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https://www.readbyqxmd.com/read/29216449/apoe4-accelerates-early-seeding-of-amyloid-pathology
#1
Chia-Chen Liu, Na Zhao, Yuan Fu, Na Wang, Cynthia Linares, Chih-Wei Tsai, Guojun Bu
Accumulation and aggregation of amyloid-β (Aβ) in the brain is an initiating step in the pathogenesis of Alzheimer's disease (AD). The ε4 allele of apolipoprotein E (apoE) gene is the strongest genetic risk factor for late-onset AD. Although there is strong evidence showing that apoE4 enhances amyloid pathology, it is not clear what the critical stage(s) is during amyloid development in which apoE4 has the strongest impact. Using apoE inducible mouse models, we show that increased expression of astrocytic apoE4, but not apoE3, during the seeding stage of amyloid development enhanced amyloid deposition and neuritic dystrophy in amyloid model mice...
December 6, 2017: Neuron
https://www.readbyqxmd.com/read/29188413/bioaccessibility-of-phenolic-compounds-and-antioxidant-capacity-of-chia-salvia-hispanica-l-seeds
#2
Marika Pellegrini, Raquel Lucas-Gonzalez, Estrella Sayas-Barberá, Juana Fernández-López, José A Pérez-Álvarez, Manuel Viuda-Martos
The aim of this work was to evaluate (i) the phenol and flavonoid recovery and bioaccessibility indexes and (ii) the antioxidant activity of both types of non-defatted and defatted chia seeds during the in vitro gastrointestinal digestion. The ground samples were subjected to in vitro simulated gastrointestinal digestion, and the resultant fractions were extracted and subjected to spectrophotometric assays. The results pointed to increasing concentrations of polyphenolic compounds during digestion, although only a low-medium percentage of phenols and a low percentage of flavonoids were available for absorption in the intestinal tract...
November 29, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/29174030/position-paper-on-vegetarian-diets-from-the-working-group-of-the-italian-society-of-human-nutrition
#3
C Agnoli, L Baroni, I Bertini, S Ciappellano, A Fabbri, M Papa, N Pellegrini, R Sbarbati, M L Scarino, V Siani, S Sieri
BACKGROUND: Interest in vegetarian diets is growing in Italy and elsewhere, as government agencies and health/nutrition organizations are emphasizing that regular consumption of plant foods may provide health benefits and help prevent certain diseases. METHODS AND RESULTS: We conducted a Pubmed search, up to September, 2015, for studies on key nutrients (proteins, vitamin B12, iron, zinc, calcium, vitamin D, and n-3 fatty acids) in vegetarian diets. From 295 eligible publications the following emerged: Vegetarians should be encouraged to supplement their diets with a reliable source of vitamin B12 (vitamin-fortified foods or supplements)...
October 31, 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29172966/antiquorum-sensing-activity-of-seed-oils-from-oleaginous-plants-and-protective-effect-during-challenge-with-chromobacterium-violaceum
#4
Macrina Pérez-López, Rodolfo García-Contreras, Marcos Soto-Hernández, José Salud Rodríguez-Zavala, Mariano Martínez-Vázquez, Francisco Javier Prado-Galbarro, Israel Castillo-Juárez
Seed oils from oleaginous plants are rich in fatty acids (FAs) that play important roles in the health of the consumers. Recent studies indicate that FA also can play an important role in communication and regulation of virulence in bacteria. Nevertheless, evidence demonstrating protection against bacterial infections mediated by their quorum sensing inhibition (QSI) activity is scarce. In this study, sunflower, chia, and amaranth oils, were assayed for their QSI capacity by inhibiting violacein production and alkaline exoprotease activity of Chromobacterium violaceum...
November 27, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29165817/development-of-mayonnaise-with-substitution-of-oil-or-egg-yolk-by-the-addition-of-chia-salvia-hisp%C3%A3-nica-l-mucilage
#5
Sibele Santos Fernandes, Myriam de Las Mercedes Salas Mellado
Chia mucilage is formed by the hydration of chia seeds and presents characteristics that potentiate its application as substitute of fat in several foods. In this study, mayonnaises were prepared with different levels of freeze-dried chia mucilage instead of oil or egg yolk. The substitution of oil in mayonnaise promoted increased stability and texture parameters, and the mayonnaise substituted by egg yolk presented similar stability and texture parameters as the control mayonnaise. The substitution of oil in mayonnaise was about 50% with 45% oil substitution, whereas for the mayonnaise with 35% of egg yolk replacement it was about 0...
