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ovarian cancer cytoreduction

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https://www.readbyqxmd.com/read/29342393/hyperthermic-intraperitoneal-chemotherapy-in-ovarian-cancer
#1
Willemien J van Driel, Simone N Koole, Karolina Sikorska, Jules H Schagen van Leeuwen, Henk W R Schreuder, Ralph H M Hermans, Ignace H J T de Hingh, Jacobus van der Velden, Henriëtte J Arts, Leon F A G Massuger, Arend G J Aalbers, Victor J Verwaal, Jacobien M Kieffer, Koen K Van de Vijver, Harm van Tinteren, Neil K Aaronson, Gabe S Sonke
BACKGROUND: Treatment of newly diagnosed advanced-stage ovarian cancer typically involves cytoreductive surgery and systemic chemotherapy. We conducted a trial to investigate whether the addition of hyperthermic intraperitoneal chemotherapy (HIPEC) to interval cytoreductive surgery would improve outcomes among patients who were receiving neoadjuvant chemotherapy for stage III epithelial ovarian cancer. METHODS: In a multicenter, open-label, phase 3 trial, we randomly assigned 245 patients who had at least stable disease after three cycles of carboplatin (area under the curve of 5 to 6 mg per milliliter per minute) and paclitaxel (175 mg per square meter of body-surface area) to undergo interval cytoreductive surgery either with or without administration of HIPEC with cisplatin (100 mg per square meter)...
January 18, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29340789/fully-sialylated-alpha-chain-of-complement-4-binding-protein-a2160-a-novel-prognostic-marker-for-epithelial-ovarian-carcinoma
#2
Koji Matsuo, Kazuhiro Tanabe, Masae Ikeda, Takeo Shibata, Hiroshi Kajiwara, Masaki Miyazawa, Mariko Miyazawa, Masaru Hayashi, Masako Shida, Takeshi Hirasawa, Lynda D Roman, Mikio Mikami
PURPOSE: Fully sialylated alpha-chain of complement 4-binding protein (A2160) is a member of the glycoprotein family and has recently been identified as a diagnostic biomarker for epithelial ovarian cancer. This study examined the utility of A2160 as a prognostic biomarker for this disease. METHODS: This is a retrospective analysis of prospectively collected plasma samples from 93 women with stage I-IV epithelial ovarian cancer who underwent primary cytoreductive surgery between 2009 and 2014...
January 16, 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29331996/relevance-of-enlarged-cardiophrenic-lymph-nodes-in-determining-prognosis-of-patients-with-advanced-ovarian-cancer
#3
Hasan Shahriar Md Nuruzzaman, Grace Hwei Ching Tan, Ravichandran Nadarajah, Melissa Teo
Ovarian cancer often presents at an advanced stage with widespread peritoneal and/or extra-abdominal metastases. Complete cytoreduction is the mainstay of treatment for disease confined to peritoneum. But in patients with distant metastases, the role and rationale is less obvious. One of the the most common sites of extra-abdominal disease is the cardiophrenic lymph node (CPLN). In this paper, we described the management of a patient with International Federation of Gynecology and Obstetrics (FIGO) stage IVB epithelial ovarian carcinoma and widespread peritoneal and extra-abdominal metastases to the CPLN, who underwent complete cytoreduction including excision of enlarged CPLN, following neoadjuvant chemotherapy...
January 13, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29325966/role-of-intraoperative-ultrasound-to-extend-the-application-of-minimally-invasive-surgery-for-treatment-of-recurrent-gynecological-cancer
#4
Floriana Mascilini, Lorena Quagliozzi, Francesca Moro, Maria Cristina Moruzzi, Valerio Gallotta, Salvatore Gueli Alletti, Giovanni Scambia, Antonia Carla Testa, Anna Fagotti
STUDY OBJECTIVE: To describe the potential role of intraoperative ultrasound (IOUS) in the detection and localization of recurrent disease in gynecological cancer patients during minimally invasive surgery (MIS). DESIGN: A prospective cohort study (Canadian Task Force II-1). SETTING: A University hospital. PATIENTS: From November 2015 to February 2017, 51 gynecological cancer patients with isolated recurrent disease and candidate for secondary cytoreductive surgery (SCS) were treated by MIS...
