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https://www.readbyqxmd.com/read/29149719/tissue-specific-bioaccumulation-of-long-chain-perfluorinated-carboxylic-acids-and-halogenated-methylbipyrroles-in-dall-s-porpoises-phocoenoides-dalli-and-harbor-porpoises-phocoena-phocoena-stranded-in-northern-japan
#1
Yukiko Fujii, Yoshihisa Kato, Kentarou Sakamoto, Takashi Matsuishi, Harada H Kouji, Akio Koizumi, Osamu Kimura, Tetsuya Endo, Koichi Haraguchi
This study investigated accumulation of perfluoroalkyl substances (PFASs), persistent organochlorines (OCs), and naturally produced halogenated compounds (NHCs), including brominated methylbipyrroles and methoxylated bromodiphenyl ethers, in liver, blood, and blubber from Dall's porpoises (Phocoenoides dalli) and harbor porpoises (Phocoena phocoena) stranded in Hokkaido, northern Japan. Profiles of the PFASs were dominated by perfluoroundecanoic acid and perfluorotridecanoic acid, both of which accounted for 70% of the total measured PFAS concentrations in both porpoise species...
November 14, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29145467/adenosine-lidocaine-and-mg2-alm-fluid-therapy-attenuates-systemic-inflammation-platelet-dysfunction-and-coagulopathy-after-non-compressible-truncal-hemorrhage
#2
Hayley Letson, Geoffrey Dobson
BACKGROUND: Systemic inflammation and coagulopathy are major drivers of injury progression following hemorrhagic trauma. Our aim was to examine the effect of small-volume 3% NaCl adenosine, lidocaine and Mg2+ (ALM) bolus and 0.9% NaCl/ALM 'drip' on inflammation and coagulation in a rat model of hemorrhagic shock. METHODS: Sprague-Dawley rats (429±4 g) were randomly assigned to: 1) shams, 2) no-treatment, 3) saline-controls, 4) ALM-therapy, and 5) Hextend®. Hemorrhage was induced in anesthetized-ventilated animals by liver resection (60% left lateral lobe and 50% medial lobe)...
2017: PloS One
https://www.readbyqxmd.com/read/29116741/high-performance-plga-magnetic-microspheres-prepared-by-rotating-membrane-emulsification-for-transcatheter-arterial-embolization-and-magnetic-ablation-in-vx2-liver-tumors
#3
Yi-Jun Liang, Hui Yu, Guodong Feng, Linlin Zhuang, Wei Xi, Ming Ma, Jun Chen, Ning Gu, Yu Zhang
Interventional embolization is a popular minimally invasive vascular therapeutic technique and has been widely applied for hepatocellular carcinoma (HCC) therapy. However, harmful effects caused by transcatheter arterial chemoembolization (TACE) and radioembolization, such as the toxicity of chemotherapy or excessive radiation damage, are serious disadvantages and significantly reduce the therapeutic efficacy. Here, a synergistic therapeutic strategy combined transcatheter arterial embolization and magnetic ablation (TAEMA) by using PLGA-magnetic microspheres (MMs) has been successfully applied to orthotopic VX2 liver tumors of rabbits...
November 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29108404/assessment-of-rotational-thromboelastometry-for-the-prediction-of-red-blood-cell-requirements-in-orthotopic-liver-transplantation
#4
Antoni Sabate, Annabel Blasi, Marta Costa, Raquel Reyes, Joan Beltran, Ferran Torres
BACKGROUND: In liver transplantation most studies were designed to predict massive transfusion rather than whether or not transfusion is required. We hypothesized that (presurgery) data from thromboelastometry may predict perioperative blood requirements. METHODS: A post-hoc analysis of data from a controlled trial was performed with the primary end point of predicting zero red blood cells. Of the 92 patients studied, 6 were excluded because of incomplete EXTEM and / or FIBTEM data...
