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https://www.readbyqxmd.com/read/28295655/characteristics-of-spitz-nevi-atypical-spitz-nevi-and-melanomas-in-patients-younger-than-20-years
#1
Efthymia Soura, Michaela Plaka, Christina Stefanaki, Vassiliki Chasapi, Erietta Christofidou, Christina Antoniou, Alexander Stratigos
The Spectrum of Spitzoid tumors and early onset melanomas has been extensively studied during the last few years.(1, 2) Although significant progress has been made in the histopathological and clinical description of these lesions, the biologic potential of the most atypical lesions of the spectrum still remains to be elucidated. This article is protected by copyright. All rights reserved.
March 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28186096/spitz-nevi-and-spitzoid-melanomas-exome-sequencing-and-comparison-with-conventional-melanocytic-nevi-and-melanomas
#2
Rossitza Lazova, Natapol Pornputtapong, Ruth Halaban, Marcus Bosenberg, Yalai Bai, Hao Chai, Michael Krauthammer
We performed exome sequencing of 77 melanocytic specimens composed of Spitz nevi (n=29), Spitzoid melanomas (n=27), and benign melanocytic nevi (n=21), and compared the results with published melanoma sequencing data. Our study highlights the prominent similarity between Spitzoid and conventional melanomas with similar copy number changes and high and equal numbers of ultraviolet-induced coding mutations affecting similar driver genes. Mutations in MEN1, PRKAR1A, and DNMT3A in Spitzoid melanomas may indicate involvement of the protein kinase A pathway, or a role of DNA methylation in the disease...
February 10, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28140545/spitzn%C3%A3-vi-unterschiedliche-klinische-dermatoskopische-und-histopathologische-merkmale-in-der-kindheit
#3
Emi Dika, Iria Neri, Pier Alessandro Fanti, Alessia Barisani, Giulia Maria Ravaioli, Annalisa Patrizi
HINTERGRUND UND ZIELE: Die Charakterisierung der klinischen Merkmale und des biologischen Potenzials von Spitznävi hat in den letzten Jahrzehnten breites Interesse gefunden. Das Ziel dieser Arbeit ist die Beschreibung der klinischen und dermatoskopischen Merkmale von Spitznävi sowie des klinischen Ergebnisses nach chirurgischer Exzision von Spitznävi in drei pädiatrischen Altersgruppen. PATIENTEN UND METHODEN: Restrospektive Studie zur Analyse von klinischen Merkmalen, videodermatoskopischen Bildern, histopathologischen Diagnosen und Behandlungsergebnissen...
January 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28140544/h%C3%A3-ufigkeit-und-muster-der-tumorerkennung-nach-selbstuntersuchung-bei-mittel-bis-hochrisiko-melanompatienten
#4
Anca Sindrilaru, Vera Neckermann, Thomas Eigentler, Panagiotis Kampilafkos, Diana Crisan, Nicolai Treiber, Karin Scharffetter-Kochanek, Lars Alexander Schneider
HINTERGRUND UND ZIELSETZUNG: Die Frage, wie oft Melanompatienten mit Mittel- bis Hochrisikomelanomen den Tumor bemerken und welche Eigenerkennungsmuster existieren ist bislang nicht beantwortet. PATIENTEN UND METHODEN: Wir haben eine retrospektive Studie an Melanompatienten durchgeführt, die sich zwischen 2004 und 2008 einer Sentinellymphknotenbiopsie unterzogen haben,. Der Fragebogen wurde von 127 der insgesamt 133 Patienten ausgefüllt. ERGEBNISSE: 25 % bemerkten den Tumor überhaupt nicht...
January 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28140538/self-detection-frequency-and-recognition-patterns-in-medium-to-high-risk-cutaneous-melanoma-patients
#5
Anca Sindrilaru, Vera Neckermann, Thomas Eigentler, Panagiotis Kampilafkos, Diana Crisan, Nicolai Treiber, Karin Scharffetter-Kochanek, Lars Alexander Schneider
BACKGROUND AND OBJECTIVES: The question of how frequently patients with medium to high-risk melanomas become aware of their tumors and which self-detection patterns exist remains unanswered. PATIENTS AND METHODS: We conducted a retrospective survey of melanoma patients who had undergone sentinel node biopsy between 2004 and 2008. One hundred twenty-seven out of a total of 133 patients completed the questionnaire. RESULTS: Twenty-five percent of patients had not noticed their tumors at all...