January 8, 2018: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29325268/-clinical-significance-of-targeting-drug-based-molecular-biomarkers-expression-in-ovarian-clear-cell-carcinoma
#5
M J Li, H R Li, X Cheng, R Bi, X Y Tu, F Liu, L H Chen
Objective: To assess the expression level of targeting drug-based molecular biomarkers in ovarian clear cell carcinoma (OCCC) tissues and its clinical significance. Methods: A total of 63 OCCC patients included 40 primary OCCC and 23 recurrent OCCC for secondary cytoreductive surgery (SCS), who had received primary surgeries at Fudan University Shanghai Cancer Center between January, 2008 and December, 2015 were enrolled, and immunohistochemistry SP method was used to test human epidermal growth factor receptor (EGFR), human epidermal growth factor receptor-2 (HER2), aurora kinase A (AURKA), breast cancer susceptibility gene 1 (BRCA1), BRCA2 and programmed death-ligand 1 (PD-L1)protein expression in paraffin-embedded tissues...
December 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/29324540/metastatic-involvement-of-lesser-sac-in-advanced-epithelial-ovarian-cancer
#6
Asima Mukhopadhyay, Nicolò Bizzarri, Melissa Bradbury, Subir Sinha, Jaydip Bhaumik, C William Helm
OBJECTIVES: In advanced epithelial ovarian cancer (AOC), lesser sac (LS) metastasis particularly to the supragastric LS (SGLS) may be overlooked, resulting in unrecognized residual disease. We aimed to identify the frequency, distribution, and predictors of LS metastasis using laparoscopic evaluation at laparotomy and perioperative surgical complications associated with evaluation and resection/ablation. METHODS: Prospective observational study in consecutive patients with AOC undergoing laparotomy for primary or interval cytoreductive surgery in 2 centers between November 2013 and December 2016...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29324538/specific-regions-rather-than-the-entire-peritoneal-carcinosis-index-are-predictive-of-complete-resection-and-survival-in-advanced-epithelial-ovarian-cancer
#7
Mikkel Rosendahl, Philipp Harter, Signe Frahm Bjørn, Claus Høgdall
BACKGROUND: Advanced epithelial ovarian cancer (EOC) often involves the peritoneum. Because complete resection of tumor and carcinosis is the most important prognostic factor, the peritoneal carcinosis index (PCI) has been evaluated in EOC. We hypothesize that specific PCI regions comprising the small intestine with mesentery (regions 9-12) and the hepatoduodenal ligament (region 2) are more predictive of complete resection (R = 0) and survival than the entire PCI. MATERIALS AND METHODS: We analyzed prospectively collected nationwide data from 507 patients with International Federation of Gynecology and Obstetrics stage IIIB to IVB EOC who underwent primary surgery with complete cytoreductive intent...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29298538/residual-tumor-less-than-0-25-centimetres-and-positive-lymph-nodes-are-risk-factors-for-early-relapse-in-recurrent-ovarian-peritoneal-carcinomatosis-treated-with-cytoreductive-surgery-hipec-and-systemic-chemotherapy
#8
Alvaro Arjona-Sanchez, Sebastian Rufian-Peña, Manuel Artiles, Juan Manuel Sánchez-Hidalgo, Ángela Casado-Adam, Antonio Cosano, Heather Thoelecke, Sharmila Ramnarine, Dimas Garcilazo, Javier Briceño-Delgado
The cytoreductive surgery (CRS) and HIPEC has showed promising results for the survival in patients with recurrent ovarian carcinomatosis, however, some of them will recur within the first year. The aim of this study is focused on identifying the risk factors to develop the recurrence within the first year after an optimal CRS-HIPEC in patients with recurrent ovarian carcinomatosis. METHODS: A total of 100 patients with peritoneal carcinomatosis from recurrent ovarian cancer treated by CRS+HIPEC were selected for analysis...
January 3, 2018: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/29288614/laparoscopic-hipec-for-peritoneal-carcinomatosis-from-gastric-cancer-technique-and-early-outcomes-of-our-first-cases
#9
Irina Bălescu, Daniela Godoroja, Mircea Gongu, Victor Tomulescu, Cătălin Copăescu
Gastric cancer remains one of the most aggressive malignancies, being associated with very poor therapeutic outcomes, especially in the advanced disease patients. Due to this evidence, finding a better treatment, a better control and higher survival rates is the current scientific focus of the medical community. Once the benefits of cytoreductive surgery in association with intraperitoneal hyperthermy (HIPEC) have been widely demonstrated in patients presenting peritoneal carcinomatosis from colorectal or ovarian origin,attention was focused on the possible benefit of this method in patients diagnosed with peritoneal carcinomatosis with gastric origin...
