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acute pancreatitis

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https://www.readbyqxmd.com/read/29230108/letter-to-the-editor-ertapenem-induced-acute-pancreatitis-in-a-cirrhotic-patient
#1
Erkin Oztas, Muhammet Yener Akpinar, Mustafa Kaplan
No abstract text is available yet for this article.
2017: Ochsner Journal
https://www.readbyqxmd.com/read/29229780/cathepsin-d-regulates-cathepsin-b-activation-and-disease-severity-predominantly-in-inflammatory-cells-during-experimental-pancreatitis
#2
Ali A Aghdassi, Daniel S John, Matthias Sendler, F Ulrich Weiss, Thomas Reinheckel, Julia Mayerle, Markus M Lerch
Acute pancreatitis is a complex disorder involving both premature intracellular protease activation and inflammatory cell invasion. An initiating event is the intracellular activation of trypsinogen by cathepsin B (CTSB), which can be induced directly via G-protein-coupled receptors on acinar cells or through inflammatory cells. Here, we studied CTSB regulation by another lysosomal hydrolase, cathepsin D (CTSD), using mice with a complete (CTSD-/-) or pancreas-specific conditional CTSD knockout (KO) (CTSDf/f/p48Cre/+)...
December 11, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29228444/rectal-indomethacin-or-intravenous-gabexate-mesylate-as-prophylaxis-for-acute-pancreatitis-post-endoscopic-retrograde-cholangiopancreatography
#3
V Guglielmi, M Tutino, V Guerra, P Giorgio
OBJECTIVE: We aimed to evaluate the results in our case series of AP ERCP over the last three years. The prophylaxis for acute pancreatitis (AP) post-endoscopic retrograde cholangiopancreatography (ERCP) consists of rectal indomethacin, but some studies are not concordant. PATIENTS AND METHODS: We compared 241 ERCP performed from January 2014 to February 2015 with intravenous gabexate mesylate (Group A), with the 387 ERCP performed from March 2015 to December 2016 with rectal indomethacin (Group B) as prophylaxis for AP post-ERCP...
November 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29227009/fetal-liver-injury-ameliorated-by-migration-inhibitory-factor-inhibition-in-a-rat-model-of-acute-pancreatitis-in-pregnancy
#4
Zheng-Da Guo, Liang Zhao, Peng Wang, Wen-Hong Deng, Qiao Shi, Teng Zuo, Yu-Pu Hong, Wei-Xing Wang
AIM: This study was designed to investigate and assess fetal liver injury in a rat model of acute pancreatitis in pregnancy (APIP) as well as its possible mechanisms and potential therapeutic targets. METHODS: The APIP model was induced by sodium taurocholate in Sprague-Dawley rats during the third trimester. ISO-1, a macrophage migration inhibitory factor (MIF) antagonist, was given before the induction of APIP. In addition, sham-operated rats at later gestation were set as controls...
December 11, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29226107/cholangitis-diagnosis-treatment-and-prognosis
#5
REVIEW
Amir Houshang Mohammad Alizadeh
Cholangitis is a serious life-threatening situation affecting the hepatobiliary system. This review provides an update regarding the clinical and pathological features of various forms of cholangitis. A comprehensive search was performed in the PubMed, Scopus, and Web of Knowledge databases. It was found that the etiology and pathogenesis of cholangitis are heterogeneous. Cholangitis can be categorized as primary sclerosing (PSC), secondary (acute) cholangitis, and a recently characterized form, known as IgG4-associated cholangitis (IAC)...
December 28, 2017: Journal of Clinical and Translational Hepatology
https://www.readbyqxmd.com/read/29225082/comparison-of-eus-with-magnetic-resonance-cholangiopancreatography-in-idiopathic-acute-pancreatitis-a-systematic-review-and-meta-analysis
#6
REVIEW
Jianhua Wan, Yaobin Ouyang, Chen Yu, Xiaoyu Yang, Liang Xia, Nonghua Lu
BACKGROUND: /Aims: Idiopathic acute pancreatitis (IAP) poses a diagnostic challenge for gastroenterologists, as confirmation of the disease etiology has important implications for the selection of the best possible treatment and the prevention of possible recurrence or the development of chronic pancreatitis. ERCP, EUS, and magnetic resonance cholangiopancreatography (MRCP) are typically used to diagnose IAP when conventional radiological methods fail. However, their exact role in the diagnosis of IAP has not yet been determined...