November 22, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29143185/osteogenic-prospective-of-deriving-human-dental-stem-cells-in-collagen-matrix-boost
#6
Tong-Jing Fang, Ding-Han Wang, Chia-Yu Wang, Raju Poongodi, Nien-Hsien Liou, Jiang-Chuan Liu, Ming-Lun Hsu, Po-Da Hong, Shih-Fang Yang, Meng-Lun Liu
Stem cells derived from oral tissue represent a highly attractive alternative source for clinical bone regeneration because they can be collected by non-invasive or minimally invasive procedures. Herein, we describe the human dental stem cells (DSCs) deriving from buccal fat pads (BFP), dental pulp (DP) of impacted teeth, and periodontal ligaments (PDL) to obtain BFPSCs, DPSCs, and PDLSCs, respectively. Cells were purified with selected medium and expanded through passages in stem cell culture medium. Purified cells were characterized for stemness by their growth rate, immunostaining, and multilineage differentiation ability...
November 15, 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/29122781/simulation-based-inter-professional-education-to-improve-attitudes-towards-collaborative-practice-a-prospective-comparative-pilot-study-in-a-chinese-medical-centre
#7
Ling-Yu Yang, Ying-Ying Yang, Chia-Chang Huang, Jen-Feng Liang, Fa-Yauh Lee, Hao-Min Cheng, Chin-Chou Huang, Shou-Yen Kao
OBJECTIVES: Inter-professional education (IPE) builds inter-professional collaboration (IPC) attitude/skills of health professionals. This interventional IPE programme evaluates whether benchmarking sharing can successfully cultivate seed instructors responsible for improving their team members' IPC attitudes. DESIGN: Prospective, pre-post comparative cross-sectional pilot study. SETTING/PARTICIPANTS: Thirty four physicians, 30 nurses and 24 pharmacists, who volunteered to be trained as seed instructors participated in 3...
November 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/29114014/arabidopsis-pollen-fertility-requires-the-transcription-factors-citf1-and-spl7-that-regulate-copper-delivery-to-anthers-and-jasmonic-acid-synthesis
#8
Jiapei Yan, Ju-Chen Chia, Huajin Sheng, Ha-Il Jung, Tetiana-Olena Zavodna, Zhang Lu, Rong Huang, Chen Jiao, Eric Craft, Zhangjun Fei, Leon Vincent Kochian, Olena K Vatamaniuk
A deficiency of the micronutrient copper (Cu) leads to infertility and grain/seed yield reduction in plants. How Cu affects fertility, which reproductive structures require Cu, and which transcriptional networks coordinate Cu delivery to reproductive organs is poorly understood. Using RNA-seq analysis, we showed that the expression of a gene encoding a novel transcription factor, CITF1 (Cu-deficiency Induced Transcription Factor 1), was strongly upregulated in Arabidopsis thaliana flowers subjected to Cu deficiency...
November 7, 2017: Plant Cell
https://www.readbyqxmd.com/read/29089622/prognosis-of-hippocampal-function-after-sub-lethal-irradiation-brain-injury-in-patients-with-nasopharyngeal-carcinoma
#9
Sharon Chia-Ju Chen, Yoshifumi Abe, Pen-Tzu Fang, Ya-Ju Hsieh, Yung-I Yang, Tzu-Ying Lu, Shoji Oda, Hiroshi Mitani, Shi-Long Lian, Yu-Chang Tyan, Chih-Jen Huang, Tatsuhiro Hisatsune
This work emphasizes the value of assessing hippocampal function by making a timely MRI-based prognosis following a minor dose of hippocampal irradiation after nasopharyngeal carcinomas (NPC) radiotherapy. A quasi-experiment with case-control design and functional assessments (e.g., neuroimaging analysis with fMRI) was conducted to assess hippocampal function after radiotherapy. We delivered 70 Gy of irradiation to nasopharyngeal carcinomas by 6MV helical radiotherapy and collected data from twenty NPC patients and 24 healthy age-matched subjects...
October 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28989578/chia-seed-salvia-hispanica-l-added-yogurt-reduces-short-term-food-intake-and-increases-satiety-randomised-controlled-trial
#10
Aylin Ayaz, Asli Akyol, Elif Inan-Eroglu, Arzu Kabasakal Cetin, Gulhan Samur, Filiz Akbiyik
BACKGROUND/OBJECTIVES: Several studies have reported that consumption of Salvia Hispanica L.,commonly known as chia seed, may exert beneficial effects on health outcomes. The main purpose of this study was to examine the influence of chia seed consumption as a mid-morning snack on short-term satiety. SUBJECTS/METHODS: Subjects (n = 24) were tested using a randomized, cross-over design consisting of three mid-morning snacks. Yogurt with no chia seed, yogurt with 7 g chia seed, and yogurt with 14 g chia seed were given to subjects on different test days...
