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https://www.readbyqxmd.com/read/29681180/amniocentesis-compared-with-antenatal-corticosteroids-prior-to-early-term-scheduled-cesarean-delivery
#1
Kelly B Zafman, Nathan S Fox
OBJECTIVE: There are a variety of maternal or fetal conditions that require late preterm or early term delivery. In cases where early delivery is indicated, optimal management is not always clear. Historically, obstetricians used amniocentesis to document fetal lung maturity, but recently, many have transitioned to administration of antenatal corticosteroids (ACS). The objective of this study was to compare neonatal outcomes between women undergoing amniocentesis or receiving ACS prior to scheduled cesarean delivery (CD) less than 39 weeks...
April 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29666294/laryngeal-responses-to-mechanically-assisted-cough-in-progressing-amyotrophic-lateral-sclerosis
#2
Tiina M Andersen, Astrid Sandnes, Ove Fondenes, Roy M Nilsen, Ole-Bjørn Tysnes, John-Helge Heimdal, Hege H Clemm, Thomas Halvorsen, Maria Vollsœter, Ola D Røksund
BACKGROUND: Respiratory complications represent the major cause of death in amyotrophic lateral sclerosis (ALS). Noninvasive respiratory support is the mainstay therapy, but treatment becomes challenging as the disease progresses, possibly due to a malfunctioning larynx, which is the entrance to the airways. We studied laryngeal response patterns to mechanically assisted cough (mechanical insufflation-exsufflation) as ALS progresses. METHODS: This prospective longitudinal study of 13 consecutively included subjects with ALS were followed up during 2011-2016 with repeated tests of lung function, neurological status, and laryngeal responses to mechanical insufflation-exsufflation using video-recorded flexible transnasal fiberoptic laryngoscopy...
April 17, 2018: Respiratory Care
https://www.readbyqxmd.com/read/29665838/fungal-infections-in-adult-patients-on-extracorporeal-life-support
#3
Yiorgos Alexandros Cavayas, Hakeem Yusuff, Richard Porter
BACKGROUND: Patients on extracorporeal membrane oxygenation (ECMO) are often among the most severely ill in the intensive care unit. They are often receiving broad-spectrum antibiotics; they have multiple entry points for pathogens; and their immune system is impaired by blood circuit interaction. These factors are thought to predispose them to fungal infections. We thus aimed to evaluate the prevalence, risk factors, and prognosis of fungal infections in adults on ECMO. METHODS: We conducted a retrospective cohort study using the Extracorporeal Life Support Organization registry, which compiles data on ECMO use from hundreds of international centers...
April 17, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29662279/there-is-only-a-modest-increase-in-neonatal-respiratory-morbidity-following-early-term-elective-cesarean-in-a-south-indian-population
#4
Nagaraja Katwa, Akhila Vasudeva, Leslie E S Lewis, Pratap Kumar
Objectives: Elective cesarean deliveries (ECD) are still performed prior to 39 weeks. This study aimed to identify risk of neonatal respiratory morbidity (NRM) following ECD near term, in a South Indian population. Specifically, study aimed to measure the additional healthcare burden due to large number of ECDs performed prior to 39 weeks, in this local population. Methods: We analyzed NRM among 1329 deliveries (584 ECD and 745 spontaneous vaginal delivery, SVD) in a tertiary hospital over 2 years...
