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https://www.readbyqxmd.com/read/28526452/gestational-age-at-initiation-of-17-alpha-hydroxyprogesterone-caproate-and-recurrent-preterm-birth
#1
Angela Ning, Catherine J Vladutiu, Sarah K Dotters-Katz, William H Goodnight, Tracy A Manuck
BACKGROUND: Preterm birth (PTB) is the leading cause of neonatal morbidity and mortality in non-anomalous neonates in the US. Women with a previous early spontaneous PTB are at highest risk for recurrence. Weekly intramuscular 17-alpha hydroxyprogesterone caproate (17-OHPC) reduces the risk of recurrent prematurity. Though current guidelines recommend 17-OHPC initiation between 16-20 weeks', in clinical practice, 17-OHPC is started across a spectrum of gestational ages. OBJECTIVE: To examine the relationship between the gestational age at 17-OHPC initiation and recurrent PTB among women a prior spontaneous PTB 16-28 weeks' gestation...
May 16, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28521038/ventricular-zone-disruption-in-human-neonates-with-intraventricular-hemorrhage
#2
James P McAllister, Maria Montserrat Guerra, Leandro Castaneyra Ruiz, Antonio J Jimenez, Dolores Dominguez-Pinos, Deborah Sival, Wilfred den Dunnen, Diego M Morales, Robert E Schmidt, Esteban M Rodriguez, David D Limbrick
To determine if ventricular zone (VZ) and subventricular zone (SVZ) alterations are associated with intraventricular hemorrhage (IVH) and posthemorrhagic hydrocephalus, we compared postmortem frontal and subcortical brain samples from 12 infants with IVH and 3 nonneurological disease controls without hemorrhages or ventriculomegaly. Birth and expiration estimated gestational ages were 23.0-39.1 and 23.7-44.1 weeks, respectively; survival ranges were 0-42 days (median, 2.0 days). Routine histology and immunohistochemistry for neural stem cells (NSCs), neural progenitors (NPs), multiciliated ependymal cells (ECs), astrocytes (AS), and cell adhesion molecules were performed...
May 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28505223/association-of-short-antenatal-corticosteroid-administration-to-birth-intervals-with-survival-and-morbidity-among-very-preterm-infants-results-from-the-epice-cohort
#3
Mikael Norman, Aurelie Piedvache, Klaus Børch, Lene Drasbek Huusom, Anna-Karin Edstedt Bonamy, Elizabeth A Howell, Pierre-Henri Jarreau, Rolf F Maier, Ole Pryds, Liis Toome, Heili Varendi, Tom Weber, Emilija Wilson, Arno Van Heijst, Marina Cuttini, Jan Mazela, Henrique Barros, Patrick Van Reempts, Elizabeth S Draper, Jennifer Zeitlin
Importance: Administration-to-birth intervals of antenatal corticosteroids (ANS) vary. The significance of this variation is unclear. Specifically, to our knowledge, the shortest effective administration-to-birth interval is unknown. Objective: To explore the associations between ANS administration-to-birth interval and survival and morbidity among very preterm infants. Design, Setting, and Participants: The Effective Perinatal Intensive Care in Europe (EPICE) study, a population-based prospective cohort study, gathered data from 19 regions in 11 European countries in 2011 and 2012 on 4594 singleton infants with gestational ages between 24 and 31 weeks, without severe anomalies and unexposed to repeated courses of ANS...
May 15, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/28504197/intravenous-injection-of-umbilical-cord-derived-mesenchymal-stromal-cells-attenuates-reactive-gliosis-and-hypomyelination-in-a-neonatal-intraventricular-hemorrhage-model
#4
Takeo Mukai, Yuka Mori, Takahisa Shimazu, Atsuko Takahashi, Hajime Tsunoda, Satoru Yamaguchi, Shigeru Kiryu, Arinobu Tojo, Tokiko Nagamura-Inoue
Intraventricular hemorrhage (IVH) is a frequent complication of preterm newborns, resulting in cerebral palsy and cognitive handicap as well as hypoxic ischemic encephalopathy and periventricular leukomalacia. In this study, we investigated the restorative effect on neonatal IVH by umbilical cord-derived mesenchymal stromal cells (UC-MSCs) cultured in serum-free medium (RM medium) for clinical application. UC-MSCs were cultured with αMEM medium supplemented with FBS or RM. A neonatal IVH mouse model at postnatal day 5 was generated by intraventricular injection of autologous blood, and mice were intravenously administered 1×10(5) UC-MSCs two days after IVH...