November 2017: Chirurgia
https://www.readbyqxmd.com/read/29285202/effective-treatment-of-a-patient-with-stage-iv-ovarian-cancer-a-case-report
#10
Zhen Huang, Hua Yan, Devendra Chavan, Zeng Yuan, Xingsheng Yang, Youzhong Zhang, Kun Song, Beihua Kong
The present case report describes a patient with stage IV ovarian cancer who survived for 9 years without achieving a complete remission since the first relapse. The patient's long-term survival may be ascribed to the slow growth of the cancer cells, limited metastasis and favorable responses to the treatments received. The patient manifested initially with malignant pleural effusion and was not able to tolerate surgical treatment. However, the disease was well-controlled using various treatments, including neoadjuvant chemotherapy, interval cytoreductive surgery and post-operative long-term chemotherapy...
January 2018: Oncology Letters
https://www.readbyqxmd.com/read/29282600/cytoreductive-surgery-plus-hyperthermic-intraperitoneal-chemotherapy-for-patients-with-peritoneal-metastases-from-endometrial-cancer
#11
Tommaso Cornali, Paolo Sammartino, Nikolaos Kopanakis, Athina Christopoulou, Marialuisa Framarino Dei Malatesta, Elias Efstathiou, Alessandra Spagnoli, Antonio Ciardi, Daniele Biacchi, John Spiliotis
BACKGROUND: More information is needed for selection of patients with peritoneal metastases from endometrial cancer (EC) to undergo cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC). METHODS: This study analyzed clinical, pathologic, and treatment data for patients with peritoneal metastases from EC who underwent CRS plus HIPEC at two tertiary centers. The outcome measures were morbidity, overall survival (OS), and progression-free survival (PFS) during a median 5 year follow-up period...
December 27, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29277802/value-of-diaphragmatic-surgery-during-interval-debulking-surgery
#12
Aurelie Pelissier, Oona Franke, Emile Darai, Gilles Houvenaeghel, Elisabeth Chereau, Roman Rouzier
BACKGROUND/AIM: The aim of this study was to assess the value of diaphragmatic surgery to achieve optimal debulking in patients with advanced ovarian cancer treated by neoadjuvant chemotherapy (NAC). PATIENTS AND METHODS: This is a retrospective review of the medical records of 182 patients. Diaphragmatic surgery was performed during interval debulking surgery (IDS) in 74 patients between January 2002 and December 2014. The patients were divided in 2 groups: with or without histological residual diaphragmatic disease...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29273308/cost-effectiveness-of-neoadjuvant-chemotherapy-followed-by-interval-cytoreductive-surgery-versus-primary-cytoreductive-surgery-for-patients-with-advanced-stage-ovarian-cancer-during-the-initial-treatment-phase
#13
Arthur-Quan Tran, Daniel O Erim, Stephanie A Sullivan, Ashley L Cole, Emma L Barber, Kenneth H Kim, Paola A Gehrig, Stephanie B Wheeler
OBJECTIVE: Advanced stage epithelial ovarian cancer (AEOC) can be treated with either neoadjuvant chemotherapy (NACT) or primary cytoreductive surgery (PCS). Although randomized controlled trials show that NACT is non-inferior in overall survival compared to PCS, there may be improvement in short-term morbidity. We sought to investigate the cost-effectiveness of NACT relative to PCS for AEOC from the US Medicare perspective. METHODS: A cost-effectiveness analysis using a Markov model with a 7-month time horizon comparing (1) 3cycles of NACT with carboplatin and paclitaxel (CT), followed by interval cytoreductive surgery, then 3 additional cycles of CT, or (2) PCS followed by 6cycles of CT...
December 19, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29262504/-expressions-and-clinical-significances-of-paired-box-gene-2-and-cyclin-d1-in-advanced-ovarian-serous-carcinoma
#14
Y Song, J Zuo, X Huang, G H Shen, X Y Liu, X Zhang
Objective: To investigate the expressions and clinical significances of paired box gene 2 (Pax2) and cyclin D1 protein in advanced ovarian serous carcinoma. Methods: From January 2003 to December 2013, the pathologic tissues of 202 patients with advanced ovarian serous cancer (Ⅲ-Ⅳ) who underwent initial cytoreductive surgery were collected. The expressions of Pax2 and cyclin D1 protein were detected by immunohistochemistry in tissue microarray. The relationships of their expressions with the clinicopathological features and prognosis of the patients were analyzed...
