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https://www.readbyqxmd.com/read/28089429/diagnosis-and-quantification-of-fibrosis-steatosis-and-hepatic-siderosis-through-multiparametric-magnetic-resonance-imaging
#1
M Stoopen-Rometti, E R Encinas-Escobar, C R Ramirez-Carmona, E Wolpert-Barraza, E Kimura-Hayama, L A Sosa-Lozano, R Favila, Y Kimura-Fujikami, J A Saavedra-Abril, A Loaeza-Del Castillo
BACKGROUND: The presence of liver fibrosis is the common denominator in numerous chronic liver diseases that can progress to fibrosis and hepatocellular carcinoma. Most important, with respect to frequency, are viral hepatitis and non-alcoholic fatty liver disease, the prevalence of which is increasing in epidemic proportions. Liver biopsy, albeit imperfect, continues to be the criterion standard, but in many clinical situations tends to be replaced with noninvasive imaging methods. OBJECTIVES: The aim of the present article was to describe our imaging department experience with magnetic resonance elastography and to analyze and discuss recently published results in gastroenterology, hepatology, and radiology from other authors in the literature, complemented with a PubMed search covering the last 10 years...
January 12, 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28070199/performance-and-utility-of-transient-elastography-and-non-invasive-markers-of-liver-fiibrosis-in-patients-with-autoimmune-hepatitis-a-single-centre-experience
#2
Olympia E Anastasiou, Matthias Büchter, Hideo A Baba, Johannes Korth, Ali Canbay, Guido Gerken, Alisan Kahraman
OBJECTIVES: Autoimmune hepatitis (AIH) is a relatively rare cause of hepatic dysfunction, which can lead to acute liver failure (ALV) and cirrhosis if not treated. The performance of transient elastography (TE) compared to liver biopsy has been evaluated in many liver diseases. The aim of the present study was to evaluate the performance of TE and other non-invasive markers for liver fiibrosis in patients with biopsy-proven AIH. METHODS: Fifty-three patients who were treated at the department of gastroenterology and hepatology of the University Clinic Essen from 2008 to 2013 included in this retrospective study...
November 2016: Hepatitis Monthly
https://www.readbyqxmd.com/read/28061338/american-gastroenterology-association-institute-technical-review-on-initial-testing-and-management-of-acute-liver-disease
#3
Steven K Herrine, Paul Moayyedi, Robert S Brown, Yngve T Falck-Ytter
No abstract text is available yet for this article.
January 3, 2017: Gastroenterology
https://www.readbyqxmd.com/read/28056348/american-gastroenterological-association-institute-guidelines-for-the-diagnosis-and-management-of-acute-liver-failure
#4
Steven L Flamm, Yu-Xiao Yang, Siddharth Singh, Yngve T Falck-Ytter
No abstract text is available yet for this article.
January 2, 2017: Gastroenterology
https://www.readbyqxmd.com/read/27975109/cholestasis-in-infancy
#5
Melissa G Andrianov, Ruba K Azzam
Jaundice is a key manifestation of hepatobiliary disease in all age groups. Jaundice is a common finding in the first 2 weeks after birth, occurring in 2.4% to 15% of newborns. The neonatal liver is at increased susceptibility to cholestasis, with an incidence ranging from 1 in 2,500 to 1 in 5,000 live births. Etiologies vary, but the most common is biliary atresia. In 2004, the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition published guidelines for the evaluation of cholestasis that clearly stated any infant with jaundice persisting beyond age 2 weeks (3 weeks in breast-fed infants with an otherwise normal history and physical examination) should be evaluated with a fractionated serum bilirubin level...
December 1, 2016: Pediatric Annals
https://www.readbyqxmd.com/read/27957247/bibliometric-analysis-of-top-100-cited-articles-in-nonalcoholic-fatty-liver-disease-research
#6
Tong-Shuo Zhang, Hua-Lei Qin, Tong Wang, Hai-Tao Li, Hai Li, Shi-Hai Xia, Xiao-Hui Xiang
AIM: To identify and assess the research situation of top 100 cited articles in nonalcoholic fatty liver disease (NAFLD). METHODS: The global scientific research articles in the Science Citation Index-Expanded relevant to NAFLD were retrieved and listed according to their citation times from the most to the least. The 100 most frequently cited original articles were selected to systematically evaluate their bibliometric parameters including times cited, publication year, journals, subject categories, and the highly related concepts of NAFLD, which reflected the history and current situation, publication distribution of leading countries and institutes as well as the research hotspots of NAFLD...
