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https://www.readbyqxmd.com/read/27894729/effect-of-diagnostic-cone-beam-computed-tomography-protocols-on-image-quality-patient-dose-and-lesion-detection
#1
Jijo Paul, Annamma Chacko, Paola Saccomandi, Thomas J Vogl, Nour-Eldin A Nour-Eldin
OBJECTIVE: To evaluate the effect of cone-beam computed tomography (CBCT) image acquisition protocols on image quality, lesion detection, delineation, and patient dose. METHODS: 100-patients and a CTDI phantom combined with an electron density phantom were examined using four different CBCT-image acquisition protocols during image-guided transarterial chemoembolization (TACE). Protocol-1 (time: 6s, tube rotation: 360°), protocol-2 (5s, 300°), protocol-3 (4s, 240°) and protocol-4 (3s, 180°) were used...
November 25, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27868414/-effect-of-shift-rotation-culture-on-formation-and-activity-of-encapsulated-hepatocytes-aggregates
#2
Yanshan Chen, Chengbo Yu, Hongcui Cao, Lanjuan Li
Objective: To observe the effect of uniform and shift rotation culture on the formation and activity of the alginate-chitosan (AC) microencapsulated HepLL immortalized human hepatocytes and HepG2 cells aggregates. Methods: AC microcapsulated HepG2 and HepLL cells were randomly divided into two groups. Each group was divided into 3 subgroups according to uniform and shift rotation culture.The size and number of aggregates were observed and measured under laser confocal microscopy and inverted microscope dynamically...
May 25, 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/27867174/operator-dose-measurements-and-image-quality-assessment-in-computed-tomography-fluoroscopy-using-bismuth-sheet
#3
Keisuke Takiguchi, Atsushi Urikura, Tsukasa Yoshida, Kenichi Hirosawa, Takahiro Ito, Yoshihiro Nakaya
OBJECTIVE: The purpose of this study was to assess the dose reduction and the image quality using bismuth sheets during the computed tomography fluoroscopy (CTF). MATERIALS AND METHODS: The bismuth sheets of 1-mm thick were put on the upper mylar ring to reduce the frontal X-ray. The dose rates of an operator were measured using a torso phantom in the patient position during the CTF. The torso phantom was set on the gantry rotation center (center) and the lower position from the center (off-center)...
2016: Nihon Hoshasen Gijutsu Gakkai Zasshi
https://www.readbyqxmd.com/read/27845655/a-hidden-markov-model-for-3d-catheter-tip-tracking-with-2d-x-ray-catheterization-sequence-and-3d-rotational-angiography
#4
Pierre Ambrosini, Ihor Smal, Daniel Ruijters, Wiro Niessen, Adriaan Moelker, Theo van Walsum
In minimal invasive image guided catheterization procedures, physicians require information of the catheter position with respect to the patient's vasculature. However, in fluoroscopic images, visualization of the vasculature requires toxic contrast agent. Static vasculature roadmapping, which can reduce the usage of iodine contrast, is hampered by the breathing motion in abdominal catheterization. In this paper, we propose a method to track the catheter tip inside the patient's 3D vessel tree using intra-operative single-plane 2D X-ray image sequences and a peri-operative 3D rotational angiography (3DRA)...
November 7, 2016: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/27768906/ultrasound-fusion-image-error-correction-using-subject-specific-liver-motion-model-and-automatic-image-registration
#5
Minglei Yang, Hui Ding, Lei Zhu, Guangzhi Wang
PURPOSE: Ultrasound fusion imaging is an emerging tool and benefits a variety of clinical applications, such as image-guided diagnosis and treatment of hepatocellular carcinoma and unresectable liver metastases. However, respiratory liver motion-induced misalignment of multimodal images (i.e., fusion error) compromises the effectiveness and practicability of this method. The purpose of this paper is to develop a subject-specific liver motion model and automatic registration-based method to correct the fusion error...