April 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29658447/-treatment-and-prognosis-of-pulmonary-hemorrhage-in-preterm-infants-during-2007-2016
#5
Wei-Wei Pan, Xiao-Mei Tong
OBJECTIVE: To study the treatment and prognosis of pulmonary hemorrhage in preterm infants. METHODS: A total of 106 preterm infants diagnosed with pulmonary hemorrhage, who were hospitalized in the neonatal ward of Peking University Third Hospital between 2007 and 2016, were enrolled. These patients were divided into 2007-2011 group (34 cases) and 2012-2016 group (72 cases) according to the time of hospitalization, divided into conventional-frequency ventilation group (43 cases) and high-frequency oscillatory ventilation (HFOV) group (63 cases) according to the respiratory support method used after the development of pulmonary hemorrhage, and divided into non-operation group (34 cases) and operation group (14 cases) according to whether PDA ligation was performed for the unclosed PDA before pulmonary hemorrhage...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29655592/development-of-a-blunt-chest-injury-care-bundle-an-integrative-review
#6
REVIEW
Sarah Kourouche, Thomas Buckley, Belinda Munroe, Kate Curtis
BACKGROUND: Blunt chest injuries (BCI) are associated with high rates of morbidity and mortality. There are many interventions for BCI which may be able to be combined as a care bundle for improved and more consistent outcomes. OBJECTIVE: To review and integrate the BCI management interventions to inform the development of a BCI care bundle. METHODS: A structured search of the literature was conducted to identify studies evaluating interventions for patients with BCI...
April 7, 2018: Injury
https://www.readbyqxmd.com/read/29630010/perinatal-outcomes-in-women-with-a-history-of-chronic-hypertension-but-normal-blood-pressures-before-20-weeks-of-gestation
#7
Mallory Youngstrom, Alan Tita, Janatha Grant, Jeff M Szychowski, Lorie M Harper
OBJECTIVE: To compare the perinatal outcomes of normotensive women with those of women with a history of chronic hypertension with normal blood pressures before 20 weeks of gestation, stratifying the latter by whether they were receiving antihypertensive medication. METHODS: We conducted a retrospective cohort study of all singletons with a history of chronic hypertension from 2000 to 2014. Exclusions were blood pressure greater than 140/90 mm Hg before 20 weeks of gestation, fetal anomalies, major medical problems other than hypertension, and diabetes...
April 6, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29622720/infant-pulmonary-function-testing-and-phenotypes-in-severe-bronchopulmonary-dysplasia
#8
Edward G Shepherd, Brian J Clouse, Kathryn A Hasenstab, Swetha Sitaram, Daniel T Malleske, Leif D Nelin, Sudarshan R Jadcherla
BACKGROUND: The definition of severe bronchopulmonary dysplasia (sBPD) is based on respiratory support needs. The management of a patient with sBPD remains empirical and is highly variable among providers. Our objective in this study was to test the hypothesis that infant pulmonary function testing (iPFT) would reveal distinct phenotypes in patients with established sBPD during the initial NICU stay. METHODS: A prospective cohort study with data prospectively collected on infants with sBPD from May 1, 2003, to June 30, 2016...
April 5, 2018: Pediatrics
https://www.readbyqxmd.com/read/29621755/reply-to-the-letter-to-the-editor-is-high-flow-nasal-cannula-useful-as-primary-respiratory-support-in-preterm-infants
#9
Srinivas Murki, Nandkishor S Kabra
No abstract text is available yet for this article.
April 5, 2018: Neonatology
https://www.readbyqxmd.com/read/29621748/is-high-flow-nasal-cannula-useful-as-primary-respiratory-support-in-preterm-infants
#10
Subhash Chandra Shaw, Kannan Venkatnarayan, Rakesh Gupta
No abstract text is available yet for this article.
April 5, 2018: Neonatology
https://www.readbyqxmd.com/read/29605340/endoscopic-percutaneous-suture-lateralization-for-neonatal-bilateral-vocal-fold-immobility
#11
Glenda Lois Montague, Randall A Bly, Garani S Nadaraja, David E Conrad, Sanjay R Parikh, Dylan K Chan
OBJECTIVE: Bilateral vocal-fold immobility (BFVI) is a rare but significant cause of severe respiratory distress in neonates. The primary aim of treatment is to provide an adequate airway while minimizing adverse effects such as aspiration and dysphonia. Our objective here is to describe the outcomes of a series of neonates undergoing percutaneous endoscopic suture lateralization for BVFI using a novel technique. METHODS: In this retrospective case series, we present 6 neonates (mean age: 18 days) with BVFI from three tertiary academic medical centers...
