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https://www.readbyqxmd.com/read/28742273/protein-secondary-structure-analysis-of-dried-blood-serum-using-infrared-spectroscopy-to-identify-markers-for-colitis-screening
#1
Jitto Titus, Hemendra Ghimire, Emilie Viennois, Didier Merlin, A G Unil Perera
There remains a great need for diagnosis of inflammatory bowel disease (IBD), for which the current technique, colonoscopy, is costly and also has risks for complications. Attenuated Total Reflectance Fourier Transform Infrared (ATR-FTIR) spectroscopy is a new screening technique to evaluate colitis. Using second derivative spectral deconvolution of the absorbance spectra, a full set of spectral markers were identified based on statistical analysis. Using this method, Amide I group frequencies, (specifically, alpha helix to beta sheet ratio of the protein secondary structure) were identified in addition to the previously reported glucose and mannose signatures in sera of chronic and acute mice models of colitis...
July 25, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28723285/case-244-systemic-amyloidosis-a-complication-of-waldenstr%C3%A3-m-macroglobulinemia
#2
Maja Hrabak-Paar, Marko Kralik
History A 68-year-old man was admitted to the hospital for work-up because of generalized fatigue, anorexia, chronic diarrhea, and weight loss. Laboratory work-up revealed an erythrocyte sedimentation rate of 58 mm/h (reference range, 3-23 mm/h), a hemoglobin level of 14.1 g/dL (reference range, 13.8-17.5 g/dL), a leukocyte count of 8.1 × 10(9)/L (reference range, [3.4-9.7] × 10(9)/L), a platelet count of 223 × 10(9)/L (reference range, [158-424] × 10(9)/L), an alkaline phosphatase level of 85 U/L (1.42 μkat/L) (normal level, <142 U/L [2...
August 2017: Radiology
https://www.readbyqxmd.com/read/28705174/extensive-colorectal-lymphomatous-polyposis-complicated-by-acute-intestinal-obstruction-a-case-report
#3
Jaques Waisberg, Amanda do Val Anderi, Pedro Augusto Soffner Cardoso, José Henrique Miranda Borducchi, Demetrius Eduardo Germini, Maria Isete Fares Franco, Cidia Vasconcellos
BACKGROUND: Multiple lymphomatous polyposis is a rare type of gastrointestinal lymphoma that extensively infiltrates the intestine. Multiple lymphomatous polyposis originates from the mantle zone of the lymphoma follicle and is considered to be a mantle cell lymphoma, which is a relatively aggressive type of B-cell non-Hodgkin's lymphoma. We report an unusual case of a patient with multiple lymphomatous polyposis with extensive colorectal involvement and acute intestinal obstruction, an atypical complication of this rare disease...
July 13, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28702775/quality-indicators-in-colonoscopy
#4
REVIEW
Kjetil Garborg, Thomas de Lange, Michael Bretthauer
Colonoscopy is one of the most commonly performed endoscopic procedures. It is the gold standard examination for work-up of colonic symptoms, for follow-up of positive colorectal cancer screening tests and for detection and removal of neoplastic polyps. Colonoscopy is a complex and invasive procedure with a potential not only for colorectal cancer prevention, but also for serious complications. Numerous factors may affect the balance of benefit versus harm of colonoscopy, including the performance of the endoscopist...
July 12, 2017: Current Treatment Options in Gastroenterology
https://www.readbyqxmd.com/read/28694130/bowel-damage-in-patients-with-long-term-crohn-s-disease-assessed-by-magnetic-resonance-enterography-and-the-lemann-index
#5
Aida Kapic Lunder, Jørgen Jahnsen, Linda Tøften Bakstad, Arne Borthne, Johannes Roksund Hov, Morten Vatn, Anne Negård
BACKGROUND AND AIMS: Magnetic Resonance Enterography (MRE) is used to evaluate the extent and complications of Crohn's disease (CD) and has recently been included in a score for bowel damage, the Lemann Index (LI). The long-term outcomes of CD are still uncertain and we aimed to assess the structural bowel changes after 20 years of CD by means of MRE and LI score. METHODS: We performed a follow-up analysis of a population-based cohort of 237 patients in southeastern Norway diagnosed with CD from 1990 through 1993...
