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paraneoplastic pleural effusion

Burcu Cirit Koçer, Yurdanur Erdoğan, Berna Akıncı Özyürek, Sertaç Büyükyaylacı Özden, Funda Demirağ
Paraneoplastic secretion of beta human chorionic gonadotropin (β-HCG) in non-small cell lung cancer (NSCLC) has been rarely reported. A 43-year old male patient was admitted with dyspnea and chest pain. Thorax computed tomography (CT) revealed bilateral multiple masses and pleural effusion at right hemithorax. Positron emission tomography (PET)-CT showed pathologic 18 FDG uptake at mass lesions and mediastinal lymph nodes. The serum β-HCG level was elevated. A bronchoscopy was performed and endobronchial lesion was observed...
December 0: Tüberküloz Ve Toraks
Amara Callistus Nwosu, Lauren Morris, Catriona Mayland, Stephen Mason, Andrew Pettitt, John Ellershaw
Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes (POEMS) syndrome is a rare paraneoplastic disorder associated with an underlying plasma cell dyscrasia and multiorgan failure. POEMS syndrome is potentially fatal and adversely affects quality of life. Oedema is common with many patients affected by pleural effusions, ascites and lower limb oedema. Bioelectrical impedance vector analysis (BIVA) is a non-invasive assessment tool, which enables rapid bedside assessments of nutrition and hydration...
September 2016: BMJ Supportive & Palliative Care
Adam H Miller, Sai-Ching J Yeung
BACKGROUND: The concurrence of ectopic adrenocorticotropic hormone (ACTH) syndrome (ectopic Cushing syndrome) and cancer is uncommon in the emergency department (ED) setting, but a constellation of nonspecific signs and symptoms can suggest the presence of Cushing syndrome. CASE REPORT: A 65-year-old woman with diabetes visited the ED complaining of severe weight loss, generalized weakness, and hypokalemia. She was treated for hypokalemia and thrush. She was found to have a lung mass with a large pleural effusion...
April 2016: Journal of Emergency Medicine
Takanori Asakura, Shuichi Yoshida, Arafumi Maeshima, Kazuyuki Fujimoto, Rie Jo, Kyoko Iwase, Yoshitaka Oyamada
Small cell lung cancer (SCLC) causes paraneoplastic syndromes, such as diabetes mellitus, by eliciting the expression of various antibodies including anti-glutamate decarboxylase (GAD) antibody. A 62-year-old woman presented to our hospital with a 1-week history of progressive dyspnea and difficulty in walking. Computed tomography showed a tumor obstructing the left bronchus and obstructive lung abscesses with pleural effusions. A biopsy during bronchoscopy revealed SCLC, and the clinical stage was ultimately determined to be IIIB...
2015: Internal Medicine
Abhinav Agrawal, Sonu Sahni, Asma Iftikhar, Arunabh Talwar
Renal cell carcinoma (RCC) accounts for majority of all primary renal neoplasms. Classic manifestations of RCC include the triad of flank pain, hematuria and a palpable renal mass. Patients with RCC can develop various extra renal manifestations including involvements of the lungs, inferior vena cava, liver and the bones. The pulmonary manifestations of renal cell carcinoma include metastatic disease including endobronchial, pleural, parenchymal or lymph node metastasis, pleural effusion or hemothorax. Pulmonary embolism and tumor embolism is another common manifestation of renal cell carcinoma...
December 2015: Respiratory Medicine
Enrico Ammirati, Miriam Stucchi, Michela Brambatti, Francesca Spanò, Edgardo Bonacina, Fabio Recalcati, Giulio Cerea, Angelo Vanzulli, Maria Frigerio, Fabrizio Oliva
No abstract text is available yet for this article.
June 20, 2015: Lancet
Yujun Dong, Mingyue Wang, Lin Nong, Lihong Wang, Xinan Cen, Wei Liu, Sainan Zhu, Yuhua Sun, Zeyin Liang, Yuan Li, Jinping Ou, Zhixiang Qiu, Hanyun Ren
This study retrospectively collected the clinical and laboratory data of 114 patients with Castleman disease (CD) from a single medical centre. Clinical classification identified 62 patients (54·4%) with unicentric Castleman disease and 52 (45·6%) with multi-centric Castleman disease. Pathological classification revealed 68 cases (59·6%) of hyaline vascular variant, 16 (14·1%) mixed cellular variant (Mix) and 30 (26·3%) plasmacytic variant. Clinical complications occurred in 69 CD patients, including 37 cases of paraneoplastic pemphigus (PNP) and 25 cases with renal complications...
