keyword
MENU ▼
Read by QxMD icon Read
search

"hyperglycemia"

keyword
https://www.readbyqxmd.com/read/29232673/association-between-urinary-alpha1-microglobulin-levels-and-nonalcoholic-fatty-liver-disease-a-cross-sectional-study
#1
Juanwen Zhang, Xuyao Zhang, Ying Zhao, Guocai Lv
BACKGROUND: We aimed to explore the association between urinary alpha1-microglobulin (A1M) levels and nonalcoholic fatty liver disease (NAFLD) in a Chinese population. STUDY: We performed a cross-sectional study among 2,215 Chinese who attended their annual health examination at First Affiliated Hospital, College of Medicine, Zhejiang University. Urinary A1M-creatinine ratio and other clinical and laboratory parameters were measured. RESULTS: A total of 20...
December 12, 2017: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/29232056/associations-between-laterality-of-orofacial-clefts-and-medical-and-academic-outcomes
#2
Emily R Gallagher, Babette Siebold, Brent R Collett, Timothy C Cox, Verena Aziz, Michael L Cunningham
Patients with oral clefts have an increased risk of other malformations, syndromes, and lower academic performance in school. Few studies have investigated if laterality of clefts is associated with medical and academic outcomes. Oral clefts have nonrandom laterality, with left-sided clefts occurring approximately twice as often as right-sided clefts. Using a retrospective study design, we examined potential associations of cleft attributes and outcomes in patients with cleft lip with or without cleft palate (CL/P) born in 2003-2010 who were treated at the Seattle Children's Craniofacial Center...
December 12, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29231167/glucose-inhibits-cardiac-muscle-maturation-through-nucleotide-biosynthesis
#3
Haruko Nakano, Itsunari Minami, Daniel Braas, Herman Pappoe, Xiuju Wu, Addelynn Sagadevan, Laurent Vergnes, Kai Fu, Marco Morselli, Christopher Dunham, Xueqin Ding, Adam Z Stieg, James K Gimzewski, Matteo Pellegrini, Peter M Clark, Karen Reue, Aldons J Lusis, Bernard Ribalet, Siavash K Kurdistani, Heather Christofk, Norio Nakatsuji, Atsushi Nakano
The heart switches its energy substrate from glucose to fatty acids at birth, and maternal hyperglycemia is associated with congenital heart disease. However, little is known about how blood glucose impacts heart formation. Using a chemically defined human pluripotent stem-cell-derived cardiomyocyte differentiation system, we found that high glucose inhibits the maturation of cardiomyocytes at genetic, structural, metabolic, electrophysiological, and biomechanical levels by promoting nucleotide biosynthesis through the pentose phosphate pathway...
December 12, 2017: ELife
https://www.readbyqxmd.com/read/29231052/efficacy-and-safety-of-ranolazine-in-diabetic-patients-a-systematic-review-and-meta-analysis
#4
Xiaofang Zeng, Yinyin Zhang, Jianhui Lin, Haikuo Zheng, Jie Peng, Wei Huang
BACKGROUND: Recent studies have discovered that the antiangina agent ranolazine exerts a glucometabolic effect. OBJECTIVE: This systematic review and meta-analysis aimed to further understand the efficacy and safety profile of ranolazine in patients with diabetes. METHODS: Randomized controlled trials (RCTs) were searched in PubMed, Cochrane, and EMBASE databases and in ClinicalTrials.gov up to July 2017. Efficacy end points were defined as the change in hemoglobin A1C (A1C) and fasting serum glucose (FSG) levels...
