence-and-controllability-on-regimen-adherence-and-negative-cardiac-health-events-in-african-american-women-with-heart-failure
#9
Kelly L Wierenga
BACKGROUND: African American women with heart failure (HF) have stressors that negatively impact HF self-management adherence and heighten the occurrence of negative cardiac health events. Perceptions of illness coherence and controllability and emotion regulation are known to facilitate self-management in the face of stressors. OBJECTIVE: The aim of this study was to determine whether difficulties with emotion regulation and negative perceptions of illness coherence and controllability are detrimental to adherence and increase negative cardiac health events in this patient population...
April 10, 2017: Journal of Cardiovascular Nursing
https://www.readbyqxmd.com/read/28398017/differential-effects-of-phosphodiesterase-5-inhibition-in-chronic-cardiac-decompensation-depending-on-the-type-whether-hfref-or-hfpef-of-heart-failure-a-meta-analysis
#10
Renato DE Vecchis, Arturo Cesaro, Carmelina Ariano
INTRODUCTION: According to 2015 ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension(PH), no specific drug is currently indicated for PH related to left heart disease( PH-LDH), i.e., the one secondary to left chronic heart failure (CHF), which coincides with the group 2 of the PH classification endorsed by the above-mentioned guidelines. In fact, adoption of therapies that specifically apply for so-called pulmonary arterial hypertension (group 1 of the PH classification) has been regarded as substantially contraindicated in patients with PH- LHD, according to current ESC/ERS guidelines...
April 10, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28395889/identification-of-acute-decompensated-heart-failure-hospitalizations-using-administrative-data
#11
Hans Huang, Matthew Turner, Srihari Raju, Jon Reich, Sarah Leatherman, Katherine Armstrong, Patricia Woods, Ryan E Ferguson, Louis D Fiore, Frank A Lederle
Hospitalization for acute decompensated heart failure (ADHF) is an important outcome in clinical trials and heart failure registries; however, the optimal strategy to identify these hospitalizations using International Classification of Diseases, Ninth Revision (ICD-9) codes is uncertain. We sought to identify diagnostic codes that improve ascertainment of ADHF hospitalizations. Heart failure-related ICD-9 principal discharge codes were used to identify 2,202 hospitalizations within the Minneapolis Veterans Affairs Medical Center from 2009 to 2014...
March 16, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28392863/efficacy-of-intravenous-administration-of-landiolol-in-patients-with-acute-heart-failure-and-supraventricular-tachyarrhythmia
#12
Shunsuke Kiuchi, Hiroto Aikawa, Shinji Hisatake, Takayuki Kabuki, Takashi Oka, Shintaro Dobashi, Takahiro Fujii, Takanori Ikeda
BACKGROUND: Patients with acute heart failure (HF) complicated by supraventricular tachyarrhythmia (SVT) often receive continuous intravenous infusion of landiolol or diltiazem for rate control. It is unclear whether the interval from initiation of infusion to commencement of oral beta-blocker (BB) therapy differs for these two drugs. METHODS: From January 2013 to July 2015, 94 consecutive patients were hospitalized for acute HF complicated by SVT. After 35 patients were excluded, the remaining 59 were divided into groups treated with diltiazem or landiolol...
May 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28389131/autophagy-metabolic-disease-and-pathogenesis-of-heart-dysfunction
#13
REVIEW
Fulong Wang, Jocelyn Jia, Brian Rodrigues
In normal physiology, autophagy is recognized as a protective housekeeping mechanism that enables elimination of unhealthy organelles, protein aggregates, and invading pathogens, as well as recycling cell components and producing new building blocks and energy for cellular renovation and homeostasis. However, overactive or depressed autophagy is often associated with the pathogenesis of multiple disorders, including cardiac disease. During metabolic disorders, such as diabetes and obesity, dysregulation of autophagy frequently leads to cell death, cardiomyopathy, and cardiac dysfunction...
January 14, 2017: Canadian Journal of Cardiology
https://www.readbyqxmd.com/read/28387083/-european-society-of-cardiology-guidelines-for-the-management-of-chronic-heart-failure
#14
REVIEW
A Ancion, V D'Orio, P Lancellotti
Heart failure is a major public health problem in industrialized countries. Its prognosis remains poor. The new European recommendations for heart failure management allow validation of the latest advances in the field. This article focuses on the definition, classification and treatment of chronic heart failure. Indeed, there are new aspects to consider such as, a new classification, a new therapeutic class and new remote monitoring solutions. On the contrary, there is no change in initial drug therapy, integration of the patient in a multidisciplinary program and the importance of treatment of comorbidities...
