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"respiratory distress-syndrome"

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https://www.readbyqxmd.com/read/29684352/nrf2-activation-protects-against-intratracheal-lps-induced-mouse-murine-acute-respiratory-distress-syndrome-by-regulating-macrophage-polarization
#1
Juan Wei, Guannan Chen, Xuan Shi, Huanping Zhou, Meiyun Liu, Yuanli Chen, Di Feng, Pengcheng Zhang, Lingmin Wu, Xin Lv
The transcription factor nuclear factor E2-related factor 2 (Nrf2) is known to control the expression of antioxidant response elements and cytoprotective genes and modulate inflammatory response, helping to ameliorate damage in many diseases. Exactly how Nrf2 regulates innate inflammatory homeostasis remains unclear. In this study, we provide in vitro and in vivo evidence that Nrf2 plays a crucial role in macrophage polarization and acute respiratory distress syndrome (ARDS). We conducted in vitro experiments using a mouse alveolar macrophage cell line as well as primary cultures of macrophages in which cells were exposed to lipopolysaccharide (LPS) or interferon-γ in order to mimic ARDS, in the presence or absence of the Nrf2 activator tert-butylhydroquinone (tBHQ)...
April 20, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29684057/serum-galactomannan-antigen-as-a-prognostic-and-diagnostic-marker-for-invasive-aspergillosis-in-heterogeneous-medicine-icu-patient-population
#2
Yubhisha Dabas, Anant Mohan, Immaculata Xess
OBJECTIVE: This study was conducted to get a complete clinical and mycological picture of invasive aspergillosis (IA) in respiratory medicine ICU of a tertiary care hospital. PATIENTS: From the cohort of 235 patients only one had proven IA. Based on AspICU algorithm, 21 had putative IA (8.9%), 12 were colonised (5.1%). RESULTS: Adjusting the confounding factors, significant risk factors for IA were chronic obstructive pulmonary disease (COPD), temperature of ≥38°C, pneumonia and acute respiratory distress syndrome (ARDS)...
2018: PloS One
https://www.readbyqxmd.com/read/29681395/chugging-in-patients-on-veno-venous-extracorporeal-membrane-oxygenation-an-under-recognized-driver-of-intravenous-fluid-administration-in-patients-with-acute-respiratory-distress-syndrome
#3
James M Walter, Chitaru Kurihara, Thomas C Corbridge, Ankit Bharat
BACKGROUND: Veno-venous extracorporeal membrane oxygenation (VV-ECMO) is increasingly utilized in the management of severe acute respiratory distress syndrome (ARDS). Providers who care for patients on VV-ECMO should be familiar with common circuit complications. OBJECTIVES: To provide an example of a common complication, circuit "chugging," and suggest a management algorithm which aims to avoid excessive fluid administration to patients with ARDS. METHODS: We use a clinical case to illustrate chugging and discuss potential management strategies...
April 19, 2018: Heart & Lung: the Journal of Critical Care
https://www.readbyqxmd.com/read/29680410/influence-of-entrapment-on-prehospital-management-and-the-hospital-course-in-polytrauma-patients-a-retrospective-analysis-in-air-rescue
#4
Christian Macke, Marika Sarakintsis, Marcel Winkelmann, Philipp Mommsen, Mohamed Omar, Christian Schröter, Christian Krettek, Christian Zeckey
BACKGROUND: Entrapment is a challenging and crucial factor in the prehospital setting. Few studies have addressed whether entrapment has an influence on on-scene treatment or on the following hospital course. OBJECTIVES: Here we aimed to investigate the influence of entrapment on prehospital management and on the hospital course of polytrauma patients. METHODS: We performed a retrospective analysis of consecutive patients with an Injury Severity Score ≥16 and aged 16-65 years that were admitted between 2005 and 2013 to a Level I trauma center...
April 18, 2018: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29679701/the-role-of-%C3%AE-2-integrin-associated-heparin-binding-protein-release-in-ards
#5
Yang Liu, Shaolin Ma, Xuebin Wang, Yajing Feng, Shouqin Zhang, Sheng Wang, Xiangyu Zhang
AIMS: PMNs (polymorphonuclear neutrophil) play important roles in early stage of inflammation induced ARDS (Acute Respiratory Distress Syndrome). Both HBP (Heparin-Binding Protein) released from active PMNs and β2 integrins on the surface of PMNs are involved in vascular leakage. The role and relationship of HBP and β2 integrins on ARDS still requires study. MATERIALS AND METHODS: We established ARDS model using C57BL/6 mice with cecal ligation and puncture and eliminating HBP and β2 integrin with respective antibodies...
