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Prostate cancer review

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https://www.readbyqxmd.com/read/29028767/prostate-specific-membrane-antigen-guided-salvage-lymph-node-dissection-in-recurrent-prostate-cancer-a-novel-technology-to-detect-lymph-node-metastases
#1
Tobias Maurer, Jürgen E Gschwend, Matthias Eiber
PURPOSE OF REVIEW: With Gallium (Ga)-prostate-specific membrane antigen (PSMA) PET/computed tomography (CT) as emerging imaging technique offering superior detection rates in biochemical recurrent prostate cancer, salvage lymph node dissection has gained increasing interest in localized oligometastatic prostate cancer. Currently, PSMA-targeting small molecules cannot only be linked to positron-emitting isotopes for imaging but also be labelled with γ-radiation emitting isotopes. These modified PSMA agents are evaluated for intraoperative guidance for resection of metastatic lymph nodes...
October 11, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29028765/preventing-clinical-progression-and-need-for-treatment-in-patients-on-active-surveillance-for-prostate-cancer
#2
Hanan Goldberg, Zachary Klaassen, Thenappan Chandrasekar, Neil Fleshner
PURPOSE OF REVIEW: Active surveillance is an established treatment option for men with localized, low-risk prostate cancer (CaP). It entails the postponement of immediate therapy with the option of delayed intervention upon disease progression. The rate of clinical progression and need for treatment on active surveillance is approximately 50% over 15 years. The present review summarizes recent data on current methods, attempting to prevent clinical progression. RECENT FINDINGS: Patient selection for active surveillance is the first mandatory step required to lower progression...
October 11, 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/29028221/quality-of-life-and-patient-reported-outcomes-following-proton-radiation-therapy-a-systematic-review
#3
Vivek Verma, Charles B Simone, Mark V Mishra
Background: As costs of cancer care rise, the importance of documenting value in oncology increases. Proton beam radiotherapy (PBT) has the potential to reduce toxicities in cancer patients, but is relatively expensive and unproven. Evaluating quality of life (QOL) and patient-reported outcomes (PROs) is essential to establishing PBT's "value" in oncologic therapy. The goal of this systematic review was to assess QOL and PROs in patients treated with PBT. Methods: Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-guided systematic searches were conducted...
April 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29026057/pathological-outcome-for-chinese-patients-with-low-risk-prostate-cancer-eligible-for-active-surveillance-and-undergoing-radical-prostatectomy-comparison-of-six-different-active-surveillance-protocols
#4
C F Tsang, J Hl Tsu, T Ct Lai, K W Wong, B Sh Ho, A Tl Ng, W K Ma, M K Yiu
INTRODUCTION: Active surveillance is one of the therapeutic options for the management of patients with low-risk prostate cancer. This study compared the performance of six different active surveillance protocols for prostate cancer in the Chinese population. METHODS: Patients who underwent radical prostatectomy for prostate cancer from January 1998 to December 2012 at a university teaching hospital in Hong Kong were reviewed. Six active surveillance protocols were applied to the cohort...
October 13, 2017: Hong Kong Medical Journal, Xianggang Yi Xue za Zhi
https://www.readbyqxmd.com/read/29023722/prevalence-and-clonality-of-synchronous-primary-carcinomas-in-the-bladder-and-prostate
#5
Ying Jing, Ruiyun Zhang, Pengfei Ma, Mei-Chun Cai, Guanglei Zhuang, Haige Chen
Incidental prostate adenocarcinoma (IPCa) has been frequently discovered during postoperative histopathological evaluation of radical cystoprostatectomy specimens in patients with bladder cancer (BCa). However, there is currently no conclusive study addressing the clinical significance of IPCa and the clonal relatedness of IPCa and BCa. Here, we performed a retrospective single-center review of 919 BCa cases and an additional meta-analysis including a total of 19,868 individuals who underwent radical cystectomy for bladder cancer...
