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Leslie Myatt

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https://www.readbyqxmd.com/read/28443479/melatonin-improves-mitochondrial-respiration-in-syncytiotrophoblasts-from-placentas-of-obese-women
#1
Kayla E Ireland, Alina Maloyan, Leslie Myatt
Maternal obesity is associated with increased oxidative stress but decreased placental mitochondrial respiration and expression of mitochondrial electron transport chain (ETC) complexes I to V. Melatonin acts as an antioxidant and prevents oxidative stress-induced changes in cytotrophoblasts. Placentas were collected at term by cesarean delivery from obese (first trimester body mass index [BMI] ≥30, n = 10) or lean (BMI < 25, n = 6) women. Cytotrophoblasts were isolated and allowed to syncytialize for 72 hours with or without melatonin (0...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28325691/preface-ifpa-meeting-2016
#2
Leslie Myatt
No abstract text is available yet for this article.
March 14, 2017: Placenta
https://www.readbyqxmd.com/read/28323983/autophagic-degradation-of-collagen-1a1-by-cortisol-in-human-amnion-fibroblasts
#3
Yabing Mi, Wangsheng Wang, Chuyue Zhang, Chao Liu, Jiangwen Lu, Wenjiao Li, Rujuan Zuo, Leslie Myatt, Kang Sun
Rupture of fetal membranes can initiate parturition at both term and preterm. Collagen is the crucial factor determining the tensile strength of the membranes. Toward the end of gestation, a feed-forward regeneration of cortisol via 11β-hydroxysteroid dehydrogenase 1 exists in fetal membranes. It remains undetermined whether cortisol contributes to collagen reduction in fetal membranes. In this study, we have examined whether cortisol accumulation is a causative factor for collagen reduction in human amnion fibroblasts, the major source of collagens in the membranes...
April 1, 2017: Endocrinology
https://www.readbyqxmd.com/read/28292470/sexual-dimorphism-in-the-effect-of-maternal-obesity-on-antioxidant-defense-mechanisms-in-the-human-placenta
#4
LaShauna Evans, Leslie Myatt
INTRODUCTION: Maternal obesity creates an adverse intrauterine environment, negatively impacts placental respiration, is associated with a higher incidence of pregnancy complications and programs the offspring for disease in adult life in a sexually dimorphic manner. We defined the effect of maternal obesity and fetal sex on pro- and anti-oxidant status in placenta and placental mitochondria. METHODS: Placental villous tissue was collected at term via c-section prior to labor from four groups of patients based on fetal sex and prepregnancy/1st trimester body mass index: lean - BMI 22...
March 2017: Placenta
https://www.readbyqxmd.com/read/28284454/ifpa-meeting-2016-workshop-report-ii-placental-imaging-placenta-and-development-of-other-organs-sexual-dimorphism-in-placental-function-and-trophoblast-cell-lines
#5
Jennifer Adibi, Graham J Burton, Vicki Clifton, Sally Collins, Antonio E Frias, Lobke Gierman, Peta Grigsby, Helen Jones, Cheryl Lee, Alina Maloyan, Udo R Markert, Diana M Morales-Prieto, Padma Murthi, Leslie Myatt, Jurgen Pollheimer, Victoria Roberts, Wendy Robinson, Carolyn Salafia, Matthias Schabel, Dinesh Shah, John Sled, Cathy Vaillancourt, Maja Weber, Perrie F O'Tierney-Ginn
Workshops are an important part of the IFPA annual meeting as they allow for discussion of specialized topics. At IFPA meeting 2016 there were twelve themed workshops, four of which are summarized in this report. These workshops addressed challenges, strengths and limitations of techniques and model systems for studying the placenta, as well as future directions for the following areas of placental research: 1) placental imaging; 2) sexual dimorphism; 3) placenta and development of other organs; 4) trophoblast cell lines...
