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Leslie Myatt

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https://www.readbyqxmd.com/read/29385440/11%C3%AE-hsd-1-in-human-fetal-membranes-as-a-potential-therapeutic-target-for-preterm-birth
#1
Wangsheng Wang, Zi-Jiang Chen, Leslie Myatt, Kang Sun
Human parturition is a complex process involving interactions between the myometrium and signals derived from the placenta, fetal membranes and fetus. Signals originating from fetal membranes are crucial components that trigger parturition, which is clearly illustrated by the labor-initiating consequence of membrane rupture. It has been recognized for a long time that among fetal tissues in late gestation the fetal membranes possess the highest capacity for cortisol regeneration by 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1)...
January 29, 2018: Endocrine Reviews
https://www.readbyqxmd.com/read/29380305/effects-of-prenatal-nutrition-and-the-role-of-the-placenta-in-health-and-disease
#2
Leslie Myatt, Kent L Thornburg
Epidemiologic studies identified the linkage between exposures to stresses, including the type and plane of nutrition in utero with development of disease in later life. Given the critical roles of the placenta in mediating transport of nutrients between the mother and fetus and regulation of maternal metabolism, recent attention has focused on the role of the placenta in mediating the effect of altered nutritional exposures on the development of disease in later life. In this chapter we describe the mechanisms of nutrient transport in the placenta, the influence of placental metabolism on this, and how placental energetics influence placental function in response to a variety of stressors...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29190847/adverse-maternal-and-neonatal-outcomes-in-indicated-compared-with-spontaneous-preterm-birth-in-healthy-nulliparas-a-secondary-analysis-of-a-randomized-trial
#3
Alan T Tita, Lindsay Doherty, Jim M Roberts, Leslie Myatt, Kenneth J Leveno, Michael W Varner, Ronald J Wapner, John M Thorp, Brian M Mercer, Alan Peaceman, Susan M Ramin, Marshall W Carpenter, Jay Iams, Anthony Sciscione, Margaret Harper, Jorge E Tolosa, George R Saade, Yoram Sorokin
No abstract text is available yet for this article.
November 30, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/29162743/akap95-mediated-nuclear-anchoring-of-pka-mediates-cortisol-induced-ptgs2-expression-in-human-amnion-fibroblasts
#4
Jiangwen Lu, Wangsheng Wang, Yabing Mi, Chuyue Zhang, Hao Ying, Luyao Wang, Yawei Wang, Leslie Myatt, Kang Sun
Phosphorylation of the transcription factors cyclic adenosine monophosphate response element-binding protein (CREB) and signal transducer and activator of transcription 3 (STAT3) by protein kinase A (PKA) is required for the cortisol-induced production of cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2) in human amnion fibroblasts, which critically mediates human parturition (labor). We found that PKA was confined in the nucleus by A-kinase-anchoring protein 95 (AKAP95) in amnion fibroblasts and that this localization was key to the cortisol-induced expression of PTGS2, the gene encoding COX-2...
November 21, 2017: Science Signaling
https://www.readbyqxmd.com/read/29074002/novel-thoughts-on-preterm-birth-research-proceedings-of-the-13th-annual-preterm-birth-international-collaborative-prebic-meeting
#5
REVIEW
Cynthia Gyamfi-Bannerman, Ramkumar Menon, Elizabeth A Bonney, Siobhan M Dolan, Mark Johnson, Ronald F Lamont, Sam Mesiano, Amy P Murtha, Leslie Myatt, Indira Mysorekar, Scott M Williams, Nanbert Zhong, Hanns Helmer
No abstract text is available yet for this article.
November 2017: Seminars in Perinatology
https://www.readbyqxmd.com/read/29045485/alterations-in-the-placental-methylome-with-maternal-obesity-and-evidence-for-metabolic-regulation
#6
Kohzoh Mitsuya, Ashley N Parker, Lu Liu, Jianhua Ruan, Margreet C M Vissers, Leslie Myatt
The inflammatory and metabolic derangements of obesity in pregnant women generate an adverse intrauterine environment, increase pregnancy complications and adverse fetal outcomes and program the fetus for obesity and metabolic syndrome in later life. We hypothesized that epigenetic modifications in placenta including altered DNA methylation/hydroxymethylation may mediate these effects. Term placental villous tissue was collected following cesarean section from lean (prepregnancy BMI<25) or obese (BMI>30) women...
2017: PloS One
https://www.readbyqxmd.com/read/28864015/availability-of-collect-a-database-for-pregnancy-and-placental-research-studies-worldwide
#7
Leslie Myatt, James M Roberts, Christopher W G Redman
Cost and availability of a database often impede research while the lack of compatibility inhibits collaboration by making merging of databases difficult or impossible. The Global Pregnancy Collaboration (CoLab) has promoted harmonization of studies and standardized data collection to facilitate pregnancy and placental research. Its online database, COLLECT, allows collection of minimal and optimal clinical datasets to accompany basic and applied science studies and provides a placental sample inventory system...