October 11, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/29020683/combination-of-androgen-deprivation-therapy-and-salvage-radiotherapy-versus-salvage-radiotherapy-alone-for-recurrent-prostate-cancer-after-radical-prostatectomy
#6
Sangjun Yoo, Dalsan You, Young Seok Kim, Jun Hyuk Hong, Hanjong Ahn, Choung-Soo Kim
INTRODUCTION: To assess the value of androgen deprivation therapy (ADT) on salvage radiotherapy (RT) in post-prostatectomy recurrent prostate cancer patients, we compared the oncologic outcomes between patients receiving RT + ADT and those receiving RT alone. MATERIALS AND METHODS: We reviewed the records of patients diagnosed with prostate cancer between 1995 and 2011, including 93 patients who underwent salvage RT and 69 patients who underwent salvage RT + ADT...
October 12, 2017: Urologia Internationalis
https://www.readbyqxmd.com/read/29019329/implications-of-observer-variation-in-gleason-scoring-of-prostate-cancer-on-clinical-management-a-collaborative-audit
#7
A Harbias, E Salmo, A Crump
BACKGROUND: Prostate cancer is the most frequently diagnosed cancer in men. Histological tumour grade is a strong predictor of outcome and helps determine what treatment options are offered. There are numerous studies on Inter-observer agreement/variability on prostate cancer grading. In this study, we were looking to establish if disconcordance between pathologists when grading prostate cancer, could affect treatment options offered to men. METHODS: In Greater Manchester West Cancer Sector, all prostate cancer biopsies undergo a central review by three pathologists with a special interest in urological pathology prior to referral for treatment at specialist centres...
September 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29019328/second-primary-tumors-associated-with-breast-cancer-kuwait-cancer-control-center-experience
#8
Salah Fayaz, Gerges Attia Demian, Heba El-Sayed Eissa, Sadeq Abuzalouf
OBJECTIVES: To review the clinico-epidemiologic characteristics of patients who presented with two or more primary cancers, one of which was breast cancer (BC) and to develop a follow-up program for the high risk patients. PATIENTS AND METHODS: Patients who were diagnosed with BC and one or more non breast cancer (NBC) were retrospectively reviewed. Medical files were retrieved and epidemiological as well as clinical data were analyzed. RESULTS: Sixty-two patients were retrieved...
September 2017: Gulf Journal of Oncology
https://www.readbyqxmd.com/read/29017811/a-randomised-trial-comparing-three-delphi-feedback-strategies-found-no-evidence-of-a-difference-in-a-setting-with-high-initial-agreement
#9
Steven MacLennan, Jamie Kirkham, Thomas B L Lam, Paula R Williamson
OBJECTIVE: To explore the impact of different feedback strategies on 1) subsequent agreement and 2) variability in Delphi studies. STUDY DESIGN AND SETTING: A two-round Delphi survey, with a list of outcomes generated from the results of a systematic review and interviews, was undertaken whilst developing a core outcomes set for prostate cancer including two stakeholder groups (health professionals and patients). Seventy-nine outcomes were scored on a scale of one (not important) to nine (critically important)...
October 7, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29017737/laparoscopic-adenomectomy-10-years-of-experience
#10
J Carpio Villanueva, A Rosales Bordes, J Ponce de León Roca, M Montlleó González, J Caparrós Sariol, H Villavicencio Mavrich
INTRODUCTION: Lower urinary tract symptoms secondary to increased prostate volume are associated with ageing and are becoming more prevalent due to increased life expectancy. We present our experience with transperitoneal laparoscopic adenomectomy for the management of bladder outlet obstruction caused by benign prostatic enlargement. MATERIALS AND METHODS: We performed a retrospective review of patients who underwent laparoscopic adenomectomy between 2005 and 2015...