May 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29605270/pumpless-arteriovenous-extracorporeal-membrane-oxygenation-a-novel-mode-of-respiratory-support-in-a-lamb-model-of-congenital-diaphragmatic-hernia
#12
Emily A Partridge, Marcus G Davey, Matthew Hornick, Kevin C Dysart, Aliza Olive, Robert Caskey, James T Connelly, Holly L Hedrick, William H Peranteau, Alan W Flake
BACKGROUND: Extracorporeal membrane oxygenation (ECMO) is commonly required in neonates with congenital diaphragmatic hernia (CDH) complicated by pulmonary hypertension (PH). ECMO carries significant risk, and is contraindicated in the setting of extreme prematurity or intracranial hemorrhage. Pumpless arteriovenous ECMO (P-ECMO) may represent an alternative for respiratory support. The present study summarizes our initial experience with P-ECMO in a lamb model of CDH. STUDY DESIGN: Surgical creation of CDH was performed at 65-75days' gestation...
March 9, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29599068/acute-responses-to-diuretic-therapy-in-extremely-low-gestational-age-newborns-results-from-the-prematurity-and-respiratory-outcomes-program-cohort-study
#13
Carol J Blaisdell, James Troendle, Anne Zajicek
OBJECTIVE: To determine if daily respiratory status improved more in extremely low gestational age (GA) premature infants after diuretic exposure compared with those not exposed in modern neonatal intensive care units. STUDY DESIGN: The Prematurity and Respiratory Outcomes Program (PROP) was a multicenter observational cohort study of 835 extremely premature infants, GAs of 230/7 -286/7 weeks, enrolled in the first week of life from 13 US tertiary neonatal intensive care units...
March 20, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29590143/short-term-evaluation-of-respiratory-effort-by-premature-infants-supported-with-bubble-nasal-continuous-airway-pressure-using-seattle-pap-and-a-standard-bubble-device
#14
Stephen E Welty, Craig G Rusin, Larissa I Stanberry, George T Mandy, Alfred L Gest, Jeremy M Ford, Carl H Backes, C Peter Richardson, Christopher R Howard, Thomas N Hansen, Charles V Smith
BACKGROUND: Almost one million prematurely born infants die annually from respiratory insufficiency, predominantly in countries with limited access to respiratory support for neonates. The primary hypothesis tested in the present study was that a modified device for bubble nasal continuous positive airway pressure (Bn-CPAP) would provide lower work of spontaneous breathing, estimated by esophageal pressure-rate products. METHODS: Infants born <32 weeks gestation and stable on Bn-CPAP with FiO2 <0...
2018: PloS One
https://www.readbyqxmd.com/read/29582542/an-observational-cohort-study-of-outcomes-in-patients-admitted-to-the-intensive-care-unit-for-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#15
Sivanth Sivakumar, Angus McNally, Jonathan Tobin, Jonathan Williamson, A Anders Aneman
BACKGROUND: Patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) are often referred to the intensive care unit (ICU) for non-invasive respiratory support. AIMS: To describe the characteristics of patients with AECOPD admitted to ICU focusing on the performance of ICU prognostic systems, decisions to limit medical therapy and mortality outcomes. METHODS: Retrospective review of patients admitted between 2009-16, separately in patients with active treatment and limitation or withdrawal of medical therapy...
March 27, 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29578644/point-of-care-diaphragm-ultrasound-in-infants-with-bronchiolitis-a-prospective-study
#16
Danilo Buonsenso, Maria C Supino, Emanuele Giglioni, Massimo Battaglia, Alessia Mesturino, Simona Scateni, Barbara Scialanga, Antonino Reale, Anna M C Musolino
BACKGROUND: Bronchiolitis is the most common reason for hospitalization of children worldwide. Many scoring systems have been developed to quantify respiratory distress and predict outcome, but none of them have been validated. We hypothesized that the ultrasound evaluation of the diaphragm could quantify respiratory distress and therefore we correlated the ultrasound diaphragm parameters with outcome. METHODS: Prospective study of infants with bronchiolitis (1-12 months) evaluated in a pediatric emergency department...