June 2015: British Journal of Haematology
Xiaofeng Shi, Shudong Hu, Xianqiu Yu, Qin Zhuang, Min Luo, Qian Jiang, Lixia Wang, Yilong Lu, Xiaoming Fei, Xiaodong Xi, Yan Zhu
BACKGROUND: POEMS syndrome, a rare paraneoplastic disease, is related to multiple organs, multiple systems, and multiple disciplines and can be mistaken for other disorders. Consequently, the diagnoses are often delayed. In this work we studied the clinicopathologic characteristics of the POEMS syndrome to improve early diagnosis to prevent irreversible damage. PATIENTS AND METHODS: We conducted a clinicopathologic analysis of 9 cases of POEMS and made a differential diagnosis with related diseases...
January 2015: Clinical Lymphoma, Myeloma & Leukemia
Genta Ishikawa, Naoki Nishimura, Sayaka Mochizuki, Yasuhiko Yamano, Atsushi Kitamura, Yutaka Tomishima, Torahiko Jinta, Koyu Suzuki, Naohiko Chohnabayashi
We experienced a case of nephrotic syndrome (membranous nephropathy) complicated by extensive small cell carcinoma of unknown primary etiology that was diagnosed based on the findings of bilateral cervical and mediastinal lymphadenopathy. A complete cancer response and proteinuria remission following radical chemoradiation therapy were documented. The status of a complete response and nephrosis remission persisted for more than three years. This is the first report to demonstrate the long-term survival of a patient with extensive small cell carcinoma of unknown primary etiology complicated by paraneoplastic nephrotic syndrome...
2014: Internal Medicine
L Martinez, R Lamaze, C Clément-Duchêne
INTRODUCTION: Lung cancer is frequently associated with paraneoplastic syndromes, sometimes uncommon, among which motor neurone disease is sometimes described, including primary lateral sclerosis, a disorder characterized by slowly progressive cortico-spinal dysfunction due to the degeneration of the upper motor neurone. CASE REPORT: We report a case of primary lateral sclerosis developing in a young woman 9 months after the diagnosis of metastatic adenocarcinoma of the lung...
March 2013: Revue des Maladies Respiratoires
Yasuhiro Toyoda, Wakio Endo, Fumiyoshi Kojima, Hiroki Matsunaga, Kaori Shimizu, Akiko Yoshioka, Yujiro Fujie, Hiroki Fukunaga, Shigeyuki Hojo, Setsuko Yoshioka, Hirofumi Ota, Hiroaki Terada, Yoshiichi Maeura
A 59-year-old woman was admitted to our hospital because of right chest pain. CT scan showed a mass on the right abdominal wall and bilateral pleural effusion. The histological diagnosis following core needle biopsy was undifferentiated sarcoma. The right pleural effusion gradually increased despite negative cytology. Although we planned chemotherapy for the clinically diagnosed pleural invasion, thrombocytopenia as a paraneoplastic syndrome appeared. The minimum thrombocyte count was 4,000/mm3. While transfusion was not effective, per os dexamethasone at 2...
November 2012: Gan to Kagaku Ryoho. Cancer & Chemotherapy
Ja Young Ryu, Seung Hyeun Lee, Eun Joo Lee, Kyung Hoon Min, Gyu Young Hur, Sung Yong Lee, Je Hyeong Kim, Sang Yeub Lee, Chol Shin, Jae Jeong Shim, Kwang Ho In, Kyung Ho Kang, Se Hwa Yoo
Paraneoplastic limbic encephalitis (PLE) is a rare syndrome characterized by memory impairment, affective and behavioral disturbances and seizures. Among many different neoplasms known to cause PLE, small cell lung cancer (SCLC) is the most frequently reported. The pathogenesis is not fully understood but is believed to be autoimmune-related. We experienced a patient with typical clinical features of PLE. A 67-year-old man presented with seizure and disorientation. Brain magnetic resonance imaging demonstrated high signal intensity in the bilateral amygdala and hippocampus in flair and T2-weighted images suggestive of limbic encephalitis...
November 2012: Tuberculosis and Respiratory Diseases
Ivica Premuzić Mestrović, Maro Dragicević, Domagoj Mosler, Tomislav Mestrović, Elvira Lazić Mosler, Damir Kozmar, Stjepan Kranjcević, Darko Pocanić, Gordana Cavrić, Kristina Narancić Skorić, Tomislav Letilović, Helena Jerkić, Hrvojka Zeljko, Ika Kardum-Skelin
Pleural mesothelioma is a rare neoplasm with the incidence of 1-2 per million people. The incidence is higher in male population (10-30/million), whereas the incidence in female population is 2 per million. It occurs predominantly at older age (65+ years). The most common clinical manifestation of pleural mesothelioma is pleural effusion with dyspnea, which makes it a diagnostic problem since many cardiac diseases can have the same presentation. We report a case of pleural mesothelioma in an 80-year-old woman that presented with dyspnea and pleural effusion, which was at first considered as a sign of heart failure...