October 7, 2017: Actas Urologicas Españolas
https://www.readbyqxmd.com/read/29016610/association-between-a-17-gene-genomic-prostate-score-and-multi-parametric-prostate-mri-in-men-with-low-and-intermediate-risk-prostate-cancer-pca
#11
Michael S Leapman, Antonio C Westphalen, Niloufar Ameli, H Jeffrey Lawrence, Phillip G Febbo, Matthew R Cooperberg, Peter R Carroll
BACKGROUND: We aimed to directly compare results from multi-parametric prostate MRI (mpMRI) and a biopsy-based 17-gene RT-PCR assay providing a Genomic Prostate Score (GPS) among individuals who were candidates for active surveillance with low and intermediate risk prostate cancer (PCa). PATIENTS AND METHODS: We evaluated the association between GPS results (scale 0-100) and endorectal mpMRI findings in men with clinically localized PCa. MR studies were reviewed to a five-tier scale of increasing suspicion of malignancy...
2017: PloS One
https://www.readbyqxmd.com/read/28994721/natriuretic-peptides-the-case-of-prostate-cancer
#12
REVIEW
Letizia Mezzasoma, Matthew J Peirce, Alba Minelli, Ilaria Bellezza
Cardiac natriuretic peptides have long been known to act as main players in the homeostatic control of blood pressure, salt and water balance. However, in the last few decades, new properties have been ascribed to these hormones. A systematic review of English articles using MEDLINE Search terms included prostate cancer, inflammation, cardiac hormones, atrial natriuretic peptide, and brain natriuretic peptide. Most recent publications were selected. Natriuretic peptides are strongly connected to the immune system, whose two branches, innate and adaptive, are finely tuned and organized to kill invaders and repair injured tissues...
October 10, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28993132/screen-failure-rates-in-contemporary-randomized-clinical-phase-ii-iii-therapeutic-trials-in-genitourinary-malignancies
#13
Sarah E Wong, Scott A North, Christopher J Sweeney, Martin R Stockler, Srikala S Sridhar
BACKGROUND: Screen failures, defined as individuals who undergo screening but are not enrolled in a clinical trial, incur significant costs without contributing valuable data to the study. Despite these costs, there are few published data about the rate or reasons for screen failures in advanced genitourinary cancer clinical trials. MATERIALS AND METHODS: We reviewed 50 phase II and III trials in advanced genitourinary cancers conducted between 1999 and 2016. RESULTS: Of the 50 trials, only 48% (24 of 50) published screen failure rates: 68% (13 of 19) of those in prostate cancer, 33% (6 of 18) in kidney cancer, and 58% (5 of 13) in bladder cancer...
September 8, 2017: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/28990727/magnetic-resonance-imaging-of-the-prostate-and-targeted-biopsy-comparison-of-pirads-and-gleason-grading
#14
Matthew Bastian-Jordan
INTRODUCTION: Multiparametric magnetic resonance imaging (mpMRI) of the prostate has become integral in the investigation of suspected prostate cancer. Regions of interest are graded using the PIRADS scoring system, and in our institution, lesions graded as PIRADS 3-5 undergo sampling by MRI-guided biopsy. Limited data currently exists on PIRADS grading and biopsy results. METHODS: Retrospective review of 343 MRI-guided biopsies (MRGB) performed between April 2013 and December 2016 was conducted...
October 9, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28988963/defining-novel-and-practical-metrics-to-assess-the-deliverables-of-multiparametric-magnetic-resonance-imaging-ultrasound-fusion-prostate-biopsy
#15
Benjamin T Ristau, David Y T Chen, Jeffrey Ellis, Aseem Malhotra, Lyudmilla DeMora, Rosaleen B Parsons, Barton Milestone, Marion Brody, Rosalia Viterbo, Richard Greenberg, Marc Smaldone, Robert Uzzo, Jordan Anaokar, Alexander Kutikov
PURPOSE: Multiparametric magnetic resonance (mpMRI)/ultrasound targeted prostate biopsy (TB) is touted as a tool to improve prostate cancer care. Yet, the true clinical utility of TB over transrectal ultrasound-guided prostate biopsy (TRUS-B) has not been systematically analyzed. We introduce two metrics to better quantify and report the deliverables of TB. MATERIALS AND METHODS: We reviewed our prospective database containing patients who underwent simultaneous TB/TRUS-B...
