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https://www.readbyqxmd.com/read/28098864/victor-vinflunine-in-advanced-metastatic-transitional-cell-carcinoma-of-the-urothelium-a-retrospective-analysis-of-the-use-of-vinflunine-in-multi-centre-real-life-setting-as-second-line-chemotherapy-through-free-of-charge-programme-for-patients-in-the-uk-and
#1
Syed A Hussain, Jawaher Ansari, Robert Huddart, Derek G Power, Jeanette Lyons, James Wylie, Maria Vilarino-Varlela, Nils O Elander, Rhona McMenemin, Lisa M Pickering, Guy Faust, Seema Chauhan, Richard J Jackson
There is no standard of care in the UK or Ireland for second-line chemotherapy for patients with advanced transitional cell carcinoma (TCCU). Vinflunine is approved for TCCU patients who have failed a platinum-based regimen, and is standard of care in Europe but is not routinely available in the UK. Data were collected retrospectively on patients who received vinfluine as a second-line treatment. The aims were to document the toxicity and efficacy in a real life setting. Data were collected on 49 patients from 9 sites across the UK and Ireland [median age, 64 (IQR, 57-70) years, 33 males]...
January 13, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28097506/bioequivalence-methodologies-for-topical-drug-products-in-vitro-and-ex-vivo-studies-with-a-corticosteroid-and-an-anti-fungal-drug
#2
Leila Bastos Leal, Sarah F Cordery, M Begoña Delgado-Charro, Annette L Bunge, Richard H Guy
OBJECTIVE: To examine whether in vitro and ex vivo measurements of topical drug product performance correlate with in vivo outcomes, such that more efficient experimental approaches can be reliably and reproducibly used to establish (in)equivalence between formulations for skin application. MATERIALS AND METHODS: In vitro drug release through artificial membranes, and drug penetration into porcine skin ex vivo, were compared with published human in vivo studies...
January 17, 2017: Pharmaceutical Research
https://www.readbyqxmd.com/read/28097417/bistability-induced-by-generalist-natural-enemies-can-reverse-pest-invasions
#3
Sten Madec, Jérôme Casas, Guy Barles, Christelle Suppo
Analytical modeling of predator-prey systems has shown that specialist natural enemies can slow, stop and even reverse pest invasions, assuming that the prey population displays a strong Allee effect in its growth. We aimed to formalize the conditions in which spatial biological control can be achieved by generalists, through an analytical approach based on reaction-diffusion equations. Using comparison principles, we obtain sufficient conditions for control and for invasion, based on scalar bistable partial differential equations...
January 17, 2017: Journal of Mathematical Biology
https://www.readbyqxmd.com/read/28097374/effects-of-5-ht1a-5-ht2a-and-5-ht2c-receptor-agonists-and-antagonists-on-responding-for-a-conditioned-reinforcer-and-its-enhancement-by-methylphenidate
#4
Paul J Fletcher, Fiona D Zeeb, Caleb J Browne, Guy A Higgins, Ashlie D Soko
OBJECTIVES: These experiments examined the effects of selective 5-HT1A, 5-HT2A and 5-HT2C receptor ligands on responding for a conditioned reinforcer (CRf). Effects of these ligands were measured under basal conditions and following elevated dopamine (DA) activity produced by the DA reuptake inhibitor methylphenidate. METHODS: Water-restricted rats learned to associate a conditioned stimulus (CS) with water in operant chambers. Subsequently, two response levers were made available; responding on one lever delivered the CS (now a CRf), while responding on the second lever had no consequences...
January 18, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28096388/competition-of-calcified-calmodulin-n-lobe-and-pip2-to-an-lqt-mutation-site-in-kv7-1-channel
#5
William Sam Tobelaim, Meidan Dvir, Guy Lebel, Meng Cui, Tal Buki, Asher Peretz, Milit Marom, Yoni Haitin, Diomedes E Logothetis, Joel Alan Hirsch, Bernard Attali
Voltage-gated potassium 7.1 (Kv7.1) channel and KCNE1 protein coassembly forms the slow potassium current IKS that repolarizes the cardiac action potential. The physiological importance of the IKS channel is underscored by the existence of mutations in human Kv7.1 and KCNE1 genes, which cause cardiac arrhythmias, such as the long-QT syndrome (LQT) and atrial fibrillation. The proximal Kv7.1 C terminus (CT) binds calmodulin (CaM) and phosphatidylinositol-4,5-bisphosphate (PIP2), but the role of CaM in channel function is still unclear, and its possible interaction with PIP2 is unknown...
