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ovarian cancer cytoreduction

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https://www.readbyqxmd.com/read/28800940/neoadjuvant-chemotherapy-and-chemotherapy-cycle-number-a-national-multicentre-study
#1
Alon D Altman, Jacob McGee, Taymaa May, Kelly Lane, Lin Lu, Wei Xu, Prafull Ghatage, Barry Rosen
OBJECTIVES: Six cycles of consolidation chemotherapy have become the standard for ovarian cancer treatment regimen following primary cytoreduction, yet with neoadjuvant chemotherapy (NAC), only 3 consolidation cycles are used. This study examines the effects of number of chemotherapy cycles in women with ovarian cancer that are being treated with neoadjuvant chemotherapy. In addition, we examined the effect of number of cycles on survival on consolidation and total chemotherapy. METHODS: All patients with stage IIIC and IV high grade serous carcinoma (HGSC) were identified at 4 major Canadian cancer centers treated with NAC...
August 8, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28795373/implementation-of-extensive-cytoreduction-resulted-in-improved-survival-outcomes-for-patients-with-newly-diagnosed-advanced-stage-ovarian-tubal-and-peritoneal-cancers
#2
Francesco Raspagliesi, Giorgio Bogani, Antonino Ditto, Fabio Martinelli, Valentina Chiappa, Chiara Borghi, Cono Scaffa, Federica Morano, Giuseppa Maltese, Domenica Lorusso
BACKGROUND: Residual disease (RD) after primary debulking surgery (PDS) is one of the main factors driving ovarian cancer prognosis. The primary end point of this study was assessment of the impact that surgery had on survival outcomes for patients with advanced ovarian cancer. METHODS: Data on the effect of newly diagnosed advanced-stage ovarian, tubal, and peritoneal cancers were analyzed during two study periods (T1: 2001-2006 and T2: 2007-2012), in which the concepts of optimal and complete cytoreduction were introduced and implemented...
August 9, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28791266/prognostic-assessment-of-sarcomatous-histologic-subtypes-of-ovarian-carcinosarcoma
#3
Hyun Jin Kim, Hyun-Mi Lee, Mi Kyung Kim, Yoo-Kyung Lee, In-Ho Lee, Ki-Heon Lee, Hyesun Kim
OBJECTIVE: Ovarian carcinosarcoma is a rare subtype of this disease that has not been thoroughly investigated. The aim of this study was to evaluate the prognostic factors and out comes in patients with ovarian carcinosarcoma. METHODS: All patients with histologically confirmed ovarian carcinosarcoma who were treated at Cheil General Hospital and Women's Healthcare Center between January 2000 and December 2015 were identified and analyzed. Data were extracted from medical records, and statistical analyses were performed to determine correlations between clinicopathological parameters and survival outcomes...
July 2017: Obstetrics & Gynecology Science
https://www.readbyqxmd.com/read/28774462/cytoreduction-of-bulky-para-aortic-lymphadenopathy-from-metastatic-ovarian-cancer
#4
Chahien Choi, Woo Young Kim, Dong Hee Lee, Sam Sae Oh
No abstract text is available yet for this article.
July 31, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28774461/phase-ii-trial-of-bevacizumab-with-dose-dense-paclitaxel-as-first-line-treatment-in-patients-with-advanced-ovarian-cancer
#5
Nicole D Fleming, Robert L Coleman, Celestine Tung, Shannon N Westin, Wei Hu, Yunjie Sun, Priya Bhosale, Mark F Munsell, Anil K Sood
OBJECTIVES: To assess the tolerability and efficacy of bevacizumab with carboplatin and weekly paclitaxel as first-line adjuvant therapy for advanced stage ovarian cancer. METHODS: After IRB approval, this single-institution, phase II study enrolled patients with stage III or IV epithelial ovarian cancer after primary cytoreductive surgery to treatment with carboplatin (AUC 5), weekly paclitaxel (80mg/m2), and bevacizumab (15mg/kg) every 3weeks for at least 6cycles...
