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ovarian cancer cytoreduction

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https://www.readbyqxmd.com/read/29781825/prognostic-value-of-serum-ca19-9-and-perioperative-ca-125-levels-in-ovarian-clear-cell-carcinoma
#1
Jun Zhu, Long Jiang, Hao Wen, Rui Bi, Xiaohua Wu, Xingzhu Ju
BACKGROUND: There are no effective biomarkers for surveillance in ovarian clear cell carcinoma (OCCC), and the value of carbohydrate antigen 125 (CA-125) is limited. We sought to determine the value of both carbohydrate antigen 19-9 (CA19-9) and CA-125 levels postoperatively on the prognosis for OCCC. METHODS: A total of 130 patients with OCCC who were consecutively treated by cytoreduction at Fudan University Shanghai Cancer Center were reviewed retrospectively...
May 18, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29770632/impact-of-increased-utilization-of-neoadjuvant-chemotherapy-on-survival-in-patients-with-advanced-ovarian-cancer-experience-from-a-comprehensive-cancer-center
#2
Yong Jae Lee, Young Shin Chung, Jung Yun Lee, Eun Ji Nam, Sang Wun Kim, Sunghoon Kim, Young Tae Kim
OBJECTIVE: The choice between primary debulking surgery (PDS) and neoadjuvant chemotherapy (NAC) in advanced ovarian cancer remains controversial. We evaluated NAC use in our center before and after results from a randomized trial were published, with the aim to determine the impact of changes in the neoadjuvant strategy on survival in advanced-stage ovarian cancer. METHODS: We retrospectively investigated the clinical course of 435 patients with ovarian, tubal, or peritoneal carcinoma (International Federation of Gynecology and Obstetrics [FIGO] stage III or IV)...
April 18, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29770618/peritoneal-cancer-index-as-a-predictor-of-survival-in-advanced-stage-serous-epithelial-ovarian-cancer-a-prospective-study
#3
Alaa A Elzarkaa, Waleed Shaalan, Doaa Elemam, Hassan Mansour, Mahmoud Melis, Eduard Malik, Amr A Soliman
OBJECTIVE: A numerical score, the peritoneal cancer index (PCI), was developed to reflect the extent of tumor growth in gastric and colorectal cancers and to tailor treatment. This study aimed to examine the value of the PCI score in advanced epithelial ovarian cancer (EOC) regarding completeness of surgical cytoreduction and survival. METHODS: This was a prospective observational cohort study. Patients with primary serous EOC at International Federation of Gynecology and Obstetrics (FIGO) stages IIIB or higher were included...
March 8, 2018: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/29767820/-role-of-visceral-surgery-in-oligometastases-of-non-gastrointestinal-tumors
#4
REVIEW
R Wahba, D Stippel, C Bruns
BACKGROUND: Patients with oligometastatic disease can benefit from local treatment of the metastases. Under these premises the resection of liver metastases and visceral metastases of non-gastrointestinal tumors is performed increasingly more frequently in selected patients. The aim of this study was to evaluate the role of visceral oncological surgery in hepatic oligometastatic disease of non-gastrointestinal tumors according to the currently available literature. MATERIAL AND METHODS: A systematic search of MEDLINE and PubMed was carried out focusing on the topics of oligometastases, liver resection and metastectomy for breast cancer, renal cell carcinoma, malignant melanoma, ovarian cancer and non-small cell lung cancer...
May 16, 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29761503/evaluation-of-the-peritoneal-surface-disease-severity-score-psdss-in-ovarian-cancer-patients-undergoing-cytoreductive-surgery-and-hipec-two-pathogenetic-types-based-study
#5
Roman Yarema, Taras Fetsych, Natalya Volodko, Myron Оhorchak, Orest Petronchak, Roman Huley, Yuriy Mylyan, Olivier Glehen
BACKGROUND AND OBJECTIVES: Clinical experience suggests that cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) play an important role in the management of ovarian cancer. In order to improve patient selection, the peritoneal surface disease severity score (PSDSS) was previously introduced for use in colorectal cancer patients. However, almost no data exist regarding the utility of the PSDSS index in ovarian cancer patients. METHODS: A retrospective study of the effectiveness of CRS and HIPEC was carried out in 59 patients with ovarian cancer...
