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https://www.readbyqxmd.com/read/29342390/household-contact-investigation-for-detection-of-tuberculosis-in-vietnam
#1
Greg J Fox, Nguyen V Nhung, Dinh N Sy, Nghiem L P Hoa, Le T N Anh, Nguyen T Anh, Nguyen B Hoa, Nguyen H Dung, Tran N Buu, Nguyen T Loi, Le T Nhung, Nguyen V Hung, Phan T Lieu, Nguyen K Cuong, Pham D Cuong, Jessica Bestrashniy, Warwick J Britton, Guy B Marks
Background Active case finding is a top priority for the global control of tuberculosis, but robust evidence for its effectiveness in high-prevalence settings is lacking. We sought to evaluate the effectiveness of household-contact investigation, as compared with standard, passive measures alone, in Vietnam. Methods We performed a cluster-randomized, controlled trial at clinics in 70 districts (local government areas with an average population of approximately 500,000 in urban areas and 100,000 in rural areas) in eight provinces of Vietnam...
January 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29342351/organic-mixed-valence-compounds-derived-from-cyclic-alkyl-amino-carbenes
#2
Max M Hansmann, Mohand Melaimi, Guy Bertrand
Readily available room temperature stable organic mixed valence compounds are prepared by one-electron reduction of cyclic bis(iminium) salts [derived from cyclic (alkyl)(amino)carbenes] bridged by various spacers. These compounds show characteristic intervalence charge transfer (IV-CT) bands in the near-infrared (NIR). Cyclic voltammetry, EPR, IR, UV-VIS and X-ray studies, as well as DFT calculations, show that depending on the nature of the spacer, these mixed valence compounds range from class III to borderline class I/II...
January 17, 2018: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29342340/faible-dose-de-sucre-pour-att%C3%A3-nuer-la-douleur-des-nouveau-n%C3%A3-s
#3
Guy Sabourin
No abstract text is available yet for this article.
January 2018: Perspective Infirmière: Revue Officielle de L'Ordre des Infirmières et Infirmiers du Québec
https://www.readbyqxmd.com/read/29342283/non-typhoidal-salmonella-serovars-associated-with-invasive-and-non-invasive-disease-in-the-lao-people-s-democratic-republic
#4
Tu Le Thi Phuong, Sayaphet Rattanavong, Manivanh Vongsouvath, Viengmon Davong, Nguyen Phu Huong Lan, James I Campbell, Thomas C Darton, Guy E Thwaites, Paul N Newton, David A B Dance, Stephen Baker
Background: Invasive non-typhoidal Salmonella (iNTS) disease is a well-described cause of mortality in children and human immunodeficiency virus (HIV)-infected adults in sub-Saharan Africa. Additionally, there is an ill-defined burden of iNTS disease in Southeast Asia. Methods: Aiming to investigate the causative serovars of non-invasive and iNTS disease and their associated antimicrobial susceptibility profiles in the Lao People's Democratic Republic, we performed multilocus sequence typing and antimicrobial susceptibility profiling on 168 NTS (63 blood and 105 faecal) organisms isolated in Lao between 2000 and 2012...
January 12, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29342264/effect-of-continuous-glucose-monitoring-on-glycemic-control-acute-admissions-and-quality-of-life-a-real-world-study
#5
Sara Charleer, Chantal Mathieu, Frank Nobels, Christophe De Block, Regis P Radermecker, Michel P Hermans, Youri Taes, Chris Vercammen, Guy T'Sjoen, Laurent Crenier, Steffen Fieuws, Bart Keymeulen, Pieter Gillard
Context: Randomized controlled trials evaluating real-time continuous glucose monitoring (RT-CGM) patients with type 1 diabetes (T1D) show improved glycemic control, but limited data are available on real-world use. Objective: To assess impact of RT-CGM in real-world settings on glycemic control, hospital admissions, work absenteeism and quality of life (QOL). Design: Prospective, observational, multicenter, cohort study. Participants: Five hundred fifteen adults with T1D on continuous subcutaneous insulin infusion (CSII) therapy starting in the Belgian RT-CGM reimbursement program...
January 12, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29341996/retinal-arterio-arterial-collaterals-in-susac-syndrome
#6
Robert A Egan, Guy Jirawuthiworavong, Norah S Lincoff, John J Chen, Courtney E Francis, Jacqueline A Leavitt
BACKGROUND: The ophthalmic findings of Susac syndrome (SS) consist of visual field defects related to branch retinal artery occlusion (BRAO), and fluorescein angiography (FA) reveals a unique staining pattern. To date, retinal arterial collateral development has been described only in a single patient. Given that the immunopathological process in SS induces retinal ischemia, it is conceivable that abnormal blood vessel development may occur in affected individuals. METHODS: This is a retrospective observational study...
