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NAD ratio AND T3

F Carlucci, A Tabucchi, B Biagioli, F Simeone, S Scolletta, F Rosi, E Marinello
Myocardial and endothelial damage is still a widely debated problem during the ischemia-reperfusion sequence in heart surgery. We evaluated myocardial purine metabolites, antioxidant defense mechanisms, oxidative status and endothelial dysfunction markers in 14 patients undergoing coronary artery by-pass graft (CABG). Heart biopsies were taken before aortic cross-clamping (t1), before clamp removal (t2) and 30 min after reperfusion (t3); perchloric extracts of the tissue were analyzed for glutathione, NAD, nucleotide nucleoside and base content by capillary electrophoresis (CE)...
December 2002: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Nava Siegelmann-Danieli, Kenneth H Buetow
This work examined the role of constitutional genetic variation at the glutathione S-transferase M1 (GSTM1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) detoxification loci in breast cancer development. Methods included contrasting patterns of genetic variations at these loci between cases with breast cancer and healthy controls and assessing the association of genotypes with tumor characteristics. Participants were Caucasian women living in the Greater Philadelphia region, recruited from 1988 to 1994, with recently diagnosed women attending breast cancer clinics at Fox Chase Cancer Center (FCCC) and network affiliated hospitals as cases, and FCCC employees or women attending noncancer clinics as controls...
2002: Oncology
C Vind, N Grunnet
The metabolism of (1R)[1-3H]ethanol, [2-3H]lactate or [2-3H]xylitol was studied in hepatocytes from fed or T3-treated rats in the presence or absence of fructose or xylitol. The yields of tritium in ethanol, lactate, water, glycerol and glucose were determined. A simple model, describing the metabolic fate of tritium from these substrates is presented. The model allows estimation of the ethanol oxidation rate by the non-alcohol dehydrogenase pathways from the relative yield of tritium in water and glucose. The calculations are based on a comparison of the fate of the 1-proR-hydrogen of ethanol and the hydrogen bound to carbon 2 of lactate (or xylitol) under identical condition...
March 1, 1985: Biochemical Pharmacology
R R Rajan, S S Katyare
The age-dependent changes in oxidative phosphorylation in rat brain mitochondria were studied in order to ascertain if the efficiency of phosphorylation with NAD(+)-linked substrates increases during the first month after birth. The state 3 respiration rates with all substrates tested increased with age but with distinctive developmental profiles for each substrate; the extent of increase was also substrate-specific. The ADP/O ratios obtained with all substrates, including NAD(+)-linked ones were comparable with the value for adult mitochondria right from the first postnatal week...
December 2, 1991: Mechanisms of Ageing and Development
D L Hardy, J Mowbray
Under defined conditions liver mitochondria from hypothyroid rats show an apparent lowering of the ADP/O ratio, which can be corrected by addition in vitro of 0.1 nM-tri-iodothyronine (T3). Nicotinamide prevents this restoration by hormone, lowers the ADP/O ratio of euthyroid-rat mitochondria to hypothyroid-rat values and induces T3-sensitivity in euthyroid-rat mitoplasts indistinguishable from that found with hypothyroid-rat preparations. Incorporation into the trichloroacetic-acid insoluble fraction of mitoplasts and hypothyroid-rat mitochondria of radiolabel from [adenine-14C]-NAD+ was stimulated by T3: this stimulation was abolished by nicotinamide...
May 1, 1992: Biochemical Journal
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