December 7, 2017: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29223944/-pancreatic-arteriovenous-malformation-as-cause-of-acute-pancreatitis-treated-by-endovascular-access
#7
Gustavo Kohan, Matías Provenzano, Martín Rosado, Grisel Farfan, Nicolás Sánchez, Denise Fastman
Arteriovenous malformation in the pancreas is a rare anatomic abnormality that may produce acute pancreatitis. The diagnosis was suspected by computed tomography with intravenous contrast and by magnetic resonance imaging and it was confirmed by arteriography of the celiac trunk and superior mesenteric artery. The treatment received was endovascular, although the other valid option for the treatment of this disease is the surgical resection. The objective of this communication is to present a case of acute pancreatitis due to arteriovenous malformation treated by endovascular approach...
2017: Medicina
https://www.readbyqxmd.com/read/29222967/stimulation-of-the-endogenous-incretin-glucose-dependent-insulinotropic-peptide-by-enteral-dextrose-improves-glucose-homeostasis-and-inflammation-in-murine-endotoxemia
#8
Faraaz Ali Shah, Srikanth Singamsetty, Lanping Guo, Byron W Chuan, Sherie McDonald, Bryce A Cooper, Brett J O'Donnell, Darko Stefanovski, Burton Wice, Yingze Zhang, Christopher P O'Donnell, Bryan J McVerry
Loss of glucose homeostasis during sepsis is associated with increased organ dysfunction and higher mortality. Novel therapeutic strategies to promote euglycemia in sepsis are needed. We have previously shown that early low-level intravenous (IV) dextrose suppresses pancreatic insulin secretion and induces insulin resistance in septic mice, resulting in profound hyperglycemia and worsened systemic inflammation. In this study, we hypothesized that administration of low-level dextrose via the enteral route would stimulate intestinal incretin hormone production, potentiate insulin secretion in a glucose-dependent manner, and thereby improve glycemic control in the acute phase of sepsis...
November 21, 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/29222263/crisis-management-in-the-treatment-of-childhood-acute-lymphoblastic-leukemia-putting-right-what-can-go-wrong-emergency-complications-of-disease-and-treatment
#9
REVIEW
Rachael Hough, Ajay Vora
The improvement in overall survival in children with acute lymphoblastic leukemia (ALL) over the last 5 decades has been considerable, with around 90% now surviving long term. The risk of relapse has been reduced to such an extent that the risk of treatment-related mortality is now approaching that of mortality caused by relapse. Toxicities may also lead to the suboptimal delivery of chemotherapy (treatment delays, dose reductions, dose omissions), potentially increasing relapse risk, and short- and long-term morbidity, adding to the "burden of therapy" in an increasing number of survivors...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29222221/acute-pancreatitis-following-oesophagogastroduodenoscopy
#10
Nnamdi Arinze Nwafo
Acute pancreatitis is a well-recognised complication of endoscopic procedures like endoscopic retrograde cholangiopancreatography but not oesophagogastroduodenoscopy (OGD). I report a case of a 33-year-old woman, admitted with severe epigastric pain and vomiting 2 hours after an elective OGD for evaluation of chronic gastrointestinal symptoms. Pancreatitis was diagnosed on the basis of elevated lipase (40 790 U/L; normal 11-82) and findings on imaging studies. Other common causes of acute pancreatitis such as gallstones, alcohol and medications were ruled out...