January 17, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28095815/assessment-of-the-ecological-bias-of-seven-aggregate-social-deprivation-indices
#6
Josephine Bryere, Carole Pornet, Nane Copin, Ludivine Launay, Gaëlle Gusto, Pascale Grosclaude, Cyrille Delpierre, Thierry Lang, Olivier Lantieri, Olivier Dejardin, Guy Launoy
BACKGROUND: In aggregate studies, ecological indices are used to study the influence of socioeconomic status on health. Their main limitation is ecological bias. This study assesses the misclassification of individual socioeconomic status in seven ecological indices. METHODS: Individual socioeconomic data for a random sample of 10,000 persons came from periodic health examinations conducted in 2006 in 11 French departments. Geographical data came from the 2007 census at the lowest geographical level available in France...
January 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28093652/structural-basis-for-the-isotype-specific-interactions-of-ferredoxin-and-ferredoxin-nadp-oxidoreductase-an-evolutionary-switch-between-photosynthetic-and-heterotrophic-assimilation
#7
Fumio Shinohara, Genji Kurisu, Guy Hanke, Caroline Bowsher, Toshiharu Hase, Yoko Kimata-Ariga
In higher plants, ferredoxin (Fd) and ferredoxin-NADP(+) reductase (FNR) are each present as distinct isoproteins of photosynthetic type (leaf type) and non-photosynthetic type (root type). Root-type Fd and FNR are considered to facilitate the electron transfer from NADPH to Fd in the direction opposite to that occurring in the photosynthetic processes. We previously reported the crystal structure of the electron transfer complex between maize leaf FNR and Fd (leaf FNR:Fd complex), providing insights into the molecular interactions of the two proteins...
January 16, 2017: Photosynthesis Research
https://www.readbyqxmd.com/read/28093641/dwell-times-and-risk-of-non-elective-removal-of-1-french-peripherally-inserted-central-catheters-according-to-catheter-tip-position-in-very-preterm-infants
#8
Daniela M Erhard, Sarah Nguyen, Katelyn J Guy, Dan M Casalaz, Kai König
: We investigated dwell times and risk of non-elective removal of 975 single-lumen 1-French peripherally inserted central catheters (1FR-PICC) according to tip position in a cohort of very preterm infants with a mean (SD) gestational age of 27(+6) (2(+1)) weeks and a mean (SD) birth weight of 988 (294) g over an eight-year period. Infants with a 1FR-PICC inserted for continuous infusion of intravenous fluids within the first 30 days of life were eligible. Dwell times of PICC with elective versus non-elective removal, risk of non-elective removal of PICC according to tip position, and differences between upper versus lower limb catheter insertion were analysed...
January 16, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28093406/sphinx-merging-knowledge-based-and-ab-initio-approaches-to-improve-protein-loop-prediction
#9
Claire Marks, Jaroslaw Nowak, Stefan Klostermann, Guy Georges, James Dunbar, Jiye Shi, Sebastian Kelm, Charlotte M Deane
MOTIVATION: Loops are often vital for protein function, however their irregular structures make them difficult to model accurately. Current loop modelling algorithms can mostly be divided into two categories: knowledge-based, where databases of fragments are searched to find suitable conformations; and ab initio, where conformations are generated computationally. Existing knowledge-based methods only use fragments that are the same length as the target, even though loops of slightly different lengths may adopt similar conformations...
January 16, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28092576/multiple-instance-learning-for-medical-image-and-video-analysis
#10
Gwenole Quellec, Guy Cazuguel, Beatrice Cochener, Mathieu Lamard
Multiple-Instance Learning (MIL) is a recent machine learning paradigm that is particularly well suited to Medical Image and Video Analysis (MIVA) tasks. Based solely on class labels assigned globally to images or videos, MIL algorithms learn to detect relevant patterns locally in images or videos. These patterns are then used for classification at a global level. Because supervision relies on global labels, manual segmentations are not needed to train MIL algorithms, unlike traditional Single-Instance Learning (SIL) algorithms...
