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https://www.readbyqxmd.com/read/29456618/an-unusual-presentation-of-adult-t-cell-leukemia-lymphoma
#1
Mohammed Tag-Adeen, Keiichi Hashiguchi, Yuko Akazawa, Ken Ohnita, Sawayama Yasushi, Niino Daisuke, Kazuhiko Nakao
Adult T-cell Leukemia/Lymphoma (ATL) is a rare disease, related to human T-lymphotropic virus-1 (HTLV-1) and presented mainly in adulthood by generalised lymphadenopathy, hepatosplenomegaly, skin lesions and hypercalcaemia, with rare gastrointestinal and/or oral manifestations. We reported this case to raise awareness and demonstrate the therapeutic challenges of this rare disease. A 49-year-old Japanese female presented with skin papules on both forearms, painful mouth ulcers and multiple neck swellings since early February 2017...
2018: Ecancermedicalscience
https://www.readbyqxmd.com/read/29450217/a-cross-sectional-assessment-of-cutaneous-lumbosacral-and-coccygeal-physical-examination-findings-in-a-healthy-newborn-population
#2
Janelle Aby, Juliann Lipps Kim
Objective. The purpose of this study is to describe the range and frequency of cutaneous lumbosacral and coccygeal findings encountered during the newborn examination in a population of apparently healthy babies, to determine if the prevalence of these findings is associated with race/ethnicity, and to report the frequency of co-occurrence of low-risk cutaneous findings. Methods . Lumbosacral physical findings of 1121 infants were documented on well newborns at least 35 weeks or greater gestational age under the authors' care...
2018: Global Pediatric Health
https://www.readbyqxmd.com/read/29441510/translating-the-combination-of-gene-therapy-and-tissue-engineering-for-treating-recessive-dystrophic-epidermolysis-bullosa
#3
A Dakiw Piaceski, D Larouche, K Ghani, F Bisson, S Cortez Ghio, S Larochelle, M J Moulin, M Caruso, L Germain
The combination of gene therapy and tissue engineering is one of the most promising strategies for the treatment of recessive dystrophic epidermolysis bullosa (RDEB). RDEB is a rare genetic disease characterised by mutations in the COL7A1 gene, encoding type VII collagen (COLVII), which forms anchoring fibrils at the dermal-epidermal junction of the skin. This disease causes severe blistering and only palliative treatments are offered. In this study, the base of a strategy combining gene therapy and a tissue-engineered skin substitute (TES), which would be suitable for the permanent closure of skin wounds, was set-up...
February 14, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29420382/an-unusual-presentation-of-conjunctival-dermolipoma-with-a-skin-tag
#4
Ofira Zloto, Mordechai Rosner
Dermolipoma is considered the second most common benign conjunctival tumor in children after nevus. Usually, dermolipoma located just deep in the superotemporal bulbar and forniceal conjunctiva. The authors describe an uncommon presentation of dermolipoma that arise in the conjunctiva as well as in the skin of the lateral canthus. A 5-month-old baby with lateral limbal lesion involving the conjunctiva and the skin underwent excision biopsy. The pathological examination found a dermolipoma in the conjunctiva as well as in the dermis...
February 7, 2018: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/29398588/preliminary-report-surgical-outcomes-following-genitoplasty-in-children-with-moderate-to-severe-genital-atypia
#5
K J Bernabé, N J Nokoff, D Galan, D Felsen, C E Aston, P Austin, L Baskin, Y-M Chan, E Y Cheng, D A Diamond, R Ellens, A Fried, S Greenfield, T Kolon, B Kropp, Y Lakshmanan, S Meyer, T Meyer, A M Delozier, L L Mullins, B Palmer, A Paradis, P Reddy, K J Scott Reyes, M Schulte, J M Swartz, E Yerkes, C Wolfe-Christensen, A B Wisniewski, D P Poppas
INTRODUCTION: Prior studies of outcomes following genitoplasty have reported high rates of surgical complications among children with atypical genitalia. Few studies have prospectively assessed outcomes after contemporary surgical approaches. OBJECTIVE: The current study reported the occurrence of early postoperative complications and of cosmetic outcomes (as rated by surgeons and parents) at 12 months following contemporary genitoplasty procedures in children born with atypical genitalia...
