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https://www.readbyqxmd.com/read/28182687/lunasin-attenuates-obesity-related-inflammation-in-raw264-7-cells-and-3t3-l1-adipocytes-by-inhibiting-inflammatory-cytokine-production
#1
Chia-Chien Hsieh, Mei-Jia Chou, Chih-Hsuan Wang
Obesity has become a major threat to public health and is accompanied by chronic low-grade inflammation, which leads to various pathological developments. Lunasin, a natural seed peptide, exhibits several biological activities, such as anti-carcinogenesis, anti-inflammatory, and antioxidant activities. However, the mechanism of action of lunasin in obesity-related inflammation has not been investigated. The aim of this study was to explore whether lunasin could reduce the inflammation induced by obesity-related mediators in RAW264...
2017: PloS One
https://www.readbyqxmd.com/read/28114972/optimizing-mesoderm-progenitor-selection-and-three-dimensional-microniche-culture-allows-highly-efficient-endothelial-differentiation-and-ischemic-tissue-repair-from-human-pluripotent-stem-cells
#2
Fengzhi Zhang, Lin Wang, Yaqian Li, Wei Liu, Fuyu Duan, Rujin Huang, Xi Chen, Sophia Chia-Ning Chang, Yanan Du, Jie Na
BACKGROUND: Generation of large quantities of endothelial cells is highly desirable for vascular research, for the treatment of ischemia diseases, and for tissue regeneration. To achieve this goal, we developed a simple, chemically defined culture system to efficiently and rapidly differentiate endothelial cells from human pluripotent stem cells by going through an MESP1 mesoderm progenitor stage. METHODS: Mesp1 is a key transcription factor that regulates the development of early cardiovascular tissue...
January 23, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28089080/salba-chia-salvia-hispanica-l-in-the-treatment-of-overweight-and-obese-patients-with-type-2-diabetes-a-double-blind-randomized-controlled-trial
#3
V Vuksan, A L Jenkins, C Brissette, L Choleva, E Jovanovski, A L Gibbs, R P Bazinet, F Au-Yeung, A Zurbau, H V T Ho, L Duvnjak, J L Sievenpiper, R G Josse, A Hanna
BACKGROUND AND AIM: Preliminary findings indicate that consumption of Salba-chia (Salvia hispanica L.), an ancient seed, improves management of type 2 diabetes and suppresses appetite. The aim of this study was to assesse the effect of Salba-chia on body weight, visceral obesity and obesity-related risk factors in overweight and obese adults with type 2 diabetes. METHODS: A double-blind, randomized, controlled trial with two parallel groups involved 77 overweight or obese patients with type 2 diabetes (HbA1c: 6...
February 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/28088290/could-post-weaning-dietary-chia-seed-mitigate-the-development-of-dyslipidemia-liver-steatosis-and-altered-glucose-homeostasis-in-offspring-exposed-to-a-sucrose-rich-diet-from-utero-to-adulthood
#4
M A Fortino, M E Oliva, S Rodriguez, Y B Lombardo, A Chicco
The present work analyzes the effects of dietary chia seeds during postnatal life in offspring exposed to a sucrose-rich diet (SRD) from utero to adulthood. At weaning, chia seed (rich in α-linolenic acid) replaced corn oil (rich in linoleic acid) in the SRD. At 150 days of offspring life, anthropometrical parameters, blood pressure, plasma metabolites, hepatic lipid metabolism and glucose homeostasis were analyzed. Results showed that chia was able to prevent the development of hypertension, liver steatosis, hypertriglyceridemia and hypercholesterolemia...
January 2017: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/28003144/self-assembled-supramolecular-polymers-with-tailorable-properties-that-enhance-cell-attachment-and-proliferation
#5
Chih-Chia Cheng, Duu-Jong Lee, Jem-Kun Chen
: Self-assembled supramolecular scaffolds, a combination of noncovalent interactions within a biocompatible polymer substrate, can be used for efficient construction of highly-controlled self-organizing hierarchical structures; these newly-developed biomaterials exhibit excellent mechanical properties, tunable surface hydrophilicity, low cytotoxicity and high biodegradability, making them highly attractive for tissue engineering and regenerative medicine applications. Herein, we demonstrate a novel supramolecular poly(ε-caprolactone) (PCL) containing self-complementary sextuple hydrogen-bonded uracil-diamidopyridine (U-DPy) moieties, which undergoes spontaneous self-assembly to form supramolecular polymer networks...