April 18, 2018: Life Sciences
https://www.readbyqxmd.com/read/29676537/recovery-of-pulmonary-functions-exercise-capacity-and-quality-of-life-after-pulmonary-rehabilitation-in-survivors-of-ards-due-to-severe-influenza-a-h1n1-pneumonitis
#6
Meng-Jer Hsieh, Wei-Juen Lee, Hsiu-Ying Cho, Meng-Fang Wu, Han-Chung Hu, Kuo-Chin Kao, Ning-Hung Chen, Ying-Huang Tsai, Chung-Chi Huang
BACKGROUND: Acute respiratory distress syndrome (ARDS) due to severe influenza A H1N1 pneumonitis would result in impaired pulmonary functions and health-related quality of life (HRQoL) after hospital discharge. OBJECTIVES: The recovery of pulmonary functions, exercise capacity and HRQoL in the survivors of ARDS due to 2009 pandemic influenza A H1N1 pneumonitis (H1N1-ARDS) were evaluated in a tertiary teaching hospital in the northern Taiwan between May 2010 and June 2011...
April 20, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29670906/desflurane-attenuates-ventilator-induced-lung-injury-in-rats-with-acute-respiratory-distress-syndrome
#7
Xue Lin, Ying-Nan Ju, Wei Gao, Dong-Mei Li, Chang-Chun Guo
Ventilator-induced lung injury aggravates the existing lung injury. This study investigated the effect of desflurane on VILI in a rat model of acute respiratory distress syndrome. Forty-eight rats were randomized into a sham (S) group, control (C) group, lipopolysaccharide/ventilation (LV) group, lipopolysaccharide/ventilation/desflurane (LVD) group, or lipopolysaccharide/low ventilation with and without desflurane (LLV and LLVD) groups. Rats in the S group received anesthesia only. Rats in the LV and LVD groups received lipopolysaccharide and were ventilated with a high tidal volume...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29670790/use-of-the-pelvic-c-clamp-to-mitigate-acute-respiratory-distress-syndrome-in-a-patient-with-an-unstable-sacral-fracture
#8
Michael J DeRogatis, Paul S Issack
Case: We present the case of a 21-year-old man who fell from a roof, sustaining a displaced sacral fracture with pelvic instability. He developed acute respiratory distress syndrome (ARDS) within 24 hours of injury. Placement of the pelvic C-clamp resulted in rapid resolution of pulmonary dysfunction, allowing for definitive internal fixation. Conclusion: The C-clamp is most commonly used to control hemorrhage in unstable posterior pelvic ring injuries. Our case demonstrates a rare use of the C-clamp to stabilize the posterior pelvis in a patient with an unstable sacral fracture and ARDS, to rapidly improve pulmonary function prior to definitive surgery...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29670676/cost-analysis-of-noninvasive-helmet-ventilation-compared-with-use-of-noninvasive-face-mask-in-ards
#9
Kwadwo Kyeremanteng, Louis-Philippe Gagnon, Raphaëlle Robidoux, Kednapa Thavorn, Dipayan Chaudhuri, Daniel Kobewka, John P Kress
Intensive care unit (ICU) costs have doubled since 2000, totalling 108 billion dollars per year. Acute respiratory distress syndrome (ARDS) has a prevalence of 10.4% and a 28-day mortality of 34.8%. Noninvasive ventilation (NIV) is used in up to 30% of cases. A recent randomized controlled trial by Patel et al. (2016) showed lower intubation rates and 90-day mortality when comparing helmet to face mask NIV in ARDS. The population in the Patel et al. trial was used for cost analysis in this study. Projections of cost savings showed a decrease in ICU costs by $2527 and hospital costs by $3103 per patient, along with a 43...
