keyword
https://read.qxmd.com/read/38461223/adamts4-is-a-crucial-proteolytic-enzyme-for-versican-cleavage-in-the-amnion-at-parturition
#1
JOURNAL ARTICLE
Meng-Die Li, Jiang-Wen Lu, Fan Zhang, Wen-Jia Lei, Fan Pan, Yi-Kai Lin, Li-Jun Ling, Leslie Myatt, Wang-Sheng Wang, Kang Sun
Hyalectan cleavage may play an important role in extracellular matrix remodeling. However, the proteolytic enzyme responsible for hyalectan degradation for fetal membrane rupture at parturition remains unknown. Here, we reveal that versican (VCAN) is the major hyalectan in the amnion, where its cleavage increases at parturition with spontaneous rupture of membrane. We further reveal that ADAMTS4 is a crucial proteolytic enzyme for VCAN cleavage in the amnion. Inflammatory factors may enhance VCAN cleavage by inducing ADAMTS4 expression and inhibiting ADAMTS4 endocytosis in amnion fibroblasts...
March 9, 2024: Communications Biology
https://read.qxmd.com/read/37598232/predicting-labor-onset-relative-to-the-estimated-date-of-delivery-using-smart-ring-physiological-data
#2
JOURNAL ARTICLE
Elise N Erickson, Neta Gotlieb, Leonardo M Pereira, Leslie Myatt, Clara Mosquera-Lopez, Peter G Jacobs
The transition from pregnancy into parturition is physiologically directed by maternal, fetal and placental tissues. We hypothesize that these processes may be reflected in maternal physiological metrics. We enrolled pregnant participants in the third-trimester (n = 118) to study continuously worn smart ring devices monitoring heart rate, heart rate variability, skin temperature, sleep and physical activity from negative temperature coefficient, 3-D accelerometer and infrared photoplethysmography sensors...
August 19, 2023: NPJ Digital Medicine
https://read.qxmd.com/read/37471169/nanomedicines-for-improved-management-of-ectopic-pregnancy-a-narrative-review
#3
REVIEW
Abraham S Moses, Tetiana Korzun, Babak Mamnoon, Maureen K Baldwin, Leslie Myatt, Oleh Taratula, Olena R Taratula
Ectopic pregnancy (EP) - the implantation of an embryo outside of the endometrial cavity, often in the fallopian tube - is a significant contributor to maternal morbidity and leading cause of maternal death due to hemorrhage in first trimester. Current diagnostic modalities including human chorionic gonadotropin (hCG) quantification and ultrasonography are effective, but may still misdiagnose EP at initial examination in many cases. Depending on the patient's hemodynamic stability and gestational duration of the pregnancy, as assessed by history, hCG measurement and ultrasonography, management strategies may include expectant management, chemotherapeutic treatment using methotrexate (MTX), or surgical intervention...
July 20, 2023: Small
https://read.qxmd.com/read/37452511/glutathione-responsive-methotrexate-polymersomes-for-potential-management-of-ectopic-pregnancy
#4
JOURNAL ARTICLE
Babak Mamnoon, Abraham S Moses, Subisha Sundaram, Constanze J Raitmayr, Terry Morgan, Maureen K Baldwin, Leslie Myatt, Oleh Taratula, Olena R Taratula
The first-line treatment for ectopic pregnancy (EP), the chemotherapeutic methotrexate (MTX), has a failure rate of more than 10%, which can lead to severe complications or death. Inadequate accumulation of administered MTX at the ectopic implantation site significantly contributes to therapeutic failure. This study reports the first glutathione-responsive polymersomes for efficient delivery of MTX to the implantation site and its triggered release in placental cells. Fluorescence and photoacoustic imaging have confirmed that the developed polymersomes preferentially accumulate after systemic administration in the implantation site of pregnant mice at early gestational stages...
July 14, 2023: Small
https://read.qxmd.com/read/37120055/care-plan-for-individuals-at-risk-for-preeclampsia-shared-approach-to-education-strategies-for-prevention-surveillance-and-follow-up
#5
JOURNAL ARTICLE
James M Roberts, Tekoa L King, John R Barton, Stacy Beck, Ira M Bernstein, Tiffany E Buck, Michele A Forgues-Lackie, Francesca L Facco, Alison D Gernand, Cornelia R Graves, Arundhati Jeyabalan, Alisse Hauspurg, Tracy A Manuck, Jenny E Myers, Trashaun M Powell, Elizabeth F Sutton, Elizabeth Tinker, Eleni Tsigas, Leslie Myatt
Preeclampsia is a multisystemic disorder of pregnancy that affects 250,000 pregnant individuals in the United States and approximately 10 million worldwide per annum. Preeclampsia is associated with significant immediate morbidity and mortality but also long-term morbidity for both mother and offspring. It is now clearly established that a low dose of aspirin given daily beginning early in pregnancy modestly reduces the occurrence of preeclampsia. Low-dose aspirin appears safe, but because there is a paucity of information about long-term effects on the infant, it is not recommended for all pregnant individuals...