March 26, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29575773/non-invasive-ventilation-practices-in-children-across-europe
#17
Juan Mayordomo-Colunga, Martí Pons-Òdena, Alberto Medina, Corsino Rey, Christophe Milesi, Merja Kallio, Andrea Wolfler, Mireia García-Cuscó, Demet Demirkol, Milagros García-López, Peter Rimensberger
OBJECTIVES: To describe the diversity in practice in non-invasive ventilation (NIV) in European pediatric intensive care units (PICUs). WORKING HYPOTHESIS: No information about the use of NIV in Pediatrics across Europe is currently available, and there might be a wide variability regarding the approach. STUDY DESIGN: Cross-sectional electronic survey. METHODOLOGY: The survey was distributed to the ESPNIC mailing list and to researchers in different European centers...
March 24, 2018: Pediatric Pulmonology
https://www.readbyqxmd.com/read/29575302/underlying-maternal-and-pregnancy-related-conditions-account-for-a-substantial-proportion-of-neonatal-morbidity-in-late-preterm-infants
#18
Anna Bonnevier, Jana Brodszki, Lars J Björklund, Karin Källén
AIM: We studied the impact of maternal and pregnancy-related conditions, and the effect of gestational age itself, on the health of infants born late preterm. METHODS: Singletons born in gestational weeks 34+0 - 41+6 in 1995-2013 in the southern region of Sweden were identified from a perinatal register. We found 14,030 infants born late preterm and 294,814 born at term. A hierarchical system was developed to examine the impact of pregnancy complications. The outcomes studied were: neonatal death, central nervous system (CNS) or respiratory disease, infection, neonatal admission and respiratory support...
March 25, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29571932/optimal-target-range-of-closed-loop-inspired-oxygen-support-in-preterm-infants-a-randomized-cross-over-study
#19
Maria Elisabeth Nicoletta van den Heuvel, Henriette A van Zanten, Tom E Bachman, Arjan B Te Pas, Anton H van Kaam, Wes Onland
OBJECTIVE: To investigate the effect of different pulse oximetry (SpO2 ) target range settings during automated fraction of inspired oxygen control (A-FiO2 ) on time spent within a clinically set SpO2 alarm range in oxygen-dependent infants on noninvasive respiratory support. STUDY DESIGN: Forty-one preterm infants (gestational age [median] 26 weeks, age [median] 21 days) on FiO2  >0.21 receiving noninvasive respiratory support were subjected to A-FiO2 using 3 SpO2 target ranges (86%-94%, 88%-92%, or 89%-91%) in random order for 24 hours each...
March 21, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29556412/incidence-and-short-term-outcomes-of-neonates-with-hypoxic-ischemic-encephalopathy-in-a-peri-urban-teaching-hospital-uganda-a-prospective-cohort-study
#20
Hellen Namusoke, Maria Musoke Nannyonga, Robert Ssebunya, Victoria Kirabira Nakibuuka, Edison Mworozi
Background: Hypoxic Ischemic Encephalopathy carries high case fatality rates ranging between 10-60%, with 25% of survivors have an adverse long-term neurodevelopment outcome. Despite the above, there is paucity of data regarding its magnitude and short term outcomes in a low resource setting like Uganda. Therefore we set out to determine the incidence and short term outcomes of Newborns with Hypoxic Ischemic Encephalopathy at St.Francis Hospital, Nsambya. Methods: This was a Prospective Cohort study conducted between October 2015 and January 2016 at St...
2018: Maternal Health, Neonatology and Perinatology
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