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https://www.readbyqxmd.com/read/28227029/automated-ongoing-data-validation-and-quality-control-of-multi-institutional-studies
#1
Lara J Kanbar, Wissam Shalish, Doina Precup, Karen Brown, Guilherme M Sant'Anna, Robert E Kearney, Lara J Kanbar, Wissam Shalish, Doina Precup, Karen Brown, Guilherme M Sant'Anna, Robert E Kearney, Robert E Kearney, Lara J Kanbar, Wissam Shalish, Doina Precup, Karen Brown, Guilherme M Sant'anna
This paper addresses the problem of ensuring the validity and quality of data in ongoing multi-disciplinary studies where data acquisition spans several geographical sites. It describes an automated validation and quality control procedure that requires no user supervision and monitors data acquired from different locations before analysis. The procedure is illustrated for the Automated Prediction of Extubation readiness (APEX) project in preterm infants, where acquisition of clinical and cardiorespiratory data occurs at 6 sites using different equipment and personnel...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226647/improving-heart-rate-estimation-in-preterm-infants-with-bivariate-point-process-analysis-of-heart-rate-and-respiration
#2
Alan H Gee, Riccardo Barbieri, David Paydarfar, Premananda Indic, Alan H Gee, Riccardo Barbieri, David Paydarfar, Premananda Indic, David Paydarfar, Riccardo Barbieri, Alan H Gee, Premananda Indic
Accurate estimation of heart rate dynamics in preterm infants is important for predicting recurrent episodes of severe bradycardia. We hypothesize that estimation of heart rate can be improved by including respiration as a state variable, based on mechanisms that underlie cardio-respiratory coherence. For ten preterm infants, we demonstrate that including respiration as a covariate improves estimation accuracy by an average of 11% across bradycardia severity, and reduces the maximum error by 8%. We also find that cardio-respiratory coherence increases in low frequency content just prior to severe bradycardia...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226644/examining-the-effect-of-mgso4-on-sharp-wave-transient-activity-in-the-hypoxic-ischemic-fetal-sheep-model
#3
Meherzad J Lakadia, Hamid Abbasi, Alistair J Gunn, Charles P Unsworth, Laura Bennet, Meherzad J Lakadia, Hamid Abbasi, Alistair J Gunn, Charles P Unsworth, Laura Bennet, Laura Bennet, Hamid Abbasi, Alistair J Gunn, Meherzad J Lakadia, Charles P Unsworth
Hypoxic-ischemic encephalopathy (HIE) due to lack of oxygen is a debilitating disorder experienced by a significant number of preterm infants during birth. Studies show that the brain undergoes different phases of injury following hypoxic insult, but the first 6-8 hours (known as a latent phase) are the key to treatment efficacy. Cerebral hypothermia is one known treatment, and for it to be effective it must be started during the latent phase and continued for several days. In order to determine the effectiveness of treatment it is important to pinpoint the time of insult...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226028/late-preterm-infants-motor-development-until-term-age
#4
Viviane Martins Santos, Cibelle Kayenne Martins Roberto Formiga, Paulo Roberto Bezerra de Mello, Cléa Rodrigues Leone
OBJECTIVES: To analyze the motor development of late preterm newborn infants (LPI) from birth to term-corrected age using the Test of Infant Motor Performance (TIMP) and to compare the obtained results with those of term infants at birth. METHODS: Prospective cohort study, 29 late preterm newborn infants were evaluated by the TIMP at birth and every two weeks until term-corrected age. The TIMP was administered to 88 term infants at birth. RESULTS: The mean TIMP score of late preterm newborn infants was 51...
January 1, 2017: Clinics
https://www.readbyqxmd.com/read/28225202/cardiac-remodeling-in-preterm-infants-with-prolonged-exposure-to-a-patent-ductus-arteriosus
#5
Koert de Waal, Nilkant Phad, Nick Collins, Andrew Boyle
BACKGROUND: Sustained volume load due to a patent ductus arteriosus (PDA) leads to cardiac remodeling. Remodeling changes can become pathological and are associated with cardiovascular disease progression. Data on remodeling changes in preterm infants is not available. METHODS: Clinical and echocardiography data were collected in preterm infants <30 weeks gestation on postnatal day 3 and then every 7-14 days until closure of the ductus arteriosus. Images were analyzed using conventional techniques and speckle tracking...
