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https://www.readbyqxmd.com/read/28214853/chronic-consumption-of-artificial-sweetener-in-packets-or-tablets-and-type-2-diabetes-risk-evidence-from-the-e3n-european-prospective-investigation-into-cancer-and-nutrition-study
#1
Guy Fagherazzi, Gaëlle Gusto, Aurélie Affret, Francesca Romana Mancini, Courtney Dow, Beverley Balkau, Françoise Clavel-Chapelon, Fabrice Bonnet, Marie-Christine Boutron-Ruault
BACKGROUND: The influence of artificial sweeteners on metabolic diseases is controversial. Artificially sweetened beverages have been associated with an increased risk of type 2 diabetes (T2D) but biases and reverse causation have been suspected to have influenced the observed association. In addition, it has been suggested that investigation into the relationship between the frequency and duration of the consumption of packet or tablet artificial sweeteners and T2D risk is necessary...
February 18, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/28214759/the-role-of-hcg-increment-in-the-48h-prior-to-methotrexate-treatment-as-a-predictor-for-treatment-success
#2
Aviad Cohen, Benny Almog, Yoni Cohen, Guy Bibi, Eli Rimon, Ishai Levin
OBJECTIVE: To evaluate the role HCG change in the 48h prior to methotrexate treatment as a predictor for treatment success. STUDY DESIGN: Medical records of all women who were diagnosed with ectopic pregnancy between January 2001 and June 2013 were reviewed. Four hundred and nine patients received methotrexate due to ectopic pregnancy. The "single dose" methotrexate protocol with 50mg/m(2) was administered to patients with progressing ectopic pregnancy. HCG levels in days 1, 4 and 7 were used to evaluate methotrexate treatment success...
February 9, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28212976/functional-lumen-imaging-probe-for-the-management-of-esophageal-disorders-expert-review-from-the-clinical-practice-updates-committee-of-the-aga-institute
#3
REVIEW
Ikuo Hirano, John E Pandolfino, Guy E Boeckxstaens
The functional luminal imaging probe is a Food and Drug Administration-approved measurement tool used to measure simultaneous pressure and diameter to guide management of various upper gastrointestinal disorders. Additionally, this tool is also approved to guide therapy during bariatric procedures and specialized esophageal surgery. Although it has been commercially available since 2009 as the endolumenal functional lumen imaging probe (EndoFLIP), the functional luminal imaging probe has had limited penetrance into clinical settings outside of specialized centers...
March 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28211757/mice-and-the-a-bomb-irradiation-systems-for-realistic-exposure-scenarios
#4
Guy Garty, Yanping Xu, Carl Elliston, Stephen A Marino, Gerhard Randers-Pehrson, David J Brenner
Validation of biodosimetry assays is normally performed with acute exposures to uniform external photon fields. Realistically, exposure to a radiological dispersal device or reactor leak will include exposure to low dose rates and likely exposure to ingested radionuclides. An improvised nuclear device will likely include a significant neutron component in addition to a mixture of high- and low-dose-rate photons and ingested radionuclides. We present here several novel irradiation systems developed at the Center for High Throughput Minimally Invasive Radiation Biodosimetry to provide more realistic exposures for testing of novel biodosimetric assays...
February 17, 2017: Radiation Research
https://www.readbyqxmd.com/read/28210834/conservative-treatment-in-uncomplicated-acute-appendicitis-reassessment-of-practice-safety
#5
Zvi Steiner, Genady Buklan, Rodica Stackievicz, Michael Gutermacher, Ita Litmanovitz, Guy Golani, Shmuel Arnon
: The success rate of conservative treatment for children with uncomplicated appendicitis was prospectively evaluated among 197 children. All who received intravenous antibiotics for 3-5 days, and if symptoms resolved, were discharged home on oral antibiotics for 5 days. Failure rate, symptoms, laboratory signs, and sonographic findings were evaluated for prognostic markers of treatment failure. Children were followed for 18 months. The success rate of conservative treatment was 87%, with shorter hospital stays compared to children who eventually needed surgery (72 [60-84] vs...
February 16, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28210327/guy-joos
#6
(no author information available yet)
ERS President, Guy Joos, gives an insight into his life http://ow.ly/T0uq304yC36.
December 2016: Breathe
https://www.readbyqxmd.com/read/28210209/lactate-shuttles-in-neuroenergetics-homeostasis-allostasis-and-beyond
#7
REVIEW
Shayne Mason
Understanding brain energy metabolism-neuroenergetics-is becoming increasingly important as it can be identified repeatedly as the source of neurological perturbations. Within the scientific community we are seeing a shift in paradigms from the traditional neurocentric view to that of a more dynamic, integrated one where astrocytes are no longer considered as being just supportive, and activated microglia have a profound influence. Lactate is emerging as the "good guy," contrasting its classical "bad guy" position in the now superseded medical literature...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28208288/-15-n-nmr-based-approach-for-amino-acids-based-13-c-metabolic-flux-analysis-of-metabolism
#8
Pierre Millard, Edern Cahoreau, Maud Heuillet, Jean-Charles Portais, Guy Lippens
NMR analysis of the isotope incorporation in amino acids can be used to derive information about the topology and operation of cellular metabolism. Although traditionally performed by (1)H and/or (13)C NMR, we present here novel experiments that exploit the (15)N nucleus to derive the same information with increased efficiency. Combined with a novel Hα-(13)CO experiment, we increase the coverage of the isotopic space that can be probed by obtaining the complete distribution of isotopic species for the first two carbons of amino acids in cellular biomass hydrolysates...