November 28, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27936481/patients-with-ultrasound-diagnosis-of-hepatic-steatosis-are-at-high-metabolic-risk
#7
J Kälsch, H Keskin, A Schütte, T Baars, H A Baba, L P Bechmann, A Canbay, J P Sowa
Background and aims: Hepatic steatosis is the basis of non-alcoholic fatty liver disease (NALFD). Mere fat accumulation within hepatocytes is considered the mild form of NAFLD, but can progress in some patients to advanced steatohepatitis (NASH), which may lead to fibrosis, cirrhosis or hepatocellular carcinoma. However, even hepatic steatosis alone may be a risk factor for cardiovascular disease (CVD). Patients and methods: In the present real life study 106 patients from the outpatient clinic of the Department for Gastroenterology and Hepatology with either NAFLD (n = 60) or other typical diagnoses (n = 46) were included...
December 2016: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27934616/pregnancy-and-cirrhosis-four-cases-at-the-lome-campus-university-teaching-hospital-togo
#8
A Bagny, D A E Akolly, L M Lawson-Ananisoh, O Bouglouga, B Douaguibe, R El Hadji Yacoubou, S Koffi, K Lawson Evi, K M Guedenon, Y D Atakouma, K Akpadza, D Redah
To evaluate the hepatic and obstetric complications in pregnant women with cirrhosis. We report the cases of four pregnant women with cirrhosis treated in the gastroenterology and obstetrics-gynecology departments of the Lome Campus University Teaching Hospital between 2013 and 2015. The women's mean age was 32 years. Three were in the first trimester of pregnancy. Almost all had signs of advanced cirrhosis, including ascites (50%), lower-limb edema (75%), and jaundice (25%). All (100%) had liver failure and anemia...
December 8, 2016: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/27924103/editorial-advancing-adoption-of-frailty-to-improve-the-care-of-patients-with-cirrhosis-time-for-a-consensus-on-a-frailty-index
#9
Jennifer C Lai
Frailty is a key determinant of outcomes in patients with cirrhosis. Two papers in this issue of the American Journal of Gastroenterology advance our understanding of the mechanism by which frailty impacts mortality-by increasing the risk of hospitalization for liver-related complications. We now have overwhelming justification to incorporate frailty into clinical practice, but this should be done in a systematic way to foster multi-center collaboration to accelerate research in this field. It is time for consensus on single frailty index to unify decision-making surrounding frailty and equalize outcomes for all cirrhotics across all centers...
December 2016: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/27895432/prevalence-of-depression-and-anxiety-in-patients-with-chronic-digestive-system-diseases-a-multicenter-epidemiological-study
#10
An-Zhong Zhang, Qing-Cai Wang, Kun-Ming Huang, Jia-Guo Huang, Chang-Hong Zhou, Fu-Qiang Sun, Su-Wen Wang, Feng-Ting Wu
AIM: To investigate the prevalence of depression and anxiety in patients with chronic digestive system diseases. METHODS: A total of 1736 patients with chronic digestive system diseases were included in this cross-sectional study, including 871 outpatients and 865 in-patients. A self-designed General Information for Patients of the Department of Gastroenterology of General Hospitals questionnaire was used to collect each patient's general information, which included demographic data (including age, sex, marital status, and education) and disease characteristics (including major diseases, disease duration, principal symptoms, chronic pain, sleep disorder, and limited daily activities)...