January 2017: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/28118479/update-on-dermoscopy-of-spitz-reed-naevi-and-management-guidelines-by-the-international-dermoscopy-society
#6
REVIEW
A Lallas, Z Apalla, D Ioannides, E Lazaridou, A Kyrgidi, P Broganelli, R Alfano, I Zalaudek, G Argenziano
Spitzoid lesions represent a challenging and controversial group of tumours, in terms of clinical recognition, biologic behavior and management strategies. Although Spitz naevi are considered benign tumours, their clinical and dermoscopic morphologic overlap with spitzoid melanoma renders the management of spitzoid lesions particularly difficult. The controversy deepens because of the existence of tumours that cannot be safely histopathologically diagnosed as naevi or melanomas (atypical Spitz tumours). The dual objective of the present study was to provide an updated classification on dermoscopy of Spitz naevi, and management recommendations of spitzoid looking lesions based on a consensus among experts in the field...
January 24, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28102445/-congenital-nevus-atypical-spitz-nevus-or-spitzoid-melanoma
#7
A Blum, M Tanaka, K S Kraemer-Schultheiss, J Bauer
No abstract text is available yet for this article.
January 19, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/27892929/a-review-of-kinase-fusions-in-melanocytic-tumors
#8
Sara C Shalin
Translocations resulting in a kinase fusion are well reported in many tumor types and indeed can be defining, particularly in the case of hematopoietic malignancies. The recent reports of multiple protein kinase fusions within melanocytic neoplasms, particularly in those with spitzoid morphology, have heralded a new era of classification of these melanocytic tumors. Seen within approximately half of all spitzoid neoplasms and present within the full spectrum of benign, atypical, and malignant lesions, kinase fusions likely represent an early oncogenic event contributing to cell proliferation and growth...
February 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/27874206/spitz-nevi-and-other-spitzoid-neoplasms-in-children-overview-of-incidence-data-and-diagnostic-criteria
#9
REVIEW
Emi Dika, Giulia Maria Ravaioli, Pier Alessandro Fanti, Iria Neri, Annalisa Patrizi
Spitz nevi are benign melanocytic neoplasms characterized by epithelioid or spindle melanocytes or both. In some rare cases their presentation overlaps with the clinical and histopathologic features of malignant melanoma, so a differential diagnosis can be difficult to make. Intermediate forms between Spitz nevi and malignant melanoma, with unpredictable behavior, have been called atypical Spitz tumors. A literature search was performed to review the clinical, dermoscopic, genetic, and histopathologic aspects of spitzoid tumors...
November 22, 2016: Pediatric Dermatology
https://www.readbyqxmd.com/read/27862191/significance-of-epidermal-mitoses-in-challenging-melanocytic-proliferations
#10
Eugen C Minca, Steven D Billings, Paul Elson, Michael T Tetzlaff, Aleodor A Andea, Jennifer S Ko
BACKGROUND: Accurate diagnosis of melanoma remains histologically challenging. Dermal mitoses support malignancy, but are only occasionally seen in melanomas. As melanomagenesis is thought to begin at the dermal-epidermal junction, we investigated the significance of epidermal melanocytic mitoses (EMM) in a spectrum of lesions with molecular characterization. METHODS: Epidermal mitoses density (EMD) was evaluated in 46 straightforward lesions (24 benign and 22 malignant) and 30 challenging lesions with expert interpretation, fluorescence in situ hybridization and myPath-score characterization (12 favor-benign, 9 favor-malignant and 9 ambiguous)...
February 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27860221/spitz-nevi-diverse-clinical-dermatoscopic-and-histopathological-features-in-childhood
#11
Emi Dika, Iria Neri, Pier Alessandro Fanti, Alessia Barisani, Giulia Maria Ravaioli, Annalisa Patrizi
BACKGROUND AND OBJECTIVES: The characterization of clinical features and biological potential of Spitz nevi has attracted a lot of interest in past decades. The aim of our paper was to describe the clinical, dermatoscopic features as well as the clinical outcome of surgically excised Spitz nevi in three different pediatric age groups. PATIENTS AND METHODS: A retrospective study analyzing clinical features, videodermatoscopic images, histopathological diagnosis and patient outcome...
