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"retinopathy of prematurity"

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https://www.readbyqxmd.com/read/29026199/probiotic-supplementation-in-preterm-infants-does-not-affect-the-risk-of-retinopathy-of-prematurity-a-meta-analysis-of-randomized-controlled-trials
#1
Giacomo Cavallaro, Eduardo Villamor-Martínez, Luca Filippi, Fabio Mosca, Eduardo Villamor
Retinopathy of prematurity (ROP) is a vascular disorder of the developing retina in preterm infants and is a leading cause of childhood blindness. Perinatal infection plays a pathogenic role in ROP. Probiotic supplementation reduces the risk of late onset sepsis (LOS) in preterm infants but it remains to be determined whether this reduction translates into a reduction of other complications. We conducted a systematic review and meta-analysis to evaluate the possible role of probiotics in altering the risk of ROP...
October 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29025171/-the-impact-of-macular-development-on-full-field-and-multifocal-erg-in-extremely-preterm-born-children-with-and-without-acute-retinopathy-of-prematurity
#2
Wadim Bowl, Silke Schweinfurth, Kerstin Holve, Knut Stieger, Birgit Lorenz, Monika Andrassi-Darida
Introduction Retinal development is a complex process that can continue into early childhood and beyond. Prematurity can affect the maturation of the central retina, characterised by a flatter foveal pit and overlying inner retinal layers (IRL), leading to a disturbed ratio of outer retinal layers to IRL ("macular developmental arrest": MDA) and functional impairment (Bowl et al. 2016 18). The purpose of this study was to correlate functional results by electrophysiology with the morphological appearance of the fovea in children with spontaneously regressed and without ROP and term-born age-matched controls...
October 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/29022295/retinopathy-of-prematurity-assist-novel-software-for-detecting-plus-disease
#3
Elias Khalili Pour, Hamidreza Pourreza, Kambiz Ameli Zamani, Alireza Mahmoudi, Arash Mir Mohammad Sadeghi, Mahla Shadravan, Reza Karkhaneh, Ramak Rouhi Pour, Mohammad Riazi Esfahani
PURPOSE: To design software with a novel algorithm, which analyzes the tortuosity and vascular dilatation in fundal images of retinopathy of prematurity (ROP) patients with an acceptable accuracy for detecting plus disease. METHODS: Eighty-seven well-focused fundal images taken with RetCam were classified to three groups of plus, non-plus, and pre-plus by agreement between three ROP experts. Automated algorithms in this study were designed based on two methods: the curvature measure and distance transform for assessment of tortuosity and vascular dilatation, respectively as two major parameters of plus disease detection...
September 22, 2017: Korean Journal of Ophthalmology: KJO
https://www.readbyqxmd.com/read/29019629/health-disparities-and-child-development-after-prematurity
#4
Frances A Carter, Michael E Msall
There is increased recognition that preterm neonates require sequential surveillance to capture the spectrum of coordination, communication, learning, and behavior regulation disorders that may occur in the first 5 years of life and beyond. In particular, the framework of follow-up needs to go beyond the detection of cerebral palsy, blindness, and deafness in the first 2 years of life for only those at highest preterm risk (ie, <28 weeks gestation, with combinations of severe cranial sonographic abnormalities, bronchopulmonary dysplasia, and retinopathy of prematurity)...
October 1, 2017: Pediatric Annals
https://www.readbyqxmd.com/read/28990934/mast-cell-hyperactivity-underpins-the-development-of-oxygen-induced-retinopathy
#5
Kenshiro Matsuda, Noriko Okamoto, Masatoshi Kondo, Peter D Arkwright, Kaoru Karasawa, Saori Ishizaka, Shinichi Yokota, Akira Matsuda, Kyungsook Jung, Kumiko Oida, Yosuke Amagai, Hyosun Jang, Eiichiro Noda, Ryota Kakinuma, Koujirou Yasui, Uiko Kaku, Yasuo Mori, Nobuyuki Onai, Toshiaki Ohteki, Akane Tanaka, Hiroshi Matsuda
Mast cells are classically thought to play an important role in protection against helminth infections and in the induction of allergic diseases; however, recent studies indicate that these cells also contribute to neovascularization, which is critical for tissue remodeling, chronic inflammation, and carcinogenesis. Here, we demonstrate that mast cells are essential for sprouting angiogenesis in a murine model of oxygen-induced retinopathy (OIR). Although mouse strains lacking mast cells did not exhibit retinal neovascularization following hypoxia, these mice developed OIR following infusion of mast cells or after injection of mast cell tryptase (MCT)...