December 7, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29221631/a-population-based-evaluation-of-the-natural-history-of-chronic-pancreatitis
#11
Jorge D Machicado, Suresh T Chari, Lawrence Timmons, Gong Tang, Dhiraj Yadav
BACKGROUND: Based on reports from tertiary care centers, chronic pancreatitis (CP) is considered to be a painful and debilitating disease frequently requiring invasive interventions. Our primary aim was to assess the natural course of CP in a population-based cohort using endoscopic and surgical interventions as surrogates for disease aggressiveness. METHODS: We identified all patients (n = 89, alcoholic [ACP = 46], non-alcoholic [NACP] = 43) with newly diagnosed definite CP from Olmsted County, Minnesota between 1977 and 2006...
November 24, 2017: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/29221438/double-catheter-lavage-combined-with-percutaneous-flexible-endoscopic-debridement-for-infected-pancreatic-necrosis-failed-to-percutaneous-catheter-drainage
#12
Pi Liu, Jun Song, Hua-Jing Ke, Nong-Hua Lv, Yin Zhu, Hao Zeng, Yong Zhu, Liang Xia, Wen-Hua He, Ji Li, Xin Huang, Yu-Peng Lei
BACKGROUND: Infected pancreatic necrosis (IPN) is a serious local complication of acute pancreatitis, with high mortality. Minimally invasive therapy including percutaneous catheter drainage (PCD) has become the preferred method for IPN instead of traditional open necrosectomy. However, the efficacy of double-catheter lavage in combination with percutaneous flexible endoscopic debridement after PCD failure is unknown compared with surgical necrosectomy. METHODS: A total of 27 cases of IPN patients with failure PCD between Jan 2014 and Dec 2015 were enrolled in this retrospective cohort study...
December 8, 2017: BMC Gastroenterology
https://www.readbyqxmd.com/read/29218844/predictors-of-hepatotoxicity-and-pancreatitis-in-children-and-adolescents-with-acute-lymphoblastic-leukemia-treated-according-to-contemporary-regimens
#13
Christopher C Denton, Yasmin A Rawlins, Matthew J Oberley, Deepa Bhojwani, Etan Orgel
BACKGROUND: Hepatotoxicity and pancreatitis are common treatment-related toxicities (TRTs) during contemporary treatment regimens for acute lymphoblastic leukemia (ALL). Limited detailed data from Children's Oncology Group (COG) regimens has been previously reported to enable identification of patient and treatment risk factors for these toxicities and their impact on outcomes. PROCEDURE: We analyzed a retrospective pediatric ALL cohort treated at a single institution according to COG regimens from 2008 to 2015...
December 8, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29217901/xanthogranulomatous-cholecystitis-analysis-of-108-patients
#14
Osman Yucel, Mehmet Ali Uzun, Metin Tilki, Sevcan Alkan, Zeynep Gamze Kilicoglu, Ceren Canbey Goret
The aim of this study was to evaluate the clinical and radiological features of xanthogranulomatous cholecystitis (XGC) and the results of surgical treatment. This retrospective study concerns clinical, radiological, and surgical data as well as histopathological findings and postoperative results of 108 patients with XGC who were identified after evaluating 7916 cholecystectomy specimens between 2004 and 2014 in a single institute. One hundred eight patients with XGC were evaluated (56 males and 52 females, mean age 62...
December 2017: Indian Journal of Surgery
https://www.readbyqxmd.com/read/29216022/yield-of-endoscopic-ultrasound-in-children-and-adolescent-with-acute-recurrent-pancreatitis
#15
Sumit Kumar Singh, Anshu Srivastava, Praveer Rai, Surender K Yachha, Ujjal Poddar
OBJECTIVES: Endoscopic ultrasound (EUS) is an established tool for evaluation of adults with acute recurrent pancreatitis (ARP) while data in pediatrics is limited. Our study assessed the role of EUS in identifying etiology including changes of chronic pancreatitis (CP) in children and adolescents with ARP. METHODS: Children with ARP (≥2 episodes of acute pancreatitis) were prospectively evaluated with a detailed clinical proforma and EUS. Subjects with known etiology of ARP or CP on ultrasonography/computed tomography and magnetic resonance cholangio-pancreatography (MRCP, Cambridge grade ≥3) were excluded...