December 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/29245346/two-independent-incidences-of-skin-metastases-in-the-umbilicus-and-abdominal-wall-in-ovarian-serous-adenocarcinoma-a-case-report-and-review-of-the-literature
#15
Hongyan Cheng, Chunmei Gao, Runtong Zhang, Zhaojie Yang, Guiyu Zhang
RATIONALE: Advanced ovarian cancer is usually associated with intra-abdominal metastases and while it commonly spreads directly to the omentum, intestine, liver, or other organs, it can also metastasize through the lymphatic channels and the hematogenous pathway. With an increasing number of invasive operations being performed with chemoradiotherapy, the incidence of extra-abdominal metastases has risen. Nevertheless, ovarian cancer with skin metastases is quite rare. PATIENT CONCERNS: We report a case of ovarian cancer with two independent incidences of skin metastases in the umbilicus and abdominal wall...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29242018/current-practice-in-cytoreductive-surgery-and-hipec-for-metastatic-peritoneal-disease-spanish-multicentric-survey
#16
Rafael Morales-Soriano, Neus Esteve-Pérez, Juan José Segura-Sampedro, Pedro Cascales-Campos, Pedro Barrios
INTRODUCTION: Radical Cytoreductive Surgery (CRS) with Hyperthermic Intraperitoneal Chemotherapy (HIPEC), has been proposed as the current standard of treatment for metastatic peritoneal disease by several tumors. Despite its widely utilization, there seems to be a great variability in their organization, clinical practice, and safety among centers. AIM OF THE STUDY: To obtain updated information on clinical practice in different perioperative areas of the CRS-HIPEC...
December 6, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29240601/efficacy-of-transanal-drainage-tube-placement-after-modified-posterior-pelvic-exenteration-for-primary-ovarian-cancer
#17
Kazuyoshi Kato, Kohei Omatsu, Maki Matoda, Hidetaka Nomura, Sanshiro Okamoto, Hiroyuki Kanao, Kuniko Utsugi, Nobuhiro Takeshima
OBJECTIVE: The aim of this study was to investigate the clinical usefulness of the placement of a transanal drainage tube (TDT) to prevent anastomotic leakage after a modified posterior pelvic exenteration (MPPE) for the treatment of primary ovarian cancer. METHODS: We performed a retrospective review of all the consecutive patients who had undergone an MPPE for primary ovarian, tubal, or peritoneal cancer between October 2012 and November 2016 at our institution...
December 13, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29232471/cytoreductive-surgery-for-ovarian-cancer-quality-assessment
#18
A H Brand, P A DiSilvestro, J Sehouli, J S Berek
Surgery is the cornerstone of treatment of ovarian cancer. Given the importance of achieving no or minimal macroscopic residual disease at primary surgery, performing an assessment of the quality of ovarian cancer surgery is crucial. Assessing the quality of care and surgical outcome allows us to establish baseline information, set standards of care and clear priorities, enable benchmarking against peers, and sustain quality improvement. We know that suboptimal care exists and variation in outcomes results...
November 1, 2017: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29203996/metachronous-synchronous-sternal-and-colonic-metastasis-with-asymptomatic-colo-colic-fistula-from-carcinoma-ovary-rare-presentation-of-ovarian-cancer
#19
Srinivas K G, Abid Ali Mirza, Shivananda Swamy, Amarendra S, Gopinath Ks
Ovarian cancer is one of the most common gynecological cancers worldwide. It is the third leading cause of cancer among women in India. Metastatic disease to the visceral organs from ovarian cancer occurs as a terminal event in the natural history of the disease. In particular, spread to the bone and large bowel is infrequently described. The risk of distant metastasis increases in a recurrent setting. We describe a case of a 77-year-old lady, who was diagnosed for ovarian carcinoma in 2007 and underwent primary cytoreductive surgery, stage IIIc...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203987/ovarian-cancer-in-young-women
#20
Eileen Lalrinpuii, Pallipuram Seshadrinathan Bhageerathy, Ajit Sebastian, Lakshmanan Jeyaseelan, VinothaThomas, Anitha Thomas, Rachel Chandy, Abraham Peedicayil
It is not clear how often epithelial tumours affect young women. This study aimed to evaluate the clinico-pathological pattern and survival outcome of women, 40 years and younger, with cancer ovary. Women 40 years and younger, operated between 2008 and 2012 for ovarian cancer, were retrospectively recruited and followed up. The study design was descriptive as well as a survival analysis. A hybrid of retrospective and prospective cohort design was used for risk factor analysis. Of the 115 women less than 40 years being operated for probable ovarian cancer, 22 were excluded for various reasons...
December 2017: Indian Journal of Surgical Oncology
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