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https://www.readbyqxmd.com/read/29030443/a-novel-metabolic-pathway-for-n-methylpyrrolidone-degradation-in-alicycliphilus-sp-bq1
#1
Claudia Julieta Solís-González, Lilianha Domínguez-Malfavón, Martín Vargas-Suárez, Itzel Gaytán, Miguel Ángel Cevallos, Luis Lozano, M Javier Cruz-Gómez, Herminia Loza-Tavera
The molecular mechanisms underlying the biodegradation of N-Methylpyrrolidone (NMP), a widely used industrial solvent that produces skin irritation in humans, and is teratogenic in rats, are unknown. Alicycliphilus sp. BQ1 degrades NMP. By studying a transposon-tagged mutant unable to degrade NMP, we identified a six-gene cluster (nmpABCDEF), transcribed as a polycistronic mRNA, encoding enzymes involved in NMP biodegradation. nmpA and the transposon-affected gene nmpB encode a N-methylhydantoin amidohydrolase that would transform NMP to γ-N-methylaminobutyric acid; this would be metabolized by an aminoacid oxidase (NMPC), either by demethylation to produce γ-aminobutyric acid (GABA), or by deamination to produce succinate semialdehyde (SSA)...
October 13, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28985332/trade-offs-influencing-the-physiological-ecology-of-hibernation-in-temperate-zone-bats
#2
Craig K R Willis
Seasonality of temperature and food availability can lead to trade-offs between the benefits of immediate reproduction and costs associated with mortality risk from starvation, inclement weather, or predation. Hibernating mammals exhibit an enormous seasonal shift in physiology and behavior and provide a useful system to examine the effect of this trade-off on key events in the annual cycle. Most of what we understand about the ecological energetics and phenology of hibernation comes from studies of rodent hibernators such as ground squirrels, chipmunks, and dormice...
July 26, 2017: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/28985028/pitfalls-in-using-fluorescence-tagging-of-nanomaterials-tecto-dendrimers-in-skin-tissue-as-investigated-by-cluster-flim
#3
Pierre Volz, Priscila Schilrreff, Robert Brodwolf, Christopher Wolff, Johannes Stellmacher, Jens Balke, Maria J Morilla, Christian Zoschke, Monika Schäfer-Korting, Ulrike Alexiev
Targeted topical application promises high drug concentrations in the skin and low systemic adverse effects. To locate drugs and drug-delivery systems like nanocarriers, fluorescent dyes are commonly used as drug surrogates or nanocarrier labels in micrographs of tissue sections. Here, we investigate how labeling degree, concentration of fluorophore, and nanocarrier may affect the interpretation of these micrographs. False-negative penetration results due to inter- and intramolecular quenching effects are likely...
October 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28982114/do-weaner-pigs-need-in-feed-antibiotics-to-ensure-good-health-and-welfare
#4
Alessia Diana, Edgar G Manzanilla, Julia A Calderón Díaz, Finola C Leonard, Laura A Boyle
Antibiotics (AB) are used in intensive pig production systems to control infectious diseases and they are suspected to be a major source of antibiotic resistance. Following the ban on AB use as growth promoters in the EU, their prophylactic use in-feed is now under review. The aim of this study was to evaluate the effect of removing prophylactic in-feed AB on pig health and welfare indicators. Every Monday for six weeks, a subset of 70 pigs were weaned, tagged and sorted into two groups of 35 pigs according to weight (9...
2017: PloS One
https://www.readbyqxmd.com/read/28979327/fabrication-and-physicochemical-investigation-of-ancient-iranian-and-pakistani-treated-silver-particles-and-their-comparison-with-silver-nanoparticles
#5
Soheyla Honary, Alireza Mozaffari Dehshiri, Mahmoud Mosaddegh
Silver compounds are known to be both toxic and carcinogenic. However, silver nanoparticles have been showed diagnostic and therapeutic value. They can be used as biological tags for a quantitative detection and/or be incorporated into wound dressings and cosmetics due to their antibacterial properties. Pakistani and Iranian traditional physicians still take the advantage of silver compounds, called silver Kushta, to treat dementia, leprosy, and skin cancers. The present study compared the physicochemical properties of silver nanoparticles (AgNPs) and silver Kushtas (Pakistani silver Kushta (PKAg) and Iranian silver) in terms of the morphology, silver content, chemical composition, and suspension stability...