February 1, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29376121/magnetosensitive-e-skins-with-directional-perception-for-augmented-reality
#6
Gilbert Santiago Cañón Bermúdez, Dmitriy D Karnaushenko, Daniil Karnaushenko, Ana Lebanov, Lothar Bischoff, Martin Kaltenbrunner, Jürgen Fassbender, Oliver G Schmidt, Denys Makarov
Electronic skins equipped with artificial receptors are able to extend our perception beyond the modalities that have naturally evolved. These synthetic receptors offer complimentary information on our surroundings and endow us with novel means of manipulating physical or even virtual objects. We realize highly compliant magnetosensitive skins with directional perception that enable magnetic cognition, body position tracking, and touchless object manipulation. Transfer printing of eight high-performance spin valve sensors arranged into two Wheatstone bridges onto 1...
January 2018: Science Advances
https://www.readbyqxmd.com/read/29361783/localization-microscopy-analyses-of-mre11-clusters-in-3d-conserved-cell-nuclei-of-different-cell-lines
#7
Marion Eryilmaz, Eberhard Schmitt, Matthias Krufczik, Franziska Theda, Jin-Ho Lee, Christoph Cremer, Felix Bestvater, Wladimir Schaufler, Michael Hausmann, Georg Hildenbrand
In radiation biophysics, it is a subject of nowadays research to investigate DNA strand break repair in detail after damage induction by ionizing radiation. It is a subject of debate as to what makes up the cell's decision to use a certain repair pathway and how the repair machinery recruited in repair foci is spatially and temporarily organized. Single-molecule localization microscopy (SMLM) allows super-resolution analysis by precise localization of single fluorescent molecule tags, resulting in nuclear structure analysis with a spatial resolution in the 10 nm regime...
January 22, 2018: Cancers
https://www.readbyqxmd.com/read/29360339/labeling-of-hyaluronic-acids-with-a-re-tricarbonyl-tag-and-percutaneous-penetration-studied-by-multimodal-imaging
#8
Lucas Henry, Nicolas Delsuc, Cécile Laugel, François Lambert, Christophe Sandt, Sarah Hostachy, Anne-Sophie Bernard, Hélène Charlotte Bertrand, Laurence Grimaud, Arlette Baillet-Guffroy, Clotilde Policar
Hyaluronic acids were labeled with a Single Core Multimodal Probe for Imaging (SCoMPI) and their penetration into human skin biopsies was studied using both IR microscopy and fluorescence imaging. The penetration was shown to be dependent on the molecular weight of the molecule and limited to the upper layer of the skin.
January 23, 2018: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/29325989/proteomic-analysis-reveals-the-important-roles-of-alpha-5-collagen-and-atp5%C3%AE-during-skin-ulceration-syndrome-progression-of-sea-cucumber-apostichopus-japonicus
#9
Zelong Zhao, Jingwei Jiang, Yongjia Pan, Hongjuan Sun, Xiaoyan Guan, Shan Gao, Zhong Chen, Ying Dong, Zunchun Zhou
Apostichopus japonicus is one of the most important aquaculture species in China. Skin ulceration syndrome (SUS) of sea cucumber is a common and serious disease affected the development of A. japonicus culture industry. To better understand the response mechanisms of A. japonicus during SUS progression, the protein variations in the body wall of A. japonicus at different stages of SUS were investigated by a comparative proteomic approach based on isobaric tags for relative and absolute quantification. A total of 1449 proteins were identified from the samples at different SUS stages...
January 8, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29246755/the-significance-of-age-group-gender-and-skin-complexion-in-relation-to-the-clinical-distribution-of-developmental-oral-mucosal-alterations-in-5-13-year-old-children
#10
Rima A Safadi, Ashraf I Shaweesh, Abed AlHadi Hamasha, Reem Azzam, Melanie Alazzam, Darshan Devang Divakar
INTRODUCTION: To describe the relationship and impact of age group, gender and skin complexion on the prevalence and clinical distribution of oral mucosal alterations of developmental origin (OMA-DO) among school children aged 5-13. METHODS: A randomized representative national survey of Jordanian school children including all Country geographic areas was performed. Cut-off age that significantly correlated with presence and distribution of OMA-DO was identified (ROC curve)...