May 14, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29759073/laparoscopic-splenectomy-for-solitary-splenic-metastasis-in-a-patient-with-ovarian-cancer-with-a-long-disease-free-interval-a-case-report
#6
Katsuhiko Yasuda, Tomoo Yoshimura, Hiroaki Kitade, Hidesuke Yanagida, Naoki Hosaka
BACKGROUND: In general, splenic metastasis of epithelial ovarian cancer is considered a terminal stage resulting in widespread metastasis. Solitary splenic metastasis of epithelial ovarian cancer is rare in patients with post-treatment ovarian cancer with long disease-free intervals. CASE PRESENTATION: We report a case of a 62-year-old Japanese woman who presented with elevated serum cancer antigen 125 due to a solitary splenic metastasis of ovarian cancer. She underwent primary open cytoreduction including resection of the right ovarian cancer and postoperative chemotherapy, followed by secondary open cytoreduction and additional postoperative chemotherapy...
May 15, 2018: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/29755762/cytoreductive-surgery-and-hyperthermic-intraperitoneal-chemotherapy-in-ovarian-and-gastrointestinal-peritoneal-carcinomatosis-results-from-a-7-year-experience
#7
Giulia Montori, Federico Coccolini, Paola Fugazzola, Marco Ceresoli, Matteo Tomasoni, Carolina Rubicondo, Stefano Raimondo, Domenico Pinelli, Michele Colledan, Luigi Frigerio, Luca Ansaloni
Background: An increasing promising evidence and increasing long-term oncologic outcomes support the use of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) as locoregional treatment for peritoneal carcinosis (PC) especially from ovarian and gastrointestinal tumors, but also for others cancers. Methods: A prospective monocentric study was performed in Papa Giovanni XXIII Hospital, Bergamo (Italy). Patients and tumor characteristics were analyzed...
April 2018: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29743148/when-should-surgery-be-used-for-recurrent-ovarian-carcinoma
#8
M Bommert, P Harter, F Heitz, A du Bois
Cytoreductive surgery is an important column in the treatment of primary ovarian cancer. Surgical outcome is one of the most important prognostic factors and one of the few prognostic variables that can be influenced by therapists. Retrospective studies suggested that only complete cytoreduction was associated with a benefit. Therefore, definition of predictors of complete resection is of the utmost importance to avoid surgical burden in patients with both limited benefit of the procedure and limited overall life expectancy...
May 7, 2018: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29737390/radiomics-of-high-grade-serous-ovarian-cancer-association-between-quantitative-ct-features-residual-tumour-and-disease-progression-within-12-months
#9
Stefania Rizzo, Francesca Botta, Sara Raimondi, Daniela Origgi, Valentina Buscarino, Anna Colarieti, Federica Tomao, Giovanni Aletti, Vanna Zanagnolo, Maria Del Grande, Nicoletta Colombo, Massimo Bellomi
OBJECTIVES: To determine if radiomic features, alone or combined with clinical data, are associated with residual tumour (RT) at surgery, and predict the risk of disease progression within 12 months (PD12) in ovarian cancer (OC) patients. METHODS: This retrospective study enrolled 101 patients according to the following inclusion parameters: cytoreductive surgery performed at our institution (9 May 2007-23 February 2016), assessment of BRCA mutational status, preoperative CT available...
May 8, 2018: European Radiology
https://www.readbyqxmd.com/read/29727055/prognostic-factors-for-maximally-or-optimally-cytoreduced-stage-iii-nonserous-epithelial-ovarian-carcinoma-treated-with-carboplatin-paclitaxel-chemotherapy
#10
Zeliha F Cuylan, Mehmet M Meydanli, Mustafa E Sari, Ozgur Akbayir, Husnu Celik, Murat Dede, Hanifi Sahin, Kemal Gungorduk, Esra Kuscu, Nejat Ozgul, Tayfun Gungor, Ali Ayhan
OBJECTIVE: To identify factors predictive of poor prognosis in women with stage III nonserous epithelial ovarian cancer (EOC) who had undergone maximal or optimal primary cytoreductive surgery (CRS) followed by six cycles of intravenous carboplatin/paclitaxel chemotherapy. METHODS: A multicenter, retrospective department database review was performed to identify patients with stage III nonserous EOC who had undergone maximal or optimal primary CRS followed by six cycles of carboplatin/paclitaxel chemotherapy at seven gynecological oncology centers in Turkey...
