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https://www.readbyqxmd.com/read/29931506/there-is-a-close-association-between-the-recovery-of-liver-injury-and-glycemic-control-after-sglt2-inhibitor-treatment-in-japanese-subjects-with-type-2-diabetes-a-retrospective-clinical-study
#1
Tomoe Kinoshita, Masashi Shimoda, Junpei Sanada, Yoshiro Fushimi, Yurie Hirata, Shintaro Irie, Atsushi Obata, Tomohiko Kimura, Hidenori Hirukawa, Kenji Kohara, Fuminori Tatsumi, Shinji Kamei, Shuhei Nakanishi, Tomoatsu Mune, Kohei Kaku, Hideaki Kaneto
INTRODUCTION: Sodium-glucose co-transporter 2 (SGLT2) inhibitors function not only to reduce hyperglycemia but also to ameliorate liver injury and reduce body weight. The aim of this study was to examine in which subjects SGLT2 inhibitors are more effective for glycemic control, liver injury, and obesity in Japanese subjects with type 2 diabetes mellitus. METHODS: We enrolled a total of 156 subjects with type 2 diabetes who initiated SGLT2 inhibitor treatment after September 1, 2014 in Kawasaki Medical School (Protocol No...
June 21, 2018: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29930382/abnormal-expressions-of-ages-tgf-%C3%AE-1-bdnf-and-their-receptors-in-diabetic-rat-colon-associations-with-colonic-morphometric-and-biomechanical-remodeling
#2
Hong Sha, Xiaolin Tong, Jingbo Zhao
Present study aims to investigate the role of AGEs, TGF-β1, BDNF and their receptors on diabetes-induced colon remodeling. Diabetes was induced by a single tail vein injection 40 mg/kg of STZ. The parameters of morphometric and biomechanical properties of colonic segments were obtained from diabetic and normal rats. The expressions of AGE, RAGE, TGF- β1, TGF- β1 receptor, BDNF and TrkB were immunohistochemically detected in different layers of the colon. The expressions of AGE, RAGE, TGF-β1 and TGF- β1 receptor were increased whereas BDNF and TrkB were decreased in the diabetic colon (P < 0...
June 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29929463/treatment-of-diabesity-beyond-pharmacotherapy
#3
Himadri Singh, Vijayalakhsmi Venkatesan
Obesity is a prominent risk factor for type 2 diabetes. Management of type 2 diabetes requires weight management in addition to glycemic parameters. For obese type 2 diabetes patients, metformin, Sodium-glucose co-transporter-2 inhibitors or Glucagon-Like Peptide-1 Receptor Agonists should be prescribed as the first priority for controlling both hyperglycemia and body weight or fat distribution. The Combination of these drugs with sulfonylureas, thiazolidinediones, and insulin may also be required in chronic cases...
June 20, 2018: Current Drug Targets
https://www.readbyqxmd.com/read/29925687/androgen-excess-in-pancreatic-%C3%AE-cells-and-neurons-predisposes-female-mice-to-type-2-diabetes
#4
Guadalupe Navarro, Camille Allard, Jamie J Morford, Weiwei Xu, Suhuan Liu, Adrien Jr Molinas, Sierra M Butcher, Nicholas Hf Fine, Manuel Blandino-Rosano, Venkata N Sure, Sangho Yu, Rui Zhang, Heike Münzberg, David A Jacobson, Prasad V Katakam, David J Hodson, Ernesto Bernal-Mizrachi, Andrea Zsombok, Franck Mauvais-Jarvis
Androgen excess predisposes women to type 2 diabetes (T2D), but the mechanism of this is poorly understood. We report that female mice fed a Western diet and exposed to chronic androgen excess using dihydrotestosterone (DHT) exhibit hyperinsulinemia and insulin resistance associated with secondary pancreatic β cell failure, leading to hyperglycemia. These abnormalities are not observed in mice lacking the androgen receptor (AR) in β cells and partially in neurons of the mediobasal hypothalamus (MBH) as well as in mice lacking AR selectively in neurons...