December 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29230196/saxagliptin-induces-%C3%AE-cell-proliferation-through-increasing-stromal-cell-derived-factor-1%C3%AE-in-vivo-and-in-vitro
#5
Chun-Jun Li, Bei Sun, Qian-Hua Fang, Min Ding, Yun-Zhi Xing, Li-Ming Chen, De-Min Yu
Dipeptidyl peptidase-4 inhibitors, such as saxagliptin, have been reported to have beneficial effects on β-cell function, but the specific underlying mechanism remains unclear. Stromal cell-derived factor-1α (SDF-1α), a chemokine produced in multiple organs, has been considered as a crucial regulator in promoting β-cell survival. Here, we speculate that SDF-1α might mediate the effect of saxagliptin on improving β-cell function. After 12-week saxagliptin treatment in high-fat diet/streptozotocin-induced diabetic rats, significant improvement in pancreas insulin secretion capacity evaluated by hyperglycemia clamp and increased β-cell to α-cell areas ratio were observed...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29229615/defective-amplifying-pathway-of-%C3%AE-cell-secretory-response-to-glucose-in-type-2-diabetes-integrated-modeling-of-in-vitro-and-in-vivo-evidence
#6
Eleonora Grespan, Toni Giorgino, Silva Arslanian, Andrea Natali, Ele Ferrannini, Andrea Mari
In vivo studies have investigated the role of β-cell dysfunction in type 2 diabetes (T2D), while in vitro research on islets has elucidated key mechanisms controlling insulin secretion rate (ISR). However, the relevance of the cellular mechanisms identified in vitro, i.e., the triggering and amplifying pathways, has not been established in vivo Furthermore, the mechanisms underpinning β-cell dysfunction in T2D remain undetermined. We propose a unifying explanation of several characteristic features of insulin secretion, both in vitro and in vivo, using a mathematical model...
December 11, 2017: Diabetes
https://www.readbyqxmd.com/read/29229234/trans-resveratrol-mitigates-type-1-diabetes-induced-oxidative-dna-damage-and-accumulation-of-advanced-glycation-end-products-in-glomeruli-and-tubules-of-rat-kidneys
#7
Heba Al-Hussaini, Narayana Kilarkaje
Hyperglycemia induces the formation of advanced glycation end products (AGEs) and their receptors (RAGEs), which alter several intracellular signaling mechanisms leading to the onset and progression of diabetic nephropathy. The present study focused on, i) modulatory effects of trans-resveratrol (3,5,4'-trihydroxy-trans-stilbene) on structural changes, AGE (NƐ-carboxymethyl-lysine), RAGE, oxidative stress and DNA damage, and apoptosis, and ii) localization of fibrotic changes, AGE, RAGE, 8-oxo-dG and 4-hydroxynonenal (4-HNE) in diabetic rat kidneys...
December 8, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29228809/attenuation-of-oxidative-stress-and-inflammation-by-portulaca-oleracea-in-streptozotocin-induced-diabetic-rats
#8
Saeed Samarghandian, Abasalt Borji, Tahereh Farkhondeh
The present study was designed to investigate the protective effect of the aqueous extract of Portulaca oleracea against hyperglycemic, oxidative damage and inflammation in the serum of streptozotocin (STZ)-induced diabetic rats. In the present study, the rats were divided into the following groups of 8 animals each: control, untreated diabetic, 3 Portulaca oleracea (100, 200, 400 mg/kg/d)-treated diabetic groups. At the end of the 4-week period, glucose, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), malondialdehyde (MDA), glutathione (GSH), and total antioxidant status (TAS) levels were measured...
January 1, 2017: Journal of Evidence-based Complementary & Alternative Medicine
https://www.readbyqxmd.com/read/29228766/the-effects-of-addition-of-coenzyme-q10-to-metformin-on-sirolimus-induced-diabetes-mellitus
#9
In O Sun, Long Jin, Jian Jin, Sun Woo Lim, Byung Ha Chung, Chul Woo Yang
Background/Aims: This study was performed to determine whether adding coenzyme Q10 (CoQ10) to metformin (MET) has a beneficial effect as a treatment for sirolimus (SRL)-induced diabetes mellitus (DM). Methods: DM was induced in rats by daily treatment with SRL (0.3 mg/kg, subcutaneous) for 28 days, and animals were treated with CoQ10 (20 mg/kg, oral) and MET (250 mg/kg, oral) alone or in combination for the latter 14 days of SRL treatment. The effects of CoQ10 and MET on SRL-induced DM were assessed with the intraperitoneal glucose tolerance test (IPGTT) and by determining plasma insulin concentration and the homeostatic model assessment of insulin resistance (HOMA-R) index...