October 13, 2016: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/27766198/igg4-related-lung-disease-extending-to-the-thoracic-vertebrae
#6
Alexandros Stamatopoulos, Davide Patrini, Efstratios Koletsis, Elaine Borg, Reena Khiroya, Martin Hayward, David Lawrence, Nikolaos Panagiotopoulos
IgG4-related disease (IgG4-RD) is a fibroinflammatory condition that can affect practically every organ. Although it was first identified in pancreas and salivary glands, major organs like liver, biliary tree, kidney, thyroid glands and lungs are commonly involved, sometimes resulting in organ failure. We describe a case of an 41-year-old man presented with back pain after a rotator cuff injury. A Computed Tomography (CT) revealed incidentally a right lower lobe paravertebral lesion extending across the T5 and T6 vertebral levels and invading into the adjacent pleural surface...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27759598/incidental-findings-in-abdominal-dual-energy-computed-tomography-correlation-between-true-noncontrast-and-virtual-noncontrast-images-considering-renal-and-liver-cysts-and-adrenal-masses
#7
Karin Slebocki, Bastian Kraus, De-Hua Chang, Martin Hellmich, David Maintz, Christopher Bangard
PURPOSE: To assess correlation between attenuation measurements of incidental findings in abdominal second generation dual-energy computed tomography (CT) on true noncontrast (TNC) and virtual noncontrast (VNC) images. MATERIALS AND METHODS: Sixty-three patients underwent arterial dual-energy CT (Somatom Definition Flash, Siemens; pitch factor, 0.75-1.0; gantry rotation time, 0.28 seconds) after endovascular aneurysm repair, consisting of a TNC single energy CT scan (collimation, 128 × 0...
October 18, 2016: Journal of Computer Assisted Tomography
https://www.readbyqxmd.com/read/27745816/the-detection-of-focal-liver-lesions-using-abdominal-ct-a-comparison-of-image-quality-between-adaptive-statistical-iterative-reconstruction-v-and-adaptive-statistical-iterative-reconstruction
#8
Sangyun Lee, Heejin Kwon, Jihan Cho
RATIONALE AND OBJECTIVES: To investigate image quality characteristics of abdominal computed tomography (CT) scans reconstructed with adaptive statistical iterative reconstruction V (ASIR-V) vs currently using applied adaptive statistical iterative reconstruction (ASIR). MATERIALS AND METHOD: This institutional review board-approved study included 35 consecutive patients who underwent CT of the abdomen. Among these 35 patients, 27 with focal liver lesions underwent abdomen CT with a 128-slice multidetector unit using the following parameters: fixed noise index of 30, 1...
October 10, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27745815/reproducibility-of-parenchymal-blood-volume-measurements-using-an-angiographic-c-arm-ct-system
#9
Kerstin Mueller, Rebecca Fahrig, Michael Manhart, Yu Deuerling-Zheng, Jarrett Rosenberg, Teri Moore, Arundhuti Ganguly, Nishita Kothary
RATIONALE AND OBJECTIVES: Intra-procedural measurement of hepatic perfusion following liver embolization continues to be a challenge. Blood volume imaging before and after interventional procedures would allow identifying the treatment end point or even allow predicting treatment outcome. Recent liver oncology studies showed the feasibility of parenchymal blood volume (PBV) imaging using an angiographic C-arm system. This study was done to evaluate the reproducibility of PBV measurements using cone beam computed tomography (CBCT) before and after embolization of the liver in a swine model...
October 10, 2016: Academic Radiology
https://www.readbyqxmd.com/read/27709612/alpha-lipoic-acid-stearylamine-conjugate-based-solid-lipid-nanoparticles-for-tamoxifen-delivery-formulation-optimization-in-vivo-pharmacokinetic-and-hepatotoxicity-study
#10
Ankit Dhaundiyal, Sunil K Jena, Sanjaya K Samal, Bhavin Sonvane, Mahesh Chand, Abhay T Sangamwar
OBJECTIVES: This study was designed to demonstrate the potential of novel α-lipoic acid-stearylamine (ALA-SA) conjugate-based solid lipid nanoparticles in modulating the pharmacokinetics and hepatotoxicity of tamoxifen (TMX). METHODS: α-lipoic acid-stearylamine bioconjugate was synthesized via carbodiimide chemistry and used as a lipid moiety for the generation of TMX-loaded solid lipid nanoparticles (TMX-SLNs). TMX-SLNs were prepared by solvent emulsification-diffusion method and optimized for maximum drug loading using rotatable central composite design...