January 10, 2017: IEEE Reviews in Biomedical Engineering
https://www.readbyqxmd.com/read/28091719/thank-you-guy
#11
EDITORIAL
Rüdiger von Kummer
No abstract text is available yet for this article.
January 2017: Neuroradiology
https://www.readbyqxmd.com/read/28090592/the-first-genome-sequences-of-human-bocaviruses-from-vietnam
#12
Tran Tan Thanh, Hoang Minh Tu Van, Nguyen Thi Thu Hong, Le Nguyen Truc Nhu, Nguyen To Anh, Ha Manh Tuan, Ho Van Hien, Nguyen Manh Tuong, Trinh Trung Kien, Truong Huu Khanh, Le Nguyen Thanh Nhan, Nguyen Thanh Hung, Nguyen Van Vinh Chau, Guy Thwaites, H Rogier van Doorn, Le Van Tan
As part of an ongoing effort to generate complete genome sequences of hand, foot and mouth disease-causing enteroviruses directly from clinical specimens, two complete coding sequences and two partial genomic sequences of human bocavirus 1 (n=3) and 2 (n=1) were co-amplified and sequenced, representing the first genome sequences of human bocaviruses from Vietnam. The sequences may aid future study aiming at understanding the evolution of the pathogen.
November 16, 2016: Wellcome Open Res
https://www.readbyqxmd.com/read/28090117/generation-of-shear-waves-by-laser-in-soft-media-in-the-ablative-and-thermoelastic-regimes
#13
Pol Grasland-Mongrain, Yuankang Lu, Frederic Lesage, Stefan Catheline, Guy Cloutier
This article describes the generation of elastic shear waves in a soft medium using a laser beam. Our experiments show two different regimes depending on laser energy. Physical modeling of the underlying phenomena reveals a thermoelastic regime caused by a local dilatation resulting from temperature increase, and an ablative regime caused by a partial vaporization of the medium by the laser. Computed theoretical displacements are close to experimental measurements. A numerical study based on the physical modeling gives propagation patterns comparable to those generated experimentally...
November 28, 2016: Applied Physics Letters
https://www.readbyqxmd.com/read/28088928/multi-modal-mri-investigation-of-volumetric-and-microstructural-changes-in-the-hippocampus-and-its-subfields-in-mild-cognitive-impairment-alzheimer-s-disease-and-dementia-with-lewy-bodies
#14
Elijah Mak, Silvy Gabel, Li Su, Guy B Williams, Robert Arnold, Luca Passamonti, Patricia Vazquez Rodríguez, Ajenthan Surendranathan, W Richard Bevan-Jones, James B Rowe, John T O'Brien
BACKGROUND: Volumetric atrophy and microstructural alterations in diffusion tensor imaging (DTI) measures of the hippocampus have been reported in people with Alzheimer's disease (AD) and mild cognitive impairment (MCI). However, no study to date has jointly investigated concomitant microstructural and volumetric changes of the hippocampus in dementia with Lewy bodies (DLB). METHODS: A total of 84 subjects (23 MCI, 17 DLB, 14 AD, and 30 healthy controls) were recruited for a multi-modal imaging (3T MRI and DTI) study that included neuropsychological evaluation...
January 16, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28088669/micro-mechanical-properties-of-the-tendon-to-bone-attachment
#15
Alix C Deymier, Yiran An, John J Boyle, Andrea G Schwartz, Victor Birman, Guy M Genin, Stavros Thomopoulos, Asa H Barber
: The tendon-to-bone attachment (enthesis) is a complex hierarchical tissue that connects stiff bone to compliant tendon. The attachment site at the micrometer scale exhibits gradients in mineral content and collagen orientation, which likely act to minimize stress concentrations. The physiological micromechanics of the attachment thus define resultant performance, but difficulties in sample preparation and mechanical testing at this scale have restricted understanding of structure-mechanical function...