April 26, 2023: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/36978967/metformin-impacts-human-syncytiotrophoblast-mitochondrial-function-from-pregnancies-complicated-by-obesity-and-gestational-diabetes-mellitus-in-a-sexually-dimorphic-manner
#6
JOURNAL ARTICLE
Jessica F Hebert, Leslie Myatt
Maternal obesity and gestational diabetes mellitus (GDM) are associated with placental dysfunction, small for gestational age (SGA) offspring, and programming of adult-onset disease. We examine how metformin, commonly used to treat type A2 GDM, affects placental metabolism as well as mitochondrial content and function. Syncytiotrophoblasts (STBs) were prepared from placentas of male and female fetuses collected at term cesarean section from lean (pre-pregnancy BMI < 25), obese (BMI > 30), and obese A2GDM women...
March 14, 2023: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/36707542/oxytocin-receptor-dna%C3%A2-methylation-is-associated-with-exogenous-oxytocin-needs-during-parturition-and-postpartum-hemorrhage
#7
JOURNAL ARTICLE
Elise N Erickson, Leslie Myatt, Joshua S Danoff, Kathleen M Krol, Jessica J Connelly
BACKGROUND: The oxytocin receptor gene (OXTR) is regulated, in part, by DNA methylation. This mechanism has implications for uterine contractility during labor and for prevention or treatment of postpartum hemorrhage, an important contributor to global maternal morbidity and mortality. METHODS: We measured and compared the level of OXTR DNA methylation between matched blood and uterine myometrium to evaluate blood as an indicator of uterine methylation status using targeted pyrosequencing and sites from the Illumina EPIC Array...
January 27, 2023: Commun Med (Lond)
https://read.qxmd.com/read/36695872/mono-2-ethylhexyl-phthalate-induces-transcriptomic-changes-in-placental-cells-based-on-concentration-fetal-sex-and-trophoblast-cell-type
#8
JOURNAL ARTICLE
Samantha Lapehn, Scott Houghtaling, Kylia Ahuna, Leena Kadam, James W MacDonald, Theo K Bammler, Kaja Z LeWinn, Leslie Myatt, Sheela Sathyanarayana, Alison G Paquette
Phthalates are ubiquitous plasticizer chemicals found in consumer products. Exposure to phthalates during pregnancy has been associated with adverse pregnancy and birth outcomes and differences in placental gene expression in human studies. The objective of this research was to evaluate global changes in placental gene expression via RNA sequencing in two placental cell models following exposure to the phthalate metabolite mono(2-ethylhexyl) phthalate (MEHP). HTR-8/SVneo and primary syncytiotrophoblast cells were exposed to three concentrations (1, 90, 180 µM) of MEHP for 24 h with DMSO (0...
January 25, 2023: Archives of Toxicology
https://read.qxmd.com/read/36447139/oxytocin-receptor-single-nucleotide-polymorphism-predicts-atony-related-postpartum-hemorrhage
#9
JOURNAL ARTICLE
Elise N Erickson, Kathleen M Krol, Allison M Perkeybile, Jessica J Connelly, Leslie Myatt
BACKGROUND: Postpartum hemorrhage remains a key contributor to overall maternal morbidity in the United States. Current clinical assessment methods used to predict postpartum hemorrhage are unable to prospectively identify about 40% of hemorrhage cases. Oxytocin is a first-line pharmaceutical for preventing and treating postpartum hemorrhage, which acts through oxytocin receptors on uterine myocytes. Existing research indicates that oxytocin function is subject to variation, influenced in part by differences in the DNA sequence within the oxytocin receptor gene...
November 29, 2022: BMC Pregnancy and Childbirth
https://read.qxmd.com/read/36394151/nano-theranostic-modality-for-visualization-of-the-placenta-and-photo-hyperthermia-for-potential-management-of-ectopic-pregnancy
#10
JOURNAL ARTICLE
Abraham S Moses, Leena Kadam, Anna St Lorenz, Maureen K Baldwin, Terry Morgan, Jessica Hebert, Youngrong Park, Hyelim Lee, Ananiya A Demessie, Tetiana Korzun, Babak Mamnoon, Adam W G Alani, Oleh Taratula, Leslie Myatt, Olena R Taratula
Ectopic pregnancy (EP) is the leading cause of maternity-related death in the first trimester of pregnancy. Approximately 98% of ectopic implantations occur in the fallopian tube, and expedient management is crucial for preventing hemorrhage and maternal death in the event of tubal rupture. Current ultrasound strategies misdiagnose EP in up to 40% of cases, and the failure rate of methotrexate treatment for confirmed EP exceeds 10%. Here the first theranostic strategy for potential management of EP is reported using a near-infrared naphthalocyanine dye encapsulated within polymeric nanoparticles...