February 7, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28207914/memories-of-intimate-partner-violence-and-the-process-of-change
#9
Matan White, David E Pollio, Barry A Hong, Carol S North
BACKGROUND: One in 4 U.S. women experience intimate partner violence (IPV) during their lives. Despite the magnitude of this problem, little is known about the natural history of relationships involving IPV and how women exit them. METHODS: Narrative interviews were conducted using open-ended qualitative narrative techniques with a convenience sample of 7 women who had ended a relationship of ≥6 months' duration involving IPV at least 6 months ago. The interviews were audio recorded and transcribed...
February 2017: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/28207272/controlling-the-release-of-indomethacin-from-glass-solutions-layered-with-a-rate-controlling-membrane-using-fluid-bed-processing-part-2-the-influence-of-formulation-parameters-on-drug-release
#10
Aswin Dereymaker, Jirka Pelgrims, Frederick Engelen, Peter Adriaensens, Guy Van den Mooter
This study aimed to investigate the pharmaceutical performance of an indomethacin-polyvinylpyrrolidone (PVP) glass solution applied using fluid bed processing as a layer on inert sucrose spheres, and subsequently top-coated with a release rate controlling membrane consisting of either ethyl cellulose or Eudragit RL. The implications of the addition of a pore former (PVP) and the coating medium (ethanol or water) on the diffusion and release behavior were also considered. In addition, the role of a charge interaction between drug and controlled release polymer on the release was investigated...
February 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28206770/controlling-the-release-of-indomethacin-from-glass-solutions-layered-with-a-rate-controlling-membrane-using-fluid-bed-processing-part-1-surface-and-cross-sectional-chemical-analysis
#11
Aswin Dereymaker, David J Scurr, Elisabeth D Steer, Clive J Roberts, Guy Van den Mooter
Fluid bed coating has been shown to be a suitable manufacturing technique to formulate poorly soluble drugs in glass solutions. Layering inert carriers with a drug-polymer mixture enables these beads to be immediately filled into capsules, thus avoiding additional, potentially destabilizing, downstream processing. In this study fluid bed coating is proposed for the production of controlled release dosage forms of glass solutions by applying a second, rate controlling membrane on top of the glass solution. Adding a second coating layer adds to the physical and chemical complexity of the drug delivery system so a thorough understanding of the physical structure and phase behavior of the different coating layers is needed...
February 16, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/28205648/identification-of-a-novel-nampt-inhibitor-by-crispr-cas9-chemogenomic-profiling-in-mammalian-cells
#12
David Estoppey, Jeffrey W Hewett, Chantale T Guy, Edmund Harrington, Jason R Thomas, Markus Schirle, Rachel Cuttat, Annick Waldt, Bertran Gerrits, Zinger Yang, Sven Schuierer, Xuewen Pan, Kevin Xie, Walter Carbone, Judith Knehr, Alicia Lindeman, Carsten Russ, Elizabeth Frias, Gregory R Hoffman, Malini Varadarajan, Nadire Ramadan, John S Reece-Hoyes, Qiong Wang, Xin Chen, Gregory McAllister, Guglielmo Roma, Tewis Bouwmeester, Dominic Hoepfner
Chemogenomic profiling is a powerful and unbiased approach to elucidate pharmacological targets and the mechanism of bioactive compounds. Until recently, genome-wide, high-resolution experiments of this nature have been limited to fungal systems due to lack of mammalian genome-wide deletion collections. With the example of a novel nicotinamide phosphoribosyltransferase (NAMPT) inhibitor, we demonstrate that the CRISPR/Cas9 system enables the generation of transient homo- and heterozygous deletion libraries and allows for the identification of efficacy targets and pathways mediating hypersensitivity and resistance relevant to the compound mechanism of action...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28205215/multicenter-validation-of-an-mmse-moca-conversion-table
#13
David Bergeron, Kelsey Flynn, Louis Verret, Stéphane Poulin, Rémi W Bouchard, Christian Bocti, Tamàs Fülöp, Guy Lacombe, Serge Gauthier, Ziad Nasreddine, Robert Jr Laforce
BACKGROUND: Accumulating evidence points to the superiority of the MoCA over the MMSE as a cognitive screening tool. To facilitate the transition from the MMSE to the MoCA in clinical and research settings, authors have developed MMSE-MoCA conversion tables. However, it is unknown whether a conversion table generated from Alzheimer's disease (AD) patients would apply to patients with other dementia subtypes like vascular dementia or frontotemporal dementia. Furthermore, the reliability and accuracy of MMSE-MoCA conversion tables has not been properly evaluated...