July 31, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28772202/the-role-of-surgical-excision-for-the-krukenberg-tumour-a-case-report
#6
David Lam, Eugene Ong
INTRODUCTION: Krukenberg tumour (KT), which represents carcinoma in the ovary, is an uncommon manifestation of metastatic colorectal cancer. It is associated with poor prognosis and a high incidence of peritoneal metastatic disease. PRESENTATION OF CASE: The authors present a case of a 51-year-old female who had a symptomatic, metachronous right ovarian KT diagnosed 12 months after her initial resection. Surgery was performed to excise the 23cm tumour as well as the contralateral ovary and isolated peritoneal disease, with an R0 resection achieved...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28768570/primary-cytoreductive-surgery-and-adjuvant-hormonal-monotherapy-in-women-with-advanced-low-grade-serous-ovarian-carcinoma-reducing-overtreatment-without-compromising-survival
#7
Amanda N Fader, Jennifer Bergstrom, Amelia Jernigan, Edward J Tanner, Kara Long Roche, Rebecca L Stone, Kimberly L Levinson, Stephanie Ricci, Stephanie Wethingon, Tian-Li Wang, Ie-Ming Shih, Bin Yang, Gloria Zhang, Deborah K Armstrong, Stephanie Gaillard, Chad Michener, Robert DeBernardo, Peter G Rose
OBJECTIVES: Women with advanced-stage, low-grade serous ovarian carcinoma (LGSC) have low chemotherapy response rates and poor overall survival. Most LGSC tumors overexpress hormone receptors, which represent a potential treatment target. Our study objective was to determine the outcomes of patients with advanced-stage LGSC treated with primary cytoreductive surgery (CRS) and hormone therapy (HT). METHODS: A retrospective study was performed at two academic cancer centers...
July 30, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28756613/phase-ii-study-of-paclitaxel-associated-with-lipid-core-nanoparticles-lde-as-third-line-treatment-of-patients-with-epithelial-ovarian-carcinoma
#8
Silvia R Graziani, Carolina G Vital, Aleksandra T Morikawa, Brigitte M Van Eyll, Hezio J Fernandes Junior, Roberto Kalil Filho, Raul C Maranhão
Ovarian cancer is often diagnosed at advanced stages, when poorly responsive to standard treatment. First-line treatment consists in schemes including cytoreductive surgery followed by adjuvant chemotherapy schemes with platinum and taxane derivatives. Second-line regimens are based on gemcitabine and liposomal doxorubicin. Third line is often not worthwhile because of the high toxicity with poor response to treatment. Previously, we showed that paclitaxel (PTX) carried in non-protein lipid core nanoparticles (LDE) resembling the chemical structure of LDL has remarkably reduced toxicity...
September 2017: Medical Oncology
https://www.readbyqxmd.com/read/28751119/utilization-of-intraperitoneal-chemotherapy-for-optimally-cytoreduced-advanced-stage-epithelial-ovarian-cancer-a-10-year-single-institution-experience-with-a-racially-diverse-urban-population
#9
Eirwen M Miller, Joan Tymon-Rosario, Xianhong Xie, Xiaonan Xue, Gregory M Gressel, Devin T Miller, Dennis Ys Kuo, Nicole S Nevadunsky
OBJECTIVES: The goal of our study was to define utilization and clinical results of intraperitoneal (IV/IP) compared to intravenous (IV) chemotherapy in a racially and ethnically diverse population with optimally debulked advanced stage epithelial ovarian cancer. METHODS: After IRB approval, all patients diagnosed with epithelial ovarian cancer that underwent primary cytoreductive surgery at our institution from 2005 to 2016 were identified. Death was verified by the National Social Security Death Index...
July 24, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28746186/laparoscopic-based-score-assessment-combined-with-a-multiple-disciplinary-team-in-management-of-recurrent-ovarian-cancer-a-single-center-prospective-study-for-personalized-surgical-therapy
#10
Weihong Yang, Zhongping Cheng, Hong Dai, Changchun Long, Hailun Liu
The aim of the study was to evaluate the effect of laparoscopic-based score combined with a multiple disciplinary team (MDT) for predicting optimal cytoreduction and perform personalized surgical treatment in recurrent ovarian cancer (ROC).The study is a single-center, prospective investigation. From March 2013 to May 2015, the consecutive treated patients with platinum-sensitive ROC were collected in Yangpu Hospital. The appropriated patients were enrolled into the study to perform the laparoscopic-based PIV (predictive index value) score assessment with an MDT for predicting optimal cytoreduction...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28741395/predictive-value-of-the-age-adjusted-charlston-co-morbidity-index-on-peri-operative-complications-adjuvant-chemotherapy-usage-and-survival-in-patients-undergoing-debulking-surgery-after-neo-adjuvant-chemotherapy-for-advanced-epithelial-ovarian-cancer
#11
Andrew Phillips, Kavita Singh, Rachel Pounds, Sudha Sundar, Sean Kehoe, James Nevin, Ahmed Elattar, Janos Balega
The aim of this study was to determine whether the age-adjusted Charlston co-morbidity index (ACCI) can predict post-operative complications, adjuvant chemotherapy usage and overall survival (OS) in patients with advanced epithelial ovarian cancer (AOC) treated with neoadjuvant chemotherapy (NACT). A review was performed of all cytoreductive surgeries performed between 16/8/07-3/2/14 for AOC at a UK Cancer Centre. All surgeries were stratified by ACCI into three groups: Low (0-1), Intermediate (2-3) and High (≥4)...