December 13, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29228603/elevating-vegf-a-and-pdgf-bb-secretion-by-salidroside-enhances-neoangiogenesis-in-diabetic-hind-limb-ischemia
#10
Agnes Dwi Ariyanti, Julita Sisjayawan, Jing Zhang, Jian-Qi Zhang, Gui-Xue Wang, Makoto Miyagishi, Shou-Rong Wu, Vivi Kasim
Hind-limb ischemia (HLI) is one of the major complication of diabetic patients. Angiogenesis potential in diabetic patients is severely disrupted, and the mechanism underlying it has not been fully elucidated, making it an obstacle for developing an efficient therapeutic angiogenesis strategy. Skeletal muscle cells, through their paracrine function, had been known to be critical for neoangiogenesis. Here we found that hyperglycemia upregulates the expression of skeletal muscle cells prolyl hydroxylase domain 3 (PHD3), which resulted in the decrease of the secretion of angiogenic factors, especially VEGF-A and PDGF-BB...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228553/activation-of-nrf2-mediated-anti-oxidant-genes-by-antrodin-c-prevents-hyperglycemia-induced-senescence-and-apoptosis-in-human-endothelial-cells
#11
Kumar K J Senthil, Vani M Gokila, Sheng-Yang Wang
In the present study, we investigated the effects of antrodin C (ADC), a maleimide derivative isolated from mycelia of Antrodia cinnamomea, on high glucose (HG, 30 mM)-accelerated endothelial dysfunction in vitro. HG-induced cytotoxicity in human umbilical vein endothelial cells (HUVECs) was significantly ameliorated by ADC. In addition, treatment with ADC significantly prevented HG-induced senescence, growth arrest at the G1-S transition phase and apoptosis in HUVECs. Moreover, the increased level of intracellular reactive oxygen species (ROS) under HG condition was significantly ameliorated by ADC...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29228048/trends-in-the-management-levels-of-metabolic-risk-factors-in-middle-aged-and-elderly-patients-with-type-2-diabetes-mellitus-the-korean-national-health-and-nutrition-examination-survey-1998-2014
#12
Sukyung Cho, Haeun Jang, Kyong Park
The present study examined the temporal trends in the management of blood pressure, glucose, and lipid levels among middle-aged and elderly patients with type 2 diabetes using data from the Korean National Health and Nutrition Examination Survey (1998-2014). A total of 3,689 patients with diabetes were included and divided into middle-aged (30-64 years old) and elderly (≥65 years old) groups. Demographic and lifestyle data were obtained using a self-reported questionnaire, and trained medical staff obtained fasting blood samples and blood pressure data...
2017: PloS One
https://www.readbyqxmd.com/read/29227833/vitamin-a-deficiency-in-mice-alters-host-and-gut-microbial-metabolism-leading-to-altered-energy-homeostasis
#13
Yuan Tian, Robert G Nichols, Jingwei Cai, Andrew D Patterson, Margherita T Cantorna
Vitamin A deficiency (A-) is a worldwide public health problem. To better understand how vitamin A status influences gut microbiota and host metabolism, we systematically analyzed urine, cecum, serum and liver samples from vitamin A sufficient (A+) and deficient (A-) mice using 1H NMR-based metabolomics, quantitative (q)PCR and 16S rRNA gene sequencing coupled with multivariate data analysis. The microbiota in the cecum of A- mice showed compositional as well as functional shifts compared to the microbiota from A+ mice...
November 5, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29227535/antidiabetic-and-lipid-lowering-effects-of-the-polyphenol-extracts-from-the-leaves-of-clausena-lansium-lour-skeels-on-streptozotocin-induced-type-2-diabetic-rats
#14
Fansheng Kong, Zhipeng Su, Xiaoming Guo, Feng Zeng, Yongguang Bi
Clausena lansium (Lour.) Skeels (Wampee) is widely grown in China and considered as a healthy fruit. Its leaves are also considered as traditional herbs. This study analyzed polyphenol compounds in polyphenol extracts of the leaves C. lansium (lour.) Skeels (PEL) and investigated the protective effect of PEL against hyperglycemia and hyperlipidemia in T2DM rats. The result showed that PEL is composed mainly of gallic acid, chlorogenic acid, coffee acid, ferulic acid, and rutin. PEL could obviously relieve some symptoms of T2DM rats, including emaciation, hyperhidrosis, polyphagia, diuresis, liver swelling, kidney, and pancreas hypertrophy, as well as reduce fasting blood glucose...
December 11, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29227292/association-of-hyperglycemia-systolic-and-diastolic-hypertension-and-hyperthermia-relative-to-baseline-in-the-acute-phase-of-stroke-with-poor-outcome-after-intravenous-thrombolysis
#15
Stefano Forlivesi, Nicola Micheletti, Giampaolo Tomelleri, Paolo Bovi, Manuel Cappellari
: In the acute phase of ischemic stroke, the trend of some physiological variables, such as blood glucose (BG), blood pressure, and body temperature (BT), might influence outcome. We aimed to assess the association of hyperglycemia, systolic and diastolic hypertension, and hyperthermia relative to baseline BG, systolic blood pressure, diastolic blood pressure and BT, respectively, in the first 12 h with poor outcome after intravenous thrombolysis (IVT). We conducted a retrospective analysis of data prospectively collected from 200 consecutive anterior ischemic stroke patients treated with IVT...