September 2011: Acta Medica Croatica: C̆asopis Hravatske Akademije Medicinskih Znanosti
Tânia Marie Ogawa, Ricardo Mauro Ghetti Cabral, Vera Demarchi Aiello
No abstract text is available yet for this article.
March 2012: Arquivos Brasileiros de Cardiologia
Girija Nair, I Lobo, T K Jaya Laxmi, Abhay G Uppe, Shivani Swami, Abhash Jain
A 67 year old man presented to us with petechial skin rash and blebs on the legs. He was on anti-tuberculous treatment for right sided pleural effusion since 1 month. A provisional diagnosis of Rifampicin induced drug rash was made and his effusion reaspirated and sent for AFB and cytology. The pleural fluid cytology demonstrated metastasis of adenocarcinoma and biopsy of skin lesion confirmed vasculitis. There was no thrombocytopenia. CT thorax showed right lower lobe mass with right sided pleural effusion...
July 2011: Journal of the Association of Physicians of India
C A Kossakowski, P Schmiegelow, K-M Müller
A 76-year-old man presented clinically with coughing and shortness of breath and was diagnosed radiologically to have massive pleural effusion as a combined feature of yellow nail syndrome. A lung biopsy was taken and revealed histologically: chronic non-specific inflammation in the pleuropulmonary border, intrapleural edema with eightfold pleural thickening in comparison to normal, angiogenesis in both the nutritive and functional intrapleural blood vessels, no abnormalities of lymphatic vessels with normal topographical distribution as detected by immunohistochemistry for antibody D2-40, granulomatous chronic foreign body reaction as a consequence of pleural effusion therapy by talcum pleurodesis...
March 2012: Der Pathologe
A Gantzer, S Regnier, A Cosnes, N Ortonne, P Wolkenstein, M Bagot, T-A Duong
BACKGROUND: Subacute cutaneous lupus erythematosus is an uncommon dermatosis characterised by a non-scarring, annular photo-distributed dermatosis associated with anti-Ro/SSA antibodies. It is remarkable as a paraneoplastic syndrome (12 cases in the literature). We report two cases of subacute cutaneous lupus erythematosus occurring in patients treated for metastatic breast adenocarcinoma. CASE REPORTS: Case 1: a 72-year-old woman with breast carcinoma relapsing after surgery, chemotherapy, hormone therapy, and without treatment for 6 months, was admitted for an acute erythematous slightly squamous and photo-distributed eruption...
May 2011: Annales de Dermatologie et de Vénéréologie
M Esther San José, Luis Valdés, Luis H Vizcaíno, Teresa Mora, Antonio Pose, Esther Soneira, Carmen Crecente, Francisco J González-Barcala
BACKGROUND AND OBJECTIVE: Pleural effusion is relatively common in pneumonia. Because traditional methods for its diagnosis are not always effective, there is a need for new biomarkers to make its differential diagnosis easier. METHODS: A total of 233 patients with pleural effusion were admitted to our hospital between 2005 and 2008. Total and differential leukocyte counts, along with blood and pleural fluid procalcitonin and C-reactive protein (CRP) were performed on all of them...
December 2010: Journal of Investigative Medicine: the Official Publication of the American Federation for Clinical Research
M Esther San José, Luis Valdes, F Javier Gonzalez-Barcala, Luis Vizcaino, Manuel Garrido, Angeles Sanmartin, Sara Mougan, Antonio Pose, Angel Segade
Pleural effusion appears in approximately 40% of patients with pneumonia. Given that microbiology results are often negative, its diagnosis is frequently based on clinical criteria. Our study consisted of 266 patients, divided into infectious (n = 34), tuberculous (n = 54), paraneoplastic (n = 63), miscellaneous exudates (n = 53), and transudates (n = 62). Interleukin (IL)-6, IL-8, and IL-1beta were measured in the pleural fluid and serum of all patients, as well as the different cell populations in the pleural fluid...
June 2010: American Journal of Clinical Pathology
Jaromir Kotyza, David Havel, Jindra Vrzalová, Vlastimil Kulda, Milos Pesek
Besides massive expression in inflammatory pleural effusions, inflammatory markers are also present in cancerinduced pleural effusions. Recent advances in cancer biology point to a role of inflammatory signaling in cancer and encourage reconsidering the diagnostic and prognostic value of inflammatory markers. Here an attempt was made to relate protein levels of inflammatory markers to underlying malignant processes in the pleural space. Pleural effusions from lung cancer patients (n=116) were subjected to a multifactorial analysis covering 13 inflammatory markers...
January 2010: International Journal of Biological Markers
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