keyword
MENU ▼
Read by QxMD icon Read
search

Melanocytic

keyword
https://www.readbyqxmd.com/read/29224244/a-histopathological-classification-system-of-tyr-nrasq61k-murine-melanocytic-lesions-a-reproducible-simplified-classification
#1
Pierre Sohier, Léa Legrand, Zackie Aktary, Christine Grill, Véronique Delmas, Florence Bernex, Edouard Reyes-Gomez, Lionel Larue, Béatrice Vergier
Genetically engineered mouse models offer essential opportunities to investigate the mechanisms of initiation and progression in melanoma. Here we report a new simplified histopathology classification of mouse melanocytic lesions in Tyr::NRASQ61K derived models, using an interactive decision tree that produces homogeneous categories. Reproducibility for this classification system was evaluated on a panel of representative cases of murine melanocytic lesions by pathologists and basic scientists. Reproducibility, measured as inter-rater agreement between evaluators using a modified Fleiss' kappa statistic revealed a very good agreement between observers...
December 10, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29223142/designing-tyrosinase-sirnas-by-multiple-prediction-algorithms-and-evaluation-of-their-anti-melanogenic-effects
#2
Ok-Seon Kwon, Soo-Jung Kwon, Jin Sang Kim, Gunbong Lee, Han-Joo Maeng, Jeongmi Lee, Gwi Seo Hwang, Hyuk-Jin Cha, Kwang-Hoon Chun
Melanin is a pigment produced from tyrosine in melanocytes. Although melanin has a protective role against UVB radiation-induced damage, it is also associated with the development of melanoma and darker skin tone. Tyrosinase is a key enzyme in melanin synthesis, which regulates the rate-limiting step during conversion of tyrosine into DOPA and dopaquinone. To develop effective RNA interference therapeutics, we designed a melanin siRNA pool by applying multiple prediction programs to reduce human tyrosinase levels...
December 8, 2017: Biomolecules & Therapeutics
https://www.readbyqxmd.com/read/29219794/-a-brown-red-papule
#3
N A Ipenburg, W J Mooi, R van Doorn
A 44-year-old woman was referred with a brown-red papule on the back. Histopathologic examination showed a melanocytic BAP1-associated intradermal tumour. A germline mutation in the BAP1 gene confirmed a diagnosis of BAP1 tumour predisposition syndrome. This syndrome is associated with various tumour types. Early diagnosis is essential for counselling and screening.
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29215322/aberrant-sirt6-expression-contributes-to-melanoma-growth-role-of-the-autophagy-paradox-and-igf-akt-signaling
#4
Liwen Wang, Weinan Guo, Jinyuan Ma, Wei Dai, Lin Liu, Sen Guo, Jiaxi Chen, Huina Wang, Yuqi Yang, Xiuli Yi, Gang Wang, Tianwen Gao, Guannan Zhu, Chunying Li
Melanoma is among the most life-threatening cancer. The pathogenesis of melanoma has not been fully elucidated. Recently, dysregulated macroautophagy/autophagy has been found to play a critical but inconsistent role in modulating melanoma growth at different stages, with the regulatory mechanism unclear. The histone deacetylase SIRT6 (sirtuin 6) is a known autophagy regulator, and its involvement in cancer development has been reported. Therefore, we sought to determine the role of SIRT6 in melanoma growth and detect its possible link with autophagy in the current study...
December 7, 2017: Autophagy
https://www.readbyqxmd.com/read/29210482/genomic-analysis-of-a-case-of-agminated-spitz-nevi-and-congenital-pattern-nevi-arising-in-extensive-nevus-spilus
#5
Caitlin Porubsky, Jamie K Teer, Yonghong Zhang, Maria Deschaine, Vernon Sondak, Jane L Messina
Nevus spilus is a melanocytic neoplasm characterized by a tan macular background punctuated by multiple hyperpigmented macules or papules that represent various types of nevi. These include junctional and compound nevi, Spitz nevi, and rarely blue nevi. We report a unique case of widespread, multiple nevi spili giving rise to agminated Spitz nevi and congenital-pattern compound nevi that underwent genetic analysis to further characterize the mutational profile of this rare entity.