January 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28088071/discrete-quasi-linear-viscoelastic-damping-analysis-of-connective-tissues-and-the-biomechanics-of-stretching
#16
Behzad Babaei, Aaron J Velasquez-Mao, Stavros Thomopoulos, Elliot L Elson, Steven D Abramowitch, Guy M Genin
The time- and frequency-dependent properties of connective tissue define their physiological function, but are notoriously difficult to characterize. Well-established tools such as linear viscoelasticity and the Fung quasi-linear viscoelastic (QLV) model impose forms on responses that can mask true tissue behavior. Here, we applied a more general discrete quasi-linear viscoelastic (DQLV) model to identify the static and dynamic time- and frequency-dependent behavior of rabbit medial collateral ligaments. Unlike the Fung QLV approach, the DQLV approach revealed that energy dissipation is elevated at a loading period of ∼10s...
December 22, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28087159/the-direct-anterior-approach-for-complex-primary-total-hip-arthroplasty-the-extensile-acetabular-approach-on-a-regular-operating-room-table
#17
Ben Molenaers, Ronald Driesen, Guy Molenaers, Kristoff Corten
BACKGROUND: The direct anterior approach on a regular operating room table has been reported with low dislocation rates. This might be beneficial for complex primary total hip arthroplasty (THA) such as in patients with cerebral palsy or following femoral or pelvic osteotomies. Extending the approach is often required to overcome problems such as acetabular deformities or severe contractures. METHODS: We retrospectively evaluated the results and complications of 29 patients with 37 complex primary THA in which an extensile approach was used...
December 22, 2016: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28086775/rapid-decline-in-the-susceptibility-of-plasmodium-falciparum-to-dihydroartemisinin-piperaquine-in-the-south-of-vietnam
#18
Ngo Viet Thanh, Nguyen Thuy-Nhien, Nguyen Thi Kim Tuyen, Nguyen Thanh Tong, Nguyen Thuy Nha-Ca, Le Thanh Dong, Huynh Hong Quang, Jeremy Farrar, Guy Thwaites, Nicholas J White, Marcel Wolbers, Tran Tinh Hien
BACKGROUND: Artemisinin resistant Plasmodium falciparum has emerged in the countries of the Greater Mekong sub-region posing a serious threat to global malaria elimination efforts. The relationship of artemisinin resistance to treatment failure has been unclear. METHODS: In annual studies conducted in three malaria endemic provinces in the south of Vietnam (Binh Phuoc, Ninh Thuan and Gia Lai) between 2011 and 2015, 489 patients with uncomplicated P. falciparum malaria were enrolled in detailed clinical, parasitological and molecular therapeutic response assessments with 42 days follow up...
January 13, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28081229/statistical-parametric-mapping-to-identify-differences-between-consensus-based-joint-patterns-during-gait-in-children-with-cerebral-palsy
#19
Angela Nieuwenhuys, Eirini Papageorgiou, Kaat Desloovere, Guy Molenaers, Tinne De Laet
Experts recently identified 49 joint motion patterns in children with cerebral palsy during a Delphi consensus study. Pattern definitions were therefore the result of subjective expert opinion. The present study aims to provide objective, quantitative data supporting the identification of these consensus-based patterns. To do so, statistical parametric mapping was used to compare the mean kinematic waveforms of 154 trials of typically developing children (n = 56) to the mean kinematic waveforms of 1719 trials of children with cerebral palsy (n = 356), which were classified following the classification rules of the Delphi study...
2017: PloS One
https://www.readbyqxmd.com/read/28079787/oral-and-vulvo-vaginal-lichenoid-reactions-due-to-mitotane-lysodren-a-case-report
#20
Arthur Schmouchkovitch, Héloïse Herry, Philippe Thuillier, Véronique Kerlan, Camille Fleuret, Guy Le Toux, Sylvie Boisramé
BACKGROUND: The purpose of pharmacovigilance (drug safety) is collection, detection, assessment, monitoring, and prevention of adverse effects with pharmaceutical products. It is meant to identify, characterize, prevent, or minimize actual or potential risks relating to medicinal products. To prevent these adverse effects and improve our practice, health professionals have a duty to report side effects to assess this risk and evaluate the benefit/risk requirements. Mitotane (Lysodren) is used for treating adrenocortical carcinoma...
January 2017: Medicine (Baltimore)
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