November 14, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/27870642/hepatocellular-carcinoma-surveillance-among-patients-with-cirrhosis-in-a-population-based-integrated-health-care-delivery-system
#11
Amit G Singal, Jasmin Tiro, Xilong Li, Beverley Adams-Huet, Jessica Chubak
PURPOSE: Fewer than 1 in 5 patients with cirrhosis receive hepatocellular carcinoma (HCC) surveillance; however, most studies were performed in select patient populations, which may not be informative of practice patterns in population-based community practices. Further, few reported guideline-concordant consistent surveillance rates. GOALS: Characterize guideline-concordant HCC surveillance rates and patient-level factors associated with surveillance among a population-based cohort of patients with cirrhosis...
November 18, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27843536/frontal-assessment-battery-a-tool-for-screening-minimal-hepatic-encephalopathy
#12
Karina Zamprogno de Souza, Maria Penha Zago-Gomes
AIM: To apply the Frontal Assessment Battery to cirrhotic patients with or without overt hepatic encephalopathy (OHE) and controls. METHODS: The frontal assessment battery (FAB) was applied to 87 patients with liver cirrhosis (16 with and 71 without OHE) and 40 control subjects without cirrhosis treated at the alcohol and liver outpatient clinics and the gastroenterology ward of the Cassiano Antônio de Moraes University Hospital (Hospital Universitário Cassiano Antônio de Moraes - HUCAM), Espírito Santo, Brazil...
October 28, 2016: World Journal of Hepatology
https://www.readbyqxmd.com/read/27821080/a-prominent-role-of-hepatitis-d-virus-in-liver-cancers-documented-in-central-africa
#13
Marie Atsama Amougou, Dominique Noah Noah, Paul Fewou Moundipa, Pascal Pineau, Richard Njouom
BACKGROUND: Hepatocellular Carcinoma (HCC) is one of the commonest cancers in Central Africa, a region with the unusual peculiarity to be hyperendemic for infections with Hepatitis B, C and D viruses. However, data estimating the respective proportions of HCC cases attributable to these viruses are still limited in this area. The current study was undertaken to determine the role of these viruses in HCC compared to non-HCC Cameroonian patients. METHODS: A case-control study was conducted in the Gastroenterology Unit of Central Hospital of Yaounde in collaboration with Centre Pasteur of Cameroon...
November 7, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27782896/variceal-bleeding-in-cirrhotic-patients-what-is-the-best-prognostic-score
#14
Asmaa N Mohammad, Khairy H Morsy, Moustafa A Ali
BACKGROUND/AIMS: To find the most accurate, suitable, and applicable scoring system for the prediction of outcome in cirrhotic patients with bleeding varices. MATERIALS AND METHODS: A prospective study was conducted comprising 120 cirrhotic patients with acute variceal bleeding who were admitted to Tropical Medicine and Gastroenterology Department in Sohag University Hospital, over a 1-year period (1/2015 to 1/2016). The clinical, laboratory, and endoscopic parameters were studied...
September 2016: Turkish Journal of Gastroenterology: the Official Journal of Turkish Society of Gastroenterology
https://www.readbyqxmd.com/read/27776171/analysis-of-research-activity-in-gastroenterology-pancreatitis-is-in-real-danger
#15
Andrea Szentesi, Emese Tóth, Emese Bálint, Júlia Fanczal, Tamara Madácsy, Dorottya Laczkó, Imre Ignáth, Anita Balázs, Petra Pallagi, József Maléth, Zoltán Rakonczay, Balázs Kui, Dóra Illés, Katalin Márta, Ágnes Blaskó, Alexandra Demcsák, Andrea Párniczky, Gabriella Pár, Szilárd Gódi, Dóra Mosztbacher, Ákos Szücs, Adrienn Halász, Ferenc Izbéki, Nelli Farkas, Péter Hegyi
OBJECTIVE: Biomedical investment trends in 2015 show a huge decrease of investment in gastroenterology. Since academic research usually provides the basis for industrial research and development (R&D), our aim was to understand research trends in the field of gastroenterology over the last 50 years and identify the most endangered areas. METHODS: We searched for PubMed hits for gastrointestinal (GI) diseases for the 1965-2015 period. Overall, 1,554,325 articles were analyzed...