December 12, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29241760/miscellaneous-skin-disease-and-the-metabolic-syndrome
#11
Sila Seremet, Mehmet Salih Gurel
The link between the metabolic syndrome (MetS) and skin diseases is increasingly important, with new associations being discovered. The association between MetS and psoriasis or MetS and hidradenitis suppurativa is well known, although the relationship between MetS and various autoimmune or inflammatory diseases has only recently attracted interest. Some inflammatory skin diseases, such as vitiligo, scleredema, recurrent aphthous stomatitis, Behçet disease, rosacea, necrobiosis lipoidica, granuloma annulare, skin tags, knuckle pads, and eruptive xanthomas, have possible associations with MetS...
January 2018: Clinics in Dermatology
https://www.readbyqxmd.com/read/29198720/mutations-in-tubb4b-cause-a-distinctive-sensorineural-disease
#12
Romain Luscan, Sabrina Mechaussier, Antoine Paul, Guoling Tian, Xavier Gérard, Sabine Defoort-Dellhemmes, Natalie Loundon, Isabelle Audo, Sophie Bonnin, Jean-François LeGargasson, Julien Dumont, Nicolas Goudin, Meriem Garfa-Traoré, Marc Bras, Aurore Pouliet, Bettina Bessières, Nathalie Boddaert, José-Alain Sahel, Stanislas Lyonnet, Josseline Kaplan, Nicholas J Cowan, Jean-Michel Rozet, Sandrine Marlin, Isabelle Perrault
Leber congenital amaurosis (LCA) is a neurodegenerative disease of photoreceptor cells that causes blindness within the first year of life. It occasionally occurs in syndromic metabolic diseases and plurisystemic ciliopathies. Using exome sequencing in a multiplex family and three simplex case subjects with an atypical association of LCA with early-onset hearing loss, we identified two heterozygous mutations affecting Arg391 in β-tubulin 4B isotype-encoding (TUBB4B). Inspection of the atomic structure of the microtubule (MT) protofilament reveals that the β-tubulin Arg391 residue contributes to a binding pocket that interacts with α-tubulin contained in the longitudinally adjacent αβ-heterodimer, consistent with a role in maintaining MT stability...
December 7, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29195813/clinical-pathologic-conference-diffuse-papillomatous-lesions-of-the-gingiva-with-posterolateral-neck-skin-tags
#13
Susie I Lin, Joseph R Mort, Paul M Hinchey, James S Lewis, Jeffrey Zwerner
No abstract text is available yet for this article.
November 6, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29178669/identification-of-polystyrene-nanoparticle-penetration-across-intact-skin-barrier-as-rare-event-at-sites-of-focal-particle-aggregations
#14
Nadine Döge, Sabrina Hadam, Pierre Volz, Alexander Wolf, Karl-Heinz Schönborn, Ulrike Blume-Peytavi, Ulrike Alexiev, Annika Vogt
The question whether nanoparticles can cross the skin barrier is highly debated. Even in intact skin rare events of deeper penetration have been reported, but technical limitations and possible artefacts require careful interpretation. In this study, horizontal scanning by two-photon microscopy (2 PM) of full-thickness human skin samples placed in a lateral position yielded highly informative images for skin penetration studies of fluorescently tagged nanoparticles. Scanning of large fields of view allowed for detailed information on interfollicular and follicular penetration in tissue blocks without damaging the sample...