February 2017: Revue Médicale de Liège
https://www.readbyqxmd.com/read/28385646/independent-risk-factors-contributing-to-acute-kidney-injury-according-to-updated-valve-academic-research-consortium-2-criteria-after-transcatheter-aortic-valve-implantation-a-meta-analysis-and-meta-regression-of-13-studies
#15
Jiayang Wang, Wenyuan Yu, Ye Zhou, Yong Yang, Chenglong Li, Nan Liu, Xiaotong Hou, Longfei Wang
OBJECTIVES: This study aimed to examine the risk factors for transcatheter aortic valve implantation (TAVI)-associated acute kidney injury (AKI) according to the AKI definition from the Valve Academic Research Consortium-2 (VARC-2). SETTING: A meta-analysis. PARTICIPANTS: A total of 661 patients with post-TAVI AKI according to the VARC-2 definition and 2,012 controls were included in the meta-analysis. INTERVENTIONS: Patients undergoing TAVI were included in this meta-analysis...
December 21, 2016: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/28381469/phase-i-clinical-trial-of-autologous-stem-cell-sheet-transplantation-therapy-for-treating-cardiomyopathy
#16
Shigeru Miyagawa, Keitaro Domae, Yasushi Yoshikawa, Satsuki Fukushima, Teruya Nakamura, Atsuhiro Saito, Yasushi Sakata, Seiki Hamada, Koichi Toda, Kyongsun Pak, Masahiro Takeuchi, Yoshiki Sawa
BACKGROUND: When transplanted into failing heart, autologous somatic tissue-derived cells yield functional recovery via paracrine effects that enhance native regeneration. However, the therapeutic effects are modest. We developed a method in which scaffold-free cell sheets are attached to the epicardial surface to maximize paracrine effects. This Phase I clinical trial tested whether transplanting autologous cell-sheets derived from skeletal muscle is feasible, safe, and effective for treating severe congestive heart failure...
April 5, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28377439/association-between-use-of-long-acting-nitrates-and-outcomes-in-heart-failure-with-preserved-ejection-fraction
#17
Shir Lynn Lim, Lina Benson, Ulf Dahlström, Carolyn S P Lam, Lars H Lund
BACKGROUND: Nitrates may be beneficial in heart failure with preserved ejection fraction (HFpEF) by enhancing cGMP signaling and improving hemodynamics, but real-world data on potential efficacy are lacking. METHODS AND RESULTS: We linked the Swedish Heart Failure Registry to national registries with International Classification of Diseases, Tenth Revision comorbidity diagnoses and demographic and socioeconomic data. In HFpEF, defined as left ventricular ejection fraction ≥40%, we derived propensity scores for nitrate use using 52 baseline variables...
April 2017: Circulation. Heart Failure
https://www.readbyqxmd.com/read/28365568/benefits-of-permanent-his-bundle-pacing-combined-with-atrioventricular-node-ablation-in-atrial-fibrillation-patients-with-heart-failure-with-both-preserved-and-reduced-left-ventricular-ejection-fraction
#18
Weijian Huang, Lan Su, Shengjie Wu, Lei Xu, Fangyi Xiao, Xiaohong Zhou, Kenneth A Ellenbogen
BACKGROUND: Clinical benefits from His bundle pacing (HBP) in heart failure patients with preserved and reduced left ventricular ejection fraction are still inconclusive. This study evaluated clinical outcomes of permanent HBP in atrial fibrillation patients with narrow QRS who underwent atrioventricular node ablation for heart failure symptoms despite rate control by medication. METHODS AND RESULTS: The study enrolled 52 consecutive heart failure patients who underwent attempted atrioventricular node ablation and HBP for symptomatic atrial fibrillation...
April 1, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28360241/protocol-for-validating-cardiovascular-and-cerebrovascular-icd-9-cm-codes-in-healthcare-administrative-databases-the-umbria-data-value-project
#19
Francesco Cozzolino, Iosief Abraha, Massimiliano Orso, Anna Mengoni, Maria Francesca Cerasa, Paolo Eusebi, Giuseppe Ambrosio, Alessandro Montedori
INTRODUCTION: Administrative healthcare databases can provide a comprehensive assessment of the burden of diseases in terms of major outcomes, such as mortality, hospital readmissions and use of healthcare resources, thus providing answers to a wide spectrum of research questions. However, a crucial issue is the reliability of information gathered. Aim of this protocol is to validate International Classification of Diseases, 9th Revision-Clinical Modification (ICD-9-CM) codes for major cardiovascular diseases, including acute myocardial infarction (AMI), heart failure (HF), atrial fibrillation (AF) and stroke...
March 29, 2017: BMJ Open
https://www.readbyqxmd.com/read/28336741/differences-between-determinants-of-in-hospital-mortality-and-hospitalisation-costs-for-patients-with-acute-heart-failure-a-nationwide-observational-study-from-japan
#20
Noriko Sasaki, Susumu Kunisawa, Hiroshi Ikai, Yuichi Imanaka
OBJECTIVES: Although current case-mix classifications in prospective payment systems were developed to estimate patient resource usage, whether these classifications reflect clinical outcomes remains unknown. The efficient management of acute heart failure (AHF) with high mortality is becoming more important in many countries as its prevalence and associated costs are rapidly increasing. Here, we investigate the determinants of in-hospital mortality and hospitalisation costs to clarify the impact of severity factors on these outcomes in patients with AHF, and examine the level of agreement between the predicted values of mortality and costs...
March 22, 2017: BMJ Open
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