March 6, 2017: Placenta
https://www.readbyqxmd.com/read/28012455/maternal-obesity-alters-brain-derived-neurotrophic-factor-bdnf-signaling-in-the-placenta-in-a-sexually-dimorphic-manner
#6
Calais S Prince, Alina Maloyan, Leslie Myatt
INTRODUCTION: Obesity is a major clinical problem in obstetrics being associated with adverse pregnancy outcomes and fetal programming. Brain derived neurotrophic factor (BDNF), a validated miR-210 target, is necessary for placental development, fetal growth, glucose metabolism, and energy homeostasis. Plasma BDNF levels are reduced in obese individuals; however, placental BDNF has yet to be studied in the context of maternal obesity. In this study, we investigated the effect of maternal obesity and sexual dimorphism on placental BDNF signaling...
January 2017: Placenta
https://www.readbyqxmd.com/read/27533889/inhibition-of-lysyl-oxidase-by-cortisol-regeneration-in-human-amnion-implications-for-rupture-of-fetal-membranes
#7
Chao Liu, Chunming Guo, Wangsheng Wang, Ping Zhu, Wenjiao Li, Yabing Mi, Leslie Myatt, Kang Sun
The mechanisms underlying human parturition are still not understood, yet we need this knowledge to combat preterm birth. Fetal membranes express abundant 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1), which converts inert cortisone to active cortisol. We examined whether cortisol regeneration in the amnion might play a role in human parturition through regulation of lysyl oxidase (LOX), a collagen cross-linking enzyme, thereby contributing to the rupture of fetal membranes. By using cultured human primary amnion fibroblasts, we demonstrated that, in addition to the induction of the key enzymes involved in prostaglandin E2 (PGE2) synthesis, cortisol stimulated 11β-HSD1 and inhibited LOX reciprocally...
October 2016: Endocrinology
https://www.readbyqxmd.com/read/27398706/cell-free-total-and-fetal-dna-in-first-trimester-maternal-serum-and-subsequent-development-of-preeclampsia
#8
Robert M Silver, Leslie Myatt, John C Hauth, Kenneth J Leveno, Alan M Peaceman, Susan M Ramin, Philip Samuels, George Saade, Yoram Sorokin, Rebecca G Clifton, Uma M Reddy
Objective The objective of this study was to assess the relationship between first trimester cell-free total and fetal DNA in maternal plasma and the subsequent development of preeclampsia. Study Design Nested case-control study of patients enrolled in the Combined Antioxidant and Preeclampsia Prediction Studies prediction study of 175 women who did and 175 women who did not develop preeclampsia. The predictive values of cell-free total and fetal DNA and the subsequent development of preeclampsia were measured using receiver operating characteristic curves...
January 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/27147475/corrigendum-to-inhibition-of-lysyl-oxidase-by-prostaglandin-e2-via-ep2-ep4-receptors-in-human-amnion-fibroblasts-implications-for-parturition-mol-cell-endocrinol-424-2016-118-127
#9
Chao Liu, Ping Zhu, Wangsheng Wang, Wenjiao Li, Qun Shu, Zi-Jiang Chen, Leslie Myatt, Kang Sun
No abstract text is available yet for this article.
June 15, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27120478/is-mid-trimester-insulin-resistance-predictive-of-subsequent-puerperal-infection-a-secondary-analysis-of-randomized-trial-data
#10
Brenna L Hughes, Rebecca G Clifton, John C Hauth, Kenneth J Leveno, Leslie Myatt, Uma M Reddy, Michael W Varner, Ronald J Wapner, Brian M Mercer, Alan M Peaceman, Susan M Ramin, Jorge E Tolosa, George Saade, Yoram Sorokin
Objective The objective of this study was to examine whether there is an association between insulin resistance and subsequent development of puerperal infection by measuring insulin resistance in the mid-trimester using the homeostasis model assessment (HOMA:IR). Methods Secondary analysis of low-risk nulliparas enrolled in a multicenter preeclampsia prevention trial. HOMA:IR was measured on fasting plasma glucose and insulin concentrations among low-risk nulliparas between 22 and 26 weeks' gestation. Median HOMA:IR was compared between women who did and did not develop puerperal infection using Wilcoxon rank sum test...