May 11, 2017: Neuroscience
https://www.readbyqxmd.com/read/28499903/utilization-of-paine-s-technique-projecting-puncture-point-to-the-skull-and-skin
#5
Hiroaki Matsuzaki, Tadahiro Otsuka, Ken Uekawa, Takashi Nakagawa, Nobuyuki Tsubota
OBJECTIVE: Ventriculostomy from Paine's point is an effective technique to obtain a slack brain for aneurysm surgery. This study aimed to use Paine's point for other neurosurgical procedures (except for those that require pterional approach) by delineation of surface landmarks for identification of Paine's point on the cranium and scalp. METHODS: Based on the anatomical knowledge and examination of 3D CT images of skull, we determined novel surface landmarks to identify Paine's point on cranium and scalp...
May 9, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28497591/hypophosphatemia-after-nontraumatic-intracranial-hemorrhage
#6
E Junttila, J Koskenkari, T Ala-Kokko
BACKGROUND: The aim of this study was to assess the incidence and contributing factors of hypophosphatemia and the association with poor long-term outcome after nontraumatic intracranial hemorrhage. METHODS: This was a prospective, observational study of patients with nontraumatic intracranial hemorrhage (i.e., aneurysmal or perimesencephalic subarachnoid hemorrhage, or spontaneous intracerebral or intraventricular hemorrhage) treated in the intensive care unit (ICU) at our university hospital...
May 11, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28497436/factors-related-to-the-development-of-shunt-dependent-hydrocephalus-following-subarachnoid-hemorrhage-in-the-elderly
#7
Tae Seok Jeong, Chan Jong Yoo, Woo Kyung Kim, Gi Taek Yee, Eun Young Kim, Myeong Jin Kim
AIM: Surgical procedures for aneurysmal subarachnoid hemorrhage (SAH) are increasing among the elderly as the population ages. Chronic shunt-dependent hydrocephalus is a recognized complication of SAH. The purpose of this study was to identify factors predictive of the development of shunt-dependent hydrocephalus among elderly patients with SAH. MATERIAL AND METHODS: We retrospectively studied 878 patients, including 275 patients ≥ 65 years old, with SAH treated between 2005 and 2015 to identify factors contributing to the development of shunt-dependent hydrocephalus...
April 4, 2017: Turkish Neurosurgery
https://www.readbyqxmd.com/read/28494827/use-of-placental-umbilical-blood-sampling-for-neonatal-admission-blood-cultures-benefits-challenges-and-strategies-for-implementation
#8
Shannon P Moore, Desi M Newberry, Amy J Jnah
Placental blood remains an underused resource for early neonatal care despite ample evidence that placental blood provides the same clinical decision making information without the need for painful, invasive blood sampling procedures. Potential benefits of placental/umbilical blood sampling (PUBS) for neonatal admission labs include decreases in pain reactivity, rates of anemia, need for blood transfusions, use of vasopressors, and rates of intraventricular hemorrhage. Here, we present a unique case study of a critically ill infant with contradictory blood culture results from PUBS and direct infant sampling...
May 1, 2017: Neonatal Network: NN
https://www.readbyqxmd.com/read/28486556/antenatal-corticosteroids-for-neonates-born-before-25-weeks-a-systematic-review-and-meta-analysis
#9
Mangesh Deshmukh, Sanjay Patole
BACKGROUND: Efficacy of antenatal corticosteroids before 25 weeks of gestation is unclear. OBJECTIVE: To assess and compare neonatal outcomes following ANC exposure at 22, 23 and 24 weeks of gestation by conducting systematic review and meta- analysis. METHODS: A systematic review of randomised controlled trials (RCT) and non-RCTs reporting on neonatal outcomes after exposure to ANC up to 246 weeks of gestation using the Cochrane systematic review methodology...