October 5, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28988618/hospital-burden-of-long-term-genitourinary-and-gastrointestinal-toxicity-after-radical-radiotherapy-for-prostate-cancer
#16
Elaine J Redmond, Katelyn S Dolbec, Aisling S Fawaz, Hugh D Flood, Subhasis K Giri
INTRODUCTION: Treatment options for prostate cancer (PCa) include radical radiotherapy (RT) and radical prostatectomy, both of which have comparable oncological outcomes. The aim of this study was to investigate the hospital burden of long-term genitourinary and gastrointestinal toxicity among patients with PCa who were treated with radiotherapy at our institution. METHODS: The radiotherapy department database was used retrospectively to identify all patients who underwent radiotherapy for PCa from January 2006 to January 2008...
October 4, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28984647/functional-genomics-of-stromal-cells-in-chronic-inflammatory-diseases
#17
Kamil Slowikowski, Kevin Wei, Michael B Brenner, Soumya Raychaudhuri
PURPOSE OF REVIEW: Stroma is a broad term referring to the connective tissue matrix in which other cells reside. It is composed of diverse cell types with functions such as extracellular matrix maintenance, blood and lymph vessel development, and effector cell recruitment. The tissue microenvironment is determined by the molecular characteristics and relative abundances of different stromal cells such as fibroblasts, endothelial cells, pericytes, and mesenchymal precursor cells. Stromal cell heterogeneity is explained by embryonic developmental lineage, stages of differentiation to other cell types, and activation states...
October 4, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/28983908/interventions-for-managing-medication-related-osteonecrosis-of-the-jaw
#18
REVIEW
Natalie H Beth-Tasdogan, Benjamin Mayer, Heba Hussein, Oliver Zolk
BACKGROUND: Medication-related osteonecrosis of the jaw (MRONJ) is a severe adverse reaction experienced by some individuals to certain medicines commonly used in the treatment of cancer and osteoporosis (e.g. bisphosphonates, denosumab and antiangiogenic agents) and involves the progressive destruction of bone in the mandible or maxilla. Depending on the drug, its dosage, and the duration of exposure, the occurrence of this adverse drug reaction may be rare (e.g. following the oral administration of bisphosphonate or denosumab treatments for osteoporosis, or antiangiogenic agent-targeted cancer treatment) or common (e...
October 6, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28983651/-cytoreductive-radical-prostatectomy-in-metastatic-prostate-cancer
#19
REVIEW
M Chaloupka, A Herlemann, A Spek, C Gratzke, C Stief
The resection of the primary tumor in patients with metastatic prostate cancer is controversially debated. Retrospective clinical studies indicate survival benefits and prevention of secondary, locoregional complications; however, results of ongoing multicenter prospective studies are still lacking. This review highlights the rationale behind the cytoreductive prostatectomy and summarizes current clinical study results.
October 5, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28983643/-radical-prostatectomy-in-locally-advanced-prostate-cancer
#20
REVIEW
P Mandel, D Tilki, M Graefen
BACKGROUND: Due to an inverse stage migration, the proportion of patients with more aggressive and locally advanced prostate cancer (PCa) has increased over the last few years. The natural history in these patients shows a higher risk of local complications and worse oncologic outcome. OBJECTIVES: To analyze the impact of radical prostatectomy (RP) in patients with locally advanced PCa. MATERIALS AND METHODS: A review of the literature was performed using PubMed and MEDLINE databases focusing on articles addressing locally advanced PCa...
October 5, 2017: Der Urologe. Ausg. A
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