January 16, 2018: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/29341813/regenerative-medicine-a-vehicle-to-infuse-laboratory-bench-modules-into-an-exercise-physiology-curriculum
#7
Jason M Brown, Breonte S Guy, Dawn X Henderson, C Edward Ebert, Jill Harp, Chad D Markert
Regenerative medicine is a novel discipline that both excites undergraduates and may be used as a vehicle to expose students to scientific concepts and opportunities. The goal of this article is to describe the implementation of a National Science Foundation-funded Targeted Infusion Project in which underrepresented minority undergraduates are exposed to laboratory-bench skills and summer research opportunities that they may not have encountered otherwise. A 3-wk infusion of laboratory-bench and data presentation skills, in the context of a regenerative medicine/bioengineering project, aimed to engage students and expose them to opportunities as summer researchers and teaching assistants...
March 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29341812/optional-anatomy-and-physiology-e-learning-resources-student-access-learning-approaches-and-academic-outcomes
#8
Richard Guy, Bruce Byrne, Marian Dobos
Anatomy and physiology interactive video clips were introduced into a blended learning environment, as an optional resource, and were accessed by ~50% of the cohort. Student feedback indicated that clips were engaging, assisted understanding of course content, and provided lecture support. Students could also access two other optional online resources, lecture capture recordings and an interactive atlas of anatomy, and individuals were tracked with respect to their access behavior, learning approach, and subject score...
March 1, 2018: Advances in Physiology Education
https://www.readbyqxmd.com/read/29340645/a-plasma-metabolomic-signature-involving-purine-metabolism-in-human-optic-atrophy-1-opa1-related-disorders
#9
Cinzia Bocca, Judith Kouassi Nzoughet, Stéphanie Leruez, Patrizia Amati-Bonneau, Marc Ferré, Mariame-Selma Kane, Charlotte Veyrat-Durebex, Juan Manuel Chao de la Barca, Arnaud Chevrollier, Chadi Homedan, Christophe Verny, Dan Miléa, Vincent Procaccio, Gilles Simard, Dominique Bonneau, Guy Lenaers, Pascal Reynier
Purpose: Dominant optic atrophy (DOA; MIM [Mendelian Inheritance in Man] 165500), resulting in retinal ganglion cell degeneration, is mainly caused by mutations in the optic atrophy 1 (OPA1) gene, which encodes a dynamin guanosine triphosphate (GTP)ase involved in mitochondrial membrane processing. This work aimed at determining whether plasma from OPA1 pathogenic variant carriers displays a specific metabolic signature. Methods: We applied a nontargeted clinical metabolomics pipeline based on ultra-high-pressure liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) allowing the exploration of 500 polar metabolites in plasma...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29340336/re-further-evidence-supporting-the-accuracy-of-quantitative-magnetic-resonance-imaging-for-evaluating-iron-load-in-dialysis-patients
#10
Guy Rostoker, Mireille Griuncelli, Yves Cohen
No abstract text is available yet for this article.
January 2018: KI Reports
https://www.readbyqxmd.com/read/29340311/hyponatremia-and-the-brain
#11
REVIEW
Fabrice Gankam Kengne, Guy Decaux
Hyponatremia is defined by low serum sodium concentration and is the most common electrolyte disorder encountered in clinical practice. Serum sodium is the main determinant of plasma osmolality, which, in turn, affects cell volume. In the presence of low extracellular osmolality, cells will swell if the adaptation mechanisms involved in the cell volume maintenance are inadequate. The most dramatic effects of hyponatremia on the brain are seen when serum sodium concentration decreases in a short period, allowing little or no adaptation...
January 2018: KI Reports
https://www.readbyqxmd.com/read/29339717/complex-reconstruction-with-flaps-after-abdominoperineal-resection-and-groin-dissection-for-anal-squamous-cell-carcinoma-a-difficult-case-involving-many-specialities
#12
Claudia Reali, Richard Guy, Christopher R Darby, Lucy Cogswell, Roel Hompes
BACKGROUND Anal squamous cell carcinoma accounts for about 2-4% of all lower gastrointestinal malignancies, with a distant disease reported in less than 5%. Although surgical treatment is rarely necessary, this often involve large dissections and difficult reconstructive procedures. CASE REPORT We present a complex but successful case of double-flap reconstruction after abdominoperineal resection and groin dissection for anal squamous cell carcinoma (cT3N3M0) with metastatic right inguinal lymph nodes and ipsilateral threatening of femoral vessels...
January 17, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29339488/ultrafast-imaging-of-cell-elasticity-with-optical-microelastography
#13
Pol Grasland-Mongrain, Ali Zorgani, Shoma Nakagawa, Simon Bernard, Lia Gomes Paim, Greg Fitzharris, Stefan Catheline, Guy Cloutier
Elasticity is a fundamental cellular property that is related to the anatomy, functionality, and pathological state of cells and tissues. However, current techniques based on cell deformation, atomic force microscopy, or Brillouin scattering are rather slow and do not always accurately represent cell elasticity. Here, we have developed an alternative technique by applying shear wave elastography to the micrometer scale. Elastic waves were mechanically induced in live mammalian oocytes using a vibrating micropipette...