December 8, 2017: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29226041/dapagliflozin-cardiovascular-safety-and-benefits-in-type-2-diabetes-mellitus
#16
REVIEW
Fatima Saleem
Sodium-glucose co-transporter 2 inhibitors (SGLT2is) such as dapagliflozin, canagliflozin, and empagliflozin, are a promising new therapy in the treatment of type 2 diabetes mellitus (T2DM). SGLT2is can effectively reduce hyperglycemia thus improving glycemic control and they offer some beneficial effects on the cardiovascular (CV) system which can benefit patients with heart failure in addition toT2DM. The United States Food and Drug Administration requires new diabetes mellitus therapies to show a CV safety profile...
October 5, 2017: Curēus
https://www.readbyqxmd.com/read/29225978/coexistence-of-gh-producing-pituitary-macroadenoma-and-meningioma-in-a-patient-with-multiple-endocrine-neoplasia-type-1-with-hyperglycemia-and-ketosis-as-first-clinical-sign
#17
A Herrero-Ruiz, H S Villanueva-Alvarado, J J Corrales-Hernández, C Higueruela-Mínguez, J Feito-Pérez, J M Recio-Cordova
We present the clinical case of a patient who was admitted with an onset of diabetes mellitus (DM) with associated ketosis and whose clinical, hormonal, and radiological evolution revealed the presence of primary hyperparathyroidism, pancreatic neuroendocrine tumor, and GH-producing pituitary macroadenoma in the context of multiple endocrine neoplasia type 1 (MEN1). DM is relatively common in cases of acromegaly, but it is not generally associated with ketosis. Simultaneously, the patient presented a meningioma, which is associated with pituitary macroadenoma only in extremely rare cases...
2017: Case Reports in Endocrinology
https://www.readbyqxmd.com/read/29225891/evaluation-of-a-type-2-diabetes-prevention-program-using-a-commercial-weight-management-provider-for-non-diabetic-hyperglycemic-patients-referred-by-primary-care-in-the-uk
#18
Carolyn Piper, Agnes Marossy, Zoe Griffiths, Amanda Adegboye
Objectives: To determine if a diabetes prevention program (DPP) delivered by a commercial weight management provider using a UK primary care referral pathway could reduce the progression to type 2 diabetes (T2D) in those diagnosed with non-diabetic hyperglycemia (NDH-being at high risk of developing T2D). Research design: This is a quasi-experimental translational research study. Methods: 14 primary care practices identified, recruited and referred patients with NDH (fasting plasma glucose ≥5...
2017: BMJ Open Diabetes Research & Care
https://www.readbyqxmd.com/read/29225740/glycemic-control-in-acute-illness
#19
REVIEW
Moritoki Egi, Nana Furushima, Shohei Makino, Satoshi Mizobuchi
Hyperglycemia is commonly observed in critical illness. A landmark large randomized controlled trial (RCT) reported that the incidence of hyperglycemia (blood glucose concentration > 108 mg/dl) was as high as 97.2% in critically ill patients. During the past two decades, a number of RCTs and several meta-analyses and network meta-analyses have been conducted to determine the optimal target for acute glycemic control. The results of those studies suggest that serum glucose concentration would be better to be maintained between 144 and 180 mg/dl...
December 2017: Korean Journal of Anesthesiology
https://www.readbyqxmd.com/read/29225202/epigenetic-modifications-an-important-mechanism-in-diabetic-disturbances
#20
Anna Rorbach-Dolata, Adriana Kubis, Agnieszka Piwowar
In the search for explanations of diabetes pathomechanisms, especially the development of its vascular complications (micro- and macrovascular ), although current, good metabolic control of diabetes, attention was drawn to the role of epigenetic inheritance associated with epigenetic modifications of histone proteins and DNA in hyperglycemia conditions. This study showed the significant role of DNA methylation and histone epigenetic modifications (a different nature and a different degree) in the transmission of information that is not connected with gene inheritance but concerns the persistent changes induced by hyperglycemia...
November 29, 2017: Postȩpy Higieny i Medycyny Doświadczalnej
keyword
keyword
111427
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"