2018: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/29670537/impact-of-different-tidal-volume-levels-at-low-mechanical-power-on-ventilator-induced-lung-injury-in-rats
#10
Lillian Moraes, Pedro L Silva, Alessandra Thompson, Cintia L Santos, Raquel S Santos, Marcos V S Fernandes, Marcelo M Morales, Vanessa Martins, Vera L Capelozzi, Marcelo G de Abreu, Paolo Pelosi, Patricia R M Rocco
Tidal volume (VT ) has been considered the main determinant of ventilator-induced lung injury (VILI). Recently, experimental studies have suggested that mechanical power transferred from the ventilator to the lungs is the promoter of VILI. We hypothesized that, as long as mechanical power is kept below a safe threshold, high VT should not be injurious. The present study aimed to investigate the impact of different VT levels and respiratory rates (RR) on lung function, diffuse alveolar damage (DAD), alveolar ultrastructure, and expression of genes related to inflammation [interleukin (IL)-6], alveolar stretch (amphiregulin), epithelial [club cell secretory protein (CC)16] and endothelial [intercellular adhesion molecule (ICAM)-1] cell injury, and extracellular matrix damage [syndecan-1, decorin, and metalloproteinase (MMP)-9] in experimental acute respiratory distress syndrome (ARDS) under low-power mechanical ventilation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29669772/a-case-of-h3n2-complicated-by-acute-kidney-injury-secondary-to-rhabdomyolysis
#11
Sriram Gonakoti, Janak Bahirwani, Raja Naga Mahesh Maddala, Sudha Vidyasagar
H3N2 was first detected in July 2011 in the USA. It is responsible for sporadic cases of influenza and localised outbreaks and has not yet taken over on an epidemic or pandemic scale. An 84-year-old man presented with a dry cough, fever and myalgia for 3 days. On examination, he had a pulse of 98 bpm and blood pressure of 124/88 mm Hg. The patient was tachypnoeic, SpO2 was 90%. Auscultation revealed bilateral diffuse wheeze and crackles. He had generalised muscle tenderness on examination. On admission, creatinine was 1...
April 18, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29666710/acute-chest-syndrome-progressing-to-ards-in-a-patient-of-25-week-gestation
#12
Jefferson Chambers, Nichole Smith, Matthew Sehring, Subramanyam Chittivelu
Acute chest syndrome is a complication of sickle cell disease and represents the highest cause of mortality in those afflicted with the disorder. Pregnancy represents an increased risk for complications of sickle cell disease in both the mother and fetus. We present a case of a 20-year-old patient with known sickle cell disease who was at 25-week gestation and developed acute chest syndrome refractory to conventional therapies and requiring emergency cesarean section. Following delivery, the patient developed acute respiratory distress syndrome (ARDS) requiring extracorporeal membrane oxygenation (ECMO)...
2018: Case Reports in Critical Care
https://www.readbyqxmd.com/read/29666203/efficacy-and-safety-of-pulmonary-application-of-corticosteroids-in-preterm-infants-with-respiratory-distress-syndrome-a-systematic-review-and-meta-analysis
#13
Mahin Delara, Bhupendrasinh F Chauhan, Mê-Linh Le, Ahmed M Abou-Setta, Ryan Zarychanski, Geert W 'tJong
BACKGROUND: Systemic corticosteroids as the frontline treatment of respiratory distress syndrome (RDS) in preterm infants are associated with adverse effects on growth and neurodevelopmental outcome, but the pulmonary administration of steroids may help prevent the development of bronchopulmonary dysplasia (BPD) without these side effects. OBJECTIVES: To evaluate the efficacy and safety of pulmonary application of corticosteroids in preterm infants with RDS. METHODS: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, ClinicalTrials...
April 17, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29664060/specialized-pro-resolving-mediators-regulate-alveolar-fluid-clearance-during-acute-respiratory-distress-syndrome
#14
REVIEW
Qian Wang, Song-Fan Yan, Yu Hao, Sheng-Wei Jin
Objective: Acute respiratory distress syndrome (ARDS) is an acute and lethal clinical syndrome that is characterized by the injury of alveolar epithelium, which impairs active fluid transport in the lung, and impedes the reabsorption of edema fluid from the alveolar space. This review aimed to discuss the role of pro-resolving mediators on the regulation of alveolar fluid clearance (AFC) in ARDS. Data Sources: Articles published up to September 2017 were selected from the PubMed, with the keywords of "alveolar fluid clearance" or "lung edema" or "acute lung injury" or "acute respiratory distress syndrome", and "specialized pro-resolving mediators" or "lipoxin" or "resolvin" or "protectin" or "maresin" or "alveolar epithelial cells" or "aspirin-triggered lipid mediators" or "carbon monoxide and heme oxygenase" or "annexin A1"...