November 6, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/29106377/an-interdimensional-correlation-framework-for-real-time-estimation-of-six-degree-of-freedom-target-motion-using-a-single-x-ray-imager-during-radiotherapy
#5
Doan Trang Nguyen, Jenny Bertholet, Jungha Kim, Ricky T O'Brien, Jeremy Todd Booth, Per Rugaard Poulsen, Paul J Keall
Increasing evidence suggests that intrafraction tumour motion monitoring needs to include both 3D translations and 3D rotations. Presently, methods to estimate the rotation motion require the 3D translation of the target to be known first. However, ideally, translation and rotation should be estimated concurrently. We present the first method to directly estimate six-degree-of-freedom (6DoF) motion from the target's projection on a single rotating x-ray imager in real-time. Methods: This novel method is based on the linear correlations between the superior-inferior translations and the motion in the other five degrees-of-freedom...
November 6, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29105019/texture-specific-bag-of-visual-words-model-and-spatial-cone-matching-based-method-for-the-retrieval-of-focal-liver-lesions-using-multiphase-contrast-enhanced-ct-images
#6
Yingying Xu, Lanfen Lin, Hongjie Hu, Dan Wang, Wenchao Zhu, Jian Wang, Xian-Hua Han, Yen-Wei Chen
PURPOSE: The bag of visual words (BoVW) model is a powerful tool for feature representation that can integrate various handcrafted features like intensity, texture, and spatial information. In this paper, we propose a novel BoVW-based method that incorporates texture and spatial information for the content-based image retrieval to assist radiologists in clinical diagnosis. METHODS: This paper presents a texture-specific BoVW method to represent focal liver lesions (FLLs)...
November 5, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/29088950/neurosurgical-applications-of-viscoelastic-hemostatic-assays
#7
Svetlana Kvint, James Schuster, Monisha A Kumar
Patients taking antithrombotic agents are very common in neurosurgical practice. The perioperative management of these patients can be extremely challenging especially as newer agents, with poorly defined laboratory monitoring and reversal strategies, become more prevalent. This is especially true with emergent cases in which rapid reversal of anticoagulation is required and the patient's exact medical history is not available. With an aging patient population and the associated increase in diseases such as atrial fibrillation, it is expected that the use of these agents will continue to rise in coming years...
November 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29059036/deep-learning-with-convolutional-neural-network-for-differentiation-of-liver-masses-at-dynamic-contrast-enhanced-ct-a-preliminary-study
#8
Koichiro Yasaka, Hiroyuki Akai, Osamu Abe, Shigeru Kiryu
Purpose To investigate diagnostic performance by using a deep learning method with a convolutional neural network (CNN) for the differentiation of liver masses at dynamic contrast agent-enhanced computed tomography (CT). Materials and Methods This clinical retrospective study used CT image sets of liver masses over three phases (noncontrast-agent enhanced, arterial, and delayed). Masses were diagnosed according to five categories (category A, classic hepatocellular carcinomas [HCCs]; category B, malignant liver tumors other than classic and early HCCs; category C, indeterminate masses or mass-like lesions [including early HCCs and dysplastic nodules] and rare benign liver masses other than hemangiomas and cysts; category D, hemangiomas; and category E, cysts)...
October 27, 2017: Radiology
https://www.readbyqxmd.com/read/29055918/rotational-thromboelastometry-or-conventional-coagulation-tests-in-liver-transplantation-comparing-blood-loss-transfusions-and-cost
#9
Laura Smart, Khalid Mumtaz, Danielle Scharpf, Nicole O'Bleness Gray, Daniel Traetow, Sylvester Black, Anthony J Michaels, Elmahdi Elkhammas, Robert Kirkpatrick, A James Hanje
INTRODUCTION: Orthotopic liver transplantation (OLT) can be associated with significant bleeding requiring multiple blood product transfusions. Rotational thromboelastometry (ROTEM) is a point-of-care device that has been used to monitor coagulation during OLT. Whether it reduces blood loss/transfusions during OLT remains controversial. MATERIALS AND METHODS: We aim to compare ROTEM with conventional coagulation tests (aPTT, PT, INR, platelet count, fibrinogen) to guide transfusion of platelets, cryoprecipitate, and fresh frozen plasma (FFP) during OLT over 3 years...