2017: Iranian Journal of Pharmaceutical Research: IJPR
https://www.readbyqxmd.com/read/28958595/the-mtdna-replication-related-genes-tfam-and-polg-are-associated-with-leprosy-in-han-chinese-from-southwest-china
#6
Dong Wang, Guo-Dong Li, Yu Fan, Deng-Feng Zhang, Rui Bi, Xiu-Feng Yu, Heng Long, Yu-Ye Li, Yong-Gang Yao
BACKGROUND: The pathogen Mycobacterium leprae of leprosy is heavily dependent on the host energy metabolites and nutritional products for survival. Previously we and others have identified associations of several mitochondrion-related genes and mitochondrial DNA (mtDNA) copy number alterations with leprosy and/or its subtype. We hypothesized that genetic variants of mtDNA replication-related genes would affect leprosy. OBJECTIVE: We aimed to identify genetic associations between the mtDNA replication-related genes TFAM, POLG and leprosy...
September 14, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28948431/vulvar-involvement-in-pediatric-crohn-s-disease-a-systematic-review
#7
REVIEW
Roberta Granese, Gloria Calagna, Giuliana Morabito, Carmine Carriero, Antonio Perino, Gabriele Tonni, Claudio Romano
PURPOSE: The aim of the study is to report a systematic review (from 2000 to 2017) of all pediatric cases of vulvar Crohn's disease (VCD) and to highlight the key-points for a correct diagnosis and management of this rare condition. METHODS: An electronic search using the Pubmed/Medline, Scopus, EMBASE, Cochrane database and Google Scholar database was performed according to PRISMA guidelines. RESULTS: Twenty pediatric studies and 22 cases of VCD were included for analysis...
September 25, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28943492/comparison-of-clinical-outcomes-of-multi-point-umbrella-suturing-and-single-purse-suturing-with-two-point-traction-after-procedure-for-prolapse-and-hemorrhoids-pph-surgery
#8
Huiyong Jiang, Xiuyan Hao, Ying Xin, Youzhen Pan
OBJECTIVES: To compare the clinical outcomes of multipoint umbrella suture and single-purse suture with two-point traction after procedure for prolapse and hemorrhoids surgery (PPH) for the treatment of mixed hemorrhoids. METHODS: Ninety patients were randomly divided into a PPH plus single-purse suture group (Group A) and a PPH plus multipoint umbrella suture (Group B). All operations were performed by an experienced surgeon. Operation time, width of the specimen, hemorrhoids retraction extent, postoperative pain, postoperative bleeding, and length of hospitalization were recorded and compared...
September 21, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28928537/antihyperlipidemic-activity-of-cassia-auriculata-flower-extract-in-oleic-acid-induced-hyperlipidemia-in-saccharomyces-cerevisiae
#9
Vijayakumar Rajendran, Anilkumar Krishnegowda, Vasanthi Nachiappan
The Cassia auriculata herb has been traditionally used in India for medicinal purposes to treat hyperglycemia, diabetes, rheumatism, asthma, and skin diseases. In the present study, ethanolic extract of Cassia auriculata flower (Et-CAF) depicted anti-hyperlipidemic effect in the budding yeast cells. The hyperlipidemic conditions were induced in the yeast cells with oleic acid which showed an increase in triacylglycerol (TAG) and sterol esters (SE), and was supported by the mRNA expression of LRO1 and DGA1 (involved in TAG formation); as well as ARE1 and ARE2 (involved in SE formation)...