November 10, 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
https://www.readbyqxmd.com/read/27776007/a-comparison-of-morphologic-and-molecular-features-of-braf-alk-and-ntrk1-fusion-spitzoid-neoplasms
#12
Sapna M Amin, Alexandra M Haugh, Christina Y Lee, Bin Zhang, Jeffrey A Bubley, Emily A Merkel, Anna Elisa Verzì, Pedram Gerami
Recent studies have identified translocations involving the kinase domains of ALK, NTRK1, BRAF, RET, and ROS in spitzoid neoplasms. Subsequent studies have also characterized morphologic features corresponding to ALK and NTRK1 translocations. In this study, we sought to further compare morphologic features across a range of 49 genetically defined spitzoid neoplasms with ALK, NTRK1, BRAF, or RET fusions to determine discriminating features. We also compared them with a group of 22 spitzoid neoplasms, which were confirmed to be negative for fusions in ALK, NTRK1, BRAF, and RET...
April 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27686456/the-utilization-of-spitz-related-nomenclature-in-the-histological-interpretation-of-cutaneous-melanocytic-lesions-by-practicing-pathologists-results-from-the-m-path-study
#13
Ge Zhao, Kachiu C Lee, Sue Peacock, Lisa M Reisch, Stevan R Knezevich, David E Elder, Michael W Piepkorn, Joann G Elmore, Raymond L Barnhill
BACKGROUND: Spitz nevi, atypical Spitz tumors and spitzoid melanomas ('spitzoid lesions') represent controversial and poorly understood cutaneous melanocytic lesions that are difficult to diagnose histologically. It is unknown how these terms are used by pathologists. METHODS: We describe use of Spitz-related terminology using data from the Melanoma Pathology (M-Path) study database comprising pathologists' interpretations of biopsy slides, a nation-wide study evaluating practicing US pathologists' (N = 187) diagnoses of melanocytic lesions (8976 independent diagnostic assessments on 240 total test cases, with 1 slide per case)...
January 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27569296/loss-of-p16-expression-and-copy-number-changes-of-cdkn2a-in-a-spectrum-of-spitzoid-melanocytic-lesions
#14
Paul W Harms, Thomas L Hocker, Lili Zhao, May P Chan, Aleodor A Andea, Min Wang, Kelly L Harms, Michael L Wang, Shannon Carskadon, Nallasivam Palanisamy, Douglas R Fullen
Spitzoid melanocytic lesions, including Spitz nevi (benign), spitzoid melanoma (malignant), and borderline atypical Spitz tumors (ASTs), frequently present challenges for accurate diagnosis and prognosis. Evaluation for loss of the tumor suppressor p16, encoded by CDKN2A gene on chromosome 9p21.3, has been proposed to be useful for evaluation of spitzoid melanocytic lesions. However, reports on the utility of p16 immunohistochemistry for spitzoid lesions have been conflicting, and few studies have directly compared p16 immunohistochemistry with fluorescence in situ hybridization (FISH) for CDKN2A genomic status...
August 25, 2016: Human Pathology
https://www.readbyqxmd.com/read/27502312/imaging-mass-spectrometry-assists-in-the-classification-of-diagnostically-challenging-atypical-spitzoid-neoplasms
#15
Rossitza Lazova, Erin H Seeley, Heinz Kutzner, Richard A Scolyer, Glynis Scott, Lorenzo Cerroni, Isabella Fried, Milena E Kozovska, Arlene S Rosenberg, Victor G Prieto, Bahig M Shehata, Megan M Durham, Gina Henry, Jose L Rodriguez-Peralto, Erica Riveiro-Falkenbach, Jochen T Schaefer, Richard Danialan, Sylvie Fraitag, Sonja Vollenweider-Roten, Alireza Sepehr, Martin Sangueza, Nouf Hijazi, Yamile Corredoira, Rachel Kowal, Olga M Harris, Francisco Bravo, Alan S Boyd, Ralitza Gueorguieva, Richard M Caprioli
BACKGROUND: Previously, using imaging mass spectrometry (IMS), we discovered proteomic differences between Spitz nevi and Spitzoid melanomas. OBJECTIVE: We sought to determine whether IMS can assist in the classification of diagnostically challenging atypical Spitzoid neoplasms (ASN), to compare and correlate the IMS and histopathological diagnoses with clinical behavior. METHODS: We conducted a retrospective collaborative study involving centers from 11 countries and 11 US institutions analyzing 102 ASNs by IMS...