2016: PloS One
https://www.readbyqxmd.com/read/27775958/predicting-efficacy-of-plastic-stents-for-posttransplantation-biliary-strictures
#16
Erwin Santo, Anna Itshak, Liat Mlynarsky, Moshe Leshno, Nathan Gluck
BACKGROUND: Biliary strictures (BS) are a common complication of liver transplantation. The standard treatment is sequential insertion of increasing numbers of plastic stents by endoscopic retrograde cholangiopancreatography (ERCP). Despite high success rates, some strictures fail to resolve and require surgery as definitive treatment. GOALS: To identify predictors of response or failure of standard endoscopic treatment, allowing earlier referral to alternative modalities when needed and avoiding unnecessary procedures...
October 21, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27773806/using-big-data-to-discover-diagnostics-and-therapeutics-for%C3%A2-gastrointestinal-and-liver-diseases
#17
REVIEW
Benjamin Wooden, Nicolas Goossens, Yujin Hoshida, Scott L Friedman
Technologies such as genome sequencing, gene expression profiling, proteomic and metabolomic analyses, electronic medical records, and patient-reported health information have produced large amounts of data from various populations, cell types, and disorders (big data). However, these data must be integrated and analyzed if they are to produce models or concepts about physiological function or mechanisms of pathogenesis. Many of these data are available to the public, allowing researchers anywhere to search for markers of specific biological processes or therapeutic targets for specific diseases or patient types...
January 2017: Gastroenterology
https://www.readbyqxmd.com/read/27725462/recognition-of-infection-status-of-outpatient-treatment-and-treatment-history-before-carcinogenesis-in-patients-with-viral-hepatitis-associated-liver-cancer
#18
Michihiko Shibata, Sota Minami, Shinji Oe, Koichiro Miyagawa, Yuichi Honma, Ryo Onitsuka, Michio Senju, Masaaki Hiura, Riko Harada, Shintaro Abe, Akinari Tabaru, Masaru Harada
We conducted a survey on the recognition of infection, status of outpatient treatment, and treatment history in hepatitis virus-associated hepatocellular carcinoma patients admitted to our department between 2005 and 2014. We compared these parameters in 75 patients with primary hepatitis B virus-associated hepatocellular carcinoma (HBV-HCC) and 307 patients with hepatitis C virus-associated hepatocellular carcinoma (HCV-HCC). Based on the presence or absence of outpatient treatment in medical institutions at the time of HCC diagnosis, the patients were divided into an outpatient treatment-free group or an outpatient treated group...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27721739/the-diagnosis-and-manifestations-of-liver-injury-secondary-to-off-label-androgenic-anabolic-steroid-use
#19
Elena Cabb, Shanna Baltar, David Wes Powers, Karthik Mohan, Antonio Martinez, Eric Pitts
Drug-induced liver injury (DILI) presents as a broad spectrum of adverse drug reactions which can range from a mild elevation in liver enzymes to fulminant liver failure. The primary goal is to identify DILI early when the patient's liver enzymes are elevated and to discontinue the offending agent as soon as possible to prevent further injury. Herbal, dietary supplements and anabolic steroids represent a significant component of the drugs thought to cause DILI in the United States. Unlike all other drugs known to cause DILI, these drugs fall into a category of injury that is neither intrinsic nor idiosyncratic due to overlapping characteristics between the two...
May 2016: Case Reports in Gastroenterology
https://www.readbyqxmd.com/read/27688665/clinical-guidelines-of-non-alcoholic-fatty-liver-disease-a-systematic-review
#20
Jin-Zhou Zhu, Kelseanna Hollis-Hansen, Xing-Yong Wan, Su-Juan Fei, Xun-Lei Pang, Fan-Dong Meng, Chao-Hui Yu, You-Ming Li
AIM: To perform a systematic review to grade guidelines and present recommendations for clinical management of non-alcoholic fatty liver disease (NAFLD). METHODS: A database search was conducted on PubMed for guidelines published before May 2016, supplemented by reviewing relevant websites. The Appraisal of Guidelines for Research and Evaluation (ARGEE) Instrument II was a tool designed to appraise the methodological rigor and transparency in which a clinical guideline is developed and it is used internationally...
September 28, 2016: World Journal of Gastroenterology: WJG
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