August 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/26993250/mitochondrial-function-and-glucose-metabolism-in-the-placenta-with-gestational-diabetes-mellitus-role-of-mir-143
#11
Sribalasubashini Muralimanoharan, Alina Maloyan, Leslie Myatt
A predisposing factor for development of the hyperglycaemic state of gestational diabetes mellitus (GDM) is obesity. We previously showed that increasing maternal obesity is associated with significant reductions in placental mitochondrial respiration. MicroRNA (miR)-143 has been previously shown to regulate the metabolic switch from oxidative phosphorylation to aerobic glycolysis in cancer tissues. We hypothesized that mitochondrial respiration is reduced and aerobic glycolysis is up-regulated via changes in miR-143 expression in the placenta of women with GDM...
June 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/26986453/sexual-dimorphism-in-activation-of-placental-autophagy-in-obese-women-with-evidence-for-fetal-programming-from-a-placenta-specific-mouse-model
#12
Sribalasubashini Muralimanoharan, Xiaoli Gao, Susan Weintraub, Leslie Myatt, Alina Maloyan
The incidence of maternal obesity and its co-morbidities (diabetes, cardiovascular disease) continues to increase at an alarming rate, with major public health implications. In utero exposure to maternal obesity has been associated with development of cardiovascular and metabolic diseases in the offspring as a result of developmental programming. The placenta regulates maternal-fetal metabolism and shows significant changes in its function with maternal obesity. Autophagy is a cell-survival process, which is responsible for the degradation of damaged organelles and misfolded proteins...
May 3, 2016: Autophagy
https://www.readbyqxmd.com/read/26972897/placental-origins-of-adverse-pregnancy-outcomes-potential-molecular-targets-an-executive-workshop-summary-of-the-eunice-kennedy-shriver-national-institute-of-child-health-and-human-development
#13
John V Ilekis, Ekaterini Tsilou, Susan Fisher, Vikki M Abrahams, Michael J Soares, James C Cross, Stacy Zamudio, Nicholas P Illsley, Leslie Myatt, Christine Colvis, Maged M Costantine, David M Haas, Yoel Sadovsky, Carl Weiner, Erik Rytting, Gene Bidwell
Although much progress is being made in understanding the molecular pathways in the placenta that are involved in the pathophysiology of pregnancy-related disorders, a significant gap exists in the utilization of this information for the development of new drug therapies to improve pregnancy outcome. On March 5-6, 2015, the Eunice Kennedy Shriver National Institute of Child Health and Human Development of the National Institutes of Health sponsored a 2-day workshop titled Placental Origins of Adverse Pregnancy Outcomes: Potential Molecular Targets to begin to address this gap...
July 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/26826430/inhibition-of-lysyl-oxidase-by-prostaglandin-e2-via-ep2-ep4-receptors-in-human-amnion-fibroblasts-implications-for-parturition
#14
Chao Liu, Ping Zhu, Wangsheng Wang, Wenjiao Li, Qun Shu, Zi-Jiang Chen, Leslie Myatt, Kang Sun
The underlying mechanism leading to rupture of the membranes at parturition is not fully understood. Lysyl oxidase (LOX) cross-links collagen fibrils thereby increasing the tensile strength of the membranes. Thus, understanding the regulation of LOX expression may be of crucial importance for elucidation of the process of rupture of the fetal membranes. Prostaglandin E2 (PGE2), mainly produced in the amnion, plays crucial roles during human parturition. However it is not known whether PGE2 regulates LOX expression in the fetal membranes...
March 15, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/26788786/waist-to-hip-ratio-versus-body-mass-index-as-predictor-of-obesity-related-pregnancy-outcomes
#15
Mollie McDonnold, Lisa M Mele, Leslie Myatt, John C Hauth, Kenneth J Leveno, Uma M Reddy, Brian M Mercer
Objective In nonpregnant populations the waist-to-hip ratio (WHR) is a better predictor of obesity-related outcomes than body mass index (BMI). Our objective was to determine, in pregnancy, the relationship between these measures of obesity, and large-for-gestational age (LGA) and cesarean delivery (CD). Methods This is a secondary analysis of data from the Combined Antioxidant and Preeclampsia Prediction Study. Women with a WHR of ≥ 0.85 and 0.80 to 0.84 at 9 to 16 weeks gestation were compared with those with a WHR < 0...