February 22, 2017: Congenital Heart Disease
https://www.readbyqxmd.com/read/28224332/association-of-single-nucleotide-polymorphisms-of-il23r-and-il17-with-necrotizing-enterocolitis-in-premature-infants
#6
Jiayi Tian, Yanjun Liu, Yanfang Jiang, Haohan Zhou, Tong Zhu, Xiaoqi Zhao, Liping Peng, Chaoying Yan
Necrotizing enterocolitis (NEC) is a severe gastrointestinal inflammatory disease in neonates, particularly in preterm infants. The interleukin (IL) 23/IL17 axis has been shown to play an important role in the gastrointestinal inflammation. However, the association of gene polymorphisms in the IL23/IL17 axis and the development of NEC remains unknown. In this study, we aimed to explore a possible genetic role of IL23R and IL17 in the development of NEC. We identified single nucleotide polymorphisms (SNPs) in IL23R (rs10889677), IL17A (rs2275913), and IL17F (rs763780) by polymerase chain reaction and Sanger sequencing...
February 21, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28224098/video-recording-of-neonatal-resuscitation-a-feasibility-study-to-inform-widespread-adoption
#7
Sandesh Shivananda, Jennifer Twiss, Enas El-Gouhary, Salhab El-Helou, Connie Williams, Prashanth Murthy, Gautham Suresh
AIM: To determine the feasibility of introducing video recording (VR) of neonatal resuscitation (NR) in a perinatal centre. METHODS: This was a prospective cohort quality improvement study on preterm infants and their caregivers. Based on evidence and experience of other centers using VR intervention, a contextually relevant implementation and evaluation strategy was designed in the planning phase. The components of intervention were pre-resuscitation team huddle, VR of NR and video debriefing (VD), all occurring on the same day...
February 8, 2017: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/28222717/causes-of-death-in-very-preterm-infants-cared-for-in-neonatal-intensive-care-units-a-population-based-retrospective-cohort-study
#8
Tim Schindler, Louise Koller-Smith, Kei Lui, Barbara Bajuk, Srinivas Bolisetty
BACKGROUND: While there are good data to describe changing trends in mortality and morbidity rates for preterm populations, there is very little information on the specific causes and pattern of death in terms of age of vulnerability. It is well established that mortality increases with decreasing gestational age but there are limited data on the specific causes that account for this increased mortality. The aim of this study was to establish the common causes of hospital mortality in a regional preterm population admitted to a neonatal intensive care unit (NICU)...
February 21, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28219614/palivizumab-prophylaxis-in-preterm-infants
#9
Paul Kiet Tang
No abstract text is available yet for this article.
February 14, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28219359/congenital-tuberculosis-in-an-extremely-preterm-infant-conceived-after-in-vitro-fertilization-case-report
#10
Veronica Samedi, Stephen K Field, Essa Al Awad, Gregory Ratcliffe, Kamran Yusuf
BACKGROUND: Congenital tuberculosis is a rare manifestation of tuberculosis. The diagnosis is often delayed, especially in preterm neonates because of the non-specific clinical presentation and the lack of awareness of maternal disease prior to pregnancy. CASE PRESENTATION: We report a case of congenital tuberculosis in an infant born at 24 weeks of gestation to a mother who presented with uncontrolled seizures during preterm labor. Maternal diagnosis was initially made by placental pathology, and later confirmed by isolation of Mycobacterium tuberculosis in urine, gastric aspirates and sputum...