December 18, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28000689/comparison-of-flax-linum-usitatissimum-and-salba-chia-salvia-hispanica-l-seeds-on-postprandial-glycemia-and-satiety-in-healthy-individuals-a-randomized-controlled-crossover-study
#6
V Vuksan, L Choleva, E Jovanovski, A L Jenkins, F Au-Yeung, A G Dias, H V T Ho, A Zurbau, L Duvnjak
BACKGROUND/OBJECTIVES: Flax and Salba-chia seeds have risen in popularity owing to their favorable nutrient composition, including a high fiber content. Despite having comparable nutritional profiles, preliminary observations suggest differences in gelling properties, an attribute that may alter the kinetics of food digestion. Thus, we compared the effect of two seeds on postprandial glycemia and satiety scores. SUBJECTS/METHODS: Fifteen healthy participants (M/F: 5/10; age: 23...
February 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27983683/lunasin-attenuates-obesity-associated-metastasis-of-4t1-breast-cancer-cell-through-anti-inflammatory-property
#7
Chia-Chien Hsieh, Chih-Hsuan Wang, Yu-Shan Huang
Obesity prevalence is increasing worldwide and is accompanied by low-grade inflammation with macrophage infiltration, which is linked with a poorer breast cancer prognosis. Lunasin is a natural seed peptide with chemopreventive properties and multiple bioactivities. This is the first study to explore the chemopreventive effects of lunasin in the obesity-related breast cancer condition using 4T1 breast cancer cells, 3T3-L1 adipocytes, and conditioned media. An obesity-related environment, such as leptin-treatment or adipocyte-conditioned medium (Ad-CM), promoted 4T1 cell proliferation and metastasis...
December 15, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27979185/gluten-free-pasta-incorporating-chia-salvia-hispanica-l-as-thickening-agent-an-approach-to-naturally-improve-the-nutritional-profile-and-the-in-vitro-carbohydrate-digestibility
#8
Valeria Menga, Mariana Amato, Tim D Phillips, Donato Angelino, Federico Morreale, Clara Fares
A gluten-free pasta was prepared adding chia at rice flour for testing the thickening and nutritional properties of this specie. Chemical analysis showed chia is a source of protein (19.52% and 15.81%, seeds and mucilage respectively), insoluble/soluble dietary fiber ratio (4.3 and 1.79 seeds and mucilage respectively), fat and ash content. The total phenolic acids content ranged from 734.5μg/g to 923.9μg/g for seeds and mucilage respectively. Chia was a good thickening agent and, improved the nutritional profile of enriched samples compared to CGF...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27979151/chemical-composition-of-brazilian-chia-seeds-grown-in-different-places
#9
Bárbara Pereira da Silva, Pamella Cristine Anunciação, Jessika Camila da Silva Matyelka, Ceres Mattos Della Lucia, Hércia Stampini Duarte Martino, Helena Maria Pinheiro-Sant'Ana
This study investigated and compared the occurrence and concentration of macronutrients, moisture, ash, dietary fiber, fatty acids, minerals, carotenoids, vitamins, flavonoids, phenolic compounds, antioxidant activity, phytate and tannin in Brazilian chia seeds grown in the states of Mato Grosso (MT) and Rio Grande do Sul (RS). High concentrations of lipids (31.2g.100g(-1), on average), proteins (18.9g.100g(-1), on average), dietary fiber (35.3g.100g(-1), on average), vitamin E (8,203.6μg.100g(-1), on average) were observed...
April 15, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27884158/rapid-visualization-of-latent-fingermarks-using-gold-seed-mediated-enhancement
#10
Chia-Hao Su, Chun-Chieh Yu, Fong-Yu Cheng
BACKGROUND: Fingermarks are one of the most important and useful forms of physical evidence in forensic investigations. However, latent fingermarks are not directly visible, but can be visualized due to the presence of other residues (such as inorganic salts, proteins, polypeptides, enzymes and human metabolites) which can be detected or recognized through various strategies. Convenient and rapid techniques are still needed to provide obvious contrast between the background and the fingermark ridges and to then visualize latent fingermark with a high degree of selectivity and sensitivity...
