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https://www.readbyqxmd.com/read/28641031/treatment-options-for-nonalcoholic-steatohepatitis-a-safety-evaluation
#1
Danny Issa, Julia Wattacheril, Arun J Sanyal
Introduction There is an urgent as yet unmet need to develop highly effective and safe therapeutics for nonalcoholic fatty liver disease (NAFLD). The remarkable progress in understanding NAFLD pathogenesis allowed the identification of injury pathways which may be recruited as therapy targets. Areas covered This article reviews the safety and tolerability data of the NAFLD therapies and explains the mechanistic basis for each of the established and investigational drugs. Treatment targets include: weight loss, anti-metabolic agents such as lipid lowering and anti-diabetic drugs, inflammation, fibrosis and others such as targeting gut microbiota, immune modulation and apoptosis...
June 22, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28636832/nutrient-deficiencies-are-common-prior-to-bariatric-surgery
#2
Leigh A Frame-Peterson, Robin D Megill, Suzanne Carobrese, Michael Schweitzer
Obesity, defined as a body mass index >30 kg/m(2), is a growing worldwide epidemic currently effecting 1 in 10 adults, with rates as high as 40% in the United States. The only proven long-term treatment of severe obesity on a population level is surgical modification of the gastrointestinal anatomy to induce weight loss, termed bariatric surgery. With adequate physician guidance and appropriate candidate criteria, bariatric surgery is an option for effective long-term treatment of obesity and its related comorbidities...
June 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/28634364/lipid-changes-8-years-post-gastric-bypass-in-adolescents-with-severe-obesity-fabs-5-study
#3
Amy S Shah, Todd Jenkins, Zhiqian Gao, Stephen R Daniels, Elaine M Urbina, Shelley Kirk, Robert Siegel, Thomas H Inge
OBJECTIVE: Severe obesity in adolescents is increasing and few effective treatments exist. Bariatric surgery is one option, but the extent to which surgery influences cardiovascular risk factors over time in youth is not clear. We hypothesized that Roux-en Y gastric bypass (RYGB) would be associated with sustained improvements in lipids over time (>5 years). PARTICIPANTS/METHODS: Youth who underwent RYGB from 2001-2007 were recruited for the Follow-up of Adolescent Bariatric Surgery-5+ (FABS-5+) in 2011-2014...
June 21, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28633561/regulation-of-energy-homeostasis-after-gastric-bypass-surgery
#4
Martin L Yarmush, Matthew D'Alessandro, Nima Saeidi
The obesity epidemic continues to escalate each year in the United States more than anywhere else in the world. The existing pharmaceutical and other nonsurgical treatments for morbid obesity produce suboptimal physiologic outcomes compared with those of Roux-en-Y gastric bypass (RYGB) surgery. RYGB has been the gold standard of bariatric surgery because the beneficial long-term outcomes, which include sustainable weight loss and type 2 diabetes mellitus (T2DM) resolution, are far superior to those obtained with other bariatric surgeries...
June 21, 2017: Annual Review of Biomedical Engineering
https://www.readbyqxmd.com/read/28622165/thoracic-imaging-after-bariatric-surgery
#5
Samuel J Galgano, Sushilkumar K Sonavane, Rupan Sanyal, Satinder P Singh, Christine O Menias, Sanjeev Bhalla
Obesity and its association with long-term health problems constitutes one of the major challenges in medicine. Though diet regulation and exercise are the primary treatment strategies, surgery is the most reliable long-term solution. Although bariatric surgical complications continue to decline, prompt recognition is essential to optimize patient outcomes. Despite their relative rarity, it is important to recognize thoracic complications, as several of these can result in severe morbidity and mortality. This article describes common bariatric surgical procedures performed, their expected postoperative appearances, and intrathoracic complications...
June 15, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28613044/for-debate-should-bariatric-surgery-be-performed-in-children-and-adolescents-with-hypothalamic-obesity
#6
EDITORIAL
Sarka Stolbova, Marek Benes, Lenka Petruzelkova, Jan Lebl, Stanislava Kolouskova
Hypothalamic dysfunction leading to severe obesity is a serious long-term consequence of paediatric craniopharyngioma. It compromises quality of life, leads to long-term metabolic hazards, and may shorten life expectancy. Therefore, a proactive approach is required. Conventional treatment of hypothalamic obesity is difficult and hardly successful. Experience with bariatric surgery is limited, especially in younger patients. Two retrospective studies recently reported on classic bariatric surgery in a small series of individuals after craniopharyngioma...
June 2017: Pediatric Endocrinology Reviews: PER
https://www.readbyqxmd.com/read/28602794/long-term-outcome-of-laparoscopic-adjustable-gastric-banding-lagb-results-of-a-swiss-single-center-study-of-405-patients-with-up-to-18-years-follow-up
#7
Fabrizio Vinzens, Ashley Kilchenmann, Valentin Zumstein, Marc Slawik, Martina Gebhart, Ralph Peterli
BACKGROUND: In the past, laparoscopic adjustable gastric banding (LAGB) seemed to be a promising bariatric procedure. However, many studies showed high rates of reoperation due to complications or insufficient weight loss. There is a lack of long-term studies with follow-up beyond 15 years. OBJECTIVE: To conduct long-term follow-up of patients after LAGB and analyze their weight loss as a primary endpoint. SETTING: Tertiary referral center for bariatric surgery, St...