May 4, 2018: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29725737/genomic-scar-signatures-associated-with-homologous-recombination-deficiency-predict-adverse-clinical-outcomes-in-patients-with-ovarian-clear-cell-carcinoma
#11
Angel Chao, Chyong-Huey Lai, Tzu-Hao Wang, Shih-Ming Jung, Yun-Shien Lee, Wei-Yang Chang, Lan-Yang Yang, Fei-Chun Ku, Huei-Jean Huang, An-Shine Chao, Chin-Jung Wang, Ting-Chang Chang, Ren-Chin Wu
We investigated whether genomic scar signatures associated with homologous recombination deficiency (HRD), which include telomeric allelic imbalance (TAI), large-scale transition (LST), and loss of heterozygosity (LOH), can predict clinical outcomes in patients with ovarian clear cell carcinoma (OCCC). We enrolled patients with OCCC (n = 80) and high-grade serous carcinoma (HGSC; n = 92) subjected to primary cytoreductive surgery, most of whom received platinum-based adjuvant chemotherapy. Genomic scar signatures based on genome-wide copy number data were determined in all participants and investigated in relation to prognosis...
May 3, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29724422/acr-appropriateness-criteria-%C3%A2-staging-and-follow-up-of-ovarian-cancer
#12
Stella K Kang, Caroline Reinhold, Mostafa Atri, Carol B Benson, Priyadarshani R Bhosale, Anuja Jhingran, Yulia Lakhman, Katherine E Maturen, Refky Nicola, Pari V Pandharipande, Gloria M Salazar, Thomas D Shipp, Lynn Simpson, William Small, Betsy L Sussman, Jennifer W Uyeda, Darci J Wall, Bradford P Whitcomb, Carolyn M Zelop, Phyllis Glanc
In the management of epithelial ovarian cancers, imaging is used for cancer detection and staging, both before and after initial treatment. The decision of whether to pursue initial cytoreductive surgery for ovarian cancer depends in part on accurate staging. Contrast-enhanced CT of the abdomen and pelvis (and chest where indicated) is the current imaging modality of choice for the initial staging evaluation of ovarian cancer. Fluorine-18-2-fluoro-2-deoxy-d-glucose PET/CT and MRI may be appropriate for problem-solving purposes, particularly when lesions are present on CT but considered indeterminate...
May 2018: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29693406/cytoreductive-surgery-and-hyperthermic-intraoperative-chemotherapy-for-management-of-peritoneal-carcinomatosis
#13
Saman Nikeghbalian, Hamed Nikoupour, Masoud Dehghani, Mohammad Yasin Karami, Rahim Hemati
BACKGROUND: Treatment of peritoneal metastases has gained interest among oncologic communities around the world. Cytoreductive surgery (CRS) and hyperthermic intraoperative chemotherapy (HIPEC) have come to be the treatment of choice for selected patients with peritoneal carcinomatosis (PC) in recent years. Prior to HIPEC, patients were treated with palliative support and only guaranteed a few months to live. We reviewed our first 30 patients who underwent CRS and HIPEC. The aim of the study was assessment of the patients' survival, morbidity, and mortality rate and identifying prognostic factors of patients treated with CRS and HIPEC...
April 1, 2018: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29682189/cisplatin-liposome-and-6-amino-nicotinamide-combination-to-overcome-drug-resistance-in-ovarian-cancer-cells
#14
Daniela Catanzaro, Silvia Nicolosi, Veronica Cocetta, Marika Salvalaio, Andrea Pagetta, Eugenio Ragazzi, Monica Montopoli, Gianfranco Pasut
Ovarian cancer is an aggressive and lethal cancer usually treated by cytoreductive surgery followed by chemotherapy. Unfortunately, after an initial response, many patients relapse owing mainly to the development of resistance against the standard chemotherapy regime, carboplatin/paclitaxel, which is also affected by heavy side effects. In view to addressing such issues here, an association of liposomal cisplatin with 6-amino nicotinamide is investigated. It is known that resistant cells increase their demand for glucose, which is partially redirected toward the pentose phosphate pathway (PPP)...
March 30, 2018: Oncotarget
https://www.readbyqxmd.com/read/29674421/anti-misrii-radiolabeled-antibodies-new-tools-for-a-theranostic-approach-in-ovarian-cancer
#15
Emmanuel Deshayes, Riad Ladjohounlou, Pierre Le Fur, Alexandre Pichard, Catherine Lozza, Vincent Boudousq, Samuel Sevestre, Marta Jarlier, Roxana Kashani, Joanna Koch, Jane Sosabowski, Julie Foster, Nicolas Chouin, Frank Bruchertseifer, Alfred Morgenstern, Pierre-Olivier Kotzki, Isabelle Navarro-Teulon, Jean-Pierre Pouget
We have developed the 16F12 mouse monoclonal antibody (mAb) that targets the MISRII receptor expressed by ovarian tumors. Here, we assessed in preclinical models the possibility to use radiolabeled 16F12 in a theranostic approach for small-volume ovarian peritoneal carcinomatosis, for instance after cytoreductive surgery. Methods: DOTA-, DTPA- or DFO-conjugated 16F12 mAb was radiolabeled with beta (177 Lu) or alpha (213 Bi) particle emitters for therapeutic use, and with 89 Zr for positron emission tomography (PET) imaging...