September 2017: Placenta
https://www.readbyqxmd.com/read/28677406/tropomyosin-receptor-kinase-b-agonist-7-8-dihydroxyflavone-improves-mitochondrial-respiration-in-placentas-from-obese-women
#8
Calais S Prince, Alina Maloyan, Leslie Myatt
Maternal obesity negatively impacts the placenta, being associated with increased inflammation, decreased mitochondrial respiration, decreased expression of brain-derived neurotrophic factor (BDNF), and its receptor, tropomyosin receptor kinase B (TRKB). TRKB induction by 7,8-dihydroxyflavone (7,8-DHF) improves energy expenditure in an obesity animal model. We hypothesized that TRKB activation would improve mitochondrial respiration in trophoblasts from placentas of obese women. Placentas were collected from lean (pre-pregnancy BMI < 25) and obese (pre-pregnancy BMI > 30) women at term following cesarean section delivery without labor...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28443479/melatonin-improves-mitochondrial-respiration-in-syncytiotrophoblasts-from-placentas-of-obese-women
#9
Kayla E Ireland, Alina Maloyan, Leslie Myatt
Maternal obesity is associated with increased oxidative stress but decreased placental mitochondrial respiration and expression of mitochondrial electron transport chain (ETC) complexes I to V. Melatonin acts as an antioxidant and prevents oxidative stress-induced changes in cytotrophoblasts. Placentas were collected at term by cesarean delivery from obese (first trimester body mass index [BMI] ≥30, n = 10) or lean (BMI < 25, n = 6) women. Cytotrophoblasts were isolated and allowed to syncytialize for 72 hours with or without melatonin (0...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28325691/preface-ifpa-meeting-2016
#10
Leslie Myatt
No abstract text is available yet for this article.
March 14, 2017: Placenta
https://www.readbyqxmd.com/read/28323983/autophagic-degradation-of-collagen-1a1-by-cortisol-in-human-amnion-fibroblasts
#11
Yabing Mi, Wangsheng Wang, Chuyue Zhang, Chao Liu, Jiangwen Lu, Wenjiao Li, Rujuan Zuo, Leslie Myatt, Kang Sun
Rupture of fetal membranes can initiate parturition at both term and preterm. Collagen is the crucial factor determining the tensile strength of the membranes. Toward the end of gestation, a feed-forward regeneration of cortisol via 11β-hydroxysteroid dehydrogenase 1 exists in fetal membranes. It remains undetermined whether cortisol contributes to collagen reduction in fetal membranes. In this study, we have examined whether cortisol accumulation is a causative factor for collagen reduction in human amnion fibroblasts, the major source of collagens in the membranes...
April 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28292470/sexual-dimorphism-in-the-effect-of-maternal-obesity-on-antioxidant-defense-mechanisms-in-the-human-placenta
#12
LaShauna Evans, Leslie Myatt
INTRODUCTION: Maternal obesity creates an adverse intrauterine environment, negatively impacts placental respiration, is associated with a higher incidence of pregnancy complications and programs the offspring for disease in adult life in a sexually dimorphic manner. We defined the effect of maternal obesity and fetal sex on pro- and anti-oxidant status in placenta and placental mitochondria. METHODS: Placental villous tissue was collected at term via c-section prior to labor from four groups of patients based on fetal sex and prepregnancy/1st trimester body mass index: lean - BMI 22...
March 2017: Placenta
https://www.readbyqxmd.com/read/28284454/ifpa-meeting-2016-workshop-report-ii-placental-imaging-placenta-and-development-of-other-organs-sexual-dimorphism-in-placental-function-and-trophoblast-cell-lines
#13
Jennifer Adibi, Graham J Burton, Vicki Clifton, Sally Collins, Antonio E Frias, Lobke Gierman, Peta Grigsby, Helen Jones, Cheryl Lee, Alina Maloyan, Udo R Markert, Diana M Morales-Prieto, Padma Murthi, Leslie Myatt, Jurgen Pollheimer, Victoria Roberts, Wendy Robinson, Carolyn Salafia, Matthias Schabel, Dinesh Shah, John Sled, Cathy Vaillancourt, Maja Weber, Perrie F O'Tierney-Ginn
Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2016 there were twelve themed workshops, four of which are summarized in this report. These workshops addressed challenges, strengths and limitations of techniques and model systems for studying the placenta, as well as future directions for the following areas of placental research: 1) placental imaging; 2) sexual dimorphism; 3) placenta and development of other organs; 4) trophoblast cell lines...
March 6, 2017: Placenta
https://www.readbyqxmd.com/read/28012455/maternal-obesity-alters-brain-derived-neurotrophic-factor-bdnf-signaling-in-the-placenta-in-a-sexually-dimorphic-manner
#14
Calais S Prince, Alina Maloyan, Leslie Myatt
INTRODUCTION: Obesity is a major clinical problem in obstetrics being associated with adverse pregnancy outcomes and fetal programming. Brain derived neurotrophic factor (BDNF), a validated miR-210 target, is necessary for placental development, fetal growth, glucose metabolism, and energy homeostasis. Plasma BDNF levels are reduced in obese individuals; however, placental BDNF has yet to be studied in the context of maternal obesity. In this study, we investigated the effect of maternal obesity and sexual dimorphism on placental BDNF signaling...
