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NQO1 AND Hydroxytyrosol

Guohua Yu, Ajun Deng, Wanbin Tang, Junzhi Ma, Chonggang Yuan, Jiyan Ma
Parkinson's disease (PD) is the second most common late-age onset neurodegenerative disease. Except for the symptomatic alleviating treatment, no disease modifying therapy is currently available. In this study, we investigated the potential neuroprotective role of hydroxytyrosol (HT), a major phenolic compound present in olive oil, against dopaminergic cell death. We found that HT effectively protected dopaminergic SH-SY5Y cells against dopamine (DA) and 6-hydroxydopamine (6-OHDA) induced cell death, but had no apparent effect on 1-methyl-4-phenylpyridinium (MPP(+))-induced cytotoxicity...
June 2016: Neurochemistry International
Shoujiao Peng, Baoxin Zhang, Juan Yao, Dongzhu Duan, Jianguo Fang
Hydroxytyrosol (3,4-dihydroxyphenylethanol, HT), a major polyphenol in olive oils, has received increasing attention due to its multiple pharmacological activities. However, it is not well understood how HT works on the neuronal system. We report herein that HT efficiently scavenges free radicals in vitro and displays cytoprotection against oxidative stress-induced damage in PC12 cells. HT completely protects the cells from hydrogen peroxide-induced death and rescues the cells from 6-hydroxydopamine-induced damage...
June 2015: Food & Function
Ilavarasi Kalaiselvan, Muniasamy Samuthirapandi, Archunan Govindaraju, Dicson Sheeja Malar, Pandima Devi Kasi
CONTEXT: Naturally occurring polyphenols including olive oil (OO) and its constituents hydroxytyrosol (HT) and tyrosol (TY), consumed in the Mediterranean diet, have shown to treat various ailments due to their remarkable antioxidant properties. OBJECTIVE: The present study investigates the hepatoprotective effects of OO and its phenolic compounds HT and TY against TCDD-induced hepatotoxicity in male Wistar rats. MATERIALS AND METHODS: TCDD was administered at a dose of 100‚ÄČng/kg p...
2016: Pharmaceutical Biology
Banu Bayram, Beraat Ozcelik, Stefanie Grimm, Thomas Roeder, Charlotte Schrader, Insa M A Ernst, Anika E Wagner, Tilman Grune, Jan Frank, Gerald Rimbach
A Mediterranean diet rich in olive oil has been associated with health benefits in humans. It is unclear if and to what extent olive oil phenolics may mediate these health benefits. In this study, we fed senescence-accelerated mouse-prone 8 (SAMP8, n=11 per group) semisynthetic diets with 10% olive oil containing either high (HP) or low amounts of olive oil phenolics (LP) for 4.5 months. Mice consuming the HP diet had significantly lower concentrations of the oxidative damage markers thiobarbituric acid-reactive substances and protein carbonyls in the heart, whereas proteasomal activity was similar in both groups...
February 2012: Rejuvenation Research
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