December 6, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29208563/malignant-perivascular-epithelioid-cell-tumor-of-the-oropharynx-with-strong-tfe3-expression-mimicking-alveolar-soft-part-sarcoma-a-case-report-and-review-of-the-literature
#6
Karan Saluja, Jaiyeola Thomas, Songlin Zhang, Erich M Sturgis, Kunal S Jain, Victor G Prieto, Adel K El-Naggar, Diana Bell
Perivascular epithelioid cell tumors (PEComas) in the head and neck region are rare with 26 cases described in literature. These distinct mesenchymal tumors normally express both myoid and melanocytic markers. We here report an interesting and challenging case of malignant PEComa that showed transcription factor E3 (TFE3) protein expression and rearrangement, paucity of muscle and melanocytic marker expression, and morphologically mimicked as alveolar soft part sarcoma. Awareness of this morphologic pitfall and recognition TFE3 gene rearranged PEComa, as a distinct subtype of PEComa is essential to avoid misdiagnosis...
December 2, 2017: Human Pathology
https://www.readbyqxmd.com/read/29207659/2-3-4-dihydroxybenzylidene-malononitrile-as-a-novel-anti-melanogenic-compound
#7
Bonggi Lee, Kyoung Mi Moon, Jong Seung Lim, Yeojin Park, Do Hyun Kim, Sujin Son, Hyoung Oh Jeong, Dae Hyun Kim, Eun Kyeong Lee, Ki Wung Chung, Hye Jin An, Pusoon Chun, Arnold Y Seo, Ju-Hye Yang, Bong-Seon Lee, Jin Yeul Ma, Won-Kyung Cho, Hyung Ryong Moon, Hae Young Chung
Tyrosinase is a key player in ultraviolet-induced melanogenesis. Because excessive melanin accumulation in the skin can induce hyperpigmentation, the development of tyrosinase inhibitors has attracted attention in cosmetic-related fields. However, side effects including toxicity and low selectivity have limited the use of many tyrosinase inhibitors in cosmetics. We synthesized 12 novel 2-(substituted benzylidene)malononitrile derivatives and investigated their anti-melanogenic activities. Of these 12 compounds, 2-(3, 4-dihydroxy benzylidene)malononitrile (BMN11) exhibited the strongest inhibitory activity against tyrosinase (IC50 = 17...
October 31, 2017: Oncotarget
https://www.readbyqxmd.com/read/29207336/cytotoxicity-molecular-modeling-cell-cycle-arrest-and-apoptotic-induction-induced-by-novel-tetrahydro-1-2-4-triazolo-3-4-a-isoquinoline-chalcones
#8
Magda F Mohamed, Hamdi M Hassaneen, Ismail A Abdelhamid
Novel tetrahydro-[1,2,4]triazolo[3,4-a]isoquinolin-3-yl)-3-arylprop-2-en-1-one derivatives were synthesized and their structures were confirmed by different spectral tools. Cytotoxicity test revealed that some compounds exhibited strong to moderate effect, while others showed weak action against different cancer cell lines (MCF7, A549, HCT116, and Hepg2). Breast carcinoma revealed higher sensitivity toward all derivatives especially compounds 5 and 8 which offered the lowest IC50 values (50.05, and 27.15 μg/ml) respectively, relative to the positive control 5-fluorouracil (5-FU) (IC50 = 178 μg/ml)...
November 21, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29206882/morphological-study-of-the-eye-and-adnexa-in-capuchin-monkeys-sapajus-sp
#9
Danielle Nascimento Silva, Arianne Pontes Oriá, Nayone Lantyer Araujo, Emanoel Martins-Filho, Caterina Muramoto, Fernanda de Azevedo Libório, Alessandra Estrela-Lima
The objective of this study was to describe the anatomic and histologic features of the Sapajus sp. eye, comparing similarities and differences of humans and other species of non-human primates for biomedical research purposes. Computed tomography (CT) of adnexa, eye and orbit live animal, as well as formolized pieces of the same structures of Sapajus sp. for anatomical and histological study were also performed. The anatomical description of the eye and adnexa was performed using the techniques of topographic dissection and exenteration...
2017: PloS One
https://www.readbyqxmd.com/read/29204386/identification-of-genotypes-and-allelic-frequencies-of-vitamin-d-receptor-gene-polymorphism-taqi-in-egyptian-melasma-patients
#10
Iman Seleit, Ola Ahmed Bakry, Eman Masoud, Shaimaa Nabil
Background: Melasma is a characteristic pattern of facial hyperpigmentation, occurring primarily on the forehead, cheeks, and chin, in a mask-like distribution. The pathogenesis of melasma is not fully understood. Vitamin D plays a role in skin pigmentation. It exerts its effect through vitamin D receptor (VDR), which is expressed in variable cells including normal melanocytes. Aim and Objective: The aim of the current work was to investigate if VDR gene polymorphism (TaqI) confers susceptibility to melasma in Egyptian patients...