October 2017: Nutrition Research and Practice
https://www.readbyqxmd.com/read/28971960/a-genetic-screen-for-pre-mrna-splicing-mutants-of-arabidopsis-thaliana%C3%A2-identifies-putative-u1-snrnp-components-rbm25-and-prp39a
#11
Tatsuo Kanno, Wen-Dar Lin, Jason L Fu, Chia-Liang Chang, Antonius J M Matzke, Marjori Matzke
In a genetic screen for mutants showing modified splicing of an alternatively-spliced GFP reporter gene in Arabidopsis thaliana, we identified mutations in genes encoding the putative U1 snRNP factors RBM25 and PRP39a. The latter has not yet been studied for its role in pre-mRNA splicing in plants. Both proteins contain predicted RNA-binding domains and have been implicated in 5' splice site selection in yeast and metazoan cells. In rbm25 mutants, splicing efficiency of GFP pre-mRNA was reduced and GFP protein levels lowered relative to wild-type plants...
September 29, 2017: Genetics
https://www.readbyqxmd.com/read/28917861/isolation-and-structural-elucidation-by-2d-nmr-of-planteose-a-major-oligosaccharide-in-the-mucilage-of-chia-salvia-hispanica-l-seeds
#12
Xiaohui Xing, Yves S Y Hsieh, Kuok Yap, Main E Ang, Jelle Lahnstein, Matthew R Tucker, Rachel A Burton, Vincent Bulone
An oligosaccharide was isolated in high purity and excellent yield from the water-extractable mucilage of chia (Salvia hispanica L.) seeds using an optimized solid-phase extraction method. LC-MS analysis showed that the compound presents a molecular mass of 504Da and trifluoroacetic acid hydrolysis revealed that it consists of galactose, glucose and fructose. Glycosidic linkage analysis showed that the oligosaccharide contains two non-reducing ends corresponding to terminal glucopyranose and terminal galactopyranose, respectively...
November 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28900797/improvement-of-chia-seeds-with-antioxidant-activity-gaba-essential-amino-acids-and-dietary-fiber-by-controlled-germination-bioprocess
#13
Mario Armando Gómez-Favela, Roberto Gutiérrez-Dorado, Edith Oliva Cuevas-Rodríguez, Vicente Adrián Canizalez-Román, Claudia Del Rosario León-Sicairos, Jorge Milán-Carrillo, Cuauhtémoc Reyes-Moreno
Chia (Salvia hispanica L.) plant is native from southern Mexico and northern Guatemala. Their seeds are a rich source of bioactive compounds which protect consumers against chronic diseases. Germination improves functionality of the seeds due to the increase in the bioactive compounds and associated antioxidant activity. The purpose of this study was to obtain functional flour from germinated chia seeds under optimized conditions with increased antioxidant activity, phenolic compounds, GABA, essential amino acids, and dietary fiber with respect to un-germinated chia seeds...
September 12, 2017: Plant Foods for Human Nutrition
https://www.readbyqxmd.com/read/28799026/obliquely-deposited-gold-nanohelices-on-lithography-free-prepared-nanoseeded-surfaces
#14
Yi-Jun Jen, Wei-Chih Liu, Chih-Yung Hsiao, Po-Cheng Lin, Chia-Liang Yu, Teh-Li Chan
A substrate surface on which gold particles are distributed is prepared by annealing an ultra-thin gold film to enable glancing angle deposition. By cooling the substrate and controlling its spin rate, two spiral-like and one screw-like gold nanohelix arrays are grown upon the seeded surfaces. The mean helix radius and pitch length are reduced to 17 and 55 nm, respectively. The g-factor of the three nanohelix arrays is measured here and associated circular dichroism peak blue shifts occur as the gold helices shrink...