October 16, 2017: Annals of Hepatology
https://www.readbyqxmd.com/read/28972369/tio2-photocatalysis-desi-ms-rotating-array-platform-for-high-throughput-investigation-of-oxidation-reactions
#10
Miina Ruokolainen, Ville Miikkulainen, Mikko Ritala, Tiina Sikanen, Tapio Kotiaho, Risto Kostiainen
We present a new high-throughput platform for studying titanium dioxide (TiO2) photocatalytic oxidation reactions by performing reactions on a TiO2-coated surface, followed by direct analysis of oxidation products from the surface by desorption electrospray ionization mass spectrometry (DESI-MS). For this purpose, we coated a round glass wafer with photocatalytically active anatase-phase TiO2 using atomic layer deposition. Approximately 70 aqueous 1 μL samples can be injected onto the rim of the TiO2-coated glass wafer, before the entire wafer is exposed to UV irradiation...
November 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28937273/cone-beam-ct-acquisition-during-transradial-tace-made-easy-use-of-the-swivel-arm-board
#11
Uei Pua, Chia Chia Teo, Pe Thet U, Lawrence Han Hwee Quek
OBJECTIVE: Transradial access for peripheral intervention often requires certain modification from its coronary counterparts. One of the challenges during transradial transarterial chemoembolization (TACE) is the need for the access arm to be repositioned during cone-beam CT (CBCT) acquisition to allow for C-arm rotation. We recently introduced a swivel arm board to allow seamless repositioning of the access arm during and after CBCT acquisition. The purpose of this study is to detail the technique and feasibility of this useful adjunct to transradial TACE...
October 26, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28858038/liver-fibrosis-quantification-by-magnetic-resonance-imaging
#12
Léonie Petitclerc, Guillaume Gilbert, Bich N Nguyen, An Tang
Liver fibrosis is a hallmark of chronic liver disease characterized by the excessive accumulation of extracellular matrix proteins. Although liver biopsy is the reference standard for diagnosis and staging of liver fibrosis, it has some limitations, including potential pain, sampling variability, and low patient acceptance. Hence, there has been an effort to develop noninvasive imaging techniques for diagnosis, staging, and monitoring of liver fibrosis. Many quantitative techniques have been implemented on magnetic resonance imaging (MRI) for this indication...
August 28, 2017: Topics in Magnetic Resonance Imaging: TMRI
https://www.readbyqxmd.com/read/28837506/coagulopathy-in-children-with-liver-disease
#13
Patricia Sachi Kawada, Aisha Bruce, Patti Massicotte, Mary Bauman, Jason Yap
It was thought that a high International Normalized Ratio (INR) predicted bleeding in patients with chronic liver disease (CLD) and patients were 'autoanticoagulated'. Contrary to this belief, while patients with CLD experienced bleeding, they also developed thromboses. In the last decade, the prevailing literature challenged the idea that an elevated INR increased bleeding risk. The global assays of coagulation such as: thromboelastography (TEG)/rotational thromboelastometry (ROTEM) and thrombin generation assays (TGA) provide additional insight into coagulation processes...
August 23, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/28795966/the-coagulation-profile-of-end-stage-liver-disease-and-considerations-for-intraoperative-management
#14
Katherine T Forkin, Douglas A Colquhoun, Edward C Nemergut, Julie L Huffmyer
The coagulopathy of end-stage liver disease results from a complex derangement in both anticoagulant and procoagulant processes. With even minor insults, cirrhotic patients experience either inappropriate bleeding or clotting, or even both simultaneously. The various phases of liver transplantation along with fluid and blood product administration may contribute to additional disturbances in coagulation. Thus, anesthetic management of patients undergoing liver transplantation to improve hemostasis and avoid inappropriate thrombosis in the perioperative environment can be challenging...
August 8, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28712715/split-vmat-technique-to-control-the-expiratory-breath-hold-time-in-liver-stereotactic-body-radiation-therapy
#15
Yen Hwa Lin, Shuichi Ozawa, Hideharu Miura, Katsunori Yogo, Takeo Nakashima, Kentaro Miki, Shintaro Tsuda, Yusuke Ochi, Daisuke Kawahara, Tomoki Kimura, Akito Saito, Yasushi Nagata
PURPOSE: In this study, we demonstrate the feasibility of using split-arcs in volumetric modulated arc therapy (VMAT), tailored for expiratory breath-hold in stereotactic body radiation therapy (SBRT) for liver tumors. We compare it with three-dimensional conformal radiation therapy (3D-CRT) and continuous-VMAT, for ten randomly selected hepatocellular carcinoma cases. METHODS: Four coplanar and four non-coplanar beams were used for the 3D-CRT plans. A pair of partial arcs, chosen using a back-and-forth rotating motion, were used for the continuous-VMAT plans...