July 7, 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28693959/value-and-limits-of-stapled-transanal-rectal-repair-for-obstructed-defecation-syndrome-10-years-experience-with-450-cases
#6
Angelo Guttadauro, Marco Chiarelli, Matteo Maternini, Melissa Baini, Nicoletta Pecora, Francesco Gabrielli
BACKGROUND/OBJECTIVE: In the late's 90' a new surgical treatment, the stapled trans-anal rectal resection (STARR) was born to treat obstructed defecation syndrome (ODS). In this study we retrospectively analyze a series of 450 cases that underwent STARR in 10 years. METHODS: Between January 2001 to December 2011, 450 patients, diagnosed with ODS syndrome caused by rectocele or intussusception, underwent to STARR procedure. The presence of rectocele and/or intussusception was verified by dynamic defecography...
July 7, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28678570/head-and-neck-subcutaneous-emphysema-a-rare-complication-of-iatrogenic-perforation-during-colonoscopy-management-review-of-reported-cases-from-2000-2016
#7
Mathew John Lee, Tara M Connelly
INTRODUCTION: Subcutaneous face and neck emphysema secondary to colonic perforation is a rare complication of colonoscopy. Presentation may be complicated by pneumothorax and/or respiratory distress. Evidence limited to case studies. Therefore, no management consensus of these rarely reported cases exists. METHODS: All cases published on PubMed between January 1(st) 2000-November 1(st) 2016 reporting subcutaneous face and/or neck emphysema after colonoscopy are included...
July 5, 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28670609/symptomatic-isolated-terminal-ileal-ulcers-etiology-and-clinical-significance
#8
Varun Mehta, Ankita Gupta, Ramit Mahajan, Vikram Narang, Vandana Midha, Neena Sood, Harpreet Kaur, Kirandeep Kaur, Ajit Sood
BACKGROUND:  With an increasing number of ileal intubations, isolated terminal ileal ulcers (ITIU) are frequently found during colonoscopies. The present study aimed at studying the etiology and clinical significance of these ulcers in patients having gastrointestinal symptoms. METHODS:  This was a prospective observational study performed on consecutive patients who underwent ileocolonoscopy for various gastrointestinal symptoms between 1 January 2014 and 31 December 2014...
July 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28650684/intentional-ingestion-of-elemental-mercury-requiring-multi-step-decontamination-and-prophylactic-appendectomy-a-case-report-and-treatment-proposal
#9
Andrea Michielan, Azzurra Schicchi, Roberto Cappuccio, Davide Lonati, Francesca Lamboglia, Alessandra Vitalba, Alessandro Caroli, Marta Crevani, Carlo A Locatelli, Giorgio Betetto
BACKGROUND: Ingestion of elemental mercury (Hg0) is considered non-toxic. After massive ingestion, local intestinal complications may develop: retention within appendix is quite frequent but treatment is debated. We describe a case of intentional ingestion of Hg0 requiring multi-step decontamination and prophylactic appendectomy. Case detail: A 19-year-old woman was admitted to ED for abdominal pain. History revealed ingestion of large amount of Hg0 as suicide attempt. To prevent absorption, facilitate elimination, and avoid complications a conservative approach was started...
June 26, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28645954/assessing-the-impact-of-colonoscopy-complications-on-use-of-colonoscopy-among-primary-care-physicians-and-other-connected-physicians-an-observational-study-of-older-americans
#10
Nancy L Keating, A James O'Malley, Jukka-Pekka Onnela, Bruce E Landon
OBJECTIVES: Psychological biases can distort treatment decision-making. The availability heuristic is one such bias, wherein events that are recent, vivid or easily imagined are readily 'available' to memory and are therefore judged more likely to occur than expected based on epidemiological data. We assessed if the occurrence of a serious colonoscopy complication for a primary care physician's patient influenced colonoscopy rates for the physician's other patients. DESIGN: Longitudinal study with time-varying exposure variables...