December 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/27469124/classification-of-indeterminate-melanocytic-lesions-by-microrna-profiling
#16
Nicholas Latchana, Sara E Martin Del Campo, Valerie P Grignol, Jennifer R Clark, Scott P Albert, Jie Zhang, Lai Wei, Jennifer H Aldrink, Kathleen K Nicol, Mark A Ranalli, Sara B Peters, Alejandro Gru, Prashant Trihka, Philip R O Payne, J Harrison Howard, William E Carson
PURPOSE: Identification of indeterminate melanocytic skin lesions capable of neoplastic progression is suboptimal and may potentially result in unnecessary morbidity from surgery. MicroRNAs (miRs) may be useful in classifying indeterminate Spitz tumors as having high or low risk for malignant behavior. METHODS: RNA was extracted from paraffin-embedded tissues of benign nevi, benign Spitz tumors, indeterminate Spitz tumors, and Spitzoid melanomas in adults (n = 62) and children (n = 28)...
July 28, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27391457/atypical-spitzoid-neoplasms-in-childhood-a-molecular-and-outcome-study
#17
Christina Y Lee, Lauren M Sholl, Bin Zhang, Emily A Merkel, Sapna M Amin, Joan Guitart, Pedram Gerami
The natural history of atypical Spitz neoplasms remains poorly understood, resulting in significant patient and clinician anxiety. We sought to better characterize outcomes that correlated with molecular features by performing a prospective cohort study of pediatric atypical spitzoid neoplasms in which fluorescence in situ hybridization studies were obtained for diagnosis. Cases with sufficient tissue underwent additional retrospective assessment for translocations in ALK, NTRK1, BRAF, RET, and ROS1. Among 246 total patients assessed, 13% had a positive fluorescence in situ hybridization result...
March 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/27348579/cutaneous-malignant-melanoma-in-children-and-adolescents-treated-in-pediatric-oncology-units
#18
Yves Réguerre, Marie Vittaz, Daniel Orbach, Caroline Robert, Christine Bodemer, Christina Mateus, Dominique Plantaz, Emmanuel Plouvier, Patrick Lutz, Josue Rakotonjanahary, Sylvie Fraitag, Ludovic Martin
OBJECTIVES: Recent progress in the understanding of tumor biology and new targeted therapies has led to improved survival in adults with malignant melanoma (MM). MM is rare in children, especially before puberty. We report here our experience with pediatric patients with MM, describe the clinical presentation, treatment and evolution, and compare prepubescent and postpubescent disease. METHODS: A retrospective, descriptive, national multicenter study was undertaken of 52 cases of MM in children and adolescents...
November 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27256160/ros1-fusions-in-cancer-a-review
#19
REVIEW
Arnaud Uguen, Marc De Braekeleer
The ROS1 gene belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. A literature review identified a ROS1 fusion in 2.54% of the patients with lung adenocarcinoma and even higher frequencies in spitzoid neoplasms and inflammatory myofibroblastic tumors. At present, 26 genes were found to fuse with ROS1, some of them already known to fuse with RET and ALK. All the fusion proteins retain the ROS1 kinase domain, but rarely its transmembrane domain. Most of the partners have dimerization domains that are retained in the fusion, presumably leading to constitutive ROS1 tyrosine kinase activation...
August 2016: Future Oncology
https://www.readbyqxmd.com/read/27222771/time-to-reconsider-spitzoid-neoplasms
#20
REVIEW
Carmelo Urso
BACKGROUND: Spitzoid neoplasms may pose significant diagnostic problems because in a fraction of them it is quite difficult or impossible to establish if they are benign or malignant lesions. An extraordinarily large number of studies have been made in attempts to solve this problem; regrettably, the histological criteria proposed and the various special sophisticated techniques employed have proven to be ineffective in making this distinction with confidence. OBJECTIVES: To explore the possible causes for this diagnostic failure and an attempt to identify the source of this problem...
April 2016: Dermatology Practical & Conceptual
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