Jesús Calahorra, José L Blaya-Cánovas, Olivia Castellini-Pérez, Ernesto Aparicio-Puerta, Candela Cives-Losada, Jose J G Marin, Markel Rementeria, Francisca E Cara, Araceli López-Tejada, Carmen Griñán-Lisón, Francesco Aulicino, Imre Berger, Juan A Marchal, Violeta Delgado-Almenta, Sergio Granados-Principal
Triple-negative breast cancer (TNBC) is characterised by its aggressiveness and resistance to chemotherapy, demanding the development of effective strategies against its unique characteristics. Derived from lapacho tree bark, β-lapachone (β-LP) selectively targets cancer cells with elevated levels of the detoxifying enzyme NQO1. Hydroxytyrosol (HT) is a phenolic compound derived from olive trees with important anticancer properties that include the inhibition of cancer stem cells (CSCs) and metastatic features in TNBC, as well as relevant antioxidant activities by mechanisms such as the induction of NQO1...
March 21, 2024: Biomedicine & Pharmacotherapy