August 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/28913302/eccrine-poroma-of-the-postauricular-area
#10
Hyun Rok Lee, Gyu Yong Jung, Hea Kyeong Shin, Dong Lark Lee, Jong Im Lee, Jung Hwan Kim
Eccrine poroma is a common benign cutaneous tumor that originates in an intraepidermal eccrine duct. This tumor exhibits acral distribution (sole, palm), and is rarely encountered in the head and neck area. In fact eccrine poroma in the postauricular area has only been rarely reported. A 55-year-old female visited our hospital with a main complaint of a mass that first developed in the left postauricular area about a year previously. The mass was painless, soft, protruding, domed, and dark red in color, and had slowly enlarged (at presentation it measured 1×1 cm)...
March 2017: Arch Craniofac Surg
https://www.readbyqxmd.com/read/28912854/comparative-proteomics-analysis-of-primary-cutaneous-amyloidosis
#11
Daxing Cai, Yang Li, Chunlei Zhou, Yulin Jiang, Jian Jiao, Lin Wu
Primary cutaneous amyloidosis (PCA) is a localized skin disorder that is characterized by the abnormal deposition of amyloid in the extracellular matrix (ECM) of the dermis. The pathogenesis of PCA is poorly understood. The objective of the present study was to survey proteome changes in PCA lesions in order to gain insight into the molecular basis and pathogenesis of PCA. Total protein from PCA lesions and normal skin tissue samples were extracted and analyzed using the isobaric tags for relative and absolute quantitation technique...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28883880/semi-lobar-holoprosencephaly-with-vertebral-segmentation-defects
#12
Birendra Rai, Farhana Sharif
Holoprosencephaly is the most common embryonic brain defect. Foetuses who survive during intrauterine life are born with varying grades of brain and facial deformities. Extra craniofacial manifestations are common. Vertebral segmentation defects are rarely seen with holoprosencephaly, mainly in association with holoprosencephaly diencephalic hamartoblastoma (HDH) association. A female infant was born at term by normal delivery. Birth head circumference was below the 3rd percentile. Antenatal scan had showed microcephaly as the only abnormality...
2017: Iranian Journal of Child Neurology
https://www.readbyqxmd.com/read/28839437/elaboration-and-validation-of-crohn-s-disease-anoperineal-lesions-consensual-definitions
#13
Clémence Horaist, Vincent de Parades, Laurent Abramowitz, Paul Benfredj, Guillaume Bonnaud, Dominique Bouchard, Nadia Fathallah, Agnès Sénéjoux, Laurent Siproudhis, Ghislain Staumont, Manuelle Viguier, Philippe Marteau
AIM: To establish consensual definitions of anoperineal lesions of Crohn's (APLOC) disease and assess interobserver agreement on their diagnosis between experts. METHODS: A database of digitally recorded pictures of APLOC was examined by a coordinating group who selected two series of 20 pictures illustrating the various aspects of APLOC. A reading group comprised: eight experts from the Société Nationale Française de Colo Proctologie group of study and research in proctology and one academic dermatologist...
August 7, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28805098/assessment-of-the-permeability-and-toxicity-of-polymeric-nanocapsules-using-the-zebrafish-model
#14
Carmen Teijeiro-Valiño, Elena Yebra-Pimentel, Jorge Guerra-Varela, Noemi Csaba, María J Alonso, Laura Sánchez
AIM: To assess the capacity of a new drug delivery nanocapsule (NC) with a double shell of hyaluronic acid and protamine to overcome biological barriers using the zebrafish model. MATERIALS & METHODS: NCs were prepared by the solvent displacement method, tagged with fluorescent makers and physicochemically characterized. Toxicity was evaluated according to the Fish Embryo Acute Toxicity test, and permeability was tested by exposing zebrafish, with and without chorion, to the fluorescent NCs...
August 14, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28751108/processing-of-mutant-n-acetyl-%C3%AE-glucosaminidase-in-mucopolysaccharidosis-type-iiib-fibroblasts-cultured-at-low-temperature
#15
O L M Meijer, H Te Brinke, R Ofman, L IJlst, F A Wijburg, N van Vlies
BACKGROUND: The autosomal recessive, neurodegenerative disorder mucopolysaccharidosis type IIIB (MPSIIIB) is caused by a deficiency of the lysosomal enzyme N-acetyl-α-glucosaminidase (NAGLU), resulting in accumulation of heparan sulfate. The disease spectrum comprises a severe, rapidly progressing (RP) phenotype and a more attenuated, slowly progressing (SP) phenotype. Previous studies showed significantly higher NAGLU activity in skin fibroblasts of SP patients when cultured at 30°C which may be relevant for development of novel therapeutic strategies...