August 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28685419/joint-deformable-liver-registration-and-bias-field-correction-for-mr-guided-hdr-brachytherapy
#16
Marko Rak, Tim König, Klaus D Tönnies, Mathias Walke, Jens Ricke, Christian Wybranski
PURPOSE: In interstitial high-dose rate brachytherapy, liver cancer is treated by internal radiation, requiring percutaneous placement of applicators within or close to the tumor. To maximize utility, the optimal applicator configuration is pre-planned on magnetic resonance images. The pre-planned configuration is then implemented via a magnetic resonance-guided intervention. Mapping the pre-planning information onto interventional data would reduce the radiologist's cognitive load during the intervention and could possibly minimize discrepancies between optimally pre-planned and actually placed applicators...
July 6, 2017: International Journal of Computer Assisted Radiology and Surgery
https://www.readbyqxmd.com/read/28617993/rigid-body-motion-correction-of-the-liver-in-image-reconstruction-for-golden-angle-stack-of-stars-dce-mri
#17
Adam Johansson, James Balter, Yue Cao
PURPOSE: Respiratory motion can affect pharmacokinetic perfusion parameters quantified from liver dynamic contrast-enhanced MRI. Image registration can be used to align dynamic images after reconstruction. However, intra-image motion blur remains after alignment and can alter the shape of contrast-agent uptake curves. We introduce a method to correct for inter- and intra-image motion during image reconstruction. METHODS: Sixteen liver dynamic contrast-enhanced MRI examinations of nine subjects were performed using a golden-angle stack-of-stars sequence...
June 15, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28612518/aggregation-induced-emission-aie-fluorophore-exhibits-a-highly-ratiometric-fluorescent-response-to-zn-2-in-vitro-and-in-human-liver-cancer-cells
#18
Hassan Mehdi, Weitao Gong, Huimin Guo, Michael Watkinson, Hua Ma, Ali Wajahat, Guiling Ning
Two novel organic fluorophores, containing bis-naphthylamide and quinoline motifs, have been designed and synthesized. One of the fluorophores contains an isobutylene unit and exhibits a significant aggregation-induced emission (AIE) and a remarkable highly selective ratiometric fluorescence response towards Zn(2+) in solution as well as in human liver cancer cells. The AIE behavior of this fluorophore was fully verified by fluorescence and UV/Vis spectroscopy, quantum yield calculations, and single-crystal X-ray diffraction, which revealed an intricate crystal packing system...
June 14, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28599825/left-ventricular-rotational-and-twist-mechanics-in%C3%A2-the-human-fetal-heart
#19
Ling Li, Mary Craft, Hao H Hsu, Ming Zhang, Berthold Klas, David A Danford, Shelby Kutty
BACKGROUND: The authors investigated left ventricular (LV) rotational indices, twist, and torsion in a large cohort of fetuses using two-dimensional speckle-tracking echocardiography. METHODS: Pregnant women (N = 102) were prospectively recruited for fetal two-dimensional speckle-tracking echocardiography. Because of variable fetal position, ventricular orientation was established using the location of the liver and LV position in relation to the right ventricle...
August 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/28589925/mesenchymal-stem-cells-support-growth-and-organization-of-host-liver-colorectal-tumor-organoids-and-possibly-resistance-to-chemotherapy
#20
Mahesh Devarasetty, Edina Wang, Shay Soker, Aleksander Skardal
Despite having yielded extensive breakthroughs in cancer research, traditional 2D cell cultures have limitations in studying cancer progression and metastasis and screening therapeutic candidates. 3D systems can allow cells to grow, migrate, and interact with each other and the surrounding matrix, resulting in more realistic constructs. Furthermore, interactions between host tissue and developing tumors influence the susceptibility of tumors to drug treatments. Host-liver colorectal-tumor spheroids composed of primary human hepatocytes, mesenchymal stem cells (MSC) and colon carcinoma HCT116 cells were created in simulated microgravity rotating wall vessel (RWV) bioreactors...
June 7, 2017: Biofabrication
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