November 17, 2022: Small
https://read.qxmd.com/read/36209198/characterization-of-placental-and-decidual-cell-development-in-early-pregnancy-loss-by-single-cell-rna-sequencing
#11
JOURNAL ARTICLE
Yuhua Zheng, Jing Pan, Chenglai Xia, Haiying Chen, Huadong Zhou, Weina Ju, Jerzy Wegiel, Leslie Myatt, James M Roberts, Xiaoling Guo, Nanbert Zhong
BACKGROUND: Early pregnancy loss (EPL) presents as sporadic or recurrent miscarriage during the first trimester. In addition to chromosomal defects, EPL may result from impairment of the placental-decidual interface at early gestational age due to gene-environmental interactions. METHODS: To better understand the pathogenesis associated with this impairment, cell development in chorionic villi and decidua of different forms of EPL (sporadic or recurrent) was investigated with single-cell RNA sequencing and compared to that of normal first-trimester tissue...
October 8, 2022: Cell & Bioscience
https://read.qxmd.com/read/36052275/advancing-understanding-of-maternal-age-correlating-epigenetic-clocks-in-blood-and-myometrium
#12
JOURNAL ARTICLE
Elise N Erickson, Anna K Knight, Alicia K Smith, Leslie Myatt
Background: Advanced maternal age is currently a term defined by chronological age. However, a group of biomarkers known as epigenetic clocks, which can predict morbidity and mortality, has been used to estimate measures of biological aging. Uterine myometrial function during the process of parturition may be influenced by aging, as labor dystocia, unplanned intrapartum cesarean birth, and postpartum hemorrhage are more common in older individuals. The purpose of this study was to evaluate the use of epigenetic clocks in maternal myometrium and blood for predicting age and to evaluate the correlation of epigenetic age between the tissues...
2022: Epigenetics Commun
https://read.qxmd.com/read/35863458/human-leukocyte-antigen-hla-c-hla-g-hla-f-and-hla-e-placental-profiles-are-altered-in-early-severe-preeclampsia-and-preterm-birth-with-chorioamnionitis
#13
JOURNAL ARTICLE
Caroline E Dunk, Matthew Bucher, Jianhong Zhang, Heyam Hayder, Daniel E Geraghty, Stephen J Lye, Leslie Myatt, Rinat Hackmon
BACKGROUND: The extravillous trophoblast expresses each of the non-classical MHC class I antigens - HLA-E, F, and G and a single classical class I antigen HLA-C. We recently demonstrated dynamic expression patterns of HLA-C, G and F during early EVT invasion and placentation. OBJECTIVE: In this study we investigate the hypothesis that the immune inflammatory mediated complications of pregnancy such as early preeclampsia and preterm labor, may show altered expression profiles of non-classical HLA...
July 18, 2022: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/35610640/role-of-ezh2-mediated-h3k27me3-in-placental-adam12-s-expression-implications-for-fetoplacental-growth
#14
JOURNAL ARTICLE
Ya-Nan Zhu, Xiao-Wen Gan, Fan Pan, Xiao-Tian Ni, Leslie Myatt, Wang-Sheng Wang, Kang Sun
BACKGROUND: Enhancer of zeste homolog 2 (EZH2)-mediated histone 3 lysine 27 trimethylation (H3K27me3) is a transcription silencing mark, which is indispensable for cell lineage specification at the early blastocyst stage. This epigenetic repression is maintained in placental cytotrophoblasts but is lifted when cytotrophoblasts differentiate into syncytiotrophoblasts. However, the physiological impact of this lift remains elusive. Here, we investigated whether lifting EZH2-mediated H3K27me3 during syncytialization upregulates the expression of a short secretory isoform of a disintegrin and metalloprotease 12 (ADAM12-S), a well-recognized placenta-derived protease that cleaves insulin-like growth factor binding protein 3 to increase insulin-like growth factor (IGF) bioavailability for the stimulation of fetoplacental growth...