February 20, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28218962/survey-of-neonatal-resuscitation-practices-showed-post-training-improvements-but-need-to-reinforce-preterm-management-monitoring-and-adrenaline-use
#11
Montserrat Izquierdo, Martín Iriondo, César Ruiz, Gonzalo Zeballos, Miguel Sánchez, Eva Gonzalez, Máximo Vento, Marta Thió
AIM: Neonatal resuscitation surveys have showed practice variations between countries, centres and levels of care. We evaluated delivery room practices after a nationwide neonatal resuscitation training programme focused on non-tertiary centres. METHODS: A 2012 survey sent to all Spanish hospitals handling deliveries covered staff availability and training, equipment and practices in the delivery room and during transfers to neonatal intensive care units. The results from 98 centres that had completed a previous survey in 2007 were analysed by levels of care...
February 20, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28218813/family-centered-care-for-infants-born-preterm-comparing-parents-and-physical-therapists-perceptions
#12
Saori Miyagishima, Nobuaki Himuro, Naoki Kozuka, Mitsuru Mori, Hiroyuki Tsutsumi
OBJECTIVES: The objective of this study was to compare perceptions between physical therapists and parents about family-centered care for preterm infants. METHODS: A translated version of The Measure of Processes of Care 20 (MPOC-20) and a Measures of Processes of Care for Service Providers (MPOC-SP) were used to evaluate the family-centered care for preterm infants. RESULTS: A total of 42 parents of 44 preterm infants and 9 physical therapists completed questionnaires...
February 20, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28213557/tension-pneumocephalus-induced-by-high-flow-nasal-cannula-ventilation-in-a-neonate
#13
Alicia Iglesias-Deus, Alejandro Pérez-Muñuzuri, Olalla López-Suárez, Pilar Crespo, Maria-Luz Couce
The use of high-flow nasal cannula (HFNC) therapy as respiratory support for preterm infants has increased rapidly worldwide. The evidence available for the use of HFNC is as an alternative to nasal continuous positive airway pressure (CPAP) and in particular to prevent postextubation failure. We report a case of tension pneumocephalus in a preterm infant as a complication during HFNC ventilation. Significant neurological impairment was detected and support was eventually withdrawn. Few cases of pneumocephalus as a complication of positive airway pressure have been reported in the neonatal period, and they all have been related to CPAP...
March 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28211916/role-of-endothelial-nitric-oxide-synthase-and-endothelin-1-polymorphism-genes-with-the-pathogenesis-of-intraventricular-hemorrhage-in-preterm-infants
#14
Dawid Szpecht, Janusz Gadzinowski, Agnieszka Seremak-Mrozikiewicz, Grażyna Kurzawińska, Marta Szymankiewicz
In the pathogenesis of neonatal intraventricular hemorrhage (IVH) in preterm infants, an important role is played by changes in venous and arterial cerebral flows. It has been shown that the ability of autoregulation of cerebral flows in response to variations in arterial blood pressure in preterm infants is impaired. This impaired autoregulation causes an increased risk of germinal matrix rupture and IVH occurrence. We examined three polymorphisms of genes, related to regulation of blood flow, for an association with IVH in 100 preterm infants born from singleton pregnancy, before 32 + 0 weeks of gestation, exposed to antenatal steroids therapy, and without congenital abnormalities...
February 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28211648/cognitive-development-in-preterm-infants-multi-faceted-deficits-reflect-vulnerability-of-rigorous-neurodevelopmental-pathways
#15
Jessie R Maxwell, Tracylyn R Yellowhair, Akosua Y Oppong, Jenny E Camacho, Jean R Lowe, Lauren L Jantzie, Robin K Ohls
Prematurity remains the major cause of neonatal morbidity and mortality, with 15 million preterm births occurring worldwide in 2010. Infants born less than 37 weeks gestation are at high risk of abnormal neurodevelopmental outcomes, given that the central nervous system is extremely sensitive to an abnormal intra- and extra-uterine environment. Children born preterm have multiple neurodevelopmental sequelae involving dynamic and complex cognitive deficits. Former preterm infants have difficulty with each domain of cognition, including executive function, language, learning and memory, complex attention, perceptual-motor function and social cognition when compared to children born at term...