October 9, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28988372/ultra-low-dose-of-intravitreal-bevacizumab-in-retinopathy-of-prematurity
#6
A Şahin, Z Gürsel-Özkurt, M Şahin, F M Türkcü, A Yıldırım, H Yüksel
AIM: We aimed to investigate the effectivity of the 0.0625 mg dose of bevacizumab in patients with retinopathy of prematurity (ROP) and compare the results with 0.625 mg dose of intravitreal bevacizumab (IVB) injection. METHODS: The medical records of the patients with type 1 ROP who received IVB monotherapy were retrospectively reviewed. Demographic and clinical characteristics of the patients were recorded. The patients were classified into two groups with respect to received dose of bevacizumab as follows: group F (n = 46) (full dose of bevacizumab-0...
October 7, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28985806/low-dose-ranibizumab-as-primary-treatment-of-posterior-type-i-retinopathy-of-prematurity
#7
Anna L Ells, Jason D Wesolosky, April D Ingram, Patrick C Mitchell, Alexander S Platt
OBJECTIVE: The aim of this study was to evaluate the visual and structural outcomes of eyes that received ranibizumab as treatment for retinopathy of prematurity (ROP). METHODS: This was a retrospective case series of infants who received a 0.2 mg (0.02 mL) intravitreal injection of ranibizumab as the primary treatment for type 1 ROP. Outcome measures included regression or recurrence of ROP, complications of treatment, and assessment of visual acuity and refractive error...
October 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/28984736/effect-of-patients-clinical-information-on-the-diagnosis-of-and-decision-to-treat-retinopathy-of-prematurity
#8
Andreas Gschließer, Eva Stifter, Thomas Neumayer, Elisabeth Moser, Andrea Papp, Niklas Pircher, Guido Dorner, Stefan Egger, Nenad Vukojević, Isabel Oberacher-Velten, Ursula Schmidt-Erfurth
PURPOSE: To evaluate the effect of patients' clinical information on experts' diagnoses of retinopathy of prematurity (ROP) and decisions to treat. METHODS: Seven experts assessed wide-field fundus photographs of eyes of 52 premature infants of ≤30 weeks' gestational age or ≤1,500 g birthweight (BW) for ROP diagnosis (stage, plus disease, and aggressive posterior ROP) and the necessity for treatment for 2 days. On Day 1, they were masked to all patient data...
October 3, 2017: Retina
https://www.readbyqxmd.com/read/28982955/mutation-spectrum-of-ndp-fzd4-and-tspan12-genes-in-indian-patients-with-retinopathy-of-prematurity
#9
Sonika Rathi, Subhadra Jalali, Ganeswara Rao Musada, Satish Patnaik, Divya Balakrishnan, Anjli Hussain, Inderjeet Kaur
AIM: Retinopathy of prematurity (ROP) is a vasoproliferative eye disease in preterm infants. Based on its phenotypic similarities with familial exudative vitreo retinopathy (FEVR), the present study was conducted to screen the Norrin signalling pathway genes (already been implicated in FEVR) for understanding their involvement among Indian patients with ROP. METHODS: The study cohort consisted of patients with ROP (n=246) and controls (n=300) that included full term (n=110) and preterm babies devoid of ROP (n=190)...
October 5, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28979360/implication-of-the-neurotrophin-receptor-p75-ntr-in-vascular-diseases-beyond-the-eye
#10
Sally L Elshaer, Azza B El-Remessy
INTRODUCTION: The p75 neurotrophin receptor (p75(NTR)) is a member of TNF-α receptor superfamily that bind all neurotrophins, mainly regulating their pro-apoptotic actions. Ischemia is a common pathology in different cardiovascular diseases affecting multiple organs, however the contribution of p75(NTR) remains not fully addressed. The aim of this work is to review the current evidence through published literature studying the impact of p75(NTR) receptor in ischemic vascular diseases...