April 19, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29664847/ovarian-cancer-surgery-in-australia-and-new-zealand-a-survey-to-determine-changes-in-surgical-practice-over-10-years
#16
Rhonda Farrell, Winston Spencer Liauw, Alison Hilary Brand
OBJECTIVE: This study aimed to survey all practicing certified gynecological oncologists (CGOs) in Australia and New Zealand to determine their current surgical practice for primary advanced epithelial ovarian cancer (EOC) and compare the findings with an identical survey conducted 10 years previously. METHODS/MATERIALS: A questionnaire was e-mailed to all 53 practicing CGOs in Australia and New Zealand in July 2017 assessing their definition of optimal debulking for EOC, their use of neoadjuvant chemotherapy, and the surgical procedures they use to achieve cytoreduction...
April 16, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29656069/-microscopic-peritoneal-metastases-of-epithelial-ovarian-cancers-clinical-relevance-diagnostic-and-therapeutic-tools
#17
Y Kerbage, G Canlorbe, J P Estevez, A Grabarz, S Mordon, C Uzan, P Collinet, H Azaïs
Understanding the biology and progression mechanisms of peritoneal metastases in ovarian epithelial cancers (EOC) is important because peritoneal carcinomatosis is present or will occur during surveillance of a majority of patients. Despite the clinical remission achieved after complete macroscopic cytoreductive surgery and platinum-based chemotherapy, 60% of patients will develop peritoneal recurrence. This suggests that microscopic lesions, which are not eradicated by surgery may be present and may participate in the mechanisms leading to peritoneal recurrence...
April 11, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29630008/ovarian-cancer-prevention-and-screening
#18
Usha Menon, Chloe Karpinskyj, Aleksandra Gentry-Maharaj
There has been much progress in ovarian cancer screening and prevention in recent years. Improved tools that combine genetic and epidemiologic factors to predict an individual's ovarian cancer risk are set to become available for tailoring preventive and screening approaches. The increasing evidence on tubal origins of a proportion of ovarian cancer has paved the way to use of opportunistic bilateral salpingectomy at tubal ligation and hysterectomy in the general population. Clinical trials are in progress to estimate the long-term effects on endocrine function...
May 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29627688/chemosensitizing-effects-of-metformin-on-cisplatin-and-paclitaxel-resistant-ovarian-cancer-cell-lines
#19
Isabella Dos Santos Guimarães, Taciane Ladislau-Magescky, Nayara Gusmão Tessarollo, Diandra Zipinotti Dos Santos, Etel Rodrigues Pereira Gimba, Cinthya Sternberg, Ian Victor Silva, Leticia Batista Azevedo Rangel
BACKGROUND: Epithelial ovarian cancer (EOC) remains the most lethal gynecologic malignancy. Primary cytoreductive surgery with adjuvant taxane-platinum chemotherapy is the standard treatment to fight ovarian cancer, however, their side effects are severe, and chemoresistance emerges at high rates. Therefore, EOC clinic urges for novel treatment strategies to reverse chemoresistance and to improve the survival rates. Metformin has been shown to act in synergy with certain anti-cancer agents, overcoming chemoresistance in various types of tumors...
November 21, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29625193/icaritin-induces-ovarian-cancer-cell-apoptosis-through-activation-of-p53-and-inhibition-of-akt-mtor-pathway
#20
Lvfen Gao, Ming Chen, Yuan Ouyang, Ruobin Li, Xian Zhang, Xuesong Gao, Xiaoyu Wang, Shaoqiang Lin
AIMS: Ovarian cancer (OC) has the highest mortality rate of all gynecological cancers. Currently, the first-line OC treatment consists of cytoreductive surgery and platinum-based chemotherapy. However, most patients develop chemoresistance after the first-line treatment limits the success of treatment. Therefore, there is an urgent need to identify effective therapeutic agents. MAIN METHODS: Cell viabilities were detected by MTS assay; Annexin V-FITC/PI assay and western blotting assay were performed to analyze the apoptotic cells in vitro; An immunofluorescence assay was performed to analyze the TUNEL+ apoptotic cells in vivo; Patient-derived xenografts were established to test the in vivo antitumor effects; The key proteins of p53, caspase-mediated apoptotic pathway and Akt/mTOR pathway were detected by Western blotting...
April 3, 2018: Life Sciences
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