June 23, 2017: BMJ Open
https://www.readbyqxmd.com/read/28643312/-comparison-of-short-term-outcomes-of-transrectal-specimen-extraction-during-laparoscopic-sigmoid-radical-resection-versus-conventional-laparoscopically-assisted-procedure
#11
Junjie Xing, Chenxin Zhang, Xiaohong Yang, Hao Wang, Hantao Wang, Enda Yu, Chuangang Fu
OBJECTIVE: To compare the short-term outcomes between transrectal specimen extraction during laparoscopic sigmoid radical resection and conventional laparoscopy-assisted sigmoid radical resection. METHODS: Sixteen patients(transrectal specimen extraction group,4 females and 12 males), who were planned to undergo laparoscopically assisted sigmoid radical resection with BMI<28 kg/m(2) and were evaluated as T1-T3 tumor by iconography without distant metastasis, were selected to undergo transrectal specimen extraction during laparoscopic sigmoid radical resection from December 2015 to April 2016 in the Department of Anorectal Surgery of Changhai Hospital...
June 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28631454/quality-of-recovery-after-gastroscopy-colonoscopy-or-both-endoscopic-procedures-an-observational-pilot-study
#12
Aiden M Brumby, Johan Heiberg, Cindy Te, Colin F Royse
BACKGROUND: Gastroscopy and colonoscopy are procedures with low complication rates and patients are usually discharged few hours after the procedures. Nevertheless, postoperative cognitive decline is a common condition, is often missed, and can potentially affect patients' ability to drive and undertake other daily living activities. The primary aim was to assess the incidence of failure to recover at Day 1 after either colonoscopy, gastroscopy, or both procedures combined. METHODS: In an observational pilot study, participants of 18 years or above undergoing endoscopy procedures, including colonoscopy (reference group), gastroscopy, or both, were included...
June 14, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28626372/acute-appendicitis-caused-by-previous-endoscopic-submucosal-dissection-for-an-adenoma-adjacent-to-the-appendiceal-orifice
#13
Ryo Kato, Keita Harada, Kei Harada, Daisuke Takei, Yuusaku Sugihara, Shiho Takashima, Toshihiro Inokuchi, Masahiro Takahara, Sakiko Hiraoka, Yasushi Omura, Wakako Oda, Hiroyuki Okada
Endoscopic submucosal dissection (ESD) is a groundbreaking treatment for tumors adjacent to the appendiceal orifice that are difficult to remove by conventional endoscopic mucosal resection, and successful cases are increasingly reported. However, little is known about the subsequent complications, especially long-term complications. A female in her early 70s with a 15-mm cecal tumor adjacent to the appendiceal orifice - discovered incidentally during a screening colonoscopy - underwent hybrid ESD of the lesion...
May 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28619975/antibiotic-associated-haemorrhagic-colitis-not-always-clostridium-difficile
#14
Olalekan Akanbi, Nasir Saleem, Mohanad Soliman, Bibek Singh Pannu
Antibiotic-associated colitis is a gastrointestinal complication of antibiotic use commonly seen in hospitalised patients, with Clostridium difficile (C. difficile) colitis being the most common type. We present a case of haemorrhagic colitis secondary to Klebsiella oxytoca following self-initiated amoxicillin-clavulanic acid use. An 85-year-old woman presented to the emergency department with abdominal pain and mucobloody diarrhoea. History was notable for an ongoing 5-day course of amoxicillin-clavulanic acid use...
June 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28617760/nonisolated-small-bowel-gastrointestinal-angiodysplasias-are-associated-with-higher-rebleeding-rates-when-compared-with-isolated-small-bowel-gastrointestinal-angiodysplasia-on-video-capsule-endoscopy
#15
Stephanie H Mai, Daniel C Chao, Shu-Yi Liao, Christian S Jackson
BACKGROUND: Gastrointestinal angiodysplasias (GIAD) are commonly diagnosed in the small bowel but can be located in other areas of the gastrointestinal tract. About half of patients diagnosed with GIAD have more than 1 lesion and 20% of patients have GIAD in both the small bowel and a source outside of the small bowel (nonisolated to small bowel GIAD or NISGIAD). The remaining patients with GIAD have lesions isolated to the small bowel (ISGIAD). Complications including rebleeding, hospitalization and mortality rates have not been previously analyzed between these 2 groups...