September 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28744073/gadolinium-based-contrast-agents-in-current-practice-risks-of-accumulation-and-toxicity-in-patients-with-normal-renal-function
#16
Anju Ranga, Yatish Agarwal, Kanika J Garg
Despite being decked as the most prized compounds in the nugget box of contrast agents for clinical radiologists, and carrying an indisputable tag of safety of the US Food and Drug Administration for close to three decades, all may not be seemingly well with the family of gadolinium compounds. If the first signs of violations of primum non nocere in relation to gadolinium-based contrast agents (GBCAs) appeared in the millennium year with the first published report of skin fibrosis in patients with compromised renal function, the causal relationship between the development of nephrogenic systemic fibrosis (NSF) and GBCAs, first proposed by two European groups in 2006, further precluded their use in renocompromised patients...
April 2017: Indian Journal of Radiology & Imaging
https://www.readbyqxmd.com/read/28743815/galectin-3-inhibits-galectin-8-parkin-mediated-ubiquitination-of-group-a-streptococcus
#17
Yi-Lin Cheng, Yan-Wei Wu, Chih-Feng Kuo, Shiou-Ling Lu, Fu-Tong Liu, Robert Anderson, Chiou-Feng Lin, Yi-Ling Liu, Wan-Yu Wang, Ying-Da Chen, Po-Xing Zheng, Jiunn-Jong Wu, Yee-Shin Lin
Group A streptococcus (GAS) is an important human pathogen that causes a wide variety of cutaneous and systemic infections. Although originally thought to be an extracellular bacterium, numerous studies have demonstrated that GAS can trigger internalization into nonimmune cells to escape from immune surveillance or antibiotic-mediated killing. Epithelial cells possess a defense mechanism involving autophagy-mediated targeting and killing of GAS within lysosome-fused autophagosomes. In endothelial cells, in contrast, we previously showed that autophagy is not sufficient for GAS killing...
July 25, 2017: MBio
https://www.readbyqxmd.com/read/28743623/novel-mannose-binding-natterin-like-protein-in-the-skin-mucus-of-atlantic-cod-gadus-morhua
#18
Binoy Rajan, Deepti M Patel, Yoichiro Kitani, Kiron Viswanath, Monica F Brinchmann
This study presents the first report of purification of natterin-like protein (Nlp) in a non-venomous fish. The peptide identities of purified cod Nlp were confirmed through LC-MSMS and matched to a cod expressed sequence tag (EST). A partial cod nlp nucleotide sequence was amplified and sequenced based on this EST. Multiple sequence alignment of cod Nlp showed considerable homology with other teleost Nlps and the presence of an N-terminal jacalin-like lectin domain coupled with a C-terminal toxin domain. nlp expression was higher in skin, head kidney, liver and spleen than in other tissues studied...
September 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28719908/ultrasound-guided-intrauterine-labeling-of-rat-fetuses
#19
Hatice Gulcin Gumus, Miriam Illa, Laura Pla, Anna Gonzalez, Elena Demicheva, David Ley, Fatima Crispi, Eduard Gratacos
AIM: To compare intra-amniotic versus fetal subcutaneous injections for selective fetal labeling in multifetal rat pregnancies. METHODS: A total of 14 pregnant rats were randomized to receive intra-amniotic injections of dyes (including Fluorescein, Indigo Carmine, or Evans Blue) or fetal subcutaneous injections (of commercial tattoo ink) both guided by ultrasound at 15-17 days of gestation. Survival, injection, and labeling success rates of both techniques were compared...
July 18, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28719437/a-12-day-old-male-with-a-skin-tag-on-the-chin
#20
Syed M Abedi, Freya Van Driessche, Jaime Alexander, Edward Heilman, Sharon Glick
No abstract text is available yet for this article.
July 14, 2017: American Journal of Dermatopathology
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