2017: Expert Review of Ophthalmology
https://www.readbyqxmd.com/read/28978600/bilateral-large-subconjunctival-haemorrhages-unmasking-immune-thrombocytopenic-purpura-during-retinopathy-of-prematurity-screening
#11
Parijat Chandra, Devesh Kumawat, Vinod Kumar, Ruchir Tewari
Although thrombocytopenia is known to be associated with pathogenesis of retinopathy of prematurity (ROP), immune thrombocytopenic purpura (ITP) is rare in infancy and not reported to occur with ROP. A preterm infant with aggressive posterior ROP developed bilateral massive subconjunctival haemorrhage after scleral indentation during screening. On evaluation, the infant was found to have severe ITP. Following intravenous transfusion of platelets and immunoglobulin, platelet counts improved and subconjunctival haemorrhage resolved over time...
October 4, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28974135/propofol-and-fentanyl-sedation-for-laser-treatment-of-retinopathy-of-prematurity-to-avoid-intubation
#12
Fiammetta Piersigilli, Alessandra Di Pede, Gino Catena, Simona Lozzi, Cinzia Auriti, Iliana Bersani, Irma Capolupo, Anna Lipreri, Vincenzo Di Ciommo, Andrea Dotta, Stefania Sgrò
BACKGROUND: Despite the optimization of neonatal assistance, severe retinopathy of prematurity (ROP, stage III-IV) remains a common condition among preterm infants. Laser photocoagulation usually requires general anesthesia and intubation, but extubation can be difficult and these infants often affected by chronic lung disease. We retrospectively evaluated the clinical charts of 13 neonates that were sedated with propofol in association with fentanyl for the laser treatment of ROP. This protocol was introduced in our unit to avoid intubation and minimize side effects of anesthesia and ventilation...
October 3, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/28969546/igf-1-as-a-drug-for-preterm-infants-a-step-wise-clinical-development
#13
Ann Hellstrom, David Ley, Boubou Hallberg, Chatarina Lofqvist, Ingrid Hansen-Pupp, Luca A Ramenghi, Jan Borg, Lois E H Smith, Anna-Lena Hard
BACKGROUND: Insulin-like growth factor 1 (IGF-1) is a mitogenic hormone involved in many processes such as growth, metabolism, angiogenesis and differentiation. After very preterm birth, energy demands increase while maternal supplies of nutrients and other factors are lost and the infant may become dependent on parenteral nutrition for weeks. Low postnatal IGF-1 concentrations in preterm infants are associated with poor weight gain, retinopathy of prematurity (ROP) and other morbidities...
October 2, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28960442/arterial-catheterisation-in-neonates-can-result-in-severe-ischaemic-complications-but-does-not-impair-long-term-extremity-function
#14
Philipp Deindl, Thomas Waldhör, Lukas Unterasinger, Angelika Berger, Maike Keck
AIM: We evaluated the incidence of arterial catheterisation and analysed the risk factors and the extent and outcome of ischaemic complications in neonates. METHODS: This was a retrospective cohort study of 1,506 neonates admitted to two, 10-bed neonatal intensive care units (NICUs) at the Medical University of Vienna, Austria, between 1 January 2011 and 31 December 2014. Medical charts, daily reports and photo documentation were reviewed for arterial catheterisation and ischaemic complications...
September 28, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28958885/pathophysiology-screening-and-treatment-of-rop-a-multi-disciplinary-perspective
#15
REVIEW
Tailoi Chan-Ling, Glen A Gole, Graham E Quinn, Samuel J Adamson, Brian A Darlow
The population of infants at risk for retinopathy of prematurity (ROP) varies by world region; in countries with well developed neonatal intensive care services, the highest risk infants are those born at less than 28 weeks gestational age (GA) and less than 1 kg at birth, while, in regions where many aspects of neonatal intensive and ophthalmological care are not routinely available, more mature infants up to 2000 g at birth and 37 weeks GA are also at risk for severe ROP. Treatment options for both groups of patients include standard retinal laser photocoagulation or, more recently, intravitreal anti-VEGF drugs...