June 21, 2018: JCI Insight
https://www.readbyqxmd.com/read/29924854/food-restriction-promotes-damage-reduction-in-rat-models-of-type-2-diabetes-mellitus
#5
Carlos Vinicius Dalto da Rosa, Jéssica Men de Campos, Anacharis Babeto de Sá Nakanishi, Jurandir Fernando Comar, Isabela Peixoto Martins, Paulo Cézar de Freitas Mathias, Maria Montserrat Diaz Pedrosa, Vilma Aparecida Ferreira de Godoi, Maria Raquel Marçal Natali
There are several animal models of type 2 diabetes mellitus induction but the comparison between models is scarce. Food restriction generates benefits, such as reducing oxidative stress, but there are few studies on its effects on diabetes. The objective of this study is to evaluate the differences in physiological and biochemical parameters between diabetes models and their responses to food restriction. For this, 30 male Wistar rats were distributed in 3 groups (n = 10/group): control (C); diabetes with streptozotocin and cafeteria-style diet (DE); and diabetes with streptozotocin and nicotinamide (DN), all treated for two months (pre-food restriction period)...
2018: PloS One
https://www.readbyqxmd.com/read/29924740/cyanidin-3-rutinoside-protects-ins-1-pancreatic-%C3%AE-cells-against-high-glucose-induced-glucotoxicity-by-apoptosis
#6
Kung-Ha Choi, Mi Hwa Park, Hyun Ah Lee, Ji-Sook Han
Exposure to high levels of glucose may cause glucotoxicity, leading to pancreatic β cell dysfunction, including cell apoptosis and impaired glucose-stimulated insulin secretion. The aim of this study was to explore the effect of cyanidin-3-rutinoside (C3R), a derivative of anthocyanin, on glucotoxicity-induced apoptosis in INS-1 pancreatic β cells. Glucose (30 mM) treatment induced INS-1 pancreatic β cell death, but glucotoxicity and apoptosis significantly decreased in cells treated with 50 μM C3R compared to that observed in 30 mM glucose-treated cells...
June 20, 2018: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
https://www.readbyqxmd.com/read/29924275/-prevalence-of-risk-factors-for-metabolic-syndrome-and-its-components-in-community-kitchen-users-in-a-district-in-lima-peru
#7
Karen J Adams, Jesús L Chirinos
OBJECTIVES: . To estimate the prevalence of risk factors for metabolic syndrome in adults who are community kitchen-users in a district in Lima. MATERIALS AND METHODS: . An observational, cross-sectional study was carried out with 20 to 59-year-old users of community kitchens selected from a two-stage cluster sampling. The metabolic syndrome was measured according to the International Diabetes Federation (IDF). Risk factors proposed by the WHO and the IDF were assessed, as well as the diet needs and intake average and its components at lunch...
January 2018: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29923997/euglycemic-diabetic-ketoacidosis-caused-by-dapagliflozin-a-case-report
#8
Yu-Mou Chou, Chen-June Seak, Zhong Ning Leonard Goh, Joanna Chen-Yeen Seak, Chen-Ken Seak, Chih-Chuan Lin
RATIONALE: Diabetic ketoacidosis is a serious and potentially life-threatening acute complication of diabetes mellitus (DM). Euglycemic diabetic ketoacidosis (eDKA) is however challenging to identify in the emergency department (ED) due to absence of marked hyperglycemia, often leading to delayed diagnosis and treatment. eDKA has been recently found to be associated with sodium-glucose cotransporter 2 (SGLT2) inhibitors, one of the newest classes of antidiabetics, though there are very limited reports implicating dapagliflozin as the offending agent in ED patients...
June 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29923773/how-should-we-assess-glycemic-variability-in-type-1-diabetes-contribution-of-principal-component-analysis-for-interstitial-glucose-indices-in-142-children
#9
Sophie Guilmin-Crépon, Jean-Claude Carel, Julien Schroedt, Erwan Scornet, Corinne Alberti, Nadia Tubiana-Rufi
BACKGROUND: Glycemic variability (GV) can be used to assess glycemic control in diabetes, but there is no clear consensus concerning the methods to use for its assessment. Methodological differences have resulted in differences in the outcome of GV metrics used in research studies, controversies over clinical impact, and an absence of integration into routine care. AIM: To identify the indicators of GV most meaningful for clinicians, patients, and clinical researchers...
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29923339/cardiovascular-disease-in-diabetes-type-2-current-concepts
#10
REVIEW
A Rosengren
Type 2 diabetes is a major and accelerating public health challenge. Between 1980 and 2014, a period of just 35 years, the number of adults with diabetes globally is estimated to have increased from 108 million to 422 million, due not only to sharply rising obesity rates, but also to increasing population size, and longer life expectancy. The increase in numbers is due to an increasing prevalence of diabetes worldwide, increasing population size, and longer life expectancy. Overall, worldwide age-standardized adult diabetes prevalence doubled from 4...