January 2017: Placenta
https://www.readbyqxmd.com/read/27533889/inhibition-of-lysyl-oxidase-by-cortisol-regeneration-in-human-amnion-implications-for-rupture-of-fetal-membranes
#15
Chao Liu, Chunming Guo, Wangsheng Wang, Ping Zhu, Wenjiao Li, Yabing Mi, Leslie Myatt, Kang Sun
The mechanisms underlying human parturition are still not understood, yet we need this knowledge to combat preterm birth. Fetal membranes express abundant 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which converts inert cortisone to active cortisol. We examined whether cortisol regeneration in the amnion might play a role in human parturition through regulation of lysyl oxidase (LOX), a collagen cross-linking enzyme, thereby contributing to the rupture of fetal membranes. By using cultured human primary amnion fibroblasts, we demonstrated that, in addition to the induction of the key enzymes involved in prostaglandin E2 (PGE2) synthesis, cortisol stimulated 11β-HSD1 and inhibited LOX reciprocally...
October 2016: Endocrinology
https://www.readbyqxmd.com/read/27398706/cell-free-total-and-fetal-dna-in-first-trimester-maternal-serum-and-subsequent-development-of-preeclampsia
#16
Robert M Silver, Leslie Myatt, John C Hauth, Kenneth J Leveno, Alan M Peaceman, Susan M Ramin, Philip Samuels, George Saade, Yoram Sorokin, Rebecca G Clifton, Uma M Reddy
Objective The objective of this study was to assess the relationship between first trimester cell-free total and fetal DNA in maternal plasma and the subsequent development of preeclampsia. Study Design Nested case-control study of patients enrolled in the Combined Antioxidant and Preeclampsia Prediction Studies prediction study of 175 women who did and 175 women who did not develop preeclampsia. The predictive values of cell-free total and fetal DNA and the subsequent development of preeclampsia were measured using receiver operating characteristic curves...
January 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/27147475/corrigendum-to-inhibition-of-lysyl-oxidase-by-prostaglandin-e2-via-ep2-ep4-receptors-in-human-amnion-fibroblasts-implications-for-parturition-mol-cell-endocrinol-424-2016-118-127
#17
Chao Liu, Ping Zhu, Wangsheng Wang, Wenjiao Li, Qun Shu, Zi-Jiang Chen, Leslie Myatt, Kang Sun
No abstract text is available yet for this article.
June 15, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27120478/is-mid-trimester-insulin-resistance-predictive-of-subsequent-puerperal-infection-a-secondary-analysis-of-randomized-trial-data
#18
Brenna L Hughes, Rebecca G Clifton, John C Hauth, Kenneth J Leveno, Leslie Myatt, Uma M Reddy, Michael W Varner, Ronald J Wapner, Brian M Mercer, Alan M Peaceman, Susan M Ramin, Jorge E Tolosa, George Saade, Yoram Sorokin
Objective The objective of this study was to examine whether there is an association between insulin resistance and subsequent development of puerperal infection by measuring insulin resistance in the mid-trimester using the homeostasis model assessment (HOMA:IR). Methods Secondary analysis of low-risk nulliparas enrolled in a multicenter preeclampsia prevention trial. HOMA:IR was measured on fasting plasma glucose and insulin concentrations among low-risk nulliparas between 22 and 26 weeks' gestation. Median HOMA:IR was compared between women who did and did not develop puerperal infection using Wilcoxon rank sum test...
August 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/26993250/mitochondrial-function-and-glucose-metabolism-in-the-placenta-with-gestational-diabetes-mellitus-role-of-mir-143
#19
Sribalasubashini Muralimanoharan, Alina Maloyan, Leslie Myatt
A predisposing factor for development of the hyperglycaemic state of gestational diabetes mellitus (GDM) is obesity. We previously showed that increasing maternal obesity is associated with significant reductions in placental mitochondrial respiration. MicroRNA (miR)-143 has been previously shown to regulate the metabolic switch from oxidative phosphorylation to aerobic glycolysis in cancer tissues. We hypothesized that mitochondrial respiration is reduced and aerobic glycolysis is up-regulated via changes in miR-143 expression in the placenta of women with GDM...
June 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/26986453/sexual-dimorphism-in-activation-of-placental-autophagy-in-obese-women-with-evidence-for-fetal-programming-from-a-placenta-specific-mouse-model
#20
Sribalasubashini Muralimanoharan, Xiaoli Gao, Susan Weintraub, Leslie Myatt, Alina Maloyan
The incidence of maternal obesity and its co-morbidities (diabetes, cardiovascular disease) continues to increase at an alarming rate, with major public health implications. In utero exposure to maternal obesity has been associated with development of cardiovascular and metabolic diseases in the offspring as a result of developmental programming. The placenta regulates maternal-fetal metabolism and shows significant changes in its function with maternal obesity. Autophagy is a cell-survival process, which is responsible for the degradation of damaged organelles and misfolded proteins...
May 3, 2016: Autophagy
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