June 14, 2017: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/28616605/splenic-laceration-after-routine-colonoscopy-a-case-report-of-a-rare-iatrogenic-complication
#16
Shuo Li, Nishant Gupta, Yogesh Kumar, Frank Mele
Colonoscopy is a common and routine procedure performed in the United States, most commonly performed for screening of colorectal cancer. Although colonoscopy is considered a safe procedure, it is associated with complications including intestinal hemorrhage and perforation. Splenic trauma, such as laceration or even complete rupture is a rarely reported, but potentially fatal complication if undetected. We present a case of splenic laceration with subcapsular hematoma status post routine colonoscopy. Fortunately, patient was able to be managed medically, without further operative intervention...
2017: Translational Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28614081/spontaneous-fungal-peritonitis-a-rare-but-severe-complication-of-liver-cirrhosis
#17
Marta Gravito-Soares, Elisa Gravito-Soares, Sandra Lopes, Graça Ribeiro, Pedro Figueiredo
INTRODUCTION AND AIM: Spontaneous bacterial peritonitis is the most common infectious complication in cirrhosis. Spontaneous fungal peritonitis is rare and remains unknown. In this work, spontaneous fungal peritonitis as well as risk factors and prognosis are characterized. PATIENTS AND METHODS: A retrospective case-control study of 253 consecutive admissions by peritonitis in cirrhotic patients was carried out between 2006 and 2015. Comparison of patients with spontaneous fungal peritonitis (cases) and spontaneous bacterial peritonitis with positive microbiologic ascitic fluid culture (controls) was performed...
June 13, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28611570/development-and-improvement-of-simple-colonic-mucosal-ulcer-during-treatment-of-severe-ulcerative-colitis-with-tacrolimus
#18
Ayumi Ito, Bunei Iizuka, Teppei Omori, Shinichi Nakamura, Katsutoshi Tokushige
Diarrhea, melena, and lower abdominal pain developed in a male in his 20s and colonoscopy showed pancolitis-type severe ulcerative colitis (UC). Treatment was initiated with 4,000 mg of 5-aminosalicylic acid and 60 mg/day of prednisolone, but the symptoms and inflammatory reaction worsened with prednisolone dose reduction. Tacrolimus was added to the treatment, which subsequently induced remission. Serial colonoscopies during the treatment showed improvement in ulcer and mucosal edema throughout the entire large intestine, but a new solitary round ulcer appeared at the end of the ileum...
January 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28611565/shock-due-to-splenic-injury-after-colonoscopy
#19
Erol G Nallayici, Reinier de Groot, René A A van Zanten, Martijn F Lutke Holzik
Colonoscopy is a common and increasingly performed procedure. It is used both as a diagnostic and therapeutic modality. Splenic injury after colonoscopy is a rare, yet life-threatening complication, most often caused by traction on the splenocolic ligament or excessive manipulation during the procedure. Although non-operative treatment is preferred upon splenic injury, early surgical or radiological intervention may be necessary in specific cases, for example in case of haemodynamic instability. A 71-year-old Caucasian man was referred to our emergency room due to shock after colonoscopy 2 days earlier...
January 2017: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/28611336/safety-of-non-anesthesia-provider-administered-propofol-sedation-in-non-advanced-gastrointestinal-endoscopic-procedures-a-meta-analysis
#20
REVIEW
Basavana Gouda, Gowri Gouda, Anuradha Borle, Akash Singh, Ashish Sinha, Preet M Singh
BACKGROUND/AIMS: The aim of the study was to evaluate the safety of non-anesthesia provider (NAPP) administered propofol sedation in patients undergoing non-advanced gastrointestinal (GI) endoscopic procedures. MATERIALS AND METHODS: Pubmed, Embase, Cochrane central register of controlled trials, Scopus, and Web of Science databases were searched for prospective observational trials involving non-advanced endoscopic procedures. From a total of 608 publications, 25 [colonoscopy (9), upper GI endoscopy (5), and combined procedures (11)] were identified to meet inclusion criteria and were analyzed...
May 2017: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
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