February 17, 2017: Minerva Pediatrica
https://www.readbyqxmd.com/read/28210010/evaluation-and-treatment-of-anemia-in-premature-infants
#16
Edo Hasanbegovic, Nermana Cengic, Snijezana Hasanbegovic, Jasmina Heljic, Ismail Lutolli, Edin Begic
INTRODUCTION: Anemia in preterm infants is the pathophysiological process with greater and more rapid decline in hemoglobin compared to the physiological anemia in infants. There is a need for transfusions and administration of human recombinant erythropoietin. AIM: To determine the frequency of anemia in premature infants at the Pediatric Clinic, University Clinical Center Sarajevo, as well as parameter values in the blood count of premature infants and to explore a relationship between blood transfusions with the advent of intraventricular hemorrhage (determine treatment outcome in preterm infants)...
December 2016: Medical Archives
https://www.readbyqxmd.com/read/28209638/the-effect-of-implementing-an-automated-oxygen-control-on-oxygen-saturation-in-preterm-infants
#17
H A Van Zanten, K L A M Kuypers, B J Stenson, T E Bachman, S C Pauws, A B Te Pas
OBJECTIVE: To evaluate the effect of implementing automated oxygen control as routine care in maintaining oxygen saturation (SpO2) within target range in preterm infants. METHODS: Infants <30 weeks gestation in Leiden University Medical Centre before and after the implementation of automated oxygen control were compared. The percentage of time spent with SpO2 within and outside the target range (90-95%) was calculated. SpO2 values were collected every minute and included for analysis when infants received extra oxygen...
February 16, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28209168/the-impact-of-preterm-birth-37%C3%A2-weeks-on-parents-and-families-a-cross-sectional-study-in-the-2%C3%A2-years-after-discharge-from-the-neonatal-intensive-care-unit
#18
Ashwini Lakshmanan, Meghana Agni, Tracy Lieu, Eric Fleegler, Michele Kipke, Philippe S Friedlich, Marie C McCormick, Mandy B Belfort
BACKGROUND: Little is known about the quality of life of parents and families of preterm infants after discharge from the neonatal intensive care unit (NICU). Our aims were (1) to describe the impact of preterm birth on parents and families and (2) and to identify potentially modifiable determinants of parent and family impact. METHODS: We surveyed 196 parents of preterm infants <24 months corrected age in 3 specialty clinics (82% response rate). Primary outcomes were: (1) the Impact on Family Scale total score; and (2) the Infant Toddler Quality of Life parent emotion and (3) time limitations scores...
February 16, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28208967/early-discharge-of-preterm-infants-an-indian-perspective
#19
Ankit Soni, Sandeep Kadam, Anand Pandit, Sanjay Patole
INTRODUCTION: Early home discharge of preterm infants is a priority in developing countries due to bed shortage and poor socio-economic status. There is wide variation in home discharge policies for preterm infants. Limited data exists on optimal timing for discharging such infants. In view of the socio-economic and medico-legal importance of the issue, we aimed to study the outcomes of our ex-preterm infants discharged home 'early', to guide our clinical practice. AIM: To study the rates of re-admissions/mortality within 4 weeks after discharge in preterm (born <34 weeks) infants...
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28207964/impaired-nephrogenesis-in-neonatal-rats-with-oxygen-induced-retinopathy
#20
Mayu Nakagawa, Naoto Nishizaki, Amane Endo, Tomonosuke Someya, Yuta Saito, Akira Mizutani, Taichi Hara, Yayoi Murano, Koji Sakuraya, Satoshi Hara, Daisuke Umino, Daishi Hirano, Shuichiro Fujinaga, Yoshiyuki Ohtomo, Toshiaki Shimizu
OBJECTIVES: Preterm neonates are born while nephrogenesis is ongoing and are commonly exposed to factors in a hyperoxic environment that can impair renal development. Oxidative stress has also been implicated in the development of retinopathy of prematurity (ROP). The rat model of oxygen-induced retinopathy (OIR) is the most clinically relevant model of ROP because its biologic features closely resemble those of ROP in preterm infants. We investigated impaired renal development in a rat model of OIR...
February 16, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
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