November 2017: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29204000/malignant-gastrointestinal-neuroectodermal-tumor-a-unique-rare-neoplasm
#11
Surbhi Kansal, Seema Rao
Malignant gastrointestinal neuroectodermal tumor (GNET) is a rare malignant tumor. It is also referred to as clear cell sarcoma-like gastrointestinal tumor (CCSLGT). It is an aggressive tumor with a high rate of local recurrence, metastases, and early death from disease. Its pathogenesis is not known. It shows evidence of neural differentiation and lacks immunohistochemical and ultrastructural evidence of melanocytic differentiation. It needs to be distinguished from various mimickers owing to its aggressive course...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29202482/ligand-activated-bmp-signaling-inhibits-cell-differentiation-and-death-to-promote-melanoma
#12
Arvind M Venkatesan, Rajesh Vyas, Alec K Gramann, Karen Dresser, Sharvari Gujja, Sanchita Bhatnagar, Sagar Chhangawala, Camilla Borges Ferreira Gomes, Hualin Simon Xi, Christine G Lian, Yariv Houvras, Yvonne J K Edwards, April Deng, Michael Green, Craig J Ceol
Oncogenomic studies indicate that copy number variation (CNV) alters genes involved in tumor progression; however, identification of specific driver genes affected by CNV has been difficult, as these rearrangements are often contained in large chromosomal intervals among several bystander genes. Here, we addressed this problem and identified a CNV-targeted oncogene by performing comparative oncogenomics of human and zebrafish melanomas. We determined that the gene encoding growth differentiation factor 6 (GDF6), which is the ligand for the BMP family, is recurrently amplified and transcriptionally upregulated in melanoma...
December 4, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29201456/use-of-oct-angiography-in-choroidal-melanocytic-tumors
#13
Juan J Toledo, Mónica Asencio-Duran, Jesús R García-Martinez, Alejandro López-Gaona
Objective: To describe OCTA findings in choroidal melanocytic tumors, especially the microcirculation patterns, and to try to correlate with the histopathological studies. Methods: Cross-sectional, comparative, observational study. 70 cases, including 55 choroidal nevi and 15 choroidal melanomas. Three different observers evaluated specific variables in the choriocapillaris layer on AOCT images and searched for images which described histopathologic vascular patterns, and also, a general description of the images was made...
2017: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29199612/involvement-of-different-genes-expressions-during-immunological-and-inflammatory-responses-in-vitiligo
#14
Chandra Kant Sharma, Monika Sharma, Kanika Prasad
Vitiligo is a condition of the skin distinguished by hypo-pigmentation. Etiology of this disorder is unknown, and several theories and mechanisms have been hypothesized. The inflammatory response in vitiligo is thought to be mediated by polymorphism in genes such as FOXP3, ACE, APE, GSTP1, TLR, SOD, CTLA-4, TAP/LMP gene cluster, etc. Theories including reactive oxygen species model, Nrf2-antioxidant response element (ARE) pathway, WNT pathway, tyrosinase activity, biochemical, molecular, and cellular alterations have been hypothesized to explain vitiligo pathogenesis...
2017: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29193203/nuclear-and-cytoplasmic-features-in-the-diagnosis-of-clark-s-nevi
#15
Manuel Valdebran, Justin Bandino, Amira Elbendary, Abdallah Gad, Sri Krishna Chaitanya Arudra, Sébastien de Feraudy, Dirk M Elston
BACKGROUND: Interpretation of Clark's nevi has generated debate over the years; although criteria has been proposed for grading morphological features of melanocytes, there is still confusion and variability in the assessment of these lesions. METHODS: This is a retrospective observational study conducted on 100 Clark's nevi and 84 melanomas. A single expert dermatopathologist evaluated all blinded and randomized photomicrographs of both the Clark's nevi and melanomas for the presence of 14 cytologic features...