June 20, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29923291/inflammation-of-brown-beige-adipose-tissues-in-obesity-and-metabolic-disease
#11
Francesc Villarroya, Rubén Cereijo, Aleix Gavaldà-Navarro, Joan Villarroya, Marta Giralt
Many of the comorbidities of obesity, including type 2 diabetes and cardiovascular diseases are related to the low-grade chronic inflammation of white adipose tissue. Under white adipocyte stress, local infiltration of immune cells and enhanced production of pro-inflammatory cytokines together reduce metabolic flexibility and lead to insulin resistance in obesity. Whereas white adipocytes act in energy storage, brown and beige adipocytes specialize in energy expenditure. Brown and beige activity protects against obesity and associated metabolic disorders, such as hyperglycemia and hyperlipidemia...
June 20, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29923016/incidence-and-management-of-postoperative-hyperglycemia-in-patients-undergoing-insulinoma-resection
#12
Pavel Nockel, Amit Tirosh, Mustapha El Lakis, Apostolos Gaitanidis, Roxanne Merkel, Dhaval Patel, Naris Nilubol, Samira M Sadowski, Craig Cochran, Phillip Gorden, Electron Kebebew
PURPOSE: It has been proposed that rebound hyperglycemia after resection of insulinoma indicates a biochemical cure. However, there is scant objective data in the literature on the rate and need for intervention in hyperglycemia in patients undergoing resection of insulinoma. The goal of our study was to evaluate the rate of postoperative hyperglycemia, any predisposing factors, and the need for intervention in a prospective cohort study of all patients undergoing routine glucose monitoring...
June 19, 2018: Endocrine
https://www.readbyqxmd.com/read/29916738/emerging-technologies-for-diabetes-care
#13
Timothy S Bailey, John Walsh, Jenine Y Stone
New therapies, monitoring, and revolutionary enabling technologies applied to healthcare represent an historic opportunity to improve the lives of people with diabetes. These advances enable more meaningful monitoring of blood glucose values with the facilitation of more optimal insulin dosing and delivery. Newer insulins and delivery systems are in development that seek to mitigate both hyperglycemia and hypoglycemia and increase time in range. Information systems now exist that may be leveraged to merge data from previously discrete systems into new models of connected care...
June 2018: Diabetes Technology & Therapeutics
https://www.readbyqxmd.com/read/29915744/prevalence-of-metabolic-syndrome-crossing-40-in-northern-india-time-to-act-fast-before-it-runs-out-of-proportions
#14
Yasmee Khan, Arati Lalchandani, Ajesh Chandra Gupta, Sagar Khadanga, Sanjeev Kumar
Background: Metabolic syndrome (MetS) is a constellation of high blood pressure, hyperglycemia, obesity, and dyslipidemia. Its presence makes the patient more prone for cardiovascular events. Its prevalence has been documented as 11%-41%. The present study was undertaken to find out the demographic profile of the MetS in Kanpur region of northern India. Materials and Methods: This is a hospital based, cross-sectional study with adequate sample size. Results: Out of the randomly selected 420 patients (232 males and 188 females), 172 cases (61 males and 111 females) were found to have MeTS adopting the National Cholesterol Education Program Adult Treatment Panel III criteria...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915736/evaluation-of-treatment-satisfaction-efficacy-and-safety-of-dipeptidyl-peptidase-4-inhibitors-in-geriatric-patients-with-type-2-diabetes-mellitus-a-cross-sectionalcomparative-study
#15
Harmanjit Singh, Avinash Chakrawarti, Harjit Singh, P Guruprasad, Yogendra Kumar Gupta
Introduction: Dipeptidyl peptidase 4 (DPP4) inhibitors are attractive agents to be used in the elderly patients with Type 2 diabetes mellitus (T2DM) because of their beneficial effects. Methods: In this cross-sectional, observational study, we evaluated and compared the treatment satisfaction using Diabetes Treatment Satisfaction Questionnaire (DTSQ) in two groups (i.e., regimens containing DPP4 inhibitors vs. other regimens). Efficacy was evaluated by assessing and comparing the glycosylated hemoglobin (HbA1c) values and the percentage of patients who achieved the glycemic control (HbA1c <7%)...