January 16, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29339216/in-vivo-biotinylated-calpastatin-improves-the-affinity-purification-of-human-m-calpain
#14
Hung Huy Nguyen, Alexander N Volkov, Guy Vandenbussche, Peter Tompa, Kris Pauwels
Recently we established a novel affinity purification method for calpain by exploiting the specific and reversible binding properties of its intrinsically disordered protein inhibitor, calpastatin. The immobilization strategy relied on the strength and specificity of the biotin - streptavidin interaction. Here, we report an improved and optimized method that even enables the general applicability of in vivo biotinylated (intrinsically disordered) proteins in any affinity capture strategy. Since in vitro chemical biotinylation is only accomplished with reagents that lack exact site specificity, it can not only cause sample heterogeneity but it can also hamper the functionality of the biotinylated molecules...
January 12, 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29338295/a-scoping-review-of-inclusive-out-of-school-time-physical-activity-programs-for-children-and-youth-with-physical-disabilities
#15
Kelly P Arbour-Nicitopoulos, Viviane Grassmann, Krystn Orr, Amy C McPherson, Guy E Faulkner, F Virginia Wright
The objective of this study was to comprehensively evaluate inclusive out-of-school time physical activity programs for children/youth with physical disabilities. A search of the published literature was conducted and augmented by international expertise. A quality appraisal was conducted; only studies with quality ratings ≥60% informed our best practice recommendations. Seventeen studies were included using qualitative (n = 9), quantitative (n = 5), or mixed (n = 3) designs. Programs had a diversity of age groups, group sizes, and durations...
January 17, 2018: Adapted Physical Activity Quarterly: APAQ
https://www.readbyqxmd.com/read/29337764/a-national-accreditation-program-for-rectal-cancer-a-long-and-winding-road
#16
Guy R Orangio
No abstract text is available yet for this article.
February 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29337561/methylammonium-cation-dynamics-in-methylammonium-lead-halide-perovskites-a-solid-state-nmr-perspective
#17
Guy M Bernard, Roderick E Wasylishen, Christopher I Ratcliffe, Victor V Terskikh, Qichao Wu, Jillian M Buriak, Tate C Hauger
In light of the intense recent interest in the methylammonium lead halides, CH3NH3PbX3 (X = Cl, Br and I) as sensitizers for photovoltaic cells, the dynamics of the methylammonium (MA) cation in these perovskite salts has been reinvestigated as a function of temperature via 2H, 14N and 207Pb NMR spectroscopy. In the cubic phase of all three salts, the MA cation undergoes pseudo-isotropic tumbling (ps time scale). For example, the correlation time, τ2, for the C-N axis of the iodide salt is 0.85 ± 0.30 ps at 330 K...
January 16, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29337178/multifocality-as-a-prognostic-factor-in-thyroid-cancer-a-meta-analysis
#18
REVIEW
Kyle R Joseph, Senarath Edirimanne, Guy D Eslick
BACKGROUND: Thyroid cancer is one of the most common endocrine cancers whose incidence has been steadily increasing. Previous studies have suggested that multifocality in thyroid cancer is associated with poor prognosis. The present study aims to quantify the data on multifocality as a factor indicating poor prognosis by meta-analysis. METHODS: A systematic search was carried out using the electronic databases PubMed and Medline. We searched for articles containing keywords of multifocality and thyroid cancer, as well as risk factors and prognostic factors for thyroid cancer (Lymph node metastases, extrathyroidal extension, distant metastases, disease recurrence, Age, tumour size...
January 11, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29337126/rigid-plate-fixation-vs-wire-cerclage-patient-reported-and-economic-outcomes-from-a-randomized-trial
#19
Keith B Allen, Vinod H Thourani, Yoshifumi Naka, Kendra J Grubb, John Grehan, Nirav Patel, T Sloane Guy, Kevin Landolfo, Marc Gerdisch, Mark Bonnell, David J Cohen
BACKGROUND: In a multicenter randomized trial, sternal closure following cardiac surgery using rigid plate fixation (RPF) compared with wire cerclage (WC) resulted in improved sternal healing, reduced sternal complications and was cost neutral at 6 months. Additional secondary endpoints are presented from this trial. METHODS: Twelve US centers randomized 236 patients to RPF (n=116) or WC (n=120). Patient reported outcomes measures (PROMs) including pain, function, and quality-of-life (QOL) scores were assessed through 6-months and correlated to computed tomographic derived sternal healing scores using logistic regression...
January 11, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29336893/a-meta-analysis-of-the-utility-of-the-neutrophil-to-lymphocyte-ratio-in-predicting-survival-after-pancreatic-cancer-resection
#20
REVIEW
Nicholas G Mowbray, David Griffith, Mohammed Hammoda, Guy Shingler, Amir Kambal, Bilal Al-Sarireh
BACKGROUND: The neutrophil-to-lymphocyte ratio (NLR) is thought to reflect cancer disease burden. To assess the prognostic ability of the NLR on overall survival in patients with resectable, pancreatic cancer a meta-analysis of published literature was undertaken. METHOD: A systematic review was performed independently by two authors using PubMed, Ovid MEDLINE and Embase databases. Included studies detailed the pre-operative NLR and overall survival of pancreatic cancer patients...
January 11, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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