December 2016: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/27706082/extraction-of-natural-antioxidants-from-the-thelephora-ganbajun-mushroom-by-an-ultrasound-assisted-extraction-technique-and-evaluation-of-antiproliferative-activity-of-the-extract-against-human-cancer-cells
#11
Dong-Ping Xu, Jie Zheng, Yue Zhou, Ya Li, Sha Li, Hua-Bin Li
The Thelephora ganbajun mushroom has been found to be a potential rich source of natural antioxidants. In this study, an ultrasound-assisted extraction (UAE) technique together with GRAS (generally recognized as safe) solvents (ethanol and water) was used to maximize the extraction of antioxidants from Thelephora ganbajun. Five extraction parameters (ethanol concentration, solvent to solid ratio, extraction time, temperature and ultrasound power) were investigated by single-factor experiments, and then a central composite rotatable design was employed to study interaction of three key extraction parameters...
October 1, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27685123/clinical-experience-with-planning-quality-assurance-and-delivery-of-burst-mode-modulated-arc-therapy
#12
Kristofer Kainz, Douglas Prah, Ergun Ahunbay, X Allen Li
"Burst-mode" modulated arc therapy (hereafter referred to as "mARC") is a form of volumetric-modulated arc therapy characterized by variable gantry rotation speed, static MLCs while the radiation beam is on, and MLC repositioning while the beam is off. We present our clinical experience with the planning techniques and plan quality assurance measurements of mARC delivery. Clinical mARC plans for five representative cases (prostate, low-dose-rate brain, brain with partial-arc vertex fields, pancreas, and liver SBRT) were generated using a Monte Carlo-based treatment planning system...
2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/27634287/rotational-thromboelastometry-can-detect-factor-xiii-deficiency-and-bleeding-diathesis-in-patients-with-cirrhosis
#13
Sotiria Bedreli, Jan-Peter Sowa, Saraa Malek, Sandra Blomeyer, Antonios Katsounas, Guido Gerken, Fuat H Saner, Ali Canbay
BACKGROUND & AIMS: Patients with progressive liver disease exhibit complex coagulation disorders. Factor XIII plays a crucial role in the last steps of haemostasis, and its deficiency is associated with an increased incidence of bleeding diathesis. However, current conventional coagulation tests cannot detect factor XIII deficiency. In this study, we examined factor XIII activity and the ability of rotational thromboelastometry to detect factor XIII deficiency and bleeding diathesis in patients with cirrhosis...
September 16, 2016: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/27587207/-the-clinical-advantage-of-using-three-dimensional-visualization-technology-in-hepatic-surgery
#14
Y Y Lau, X X Lau
The three-dimensional body visible system is a further development of the three-dimensional CT reconstruction system. It has a lot of merits over the latter system. Clinical application of the three-dimensional body visible system in liver surgery showed the system to have the following merits: (1) The system can support the Couinaud classification of liver anatomy into two hemilivers, four sectors and eight segments. As the system can rotate the liver to any angle and it has the ability to make part or whole of the liver transparent thus making the internal blood vessels and bile ducts visible...
September 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27581644/molecular-dynamics-simulations-to-determine-the-structure-and-dynamics-of-hepatitis-b-virus-capsid-bound-to-a-novel-anti-viral-drug
#15
Go Watanabe, Shunsuke Sato, Mitsuo Iwadate, Hideaki Umeyama, Michiyo Hayakawa, Yoshiki Murakami, Shigetaka Yoneda
Hepatitis B virus (HBV) chronically infects millions of people worldwide and is a major cause of serious liver diseases, including liver cirrhosis and liver cancer. In our previous study, in silico screening was used to isolate new anti-viral compounds predicted to bind to the HBV capsid. Four of the isolated compounds have been reported to suppress the cellular multiplication of HBV experimentally. In the present study, molecular dynamics simulations of the HBV capsid were performed under rotational symmetry boundary conditions, to clarify how the structure and dynamics of the capsid are affected at the atomic level by the binding of one of the isolated compounds, C13...