January 2018: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29915446/refractory-hypotension-due-to-nivolumab-induced-adrenal-insufficiency
#16
Yoshiaki Tsukizawa, Keisuke Kondo, Toshihisa Ichiba, Hiroshi Naito, Kazuhito Mizuki, Ken Masuda
Nivolumab, a new immune checkpoint inhibitor that has been found to improve outcomes for patients with some advanced cancers, is being increasingly used. Immune checkpoint inhibitors can cause immune-related adverse events, including dermatitis, enterocolitis, hepatitis and hypophysitis, but adrenal insufficiency rarely occurs. We present a case of Nivolumab-induced adrenal insufficiency in a man who complained of refractory hypotension. A 52-year-old man with non-small cell lung cancer visited our emergency department complaining of fatigue and diarrhea...
May 2018: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/29913560/maternal-folic-acid-supplementation-with-vitamin-b-12-deficiency-during-pregnancy-and-lactation-affects-the-metabolic-health-of-adult-female-offspring-but-is-dependent-on-offspring-diet
#17
Amanda M Henderson, Daven C Tai, Rika E Aleliunas, Abeer M Aljaadi, Melissa B Glier, Eric E Xu, Joshua W Miller, C Bruce Verchere, Tim J Green, Angela M Devlin
Epidemiologic studies have reported relationships between maternal high folate and/or low B12 status during pregnancy and greater adiposity and insulin resistance in children. The goal of this study was to determine the effects of maternal folic acid supplementation (10 mg/kg diet), with (50 μg/kg diet) and without B12 , on adult, female offspring adiposity and glucose homeostasis. Female C57BL/6J mice were fed 1 of 3 diets from weaning and throughout breeding, pregnancy, and lactation: control (2 mg/kg diet folic acid, 50 μg/kg diet B12 ), supplemental folic acid with no B12 (SFA-B12 ), or supplemental folic acid with adequate B12 (SFA+B12 )...
April 17, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29913098/radiofrequency-radiation-emitted-from-wi-fi-2-4-ghz-causes-impaired-insulin-secretion-and-increased-oxidative-stress-in-rat-pancreatic-islets
#18
Ali Masoumi, Narges Karbalaei, S M J Mortazavi, Mohammad Shabani
PURPOSE: There is a great concern regarding the possible adverse effects of electromagnetic radiation (EMR). This study investigated the effects of EMR induced by Wi-Fi (2.45GHz) on insulin secretion and antioxidant redox systems in the rat pancreas. MATERIALS AND METHODS: Adult male Sprague-Dawley rats in the weight range of 230 to 260 g were divided into control, sham, Wi-Fi exposed groups. After long term exposure (4 h/day for 45 days) to Wi-Fi electromagnetic radiation, plasma levels of glucose and insulin during intraperitoneal glucose tolerance test were measured...
June 18, 2018: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/29911757/reduction-in-serum-triglyceride-levels-in-diabetic-patients-may-result-in-decreased-insulin-dependence-and-disease-regression
#19
Nadav Shinhar, Dana Marcoviciu, Dror Dicker
BACKGROUND: Type 2 diabetes mellitus is a multifactorial disease in which genetic susceptibility and environmental factors induce pancreatic β-cell dysfunction and insulin resistance. Additional factors such as hyperglycemia and hyperlipidemia have roles in β-cell dysfunction and disease progression. The phenomenon of lipid-induced pancreatic β-dysfunction, designated as lipotoxicity, has been observed in several in vitro and in vivo experiments; however, there is still no solid evidence for the occurrence of this event in humans...
June 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29911075/trace-element-status-in-type-2-diabetes-a-meta-analysis
#20
Namrata Sanjeevi, Jeanne Freeland-Graves, S Natasha Beretvas, Prageet K Sachdev
Introduction: Type 2 diabetes is a chronic metabolic disorder that has been associated with alterations in the status of trace elements, including zinc, copper, iron and manganese. However, clinical studies reporting statuses of these trace elements in type 2 diabetes patients compared to controls have shown conflicting results. Objective: This meta-analysis aimed to summarize the existing literature on the statuses of zinc, copper, iron, and manganese in Type 2 diabetes mellitus patients...
May 2018: Journal of Clinical and Diagnostic Research: JCDR
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