April 29, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28601866/cost-utility-analysis-of-bariatric-surgery-in-italy-results-of-decision-analytic-modelling
#8
Marcello Lucchese, Oleg Borisenko, Lorenzo Giovanni Mantovani, Paolo Angelo Cortesi, Giancarlo Cesana, Daniel Adam, Elisabeth Burdukova, Vasily Lukyanov, Nicola Di Lorenzo
OBJECTIVE: To evaluate the cost-effectiveness of bariatric surgery in Italy from a third-party payer perspective over a medium-term (10 years) and a long-term (lifetime) horizon. METHODS: A state-transition Markov model was developed, in which patients may experience surgery, post-surgery complications, diabetes mellitus type 2, cardiovascular diseases or die. Transition probabilities, costs, and utilities were obtained from the Italian and international literature...
June 10, 2017: Obesity Facts
https://www.readbyqxmd.com/read/28600117/long-term-effects-of-bariatric-surgery-in-patients-with-obesity-and-chromosome-16-p11-2-microdeletion
#9
Felipe M Kristensson, Johanna C Andersson-Assarsson, Noora Kanerva, Markku Peltonen, Björn Carlsson, Lena M S Carlsson
BACKGROUND: Chromosome 16 p11.2 microdeletion is associated with early-onset obesity. Information is limited about the effect of bariatric surgery in patients with genetic obesity. OBJECTIVE: To examine the effects of bariatric surgery in obese patients with chromosome 16 p11.2 microdeletion. SETTING: Academic research institution. METHODS: The Swedish Obese Subjects study is a prospective study with 2010 participants receiving bariatric surgery...
April 26, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28600115/examination-of-bariatric-surgery-facebook-support-groups-a-content-analysis
#10
Afton M Koball, Dylan J Jester, Sarah E Domoff, Kara J Kallies, Karen B Grothe, Shanu N Kothari
BACKGROUND: Support following bariatric surgery is vital to ensure long-term postoperative success. Many individuals undergoing bariatric surgery are turning to online modalities, especially the popular social media platform Facebook, to access support groups and pages. Despite evidence suggesting that the majority of patients considering bariatric surgery are utilizing online groups, little is known about the actual content of these groups. OBJECTIVES: The purpose of the present study was to conduct a content analysis of bariatric surgery support groups and pages on Facebook...
April 26, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28593706/does-the-ileal-brake-mechanism-contribute-to-sustained-weight-loss-after-bariatric-surgery
#11
REVIEW
Savio G Barreto, Stijn Soenen, Jacob Chisholm, Ian Chapman, Lilian Kow
Bariatric surgery is currently the most effective strategy for treating morbid obesity. Weight regain following significant weight loss, however, remains a problem, with the outcome proportional to the period of follow-up. This review revisits a well-established physiological neurohormonally-mediated feedback loop, the so called ileal brake mechanism, with a special emphasis on the gut hormone peptide tyrosine tyrosine. The manuscript not only highlights the potential role of the ileal brake mechanism in weight loss and weight maintenance thereafter following obesity surgery, it also provides a compelling argument for using this appetite suppressing feedback loop to enable sustained long-term weight loss in patients undergoing surgery for morbid obesity...
June 8, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28593484/reflux-sleeve-dilation-and-barrett-s-esophagus-after-laparoscopic-sleeve-gastrectomy-long-term-follow-up
#12
Daniel Moritz Felsenreich, Ronald Kefurt, Martin Schermann, Philipp Beckerhinn, Ivan Kristo, Michael Krebs, Gerhard Prager, Felix B Langer
BACKGROUND: Laparoscopic sleeve gastrectomy (SG) has become the most frequently performed bariatric procedure worldwide. De novo reflux might impact patients' quality of life, requiring lifelong proton pump inhibitor medication. It also increases the risk of esophagitis and formation of Barrett's metaplasia. Besides weight regain, gastroesophageal reflux disease (GERD) is the most common reason for conversion to Roux-en-Y gastric bypass. METHODS: We performed 24-h pH metries, manometries, gastroscopies, and questionnaires focusing on reflux (GIQLI, RSI) in SG patients with a follow-up of more than 10 years who did not suffer from symptomatic reflux or hiatal hernia preoperatively...
June 8, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28589529/dietary-intake-and-weight-changes-5%C3%A2-years-after-laparoscopic-sleeve-gastrectomy
#13
Ju-Jun Chou, Wei-Jei Lee, Owaid Almalki, Jung-Chien Chen, Pei-Ling Tsai, Shwu-Huey Yang
BACKGROUND: Laparoscopic sleeve gastrectomy (LSG) is becoming a leading primary bariatric surgery but long-term outcome remains unclear. The amount of food eaten is drastically reduced after LSG and may lead to nutritional deficiencies potentially. The aim of this study is to investigate long-term dietary intake and weight status after LSG. METHODS: Forty patients underwent LSG had more than 5-year follow-up with complete clinical data and food frequency questionnaires were analyzed...