July 25, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28740958/the-outcomes-of-intestinal-resection-during-debulking-surgery-for-ovarian-cancer
#12
Serdar Gökay Terzioğlu, Murat Özgür Kılıç, Nilüfer Çetinkaya, Eralp Baser, Tayfun Güngör, Cevdet Adıgüzel
OBJECTIVE: To evaluate the clinical and surgical outcomes of intestinal resection during primary debulking surgery for ovarian cancer. MATERIAL AND METHODS: This retrospective study was conducted at Zekai Tahir Burak Women's Health Training and Research Hospital between 2009 and 2013. The patients who underwent intestinal resection during debulking surgery for stage 3 ovarian cancer were included in the analysis. Data regarding patient age, body mass index, tumor histology, disease stage, the site of intestinal resection, all postoperative complications, duration of intensive care unit admission and hospital stay were collected and analyzed...
2017: Turk J Surg
https://www.readbyqxmd.com/read/28730323/the-pathogenesis-diagnosis-and-management-of-metastatic-tumors-to-the-ovary-a-comprehensive-review
#13
REVIEW
Ondřej Kubeček, Jan Laco, Jiří Špaček, Jiří Petera, Jindřich Kopecký, Alena Kubečková, Stanislav Filip
Secondary tumors of the ovary account for 10-25% of all ovarian malignancies. The most common tumors that give rise to ovarian metastases include breast, colorectal, endometrial, stomach, and appendix cancer. The correct diagnosis of secondary ovarian tumors may be challenging as they are not infrequently misdiagnosed as primary ovarian cancer, particularly in the case of mucinous adenocarcinomas. The distinction from the latter is essential, as it requires different treatment. Immunohistochemistry plays an important role in distinguishing primary ovarian tumors from extra-ovarian metastases and, furthermore, may suggest the primary tumor site...
July 20, 2017: Clinical & Experimental Metastasis
https://www.readbyqxmd.com/read/28727692/short-term-outcomes-following-cytoreductive-surgery-and-heated-intra-peritoneal-chemotherapy-at-waikato
#14
Ngov Jasen Ly, Linus Wu, Ralph Van Dalen, Simione Lolohea
AIM: Pseudomyxoma peritonei is a rare disease that affects 1-2 per million population per year. Treatment with cytoreductive surgery with heated intraperitoneal chemotherapy (CRS with IPC) has been well described. The purpose of this study was to look at the short-term outcomes following CRS with IPC for all such patients treated in Waikato. METHOD: Records for all patients presenting to surgery for CRS with IPC were retrospectively reviewed. CRS with IPC was performed in accordance with the techniques described by Sugarbaker...
July 21, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28720378/a-novel-technique-carbon-dioxide-gas-assisted-total-peritonectomy-diaphragm-and-intestinal-meso-stripping-in-open-surgery-for-advanced-ovarian-cancer-%C3%A3-ukurova-technique
#15
Ghanim Khatib, Ahmet Baris Guzel, Umran Kucukgoz Gulec, Mehmet Ali Vardar
OBJECTIVE: Most of the ovarian cancers are diagnosed at advanced stages. As peritoneal carcinomatosis increases, especially when it extends to the diaphragm and intestinal mesos, probability of obtaining complete cytoreduction is reduced. Complete cytoreduction (residue zero: R0) is one of the main factors affecting survival [1-3]. Here we present a novel technique of stripping the peritoneal surfaces as a part of cytoreductive surgery in such cases. METHODS: A 55year-old woman diagnosed with peritoneal carcinomatosis was considered appropriate for primary cytoreduction after assessment of her thorax-abdominopelvic tomography, which revealed resectable intra-abdominal disease...