December 5, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29215631/which-patients-with-mild-acute-pancreatitis-require-prolonged-hospitalization
#16
Harkirat Singh, Amir Gougol, Rawad Mounzer, Dhiraj Yadav, Efstratios Koutroumpakis, Adam Slivka, David C Whitcomb, Georgios I Papachristou
OBJECTIVES: In our experience, a subset of mild acute pancreatitis (AP) patients, as defined by the Revised Atlanta Classification, has longer than expected hospitalization. Our aims are to report the prevalence of patients with mild AP who have a prolonged length of stay (LOS), evaluate the etiology, thoroughly phenotype, and finally compare this subset to those with expected LOS. METHODS: Patients admitted with AP from 2003 to 2015 were prospectively enrolled into this cohort study...
December 7, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/29215619/endoscopic-placement-of-a-u-shaped-plastic-stent-in-patients-with-recurrent-acute-pancreatitis-and-incomplete-pancreas-divisum
#17
Qi-Shan Zeng, Chun-Cheng Wu, Wei Liu, Lian-Song Ye, Shan Jiang, Yu-Hang Zhang, Bing Hu
No abstract text is available yet for this article.
December 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/29215544/the-251-a-t-polymorphism-in-the-il8-promoter-is-a-risk-factor-for-acute-pancreatitis
#18
Shrinivas Bishu, Efstratios Koutroumpakis, Rawad Mounzer, Kimberly Stello, Nijole Pollock, Anna Evans, David C Whitcomb, Georgios I Papachristou
OBJECTIVES: Inflammation in the setting of acute pancreatitis (AP) is partially driven by pathogen recognition receptors that recognize damage-associated molecular patterns. Interleukin (IL)-8 is a chemotactic factor produced by pathogen recognition receptor-expressing cells. A single-nucleotide polymorphism in IL8 promoter region (-251 A/T) has been implicated in inflammatory diseases. We examined whether this IL8 polymorphism confers susceptibility to AP. METHODS: Patients with AP (n = 357) were prospectively recruited...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29215543/fungal-infections-in-patients-with-infected-pancreatic-necrosis-and-pseudocysts-risk-factors-and-outcome
#19
Philipp A Reuken, Hanna Albig, Jürgen Rödel, Michael Hocke, Uwe Will, Andreas Stallmach, Tony Bruns
OBJECTIVES: Fungal infections in patients with acute pancreatitis are common and potentially life threatening. Data on fungal pancreatic infections are inconsistent. Therefore, the aim of this study was to identify risk factors for fungal infection and to determine their impact on survival. METHODS: This was a retrospective analysis of pathogen spectrum and outcome of infected pancreatic necrosis or pseudocysts from 3 German hospitals from 2002 to 2016. RESULTS: A total of 187 fine-needle aspirations were performed in 113 patients...
December 5, 2017: Pancreas
https://www.readbyqxmd.com/read/29215538/cortisol-outperforms-novel-cardiovascular-inflammatory-and-neurohumoral-biomarkers-in-the-prediction-of-outcome-in-acute-pancreatitis
#20
Christian A Nebiker, Sebastian Staubli, Juliane Schäfer, Roland Bingisser, Mirjam Christ-Crain, Salome Dell-Kuster, Christian Mueller, Karla Scamardi, Carsten T Viehl, Dieter Kolleth, Urs von Holzen, Daniel Oertli, Rachel Rosenthal
OBJECTIVES: The aims of this study were to assess whether copeptin, pro-atrial natriuretic peptide, proadrenomedullin, and cortisol are associated with disease severity in patients with acute pancreatitis (AP) and to compare their ability in predicting organ failure or death. METHODS: From April 2011 to January 2015, 142 patients with AP were included in this prospective single-center study and observed for 4 days. Disease severity was rated by the Atlanta 1992 and 2012 criteria and organ failure by the modified Marshall score...
December 5, 2017: Pancreas
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