November 28, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/29191620/genetic-alterations-in-primary-acral-melanoma-and-acral-melanocytic-nevus-in-korea-common-mutated-genes-show-distinct-cytomorphological-features
#16
Ki Rang Moon, Yoo Duk Choi, Jung Min Kim, Suna Jin, Min-Ho Shin, Hyun-Jeong Shim, Jee-Bum Lee, Sook Jung Yun
Acral melanoma occurring on the palms, soles, and nails is the most common subtype of cutaneous melanoma in Asians. Genetic alterations in acral melanoma and acral melanocytic nevus are not well known. We performed next-generation sequencing and evaluated the correlations between genetic information and the clinicopathologic characteristicsfrom 85 Korean patients with acral melanocytic neoplasms. Of the 64 patients with acral melanoma, most had ≥ T2 stage, and the heel was the most common anatomical site of melanoma (n = 34, 53...
November 27, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29187213/jmjd6-promotes-melanoma-carcinogenesis-through-regulation-of-the-alternative-splicing-of-pak1-a-key-mapk-signaling-component
#17
Xujun Liu, Wenzhe Si, Xinhua Liu, Lin He, Jie Ren, Ziran Yang, Jianguo Yang, Wanjin Li, Shumeng Liu, Fei Pei, Xiaohan Yang, Luyang Sun
BACKGROUND: Melanoma, originated from melanocytes located on the basal membrane of the epithelial tissue, is the most aggressive form of skin cancer that accounts for 75% of skin cancer-related death. Although it is believed that BRAF mutation and the mitogen-activated protein kinase (MAPK) pathway play critical roles in the pathogenesis of melanoma, how the MAPK signaling is regulated in melanoma carcinogenesis is still not fully understood. METHODS: We characterized JMJD6 expression in melanoma tissue array by immunohistochemistry analysis...
November 29, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/29186858/differential-expression-of-nitric-oxide-synthase-isoforms-nnos-and-inos-in-patients-with-non-segmental-generalized-vitiligo
#18
Mario Vaccaro, Natasha Irrera, Giuseppina Cutroneo, Giuseppina Rizzo, Federico Vaccaro, Giuseppe P Anastasi, Francesco Borgia, Serafinella P Cannavò, Domenica Altavilla, Francesco Squadrito
Nitric oxide (NO) is involved in several biological processes, but its role in human melanogenesis is still not well understood. Exposure to UVA and UVB induces nitric oxide production in keratinocytes and melanocytes through the activation of constitutive nitric oxide synthase, increasing tyrosinase activity and melanin synthesis, whereas inducible nitric oxide synthase over expression might be involved in hypopigmentary disorders. The aim of this study was to evaluate whether inducible nitric oxide synthase and neuronal nitric oxide synthase expression were modified in vitiligo skin compared to healthy controls...
November 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29186251/histopathological-diagnosis-of-small-melanocytic-lesions-suspicious-for-malignant-melanoma
#19
Danielle Carvalho Quintella, Gabriella Campos-do-Carmo, Leonardo Pereira Quintella, Tullia Cuzzi
The concern about malignant skin neoplasms leads to the excision of smaller lesions. This study on small melanocytic lesions aims to evaluate the range of possible histopathological diagnoses, describe histopathological aspects, and assess the usefulness of serial histological sections. We performed a cross-sectional descriptive histopathological study examining 76 pigmented skin lesions up to 6 mm in diameter. Histopathological diagnoses included atypical melanocytic nevi (n=38), common melanocytic nevi (n=18), atypical lentiginous melanocytic hyperplasia with architectural features of atypical melanocytic nevi (n=7), lentigo simplex (n=2), and malignant melanoma (n=1)...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29186245/dermoscopic-patterns-of-melanocytic-nevi-in-children-and-adolescents-a-cross-sectional-study
#20
Christiane Donato Piazza, Sergio Yamada, Aline P Marcassi, Marina G Maciel, Maria P Seize, Silmara C P Cestari
BACKGROUND: Childhood is a dynamic period regarding nevogenesis. Dermoscopy is a noninvasive technique, recommended for the evaluation of pigmented cutaneous lesions. OBJECTIVES: The purpose of this study was to describe the structures and dermoscopic patterns of melanocytic nevi observed in children and adolescents. METHODS: Dermoscopy with photographic documentation was used for nevi located on the face, trunk, and extremities of 38 patients aged from one to 16 years examined at the Pediatric Dermatology Outpatient Clinic of the Federal University of São Paulo...
May 2017: Anais Brasileiros de Dermatologia
keyword
keyword
111530
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"