May 2016: American Journal of Perinatology
https://www.readbyqxmd.com/read/26734917/obesity-and-placental-function
#16
REVIEW
Leslie Myatt, Alina Maloyan
An increasing number of women of reproductive age are obese which affects the continuum of pregnancy and is associated with an increased incidence of adverse maternal and fetal outcomes, including preeclampsia, preterm birth, stillbirth, congenital anomalies, and macrosomia. Maternal obesity is associated with an increased incidence of metabolic and cardiovascular disease later in life in the mother and in the offspring who are developmentally programed by the obese pregnancy environment. The placenta transduces and mediates the effect of the adverse maternal environment to the fetus...
January 2016: Seminars in Reproductive Medicine
https://www.readbyqxmd.com/read/26667417/pregnancy-and-long-term-maternal-cardiovascular-health-progress-through-harmonization-of-research-cohorts-and-biobanks
#17
REVIEW
Anne Cathrine Staff, Christopher W G Redman, David Williams, Paul Leeson, Kjartan Moe, Basky Thilaganathan, Per Magnus, Eric A P Steegers, Eleni Z Tsigas, Roberta B Ness, Leslie Myatt, Lucilla Poston, James M Roberts
No abstract text is available yet for this article.
February 2016: Hypertension
https://www.readbyqxmd.com/read/26508788/phosphorylation-of-stat3-mediates-the-induction-of-cyclooxygenase-2-by-cortisol-in-the-human-amnion-at-parturition
#18
Wangsheng Wang, Chunming Guo, Ping Zhu, Jiangwen Lu, Wenjiao Li, Chao Liu, Huiliang Xie, Leslie Myatt, Zi-Jiang Chen, Kang Sun
The induction of cyclooxygenase-2 (COX-2) and subsequent production of prostaglandin E2 (PGE2) by cortisol in the amnion contrast with the effect of cortisol on most other tissues, but this proinflammatory effect of cortisol may be a key event in human parturition (labor). We evaluated the underlying mechanism activated by cortisol in primary human amnion fibroblasts. Exposure of the amnion fibroblasts to cortisol led to the activation of the cyclic adenosine monophosphate (cAMP)-protein kinase A (PKA) pathway, which induced the phosphorylation of the kinase SRC and STAT3 (signal transducer and activator of transcription 3)...
October 27, 2015: Science Signaling
https://www.readbyqxmd.com/read/26362531/preeclampsia-syndrome-or-disease
#19
REVIEW
Leslie Myatt, James M Roberts
The focus on disease mechanisms underlying the hypertension and proteinuria defining preeclampsia has increased knowledge of the pathophysiology yet we lack both therapy and predictors. We propose this is in part due to the fact that diagnostic findings identify a "preeclampsia syndrome" but do not necessarily indicate the most important pathophysiology nor if organs are involved as cause or consequence. The increased risk for later life cardiovascular disease in women who develop preeclampsia suggests the stress test of pregnancy exposes pre-existing subclinical vascular disease...
November 2015: Current Hypertension Reports
https://www.readbyqxmd.com/read/26352680/relationship-of-early-pregnancy-waist-to-hip-ratio-versus-body-mass-index-with-gestational-diabetes-mellitus-and-insulin-resistance
#20
RANDOMIZED CONTROLLED TRIAL
Sanmaan K Basraon, Lisa Mele, Leslie Myatt, James M Roberts, John C Hauth, Kenneth J Leveno, Michael W Varner, Ronald J Wapner, John M Thorp, Alan M Peaceman, Susan M Ramin, Anthony Sciscione, Jorge E Tolosa, Yoram Sorokin
OBJECTIVE: To determine the risk of gestational diabetes mellitus (GDM) and insulin resistance (IR) in obesity defined by body mass index (BMI), waist-to-hip ratio (WHR), or both combined. METHODS: Secondary analysis of a randomized multicenter trial of antioxidant supplementation versus placebo in nulliparous low-risk women to prevent pregnancy associated hypertension. Women between 9 and 16 weeks with data for WHR and BMI were analyzed for GDM (n = 2,300)...
January 2016: American Journal of Perinatology
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