August 10, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28764759/effect-of-acetic-acid-on-ethanol-production-by-zymomonas-mobilis-mutant-strains-through-continuous-adaptation
#15
Yu-Fan Liu, Chia-Wen Hsieh, Yao-Sheng Chang, Being-Sun Wung
BACKGROUND: Acetic acid is a predominant by-product of lignocellulosic biofuel process, which inhibits microbial biocatalysts. Development of bacterial strains that are tolerant to acetic acid is challenging due to poor understanding of the underlying molecular mechanisms. RESULTS: In this study, we generated and characterized two acetic acid-tolerant strains of Zymomonas mobilis using N-methyl-N'-nitro-N-nitrosoguanidine (NTG)-acetate adaptive breeding. Two mutants, ZMA-142 and ZMA-167, were obtained, showing a significant growth rate at a concentration of 244 mM sodium acetate, while the growth of Z...
August 1, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28755594/characteristics-and-applications-of-ecological-soil-substrate-for-rocky-slope-vegetation-in-cold-and-high-altitude-areas
#16
Hua Xu, Tian-Bin Li, Jian-Nan Chen, Chia-Nan Liu, Xiong-Hua Zhou, Lei Xia
Ecological restoration of steep rocky slopes generated by road cutting is usually difficult especially, in the cold and high-altitude environment, which is unfavorable for the growth of vegetation. With the focus on slope vegetation, an ecological soil substrate, synthesized with polyacrylamide (PAM), carboxymethyl cellulose (CMC), and Fly ash (FA) as the main components, was developed for spray seeding on the rocky slopes in cold and high-altitude regions, to provide a favorable environment for vegetation growth...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28720954/effect-of-partial-substitution-of-gluten-free-flour-mixtures-with-chia-salvia-hispanica-l-flour-on-quality-of-gluten-free-noodles
#17
Hacer Levent
In this study, chia seed flour (CSF) was used in gluten-free noodle formulation at different levels (0, 10, 20 and 30%, w/w) with and without diacetyl tartaric esters of mono (and di) glycerides (DATEM). Chemical, nutritional, sensory properties and cooking quality of gluten-free noodle samples were investigated. Protein, fat, antioxidant activity and total phenolic content of gluten-free noodles increased by 1.7, 5.5, 2.6 and 2.0 times at 30% usage level of CSF as compared to control sample. Phytic acid and phytate phosphorus content increased from 168...
June 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28651695/dietary-salba-salvia-hispanica-l-improves-the-altered-metabolic-fate-of-glucose-and-reduces-increased-collagen-deposition-in-the-heart-of-insulin-resistant-rats
#18
Agustina Creus, Adriana Benmelej, Noelia Villafañe, Yolanda B Lombardo
This study reports the effects of dietary Salba (chia) seeds on the mechanisms underlying impaired glucose metabolism in the heart of dyslipemic insulin-resistant rats fed a sucrose-rich diet (SRD). Wistar rats were fed a SRD for 3 months. Afterwards, half the animals continued with the SRD; in the other half's diet chia seeds replaced corn oil (CO) for three months (SRD+chia). In the control group, corn starch replaced sucrose. The replacement of CO by chia seeds in the SRD restored the activities of key enzymes involved in heart glucose metabolism decreasing fatty acid oxidation...
June 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28651384/agaricus-bisporus-production-on-substrates-pasteurized-by-self-heating
#19
Stephania Colmenares-Cruz, José E Sánchez, Javier Valle-Mora
The aim of this work was to determine if the self-heating pasteurization procedure is technically applicable to the cultivation of Agaricus bisporus. Firstly the substrates alone (corncob, Pangola grass and a mixture of both ingredients with wood shavings) were tested. Two supplementation trials were then undertaken using soybean, wheat bran, sheep manure, sesame seed, black bean and chia. Highest production values (BE = 176.3% and Y = 26.6 kg/m(2)) were obtained using a 9% supplement, with a formula consisting of 25% each of soybean, black bean, wheat bran and chia, added at spawning and at casing...
December 2017: AMB Express
https://www.readbyqxmd.com/read/28646829/chia-seeds-salvia-hispanica-health-promoting-properties-and-therapeutic-applications-%C3%A2-a-review
#20
REVIEW
Katarzyna Marcinek, Zbigniew Krejpcio
Chia has been known for over 5,500 years. Chia seeds were one of the most important components of the diet of Mayas and Aztecs. The chemical composition and technological properties of chia give the plant a high nutritional potential. Chia is a good source of polyunsaturated fatty acids: omega-3 and omega-6, soluble dietary fiber. It also contains appreciable amount of proteins and phytochemicals. Nutritional value of chia is the reason why it is used in prophylaxis of several non-infectious diseases such as obesity, hypertension, cardiovascular diseases (CVDs), cancer and diabetes...
2017: Roczniki Państwowego Zakładu Higieny
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