May 25, 2022: BMC Medicine
https://read.qxmd.com/read/35579965/neutralizing-antibody-activity-against-sars-cov-2-variants-in-gestational-age-matched-mother-infant-dyads-after-infection-or-vaccination
#15
JOURNAL ARTICLE
Yusuke Matsui, Lin Li, Mary Prahl, Arianna G Cassidy, Nida Ozarslan, Yarden Golan, Veronica J Gonzalez, Christine Y Lin, Unurzul Jigmeddagva, Megan A Chidboy, Mauricio Montano, Taha Y Taha, Mir M Khalid, Bharath Sreekumar, Jennifer M Hayashi, Pei-Yi Chen, G Renuka Kumar, Lakshmi Warrier, Alan Hb Wu, Dongli Song, Priya Jegatheesan, Daljeet S Rai, Balaji Govindaswami, Jordan Needens, Monica Rincon, Leslie Myatt, Ifeyinwa V Asiodu, Valerie J Flaherman, Yalda Afshar, Vanessa L Jacoby, Amy P Murtha, Joshua F Robinson, Melanie Ott, Warner C Greene, Stephanie L Gaw
Pregnancy confers unique immune responses to infection and vaccination across gestation. To date, there are limited data comparing vaccine- and infection-induced neutralizing Abs (nAbs) against COVID-19 variants in mothers during pregnancy. We analyzed paired maternal and cord plasma samples from 60 pregnant individuals. Thirty women vaccinated with mRNA vaccines (from December 2020 through August 2021) were matched with 30 naturally infected women (from March 2020 through January 2021) by gestational age of exposure...
June 22, 2022: JCI Insight
https://read.qxmd.com/read/34639216/differences-in-glycolysis-and-mitochondrial-respiration-between-cytotrophoblast-and-syncytiotrophoblast-in-vitro-evidence-for-sexual-dimorphism
#16
COMPARATIVE STUDY
Matthew Bucher, Leena Kadam, Kylia Ahuna, Leslie Myatt
In the placenta the proliferative cytotrophoblast cells fuse into the terminally differentiated syncytiotrophoblast layer which undertakes several energy-intensive functions including nutrient uptake and transfer and hormone synthesis. We used Seahorse glycolytic and mitochondrial stress tests on trophoblast cells isolated at term from women of healthy weight to evaluate if cytotrophoblast (CT) and syncytiotrophoblast (ST) have different bioenergetic strategies, given their different functions. Whereas there are no differences in basal glycolysis, CT have significantly greater glycolytic capacity and reserve than ST...
October 8, 2021: International Journal of Molecular Sciences
https://read.qxmd.com/read/34450420/the-global-pregnancy-collaboration-colab-biobank-of-rare-placentas
#17
JOURNAL ARTICLE
Jennifer Makin, Kasey Blount, Leslie Myatt, James M Roberts
Many adverse pregnancy outcomes are the result of placental disorders. It has been difficult to decipher the root cause of many of these disorders due to an overlap in identifiable placental pathology and pregnancy outcomes. The reason for this confusion may be related to the lack of an appropriate control placenta. An ideal control placenta that is not related to adverse pregnancy outcomes is rare. We propose our pooled database at the Global Pregnancy Collaboration (CoLab) could be a solution for researchers...
October 2021: Placenta
https://read.qxmd.com/read/34185432/c-ebp%C3%AE-drives-key-endocrine-signals-in-the-human-amnion-at-parturition
#18
JOURNAL ARTICLE
Jiang-Wen Lu, Wang-Sheng Wang, Qiong Zhou, Li-Jun Ling, Hao Ying, Yun Sun, Leslie Myatt, Kang Sun
Amnion-derived prostaglandin E2 (PGE2) and cortisol are key to labor onset. Identification of a common transcription factor driving the expression of both cyclooxygenase-2 (COX-2) and 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), the key enzymes in their production, may hold the key to the treatment of pre-term labor. Here, we have found that the CCAAT enhancer binding protein δ (C/EBPδ) is such a transcription factor which underlies the feed-forward induction of COX-2 and 11β-HSD1 expression by their own products PGE2 and cortisol in human amnion fibroblasts so that their production would be ensured in the amnion for the onset of labor...
June 2021: Clinical and Translational Medicine
https://read.qxmd.com/read/33785181/the-prediction-of-preeclampsia-the-way-forward
#19
REVIEW
Leslie Myatt
Despite intensive investigation, we still cannot adequately predict, treat, or prevent preeclampsia. We have gained awareness that preeclampsia is a syndrome not a disease and is heterogeneous in its presentation and pathophysiology, which may indicate differing underlying phenotypes, and that the impact extends beyond pregnancy per se. Effects on the fetus and mother extend many years after pregnancy, as evidenced by fetal programming of adult disease and increased risk of the development of maternal cardiovascular disease...
February 2022: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/33775113/subtypes-of-preeclampsia-recognition-and-determining-clinical-usefulness
#20
REVIEW
James M Roberts, Janet W Rich-Edwards, Thomas F McElrath, Lana Garmire, Leslie Myatt
The concept that preeclampsia is a multisystemic syndrome is appreciated in both research and clinical care. Our understanding of pathophysiology recognizes the role of inflammation, oxidative and endoplasm reticulum stress, and angiogenic dysfunction. Yet, we have not progressed greatly toward clinically useful prediction nor had substantial success in prevention or treatment. One possibility is that the maternal syndrome may be reached through different pathophysiological pathways, that is, subtypes of preeclampsia, that in their specificity yield more clinical utility...
May 5, 2021: Hypertension
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