2017: PloS One
https://www.readbyqxmd.com/read/28484566/unusual-presentation-of-an-intraventricular-hydatid-cyst-as-a-bleeding-cystic-tumor-a-case-report-and-brief-review
#10
Sumyra Khurshid Qadri, Nissar Hussain Hamdani, Abdul Rashid Bhat, Mohammad Iqbal Lone
Hydatid cysts constitute only 2% of all intracranial masses, commonly involve parenchyma and very rarely ventricles. Here, we report an unusual case of a primary, isolated intraventricular hydatid cyst that mimicked a tumor and presented as intraventricular hemorrhage with hydrocephalus in a boy, causing a diagnostic dilemma. Although, preoperative modalities like computed tomography, magnetic resonance image and serology generally help in establishing the diagnosis, but hydatid cysts with unusual localizations and atypical imaging findings may complicate the diagnosis and need be considered in the differential diagnosis of all cystic masses in all anatomic locations, especially in endemic areas, so as to reduce the patient morbidity and mortality...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28484554/a-rare-case-of-dural-arteriovenous-fistula-presenting-as-primary-intraventricular-hemorrhage
#11
Trilochan Srivastava, Raghavendra Bakki Sannegowda, V D Sinha, R S Jain, Rahul Jain, Tarun Mathur
Primary intraventricular haemorrhage (PIVH) is rare. Dural arteriovenous fistula causing PIVH is extremely rare. We report a case of a 17 year old boy who presented with left hemiparesis, left lower motor neuron facial palsy and ataxia. His computed tomography head revealed primary intraventricular hemorrhage. Catheter super selective angiography revealed a dural arterio venous fistula with arterial feeder arising from the middle meningeal artery as well as from the inferior marginal tentorial artery. Glue injection led to successful disappearance of the fistula and eventual clinical recovery...
April 2017: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/28474990/radiodensity-of-intraventricular-hemorrhage-associated-with-aneurysmal-subarachnoid-hemorrhage-may-be-a-negative-predictor-of-outcome
#12
Ha Son Nguyen, Luyuan Li, Mohit Patel, Shekar Kurpad, Wade Mueller
OBJECTIVE The presence, extent, and distribution of intraventricular hemorrhage (IVH) have been associated with negative outcomes in aneurysmal subarachnoid hemorrhage (SAH). Several qualitative scores (Fisher grade, LeRoux score, and Graeb score) have been established for evaluating SAH and IVH. However, no study has assessed the radiodensity within the ventricular system in aneurysmal SAH patients with IVH. Prior studies have suggested that hemorrhage with a higher radiodensity, as measured by CT Hounsfield units, can cause more irritation to brain parenchyma...
May 5, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28471443/the-role-of-near-infrared-spectroscopy-monitoring-in-preterm-infants
#13
P Korček, Z Straňák, J Širc, G Naulaers
Neurological morbidities such as peri/intraventricular hemorrhage and periventricular leukomalacia largely determine the neurodevelopmental outcome of vulnerable preterm infants and our aim should be to minimize their occurrence or severity. Bed-side neuromonitoring could provide valuable pieces of information about possible hemodynamic disturbances that are significantly associated with neurological morbidities and increased mortality. Near-infrared spectroscopy offers evaluation of regional cerebral oxygenation, which in conjunction with other non-invasive methods may give us a more complete picture about end-organ perfusion...
May 4, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/28453903/perfusion-monitoring-and-intraventricular-hemorrhage-in-preterm-infants
#14
Akio Ishiguro
Cardiovascular instability in preterm infants during the early postnatal period correlates with the development of intraventricular hemorrhage (IVH). Due to the correlation between hypotension and fluctuation of blood pressure, treatment especially aimed at hypotension has been attempted to prevent IVH. However, these attempts have seemed to result in failure. Recently, several novel perfusion markers have been found to be correlated with the development of IVH, and they are of current interest in cardiovascular management...
April 28, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28452657/shunting-outcomes-in-posthemorrhagic-hydrocephalus-results-of-a-hydrocephalus-clinical-research-network-prospective-cohort-study
#15
John C Wellons, Chevis N Shannon, Richard Holubkov, Jay Riva-Cambrin, Abhaya V Kulkarni, David D Limbrick, William Whitehead, Samuel Browd, Curtis Rozzelle, Tamara D Simon, Mandeep S Tamber, W Jerry Oakes, James Drake, Thomas G Luerssen, John Kestle
OBJECTIVE Previous Hydrocephalus Clinical Research Network (HCRN) retrospective studies have shown a 15% difference in rates of conversion to permanent shunts with the use of ventriculosubgaleal shunts (VSGSs) versus ventricular reservoirs (VRs) as temporization procedures in the treatment of hydrocephalus due to high-grade intraventricular hemorrhage (IVH) of prematurity. Further research in the same study line revealed a strong influence of center-specific decision-making on shunt outcomes. The primary goal of this prospective study was to standardize decision-making across centers to determine true procedural superiority, if any, of VSGS versus VR as a temporization procedure in high-grade IVH of prematurity...