June 6, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28586904/should-this-patient-have-weight-loss-surgery-grand-rounds-discussion-from-beth-israel-deaconess-medical-center
#14
Gerald W Smetana, Daniel B Jones, Christina C Wee
Obesity is an important public health priority in the United States. One third of U.S. adults are obese and therefore can expect higher rates of diabetes mellitus, other obesity-related comorbidities, and mortality. In 2013, the American Association of Clinical Endocrinologists, the Obesity Society, and the American Society for Metabolic and Bariatric Surgery issued a guideline that recommended weight loss (bariatric) surgery for all patients with a body mass index (BMI) of 40 kg/m2 or higher and for those with a BMI of 35 kg/m2 or greater in the presence of at least 1 obesity-related comorbidity...
June 6, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28580346/prospective-double-center-1-year-results-of-adjustable-gastric-banding-with-midband-gastro-gastric-suture-vs-non-gastro-gastric-suture
#15
Sang-Moon Han, Seong Min Kim
PURPOSE: Although laparoscopic adjustable gastric banding (LAGB) is a popular bariatric procedure, few comprehensive studies have been investigated on the use of non-gastro-gastric sutures (NGGSs) for decreasing postoperative complications. This study aimed to assess and compare the safety and effectiveness of MIDBAND with or without gastro-gastric sutures (GGSs). METHODS: Between February 2013 and March 2014, 41 severely obese patients underwent primary LAGB using pars flaccid technique at double center in South Korea...
June 2017: Annals of Surgical Treatment and Research
https://www.readbyqxmd.com/read/28579220/the-polymorphism-rs17782313-near-mc4r-gene-is-related-with-anthropometric-changes-in-women-submitted-to-bariatric-surgery-over-60-months
#16
Cristina Maria Mendes Resende, Danielle Fernandes Durso, Karina Braga Gomes Borges, Rafaela Messias Pereira, Gisele Kuhlmann Duarte Rodrigues, Kathryna Fontana Rodrigues, José Luiz Padilha Silva, Erica Castilho Rodrigues, Gloria Regina Franco, Jacqueline Isaura Alvarez-Leite
OBJECTIVE: Evaluate whether the polymorphism rs17782313 near MC4R gene influences long-term outcomes after bariatric surgery. METHODS: The rs16782313 polymorphism was genotyped in 217 individuals undergoing bariatric surgery and analyzed in detail in 141 women. Data for comorbidities, BMI, excess weight loss (EWL), and body composition were obtained before and during 60 months after surgery. RESULTS: The risk allele was found in 65 (47%) of the 141 women...
May 22, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28579203/comment-on-long-term-effects-of-bariatric-surgery-on-patients-with-obesity-and-chromosome-19-11-2-microdeletion
#17
EDITORIAL
Robert B Lim
No abstract text is available yet for this article.
May 11, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28579202/use-of-prescribed-opioids-before-and-after-bariatric-surgery-prospective-evidence-from-a-u-s-multicenter-cohort-study
#18
Wendy C King, Jia-Yuh Chen, Steven H Belle, Anita P Courcoulas, Gregory F Dakin, David R Flum, Marcelo W Hinojosa, Melissa A Kalarchian, James E Mitchell, Walter J Pories, Konstantinos Spaniolas, Bruce M Wolfe, Susan Z Yanovski, Scott G Engel, Kristine J Steffen
BACKGROUND: Limited evidence suggests bariatric surgery may not reduce opioid analgesic use, despite improvements in pain. OBJECTIVE: To determine if use of prescribed opioid analgesics changes in the short and long term after bariatric surgery and to identify factors associated with continued and postsurgery initiated use. SETTING: Ten U.S. hospitals. METHODS: The Longitudinal Assessment of Bariatric Surgery-2 is an observational cohort study...
April 7, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28574521/post-bariatric-surgery-patients-your-role-in-their-long-term-care
#19
Amy Kreykes, Hetal Choxi, Amy Rothberg
Nutritional deficiencies, decreased bone mineral density,and dumping syndrome are just some of the challenges these patients face. Here's how to optimize their care.
June 2017: Journal of Family Practice
https://www.readbyqxmd.com/read/28573535/long-term-outcome-of-bariatric-surgery-in-morbidly-obese-adolescents-a-systematic-review-and-meta-analysis-of-950-patients-with-a-minimum-of-3%C3%A2-years-follow-up
#20
Saeed Shoar, Habibollah Mahmoudzadeh, Mohammad Naderan, Shahram Bagheri-Hariri, Catherine Wong, Ahmad Shahabeddin Parizi, Nasrin Shoar
BACKGROUND: Obesity in pediatric and adolescent population has reached a universal pandemic. This study aimed to summarize the literature on the longest available outcome of bariatric surgery in morbidly obese adolescents. METHODS: A systematic review was conducted to pool available data on the longest available (>3 years) weight loss and comorbidity resolution outcome in adolescent bariatric surgery. RESULTS: A total of 14 studies reporting the result of bariatric surgery after 3 years in 950 morbidly obese adolescents were included...
June 2, 2017: Obesity Surgery
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