Yusuke Matsui, Lin Li, Mary Prahl, Arianna G Cassidy, Nida Ozarslan, Yarden Golan, Veronica J Gonzalez, Christine Y Lin, Unurzul Jigmeddagva, Megan A Chidboy, Mauricio Montano, Taha Y Taha, Mir M Khalid, Bharath Sreekumar, Jennifer M Hayashi, Pei-Yi Chen, G Renuka Kumar, Lakshmi Warrier, Alan Hb Wu, Dongli Song, Priya Jegatheesan, Daljeet S Rai, Balaji Govindaswami, Jordan Needens, Monica Rincon, Leslie Myatt, Ifeyinwa V Asiodu, Valerie J Flaherman, Yalda Afshar, Vanessa L Jacoby, Amy P Murtha, Joshua F Robinson, Melanie Ott, Warner C Greene, Stephanie L Gaw
Pregnancy confers unique immune responses to infection and vaccination across gestation. To date, there are limited data comparing vaccine- and infection-induced neutralizing Abs (nAbs) against COVID-19 variants in mothers during pregnancy. We analyzed paired maternal and cord plasma samples from 60 pregnant individuals. Thirty women vaccinated with mRNA vaccines (from December 2020 through August 2021) were matched with 30 naturally infected women (from March 2020 through January 2021) by gestational age of exposure...
June 22, 2022: JCI Insight