April 28, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28452086/the-effects-of-nifedipine-and-atosiban-on-perinatal-brain-injury-a-secondary-analysis-of-the-apostel-iii-trial
#16
T A J Nijman, M M Goedhart, C N Naaktgeboren, T R de Haan, D C Vijlbrief, B W Mol, M J N Benders, A Franx, M A Oudijk
OBJECTIVE: Brain injury in prematurely born neonates is strongly associated with poor neurodevelopmental outcome. The aim of our study is to evaluate if nifedipine reduces overall brain injury compared to atosiban in women with threatened preterm birth. METHODS: We performed a secondary analysis of the APOSTEL III-trial (Dutch Clinical Trial Registry, number NTR2947). This was a randomized clinical trial that allocated women with threatened preterm labor between 25-34 weeks of gestation to nifedipine or atosiban...
April 28, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28444780/fetal-brain-injury-in-complicated-monochorionic-pregnancies-diagnostic-yield-of-prenatal-mri-following-surveillance-ultrasound-and-influence-on-prognostic-counselling
#17
Alice Robinson, Mark Teoh, Andrew Edwards, Michael Fahey, Stacy Goergen
OBJECTIVE: To determine the additional diagnostic information provided by prenatal (fetal) magnetic resonance imaging (pMRI) following tertiary ultrasound (US) for fetal cranial abnormalities in complicated monochorionic gestations (cMCGs) METHODS: Women with cMCGs complicated by twin - twin transfusion syndrome (TTTS), co-twin demise (CD), selective intrauterine growth restriction (sIUGR), and / or twin anemia - polycythemia sequence (TAPS) who were referred for pMRI after tertiary US were included...
April 26, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/28439195/the-role-of-serial-measurements-of-serum-insulin-like-growth-factor-1-levels-in-the-development-of-retinopathy-of-prematurity
#18
Bayram Ali Dorum, Cansu Canbolat Yılmaz, Nilgün Köksal, Hilal Özkan, Meral Yıldız, Ahmet Tuncer Özmen
AIM: To determine the role of serum insulin-like growth factor-1 levels in the development of retinopathy of prematurity, which is a major cause of childhood blindness worldwide. MATERIAL AND METHODS: We prospectively studied newborn infants born at a postmenstrual age of <32 weeks and birth weights <1 500 gr, between January 1(st), 2015, and December 31(st), 2015. A total of 40 infants were enrolled in the study. The retinal examination time was determined in accordance with the American Academy of Pediatrics recommendations for retinopathy of prematurity screening and follow-up...
March 2017: Türk Pediatri Arşivi
https://www.readbyqxmd.com/read/28430838/elevated-pulse-pressure-levels-are-associated-with-increased-in-hospital-mortality-in-acute-spontaneous-intracerebral-hemorrhage
#19
Jason J Chang, Yasser Khorchid, Kira Dillard, Ali Kerro, Lucia Goodwin Burgess, Georgy Cherkassky, Nitin Goyal, Kristina Chapple, Anne W Alexandrov, David Buechner, Andrei V Alexandrov, Georgios Tsivgoulis
OBJECTIVES: Clinical outcome after intracerebral hemorrhage (ICH) remains poor. Definitive phase-3 trials in ICH have failed to demonstrate improved outcomes with intensive systolic blood pressure (SBP) lowering. We sought to determine whether other BP parameters-diastolic BP (DBP), pulse pressure (PP), and mean arterial pressure (MAP)-showed an association with clinical outcome in ICH. METHODS: We retrospectively analyzed a prospective cohort of 672 patients with spontaneous ICH and documented demographic characteristics, stroke severity, and neuroimaging parameters...
April 19, 2017: American Journal of Hypertension
https://www.readbyqxmd.com/read/28421173/cerebral-autoregulation-brain-injury-and-the-transitioning-premature-infant
#20
REVIEW
Zachary A Vesoulis, Amit M Mathur
Improvements in clinical management of the preterm infant have reduced the rates of the two most common forms of brain injury, such as severe intraventricular hemorrhage and white matter injury, both of which are contributory factors in the development of cerebral palsy. Nonetheless, they remain a persistent challenge and are associated with a significant increase in the risk of adverse neurodevelopment outcomes. Repeated episodes of ischemia-reperfusion represent a common pathway for both forms of injury, arising from discordance between systemic blood flow and the innate regulation of cerebral blood flow in the germinal matrix and periventricular white matter...
2017: Frontiers in Pediatrics
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