2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27569084/silybin-nanoparticles-for-liver-cancer-development-optimization-and-in-vitro-in-vivo-evaluation
#16
Han Zhang, Cheng-Bao Wang, Jin-Ling Liu
PURPOSE: Hepatocellular carcinoma (HCC) is a most common liver malignancy. The objective of this study was to prepare silybin nanoparticles (NPs) and optimize the prepared nanoparticles using central composite rotatable design-response surface methodology. METHODS: HCC was induced in rats by supplementing 100 mg/L of diethylnitrosamine (DENA) in drinking water for 8 weeks. Saline, silybin 30 mg/kg body weight and nanoformulation of silybin equivalent to silybin dose were administered orally to 3 groups of 6 animals each...
May 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/27523628/xurography-actuated-valving-for-centrifugal-flow-control
#17
David J Kinahan, Philip L Early, Abhishek Vembadi, Eoghan MacNamara, Niamh A Kilcawley, Thomas Glennon, Dermot Diamond, Dermot Brabazon, Jens Ducrée
We introduce a novel instrument controlled valving scheme for centrifugal platforms which is based upon xurography. In a first approach, which is akin to previously presented event-triggered flow control, the valves are composed of a pneumatic chamber sealed by a dissolvable film (DF) and by a pierceable membrane. Liquid is initially prevented from wetting the DF by the counter pressure of a trapped gas. Via a channel, this pocket is pneumatically connected to a vent, sealed by the pierceable membrane, located on the top surface of the disc...
September 21, 2016: Lab on a Chip
https://www.readbyqxmd.com/read/27506929/novel-educational-interventions-in-residency-increase-knowledge-of-chronic-liver-disease-and-career-interest-in-hepatology
#18
Adam E Mikolajczyk, Jeanne M Farnan, John F McConville, Donald M Jensen, K Gautham Reddy, Helen S Te, Nancy Reau, Andrew I Aronsohn
: There is an increasing burden of chronic liver disease (CLD) in the United States but a significant shortage of hepatologists. Thus, it is necessary to develop new recruitment strategies to the field of hepatology as well as ensure that non-gastroenterology-trained physicians are able to capably assist in the care of CLD. We established a novel, nonelective, inpatient hepatology rotation that uses required modules in the American Association for the Study of Liver Diseases Curriculum and Training-First Hepatitis B and C curriculums as well as in LiverLearning...
August 10, 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/27452760/-comparative-study-of-ct-versus-gross-pathology-in-rabbit-vx2-colorectal-cancer-model
#19
Guoyang Sun, Fengqi Lu, Zhuiyang Zhang, Danping Wu, Jianming Ni, Xiaoping Wu, Rongrong Zhang, Hongbo Huang
OBJECTIVE: To establish rabbit VX2 colorectal cancer(CRC) model and to compare CT images with gross pathology in order to offer help for TNM staging in patients with CRC. METHODS: VX2 tumor pieces were implanted into colonic wall in 9 New Zealand white rabbits and rectal wall in 2 New Zealand white rabbits. Four weeks after inoculation, Ultravist(370 mg/ml) was injected through ear marginal vein with high pressure injector for stage 3 scanning of chest, abdomen and pelvis, and enhanced CT (collimation 0...
July 2016: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27428015/recombinant-human-prothrombin-reduced-blood-loss-in-a-porcine-model-of-dilutional-coagulopathy-with-uncontrolled-bleeding
#20
Kenny M Hansson, Karin J Johansson, Cecilia Wingren, Dietmar Fries, Karin Nelander, Ann Lövgren
Uncontrolled bleeding remains one of the leading causes of trauma-induced death. Treatment recommendations focus on fresh frozen plasma and blood cell transfusions, whereas plasma concentrates or single coagulation factors have been studied in recent years. The effect of recombinant human prothrombin factor II (rhFII, 8 mg/kg), activated recombinant human factor VII (rhFVIIa, 300 μg/kg), plasma-derived human fibrinogen (pdhFib) (200 mg/kg), activated prothrombin complex concentrate (aPCC, 40 IU/kg), a three-factor combination intended as a minimal PCC (8 mg/kg rhFII, 640 μg/kg recombinant human factor X (rhFX), and 12 μg/kg rhFVIIa), and vehicle were investigated in a porcine model of dilutional coagulopathy with uncontrolled bleeding...
July 15, 2016: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
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