February 15, 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28201979/wide-variation-in-sexually-transmitted-infection-testing-and-counselling-at-aboriginal-primary-health-care-centres-in-australia-analysis-of-longitudinal-continuous-quality-improvement-data
#14
Barbara Nattabi, Veronica Matthews, Jodie Bailie, Alice Rumbold, David Scrimgeour, Gill Schierhout, James Ward, Rebecca Guy, John Kaldor, Sandra C Thompson, Ross Bailie
BACKGROUND: Chlamydia, gonorrhoea and syphilis are readily treatable sexually transmitted infections (STIs) which continue to occur at high rates in Australia, particularly among Aboriginal Australians. This study aimed to: explore the extent of variation in delivery of recommended STI screening investigations and counselling within Aboriginal primary health care (PHC) centres; identify the factors associated with variation in screening practices; and determine if provision of STI testing and counselling increased with participation in continuous quality improvement (CQI)...
February 15, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28200071/adaptive-mcmc-in-bayesian-phylogenetics-an-application-to-analyzing-partitioned-data-in-beast
#15
Guy Baele, Philippe Lemey, Andrew Rambaut, Marc A Suchard
No abstract text is available yet for this article.
February 13, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28199990/activation-of-nk-cells-and-disruption-of-pd-l1-pd-1-axis-two-different-ways-for-lenalidomide-to-block-myeloma-progression
#16
REVIEW
Massimo Giuliani, Bassam Janji, Guy Berchem
Natural Killer (NK) cells play a critical role against tumor cells in hematological malignancies. Their activating receptors are essential in tumor cell killing. In Multiple Myeloma (MM) patients, NK cell differentiation, activation and cytotoxic potential are strongly impaired leading to MM escape from immune surveillance in tissues and bone marrow. Mechanisms used by MM to affect NK cell functions are mediated by the release of soluble factors, the expression of activating and inhibitory NK cell ligands, and the expression of immune check-point inhibitors...
February 9, 2017: Oncotarget
https://www.readbyqxmd.com/read/28198781/biomechanical-analysis-of-two-level-cervical-disc-replacement-with-a-stand-alone-u-shaped-disc-implant
#17
Yang Li, Guy R Fogel, Zhenhua Liao, Rajnesh Tyagi, Gaolong Zhang, Weiqiang Liu
STUDY DESIGN: Biomechanical study using a three-dimensional nonlinear finite element (FE) model. OBJECTIVE: To analyze biomechanical changes with three prostheses based on two-level arthroplasty and to verify the biomechanical efficiency of dynamic cervical implants (DCIs) with a stand-alone U-shaped structure. SUMMARY OF BACKGROUND DATA: Few studies have compared biomechanical behavior of various prostheses as they relate to clinical results after two-level total disc replacement (TDR)...
February 14, 2017: Spine
https://www.readbyqxmd.com/read/28197703/contemporary-dual-mobility-cup-regional-and-private-register-methodology-and-results
#18
André Ferreira, Jean-Louis Prudhon, Régis Verdier, Jean-Marc Puch, Loys Descamps, Guy Dehri, Marcel Remi, Jacques H Caton
INTRODUCTION: The dual-mobility cup (DMC) was introduced in 1979. Due to lack of referenced publications, this interesting and innovating concept was ignored during close to 20 years. However, 180 studies (level III or IV) have now been published. Evidence-based medicine is based on level I studies. Over the past three decades, the role of national registries developed with the intention of surveying orthopaedic implants. In 2012, we developed, registered, and implemented a specific database for contemporary DMC...
February 14, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28197185/not-only-a-bad-guy-potential-proneurogenic-role-of-the-rage-nf-%C3%AE%C2%BAb-axis-in-alzheimer-s-disease-brain
#19
Valeria Bortolotto, Mariagrazia Grilli
No abstract text is available yet for this article.
December 2016: Neural Regeneration Research
https://www.readbyqxmd.com/read/28197029/stepwise-case-selection-using-guy-s-stone-score-reduces-complications-during-percutaneous-nephrolithotomy-training
#20
Jiten Jaipuria, Manav Suryavanshi, Amitsinh P Desai, Sanjay Goyal, Kaushal Patel, Sandip S Parhad, Santosh K Subudhi, Chandrashekar V Rao, Satish P Kumar, Tridib K Sen
INTRODUCTION: Traditional percutaneous nephrolithotomy (PCNL) training involved subjective award of cases to the trainee. We restructured this according to the Guy's stone score (GSS) such that each trainee stepwise completed 25 cases of each grade before progressing. This study compares the outcomes of training with traditional versus stepwise approach. METHODS: Four hundred consecutive cases equally distributed for two trainees in each group were compared in terms of complications (Clavien-Dindo), stone free rate (SFR), operative and fluoroscopy time...
January 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
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