November 25, 2016: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/27882891/a-comparative-mass-spectrometric-study-of-fatty-acids-and-metals-in-some-seed-extracts
#11
Sonia Niculina Suvar, R Bleiziffer, P Podea, A Iordache, C Voica, R Zgavarogea, M Culea
A major cause of cardiovascular diseases and cancer is diet content, so the optimization of micronutrients in food is very important. Omega-3 fatty acids supplementation for patients had beneficial effects on subjective global assessment score and metabolic profiles. Fatty acids content and the metal ions in different seeds (e.g. linseed, poppy, grape, hemp, nuts, pumpkin, sesame, watermelon, chia) recommended as food supplements, purchased on the Romanian market, were compared. Gas chromatography coupled to mass spectrometry (GC-MS) was used as an excellent technique for fatty acids identification and quantitation, and inductively coupled plasma mass spectrometer (ICP-MS) for analytical measurements of metals...
2016: European Journal of Mass Spectrometry
https://www.readbyqxmd.com/read/27828455/40-%C3%A2%C2%B5j-passively-cep-stable-seed-source-for-ytterbium-based-high-energy-optical-waveform-synthesizers
#12
Hüseyin Çankaya, Anne-Laure Calendron, Chun Zhou, Shih-Hsuan Chia, Oliver D Mücke, Giovanni Cirmi, Franz X Kärtner
We demonstrate experimentally for the first time a ~40-µJ two-octave-wide passively carrier-envelope phase (CEP)-stable parametric front-end for seeding an ytterbium (Yb)-pump-based, few-optical-cycle, high-energy optical parametric waveform synthesizer. The system includes a CEP-stable white-light continuum and two-channel optical parametric chirped pulse amplifiers (OPCPAs) in the near- and mid-infrared spectral regions spanning altogether a two-octave-wide spectrum driven by a regenerative amplifier. The output pulses are compressed and fully characterized to demonstrate the well-behaved spectral phase of this seed source...
October 31, 2016: Optics Express
https://www.readbyqxmd.com/read/27784915/development-and-characterization-of-functional-o-w-emulsions-with-chia-seed-salvia-hispanica-l-by-products
#13
Luciana Magdalena Julio, Vanesa Yanet Ixtaina, Mariela Fernández, Rosa Maria Torres Sánchez, Susana María Nolasco, Mabel Cristina Tomás
The present work investigated the physicochemical properties of O/W emulsions containing functional ingredients (oil with high ω-3 fatty acid content, protein and/or soluble fiber) from chia seeds. The effect of different protein-carbohydrate combinations (sodium caseinate and lactose, sodium caseinate and maltodextrin, chia protein-rich fraction and maltodextrin) and the presence of chia mucilage (0 and 0.2 % wt/wt) in the aqueous phase of chia O/W emulsions was studied as a function of droplet size distribution, Sauter mean diameter, ζ-potential, rheological properties and backscattering profiles...
August 2016: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/27719895/simultaneous-determination-of-atropine-and-scopolamine-in-buckwheat-and-related-products-using-modified-quechers-and-liquid-chromatography-tandem-mass-spectrometry
#14
Hongping Chen, Jesús Marín-Sáez, Roberto Romero-González, Antonia Garrido Frenich
A method was developed for the determination of atropine and scopolamine in buckwheat and related products. A modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) extraction procedure was evaluated. Dispersive solid phase extraction (d-SPE) was studied as clean-up step, using graphitized black carbon (GBC) and primary secondary amine (PSA). The extract was diluted with water (50:50, v/v) prior to chromatographic analysis. The method was validated and recoveries (except chia samples spiked at 10μg/kg) ranged from 75% to 92%...
March 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27660774/draft-genome-sequences-of-two-salmonella-enterica-strains-isolated-from-sprouted-chia-and-flax-seed-powders
#15
Jennifer Ronholm, Nicholas Petronella, Sandeep Tamber
A 2014 foodborne salmonellosis outbreak in Canada and the United States implicated, for the first time, sprouted chia seed powder as the vehicle of transmission. Here, we report the draft whole genome sequences of two Salmonella enterica strains isolated from sprouted powders related to the aforementioned outbreak.