November 27, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/29152236/low-levels-of-very-long-chain-n-3-pufa-in-atlantic-salmon-salmo-salar-diet-reduce-fish-robustness-under-challenging-conditions-in-sea-cages
#15
Marta Bou, Gerd M Berge, Grete Baeverfjord, Trygve Sigholt, Tone-Kari Østbye, Bente Ruyter
The present study aimed to determine the minimum requirements of the essential n-3 fatty acids EPA and DHA in Atlantic salmon (Salmo salar) that can secure their health under challenging conditions in sea cages. Individually tagged Atlantic salmon were fed 2, 10 and 17 g/kg of EPA + DHA from 400 g until slaughter size (about 3·5 kg). The experimental fish reared in sea cages were subjected to the challenging conditions typically experienced under commercial production. Salmon receiving the lowest EPA + DHA levels showed lower growth rates in the earlier life stages, but no significant difference in final weights at slaughter...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29133662/a-tiny-tick-can-cause-a-big-health-problem
#16
Manuel John, M Raman, Keith Ryan
Ticks are tiny crawling bugs in the spider family that feed by sucking blood from animals. They are second only to mosquitoes as vectors of human disease, both infectious and toxic. Infected ticks spread over a hundred diseases, some of which are fatal if undetected. They spread the spirochete (which multiplies in the insect's gut) with a subsequent bite to the next host. We describe the only reported cases of peri ocular tick bite from India that presented to us within a span of 3 days and its management. Due suspicion and magnification of the lesions revealed the ticks which otherwise masqueraded as small skin tags/moles on gross examination...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29094481/cxcl-10-and-interleukin-6-are-reliable-serum-markers-for-vitiligo-activity-a-multicenter-cross-sectional-study
#17
Marwa Abdallah, Medhat El-Mofty, Tag Anbar, Hoda Rasheed, Samia Esmat, Amira Al-Tawdy, Marwa M Fawzy, Dalia Abdel-Halim, Rehab Hegazy, Heba Gawdat, Dalia Bassiouny, Mona A Ibrahim, Iman Sany, Mahy El-Bassiouny, Mohamed Khalil, Abeer Abdel-Aziz, Zeinab M El Maadawi, Wedad Z Mostafa
This cross-sectional multicenter study aimed to evaluate serum CXCL-10, as an activity marker for vitiligo, and compare it with other putative serum and tissue markers. Serum CXCL-10 was compared to interferon gamma (IFN-γ), interleukin 6 (IL-6), and IL-17 using ELISA in 55 non-segmental vitiligo patients (30 active and 25 stable) and 30 healthy controls. Marginal skin biopsy was taken for immunohistochemical evaluation of CD8+T cells and CXCL-10+ve cells. Serum levels of CXCL-10, IL-17, and IL-6 were elevated in all vitiligo patients compared to controls (p < ...
November 1, 2017: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29060797/nfc-enabled-tattoo-like-stretchable-biosensor-manufactured-by-cut-and-paste-method
#18
Hyoyoung Jeong, Taewoo Ha, Irene Kuang, Linxiao Shen, Zhaohe Dai, Nan Sun, Nanshu Lu
The wearables industry is lacking in devices that have the ability to provide valuable biometrics data in a soft, wireless and disposable system. Such a system should be high performance, multifunctional, but battery-free and low cost. Near field communication (NFC) is a wireless communication protocol built in many smartphones nowadays that can read data from battery-free passive tags. As a result, NFC-enabled wearable biosensors have been reported, but they are either unstretchable or have to be manufactured by labor- and time-intensive photolithography and transfer-printing processes...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29051401/symptomatic-pile-tailored-procedure-a-new-perspective-for-hemorrhoidal-disease-treatment
#19
Claudio Elbetti, Iacopo Giani, Eugenio Novelli, Jacopo Martellucci, Francesco Feroci
AIM: Aim of the present paper was to evaluate the role of tailored different single pile treatment in the clinical outcome of hemorrhoids. MATERIAL OF STUDY: The surgical strategy considered to treat only pathological piles with different procedure according to each pathological Goligher's degree, presence of fibrous, inelastic redundant internal pile(F) and presence of external pathological pile (external pile congestion or subversion of dental line (E) and skin tag not tolerated from the patient (S))...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29030443/a-novel-metabolic-pathway-for-n-methylpyrrolidone-degradation-in-alicycliphilus-sp-bq1
#20
Claudia Julieta Solís-González, Lilianha Domínguez-Malfavón, Martín Vargas-Suárez, Itzel Gaytán, Miguel Ángel Cevallos, Luis Lozano, M Javier Cruz-Gómez, Herminia Loza-Tavera
The molecular mechanisms underlying the biodegradation of N-Methylpyrrolidone (NMP), a widely used industrial solvent that produces skin irritation in humans, and is teratogenic in rats, are unknown. Alicycliphilus sp. BQ1 degrades NMP. By studying a transposon-tagged mutant unable to degrade NMP, we identified a six-gene cluster (nmpABCDEF), transcribed as a polycistronic mRNA, encoding enzymes involved in NMP biodegradation. nmpA and the transposon-affected gene nmpB encode a N-methylhydantoin amidohydrolase that would transform NMP to γ-N-methylaminobutyric acid; this would be metabolized by an aminoacid oxidase (NMPC), either by demethylation to produce γ-aminobutyric acid (GABA), or by deamination to produce succinate semialdehyde (SSA)...
October 13, 2017: Applied and Environmental Microbiology
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