July 15, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28718942/the-shift-toward-neo-adjuvant-chemotherapy-and-interval-debulking-surgery-for-management-of-advanced-ovarian-and-related-cancers-in-a-population-based-setting-impact-on-clinical-outcomes
#16
James L Nicklin, Shaun McGrath, Lee Tripcony, Andrea Garrett, Russell Land, Amy Tang, Lewis Perrin, Naven Chetty, Nisha Jagasia, Alex J Crandon, Marcelo Nascimento, Graeme Walker, Karen Sanday, Andreas Obermair
OBJECTIVES: The aim of this study was to determine the proportion of patients with advanced ovarian and related cancers (EOC+RC), treated with neoadjuvant chemotherapy and interval debulking surgery (NACT - IDS), and to determine if there was any relationship with optimal cytoreduction rates and overall survival (OS) in a state-wide gynaecologic oncology service over time. METHODS: A retrospective review was undertaken using a population-based database of patients with stages 3 and 4 EOC+RC treated from 1982 till 2013 at the Queensland Centre for Gynaecological Cancer (QCGC)...
July 18, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28718034/hepatoceliac-lymph-node-involvement-in-advanced-ovarian-cancer-patients-prognostic-role-and-clinical-considerations
#17
Valerio Gallotta, Gabriella Ferrandina, Giuseppe Vizzielli, Carmine Conte, Alessandro Lucidi, Barbara Costantini, Agostino Maria De Rose, Andrea Di Giorgio, Gian Franco Zannoni, Anna Fagotti, Giovanni Scambia, Vito Chiantera
BACKGROUND: The study aimed too investigate the rate of hepatoceliac lymph node (HCLN) involvement, as well as its association with clinicopathologic features, together with morbidity of HCLN resection and the prognostic impact of metastatic HCLN status on patients with advanced ovarian cancer (OC) undergoing cytoreductive surgery. METHODS: All consecutive patients with stages 3c to 4 epithelial OC who underwent HCLN surgery from January 2010 to September 2016 were analyzed for surgical procedures, pathology, and oncologic outcomes...
July 17, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28716306/tertiary-cytoreductive-surgery-in-recurrent-epithelial-ovarian-cancer-a-multicentre-mito-retrospective-study
#18
F Falcone, G Scambia, P Benedetti Panici, M Signorelli, G Cormio, G Giorda, S Bogliolo, M Marinaccio, F Ghezzi, E Rabaiotti, E Breda, G Casella, F Fanfani, V Di Donato, U Leone Roberti Maggiore, S Greggi
OBJECTIVES: To evaluate the impact of tertiary cytoreductive surgery (TCS) on survival in recurrent epithelial ovarian cancer (EOC), and to determine predictors of complete cytoreduction. METHODS: A multi-institutional retrospective study was conducted within the MITO Group on a 5-year observation period. RESULTS: A total of 103 EOC patients with a ≥6month treatment-free interval (TFI) undergoing TCS were included. Complete cytoreduction was achieved in 71 patients (68...
July 14, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28698755/primary-fallopian-tube-carcinoma-a-case-report-and-literature-review
#19
Meral Rexhepi, Elizabeta Trajkovska, Hysni Ismaili, Florin Besimi, Nagip Rufati
BACKGROUND: Primary fallopian tube carcinoma (PFTC) is a rare tumour of the female genital tract with an incidence of 0.1-1.8% of all genital malignancies, and it is very difficult to diagnose preoperatively, because of its non-specific symptomatology. In most cases, it is an intraoperative finding or a histopathological diagnosis. It is a tumour that histologically and clinically resembles epithelial ovarian cancer. CASE PRESENTATION: We are reporting a case of a 62-year-old, postmenopausal women with primary fallopian tube carcinoma of the right fallopian tube in stage IA...
June 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28697111/ninety-day-mortality-as-a-reporting-parameter-for-high-grade-serous-ovarian-cancer-cytoreduction-surgery
#20
Ryan J Spencer, Kari E Hacker, Jennifer J Griggs, Laurel W Rice, R Kevin Reynolds, Shitanshu Uppal
OBJECTIVE: To evaluate the utility of using 90-day as an adjunct to 30-day mortality rates after surgical cytoreduction for serous ovarian cancer and to compare them across hospitals of differing case volumes over time. METHODS: We performed a retrospective cohort study using the National Cancer Database of women undergoing cytoreductive surgery for high-grade serous carcinoma between 2004 and 2012. The primary outcome of the study was mortality rate by hospital volume...
August 2017: Obstetrics and Gynecology
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