2016: Genome Announcements
https://www.readbyqxmd.com/read/27647503/fatty-acids-characterization-oxidative-perspectives-and-consumer-acceptability-of-oil-extracted-from-pre-treated-chia-salvia-hispanica-l-seeds
#16
Muhammad Imran, Muhammad Nadeem, Muhammad Faisal Manzoor, Amna Javed, Zafar Ali, Muhammad Nadeem Akhtar, Muhammad Ali, Yasir Hussain
BACKGROUND: Chia (Salvia hispanica L.) seeds have been described as a good source of lipids, protein, dietary fiber, polyphenolic compounds and omega-3 polyunsaturated fatty acids. The consumption of chia seed oil helps to improve biological markers related to metabolic syndrome diseases. The oil yield and fatty acids composition of chia oil is affected by several factors such as pre-treatment method and size reduction practices. Therefore, the main mandate of present investigate was to study the effect of different seed pre-treatments on yield, fatty acids composition and sensory acceptability of chia oil at different storage intervals and conditions...
September 20, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27596397/effective-lactobacillus-plantarum-and-bifidobacterium-infantis-encapsulation-with-chia-seed-salvia-hispanica-l-and-flaxseed-linum-usitatissimum-l-mucilage-and-soluble-protein-by-spray-drying
#17
Mariela Bustamante, B Dave Oomah, Mónica Rubilar, Carolina Shene
Mucilage (M) and soluble protein (SP) extracted from chia seed and flaxseed were used as encapsulating material for two probiotic bacteria: Bifidobacterium infantis and Lactobacillus plantarum by spray drying. Probiotic survival and viability after spray drying and during storage were evaluated. B. infantis and L. plantarum displayed high survival (⩾98%) after encapsulation with mixtures of maltodextrin (MD) combined with M and SP from flaxseed (MD:FM:FSP - 7.5:0.2:7.5%, w/w/w) and chia seed (MD:CM:CSP - 7...
February 1, 2017: Food Chemistry
https://www.readbyqxmd.com/read/27566476/dietary-salba-salvia-hispanica-l-ameliorates-the-adipose-tissue-dysfunction-of-dyslipemic-insulin-resistant-rats-through-mechanisms-involving-oxidative-stress-inflammatory-cytokines-and-peroxisome-proliferator-activated-receptor-%C3%AE
#18
M R Ferreira, S M Alvarez, P Illesca, M S Giménez, Y B Lombardo
PURPOSE: Rats fed a long-term sucrose-rich diet (SRD) developed adipose tissue dysfunction. In the adipose tissue of these SRD-fed rats, the present study analyzed the possible beneficial effects of dietary Salba (chia) seeds in improving or reversing the depletion of antioxidant defenses, changes in pro-inflammatory cytokines and ROS production. METHODS: Wistar rats were fed a SRD for 3 months. After that, half of the animals continued with the SRD until month 6, while in the other half, corn oil was replaced by chia seeds for 3 months (SRD + chia)...
August 26, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27508985/transcriptomic-and-proteomic-research-to-explore-bruchid-resistant-genes-in-mungbean-isogenic-lines
#19
Wu-Jui Lin, Chia-Yun Ko, Mao-Sen Liu, Chien-Yen Kuo, Dung-Chi Wu, Chien-Yu Chen, Roland Schafleitner, Long-Fang O Chen, Hsiao-Feng Lo
Mungbean (Vigna radiata (L.) Wilczek) is an important rotation legume crop for human nutrition in Asia. Bruchids (Callosobruchus spp.) currently cause heavy damage as pests of grain legumes during storage. We used omics-related technologies to study the mechanisms of bruchid resistance in seeds of the nearly isogenic lines VC1973A (bruchid-susceptible) and VC6089A (bruchid-resistant). A total of 399 differentially expressed genes (DEGs) were identified between the two lines by transcriptome sequencing. Among these DEGs, 251 exhibited high expression levels and 148 expressed low expression levels in seeds of VC6089A...
August 31, 2016: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/27465402/assessing-gelling-properties-of-chia-salvia-hispanica-l-flour-through-rheological-characterisation
#20
S Ramos, P Fradinho, P Mata, A Raymundo
BACKGROUND: Chia seeds (Salvia hispanica L.) are considered a promising ingredient for the development of functional products, due to its high nutritional value: 343 g Kg(-1) of lipids, 251 g Kg(-1) proteins and 226 g Kg(-1) fibre. Considering chia's technological capacities, mainly the ability to swell when absorbing water and gel forming properties, its addition to a food matrix can affect texture and rheological behaviour, acting as texturing and stabilizing agent. The present work intends to assess the gelling properties of chia flour through the rheological characterisation of 100, 130 and 150 g Kg(-1) chia flour gels...
July 28, 2016: Journal of the Science of Food and Agriculture
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