September 25, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28952674/consent-for-routine-neonatal-procedures-a-study-of-practices-in-irish-neonatal-units-how-do-we-compare-with-the-gold-standard-bapm-guidelines
#16
M A Ryan, C A Ryan, E Dempsey, R O'Connell
The Irish National Consent Policy (NCP) proposes that the legal requirement for consent extends to all forms of interventions, investigations and treatment, carried out on or behalf of the Health Service Executive (HSE). This study employs a quantitative descriptive approach to investigate the practices for obtaining consent for an identified group of routine neonatal procedures in neonatal facilities throughout Ireland. The BAPM (British Association of Perinatal Medicine) guidelines were identified as 'gold standard' for the purposes of this study...
June 9, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/28945484/evaluation-of-maternal-attachment-self-efficacy-levels-of-depression-and-anxiety-in-mothers-who-have-babies-diagnosed-with-retinopathy-of-prematurity
#17
Gonca Özyurt, Ayhan Özyurt, Taylan Özyurt, Aylin Yaman, A Tulin Berk
PURPOSE: The aim of this study is to evaluate the emotional stress and its effects on parental self-efficacy and mother-infant attachment in mothers whose babies were diagnosed with retinopathy of prematurity (ROP). METHODS: Study sample was consisted of voluntarily participating 82 mothers whose babies were first diagnosed with ROP, 83 mothers of preterm babies without ROP, and 85 mothers of term babies admitting for their routine visits. Sociodemographic data form maternal attachment scale, state-trait anxiety inventory, Edinburgh postnatal depression scale, and parental self-efficacy scale were applied to study participants, and the overall results of three groups were statistically compared...
September 25, 2017: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/28944318/intereye-agreement-of-retinopathy-of-prematurity-from-image-evaluation-in-the-telemedicine-approaches-to-evaluating-of-acute-phase-rop-e-rop-study
#18
Gui-Shuang Ying, Wei Pan, Graham E Quinn, Ebenezer Daniel, Michael X Repka, Agnieshka Baumritter
PURPOSE: To determine the symmetry on retinal image grading of fellow eyes for retinopathy of prematurity (ROP) features (stage, zone and plus disease) and severity, to provide the basis for the within subject comparison for ROP trials. DESIGN: Secondary analyses of data from the Telemedicine Approaches to Evaluating of Acute-Phase ROP (e-ROP) Study. SUBJECTS: Infants with birth weight less than 1251g. METHODS: Infants underwent serial retinal imaging sessions in both eyes by certified imagers starting at 32-weeks postmenstrual age (PMA)...
July 2017: Ophthalmology retina
https://www.readbyqxmd.com/read/28943321/a-randomized-pilot-study-comparing-the-role-of-peep-o2-flow-and-high-flow-air-for-weaning-of-ventilatory-support-in-very-low-birth-weight-infants
#19
Chang-Yo Yang, Mei-Chin Yang, Shih-Ming Chu, Ming-Chou Chiang, Reyin Lien
BACKGROUND: There is a lack of evidence to guide step-wise weaning of positive pressure respiratory support for premature infants. This study sought to compare the efficacy of three weaning protocols we designed to facilitate weaning of very low birth weight (VLBW, less than 1500 g) preterm infants from nasal continuous positive airway pressure (NCPAP) support. METHODS: This was a prospective, randomized, controlled trial of VLBW preterm infants who received positive pressure ventilatory support in our neonatal intensive care unit (NICU) from April 2008 through March 2009...
September 6, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/28937236/impact-of-early-aggressive-nutrition-on-retinal-development-in-premature-infants
#20
N Lenhartova, K Matasova, Z Lasabova, K Javorka, A Calkovska
The normal retinal development is interrupted by preterm birth and a retinopathy of prematurity (ROP) may develop as its consequence. ROP is characterized by aberrant vessel formation in the retina as a response to multiple risk factors influencing the process of retinal angiogenesis. Insulin-like growth factor I (IGF-1) and vascular endothelial growth factor (VEGF) play an important role in the process of normal retinal vascularization. Insufficient nutrition during the first 4 postnatal weeks results in low serum levels of IGF-1, which is essential for correct retinal vessels formation, ensuring survival of the newly formed endothelial cells...
September 22, 2017: Physiological Research
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