April 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29663987/-effects-of-hippo-signaling-on-anti-oxidative-stress-of-mesenchymal-stem-cells-in-vitro
#15
Lang Li, Liang Dong, Jiaojie Hui, Fei Gao, Qiuhui Wang, Lan Yang, Jiangqian Zhang, Jie Yan
OBJECTIVE: To explore the effects of Hippo signaling on anti-oxidative stress of mouse marrow mesenchymal stem cells (mMSCs) in vitro. METHODS: mMSCs derived from C57BL/6 mice were identified using fluorescence-activated cell sorting analysis and the capabilities of osteogenic, chondrogenic and adipogenic differentiation were evaluated. 2-deoxy-D-glucose (2-DG) or XMU-MP-1 was used to modulate Hippo signaling. Oxidative stress was induced by H2 O2 treatment and the effect of oxidative stress induced by H2 O2 on survival of mMSCs was evaluated using methyl thiazolyl tetrazolium (MTT) assay...
April 2018: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29658450/-influence-of-acute-pancreatitis-in-pregnancy-on-pregnancy-outcomes-and-neonates
#16
Shu-Juan Fan, Jun-Xi Xiang, Mi Xiao, Fang-Hui Wang, Xiao-Jie Lin, Xi-Hui Zhou, Ting Ai, Li Liu
OBJECTIVE: To study the influence of acute pancreatitis in pregnancy (APIP) on pregnancy outcomes and neonates. METHODS: A retrospective analysis was performed for 33 APIP patients and 31 neonates born alive. RESULTS: Of the 33 APIP patients, 26 (79%) developed APIP in the late pregnancy. Fourteen (45%) patients had hyperlipidemic APIP, 13 (42%) had biliary APIP, and 4 (13%) had other types of APIP. According to the severity, 22 (67%) were mild APIP, 5 (15%) were moderate APIP, and 6 were severe APIP...
April 2018: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29657726/high-dose-steroid-therapy-for-acute-respiratory-distress-syndrome-lacking-common-risk-factors-predictors-of-outcome
#17
Yoshiaki Kinoshita, Hiroshi Ishii, Hisako Kushima, Kentaro Watanabe, Masaki Fujita
Aim: Acute respiratory distress syndrome (ARDS) is a life-threatening lung disease that usually occurs in patients with the underling risk factors that triggers lung inflammation. We sometimes encounter patients with ARDS lacking common risk factors. Recent studies have indicated the effectiveness of corticosteroids for this cohort. However, the characteristics of survivors with ARDS who lack common risk factors, and who received high-dose methylprednisolone pulse therapy (MPPT), are not known...
April 2018: Acute Medicine & Surgery
https://www.readbyqxmd.com/read/29657373/severe-varicella-pneumonia-in-adults-seven-years-single-center-experience-from-india
#18
Akashdeep Singh, Siddharth Parkash, Sunil K Gupta, R K Soni
Context: Varicella pneumonia is a rare but a serious complication of chickenpox in adults. There is paucity of data on varicella pneumonia from India. Aims: The aim of this study is to describe the clinical manifestations, hospital course, treatment, and outcome of adult patients with severe varicella pneumonia. Settings and Design: This was a retrospective, observational study of patients with severe varicella pneumonia attending a tertiary care teaching hospital...
March 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29652717/time-for-targeted-therapies-in-acute-respiratory-distress-syndrome-understanding-every-single-piece-of-the-puzzle
#19
Alexandre Gaudet, Julien Poissy, Daniel Mathieu
No abstract text is available yet for this article.
May 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29652713/-size-matters-in-regard-to-acute-respiratory-distress-syndrome-case-volume-and-mortality
#20
Robert M Kacmarek, Jesús Villar, Lorenzo Berra
No abstract text is available yet for this article.
May 2018: Critical Care Medicine
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